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  • November 18, 2015
  • 02:00 PM
  • 1,034 views

Predictors of Poor Outcome After Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

The outcome following traumatic brain injury (TBI) is often unpredictable and variable.Two individuals with similar types of TBI can have quite different outcomes ranging from total disability to functional employment.Torun Finnanger and colleagues from Norway and Australia recently reported on a study that examined a number of predictor variables on self-reported outcome following TBI.In this study, 67 adolescents and adults with moderate to severe TBI completed baseline assessments and were fo........ Read more »

  • November 16, 2015
  • 12:40 PM
  • 988 views

Smell Test in Screening for Parkinson's Disease Risk

by William Yates, M.D. in Brain Posts

Molecular model of polypeptide parkinIdentification of early or prodromal stages of the diseases of neuroscience medicine is an important clinical and research goal.Identification of prodromal illness allows for enhanced surveillance and initiation of secondary prevention interventions.Impairment of smell or olfactory sensation is a key early clue for Parkinson's disease (PD).Danna Jennings and colleagues recently published an important study of the role of smell impairment in prodromal PD.This ........ Read more »

Jennings D, Siderowf A, Stern M, Seibyl J, Eberly S, Oakes D, Marek K, & PARS Investigators. (2014) Imaging prodromal Parkinson disease: the Parkinson Associated Risk Syndrome Study. Neurology, 83(19), 1739-46. PMID: 25298306  

  • November 13, 2015
  • 05:25 AM
  • 947 views

Attention Deficit Hyperactivity Disorder and the Influence of Stimulant Medication on Neurocognitive Test Performance

by Diana Marquez & Gerard Talbot-Paul in Sports Medicine Research (SMR): In the Lab & In the Field

Athletic trainers should be aware of an athlete’s medication at the time of baseline or post-concussion testing because they may influence neurocognitive testing results.... Read more »

  • November 12, 2015
  • 05:06 PM
  • 821 views

Study Supports Shared Biology Between Schizophrenia and Epilepsy

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Frederick W. Vonberg, MA, MBBS Research Fellow in Neurocritical Care Boston Children’s Hospital and Harvard Medical School Medical Research: What is the background for this study? What are the main findings? Response: An association between schizophrenia and epilepsy has long … Continue reading →
The post Study Supports Shared Biology Between Schizophrenia and Epilepsy appeared first on MedicalResearch.com.
... Read more »

Frederick W. Vonberg, MA, MBBS. (2015) Study Supports Shared Biology Between Schizophrenia and Epilepsy. MedicalResearch.com. info:/

  • November 12, 2015
  • 12:51 PM
  • 814 views

Screening for Cognitive Impairment in Parkinson's Disease

by William Yates, M.D. in Brain Posts

Sunset in Blanchard, OK courtesy of Dr. Tim YatesThere is a significant need for improvement in the tools available for screening for cognitive impairment in a variety of disorders in neuroscience medicine.The Mini-Mental State Examination Score (MMSE) is a widely used 30-item scale for screening dementia and other neurological conditions.However, the MMSE has some significant weaknesses for use in the clinical setting.Jin Qiao and colleagues from China recently published a study testing th........ Read more »

  • November 10, 2015
  • 12:35 PM
  • 811 views

Brain Inflammation in Dementia with Lewy Bodies

by William Yates, M.D. in Brain Posts

The role of inflammation in the brain is receiving increased attention in dementia and other disorders in neuroscience medicine.Dementia with Lewy bodies (DLB) is the third leading cause of dementia. This disorder has received increased attention with the finding of the condition in the autopsy of comedian and actor Robin Williams.Patrick Ejlerskov and colleagues from Denmark, Sweden, Germany and the United Kingdom recently published an informative study in the journal Cell on this topic.Cytokin........ Read more »

Ejlerskov P, Hultberg JG, Wang J, Carlsson R, Ambjørn M, Kuss M, Liu Y, Porcu G, Kolkova K, Friis Rundsten C.... (2015) Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia. Cell, 163(2), 324-39. PMID: 26451483  

  • November 4, 2015
  • 02:50 PM
  • 974 views

Brain Imaging in Diagnosis of Lewy Body Dementia

by William Yates, M.D. in Brain Posts

Brain image highlighting right insula implicated in DLBRecent information has emerged concerning the suicide death of the comedian/actor Robin Williams.Autopsy results have demonstrated that Robin Williams suffered from dementia with Lewy bodies (DLB).This public case demonstrates the difficulty in making a correct diagnosis of DLB prior to the findings at autopsy.In a previous post I reported on a screening tool for clinicians that appears to have some promise for screening for high-risk DLB pa........ Read more »

  • October 30, 2015
  • 12:06 PM
  • 1,180 views

Wii Fit Games for Children with Coordination Problems

by William Yates, M.D. in Brain Posts

Among the types of development problems of childhood is developmental coordination disorder or DCD.In DCD, children show delay and subnormal performance in coordinated motor skills.This may be noted as a general tendency of clumsiness with difficulties in activities such as catching a ball, using scissors, handwriting or riding a bike.Computer games such as the Nintendo Wii platform provide a method to improve a variety of motor and coordination skills in a fun environment.A South African team r........ Read more »

  • October 27, 2015
  • 12:10 PM
  • 1,081 views

Improving Diagnosis of Lewy Body Dementia

by William Yates, M.D. in Brain Posts

This month I have been focusing on research advances in neuropsychology in neuroscience medicine.My daily feed screener picked up a report of a screening tool for Lewy Body Dementia (LBD) today.LBD is often confused with Alzheimer's disease. Distinguishing the two is important for management and selection of appropriate drug treatment.This research is not published in a free full-text manuscript format but there is a link to the scale for readers with more interest.The research study examined th........ Read more »

  • October 21, 2015
  • 09:30 AM
  • 1,297 views

Mostly Dead Is Slightly Alive

by Mark Lasbury in As Many Exceptions As Rules

Halloween brings stories of the undead, the dead coming back to life, and the dead staying dead but still coming to visit you. But the scariest of all is the prospect of being buried alive. It happened all to often in the most recent three centuries, so people devised some amazing precautions to prevent premature burial. Nowadays it’s less likely to happen, but there are several conditions that can mimic death and could lead to fingernail scratches inside the lid of a casket.... Read more »

Christopher Dibble. (2010) The Dead Ringer: Medicine, Poe, and the fear of premature burial. Historia Medicinae. info:/

  • October 20, 2015
  • 01:50 PM
  • 769 views

Hopelessness as Risk Factor for Alzheimer's Disease

by William Yates, M.D. in Brain Posts

Original figure from Hakansson K et al. (citation below)I have been reviewing advances in neuropsychology in neuroscience medicine.One important relevant topic is the art of neuropsychological testing for the early diagnosis and monitoring of Alzheimer's and other dementias.Another important focus is finding neuropsychological risk factors for later development of cognitive impairment.Mid-life depression has been identified as a risk factor for later life cognitive impairment and Alzheimer's dis........ Read more »

  • October 15, 2015
  • 12:54 PM
  • 844 views

Tools for Alzheimer's Screening: BrainCheck

by William Yates, M.D. in Brain Posts

Screening for cognitive decline and early Alzheimer's disease presents a clinical challenge for primary care providers.A variety of tests and tools are available for use but limited research has focused on testing in primary care settings.Michael Ehrensperger and colleagues recently published a study of a brief tool for screening for cognitive decline called BrainCheck.This tool combines a patient interview, an informant interview and the Clock Drawing Test administered in combination.The import........ Read more »

  • October 14, 2015
  • 09:10 AM
  • 1,088 views

Blood --- Not Just For Vampires Anymore

by Mark Lasbury in As Many Exceptions As Rules

Halloween brings talk of vampires, but is consuming blood what makes a person a vampire? If so, almost everyone is a vampire. The vampire bat is an amazing biological exception, and it’s biology saves lives and has inspired a new drone. But not ever person who looks like a vampire sucks blood; several diseases mimic vampirism.... Read more »

  • October 12, 2015
  • 12:29 PM
  • 890 views

Neuroplasticity and Training the Older Brain

by William Yates, M.D. in Brain Posts

Neuroplasticity is the brain and nervous systems ability to evolve and to repair deficits.At a basic level it represents the ability to learn and develop a structural and functional system to interact with the environment.The brain's neuroplasticity is maximized during childhood and adolescence. This adaptability wanes with age. However, some neuroplasticity ability persists in the older brain.This persistence was highlighted in a study from Hong Kong recently published in the journal Neural Pla........ Read more »

Leung NT, Tam HM, Chu LW, Kwok TC, Chan F, Lam LC, Woo J, & Lee TM. (2015) Neural Plastic Effects of Cognitive Training on Aging Brain. Neural plasticity, 535618. PMID: 26417460  

  • October 1, 2015
  • 01:04 PM
  • 622 views

Does Brain Injury Increase Criminal Behavior?

by William Yates, M.D. in Brain Posts

Traumatic brain injury produces a variety of cognitive effects.Some individuals will have behavioral disturbances including anger outbursts and interpersonal conflict.A recent study examined the rates of first criminal conviction in a group of 7694 men and women hospitalized with traumatic brain injury (TBI).The study found about a 50 to 75% increase in rates of post-TBI criminal convictions including violent convictions. This effect was noted using either general population controls or sibling ........ Read more »

  • September 30, 2015
  • 08:55 AM
  • 1,135 views

Twins of Different Seasons

by Mark Lasbury in As Many Exceptions As Rules

Twins are born near the same time, that’s one of the things that makes them twins. But do they have to be born close to one another? The record is twins born 104 days apart. The key is to get the twins past 25 weeks so the lungs will be mature enough, but if one twin is delivered, the second might be subjected to delayed interval delivery to give the lungs longer to grow.... Read more »

Reinhard, J., Reichenbach, L., Ernst, T., Reitter, A., Antwerpen, I., Herrmann, E., Schlösser, R., & Louwen, F. (2012) Delayed interval delivery in twin and triplet pregnancies: 6 years of experience in one perinatal center. Journal of Perinatal Medicine, 40(5). DOI: 10.1515/jpm-2011-0267  

Padilla-Iserte, P., Vila-Vives, J., Ferri, B., Gómez-Portero, R., Diago, V., & Perales-Marín, A. (2014) Delayed Interval Delivery of the Second Twin: Obstetric Management, Neonatal Outcomes, and 2-Year Follow-Up. The Journal of Obstetrics and Gynecology of India, 64(5), 344-348. DOI: 10.1007/s13224-014-0544-1  

Lewi, L., Devlieger, R., De Catte, L., & Deprest, J. (2014) Growth discordance. Best Practice , 28(2), 295-303. DOI: 10.1016/j.bpobgyn.2013.12.003  

  • September 29, 2015
  • 12:04 PM
  • 751 views

Cognitive Enhancers in Neuroscience Medicine

by William Yates, M.D. in Brain Posts

Neuropsychiatric disorders cause impairment via multiple pathways. One pathway to impairment is cognitive impairment via attention problems, cognitive slowing and memory disruption.Barbara Sahakian and colleagues recently published an interesting manuscript examining the issue of cognitive enhancement.Their review begins by summarizing some of the research related to cognitive enhancement in four neuropsychiatric syndromes. I will summarize their main points by specific disorder.Alzheimer's Dise........ Read more »

Sahakian BJ, Bruhl AB, Cook J, Killikelly C, Savulich G, Piercy T, Hafizi S, Perez J, Fernandez-Egea E, Suckling J.... (2015) The impact of neuroscience on society: cognitive enhancement in neuropsychiatric disorders and in healthy people. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 370(1677). PMID: 26240429  

  • September 28, 2015
  • 01:05 AM
  • 811 views

Our Genes May Affect Our Long-Term Outcome After Mild Traumatic Brain Injury

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Take Home Message: Single and repetitive mild traumatic brain injury (mTBI) accelerates tauopathy among mice genetically predisposed to tau build up.... Read more »

  • September 15, 2015
  • 10:55 AM
  • 425 views

Low Vitamin D Associated With Accelerated Cognitive Decline

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Joshua W. Miller, PhD Professor and Chair Dept. of Nutritional Sciences Rutgers The State University of New Jersey New Brunswick, NJ 08901  Medical Research: What is the background for this study? What are the main findings? Response: … Continue reading →
The post Low Vitamin D Associated With Accelerated Cognitive Decline appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
... Read more »

Joshua W. Miller, PhD. (2015) Low Vitamin D Associated With Accelerated Cognitive Decline. MedicalResearch.com. info:/

  • September 14, 2015
  • 01:05 AM
  • 812 views

Athletic Trainers and Physicians Are Under Pressure to Release Concussed Athletes Prematurely

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

More than half of the sports medicine staff experience pressure from coaches and athletes to release athletes prematurely to play following a concussion.... Read more »

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