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  • April 6, 2015
  • 10:46 AM
  • 927 views

Rare Variants in Complex Disease: ABCA7 and Alzheimer’s

by Daniel Koboldt in Massgenomics

Although the cost of sequencing continues to fall precipitously (cue the NIH sequencing-versus-Moore’s-Law figure), it’s still expensive relative to high-throughput genotyping. Whole-genome sequencing on the X Ten costs around $2500 per sample by the time you account for basic analysis and data storage. This means that a well-powered genetic association study for complex disease (10,000 […]... Read more »

Steinberg S, Stefansson H, Jonsson T, Johannsdottir H, Ingason A, Helgason H, Sulem P, Magnusson OT, Gudjonsson SA, Unnsteinsdottir U.... (2015) Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease. Nature genetics. PMID: 25807283  

  • April 6, 2015
  • 01:05 AM
  • 748 views

Concussions and Depression… Is There a Connection?

by Jessica Herek and Adam Rosen in Sports Medicine Research (SMR): In the Lab & In the Field

Athletes demonstrated greater rates of depression post-concussion. Older age, baseline depression symptoms, and increased concussion-related symptoms were factors most associated with post-concussion depression.... Read more »

  • March 30, 2015
  • 01:05 AM
  • 806 views

On-field Management and Return-to-Play in Concussed Children are Lacking

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Only 58% of concussed children were managed according to recommended guidelines and 13% returned to play while symptomatic. Additionally, 93% of parents and 96% of players were unaware of their organization’s return-to-play guidelines following a concussion.... Read more »

  • March 17, 2015
  • 09:00 AM
  • 1,934 views

I See, Said The Blind Man

by Mark E. Lasbury in The 'Scope

I can’t stand it when I get dust in my eye. Can you imagine having a neural implant in your eye? Star Trek’s Geordi LaForge had implanted electrodes that, along with his visor, let him see. Visual neural prostheses are no longer a thing of science fiction, making the blind see is science fact. The only difference is that he saw in all wavelengths of the electromagnetic spectrum. But there’s no reason we can’t do that as well. ... Read more »

Jung, J., Aloni, D., Yitzhaky, Y., & Peli, E. (2014) Active confocal imaging for visual prostheses. Vision Research. DOI: 10.1016/j.visres.2014.10.023  

Nirenberg, S., & Pandarinath, C. (2012) Retinal prosthetic strategy with the capacity to restore normal vision. Proceedings of the National Academy of Sciences, 109(37), 15012-15017. DOI: 10.1073/pnas.1207035109  

Stingl, K., Bartz-Schmidt, K., Gekeler, F., Kusnyerik, A., Sachs, H., & Zrenner, E. (2013) Functional Outcome in Subretinal Electronic Implants Depends on Foveal Eccentricity. Investigative Ophthalmology , 54(12), 7658-7665. DOI: 10.1167/iovs.13-12835  

  • March 16, 2015
  • 06:47 AM
  • 853 views

Update on the BROADEN Trial of DBS for Treatment-Resistant Depression

by The Neurocritic in The Neurocritic

Website for the BROADEN™ study, which was terminatedIn these days of irrational exuberance about neural circuit models, it's wise to remember the limitations of current deep brain stimulation (DBS) methods to treat psychiatric disorders. If you recall (from late 2013), Neurotech Business Report revealed that "St. Jude Medical failed a futility analysis of its BROADEN trial of DBS for treatment of depression..."A recent comment on my old post about the BROADEN Trial1 had an even more pessimist........ Read more »

  • March 16, 2015
  • 06:00 AM
  • 723 views

Don’t Blink. The King-Devick Test: A Rapid, Sideline Visual Assessment Tool to Assist in Detection of Concussion

by Adam Rosen and Andrew Sheridan in Sports Medicine Research (SMR): In the Lab & In the Field

The King-Devick test is a quick and reliable method to assess vision, eye movements, language function, and attention. An athlete with a concussion tends to complete the test slower than his/her preseason assessment while other athletes improve over time. ... Read more »

  • March 11, 2015
  • 10:03 AM
  • 799 views

After Consulting Dr. Wiki, You Should Get a Second Opinion

by Vivek Misra in Uberbrain Research Frontier

We have all been there: waking up in the middle of the night with a pounding headache, nausea, rashes on skin or another ailment with an unexplained origin. More often than not, first thing we’re inclined to do is begin... Read more »

Hasty RT, Garbalosa RC, Barbato VA, Valdes PJ Jr, Powers DW, Hernandez E, John JS, Suciu G, Qureshi F, Popa-Radu M.... (2014) Wikipedia vs peer-reviewed medical literature for information about the 10 most costly medical conditions. The Journal of the American Osteopathic Association, 114(5), 368-73. PMID: 24778001  

  • March 4, 2015
  • 12:48 PM
  • 431 views

Some mRNAs Related To Onset and Extent of Huntington’s Disease

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. Richard H. Myers Ph.D. Department of Neurology and Genome Science Institute Boston University School of Medicine, Boston, MA MedicalResearch: What is the background for this study? What are the main findings? Dr. Myers:  Andy Hoss, who … Continue reading →... Read more »

MedicalResearch.com Interview with:, Dr. Richard H. Myers Ph.D., Department of Neurology and Genome Science Institute, & Boston University School of Medicine, Boston, MA. (2015) Some mRNAs Related To Onset and Extent of Huntington's Disease. MedicalResearch.com. info:/

  • February 24, 2015
  • 09:48 AM
  • 724 views

Cognitive Function Test Helps Predict Future Memory Loss

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. Rebecca E. Amariglio Ph.D. Massachusetts Alzheimers Disease Research Center Massachusetts General Hospital Medical Research: What is the background for this study? What are the main findings? Dr. Amariglio: As the field of Alzheimer’s disease moves towards … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Dr. Rebecca E. Amariglio Ph.D. (2015) Cognitive Function Test Helps Predict Future Memory Loss. MedicalResearch.com. info:/

  • February 18, 2015
  • 08:30 AM
  • 953 views

Space - It'll Mess You Up

by Mark Lasbury in As Many Exceptions As Rules

Extended spaceflight can wreak havoc on your body – your bones, muscles, brain and vestibular system all pay the price for exploration. And while your body might adapt to space, big problems can occur when you return to Earth gravity. You go into space as a virile astronaut, but return as fragile as a your great grandmother. ... Read more »

Finetti, F., Paccani, S., Rosenbaum, J., & Baldari, C. (2011) Intraflagellar transport: a new player at the immune synapse. Trends in Immunology, 32(4), 139-145. DOI: 10.1016/j.it.2011.02.001  

Troshichev, O., Gorshkov, E., Shapovalov, S., Sokolovskii, V., Ivanov, V., & Vorobeitchikov, V. (2004) Variations of the gravitational field as a motive power for rhythmics of biochemical processes. Advances in Space Research, 34(7), 1619-1624. DOI: 10.1016/j.asr.2004.02.013  

Fitts, R., Trappe, S., Costill, D., Gallagher, P., Creer, A., Colloton, P., Peters, J., Romatowski, J., Bain, J., & Riley, D. (2010) Prolonged space flight-induced alterations in the structure and function of human skeletal muscle fibres. The Journal of Physiology, 588(18), 3567-3592. DOI: 10.1113/jphysiol.2010.188508  

  • February 16, 2015
  • 04:54 PM
  • 814 views

Cigarette Smoking Leads to Thinning of the Brain’s Cortex

by Vivek Misra in Uberbrain Research Frontier

Cigarette smoking is associated with cognitive decline and dementia, but the extent of the association between smoking and structural brain changes remains unclear. According to recent study published by Karama et.al., in Molecular Psychiatry, “long-term smoking could cause thinning of the outer layer of the brain involved in critical cognitive functions such as memory and language.” Although the cortex grows thinner with normal ageing, the study found that smoking appears to accelerate the ........ Read more »

Karama, S., Ducharme, S., Corley, J., Chouinard-Decorte, F., Starr, J., Wardlaw, J., Bastin, M., & Deary, I. (2015) Cigarette smoking and thinning of the brain’s cortex. Molecular Psychiatry. DOI: 10.1038/mp.2014.187  

  • February 15, 2015
  • 04:32 PM
  • 424 views

ISC 2015: Analysis of MR CLEAN Trial for Endovascular Therapy in Acute Ischemic Stroke

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Dr. May Nour MD PhD Neurology Fellow UCLA Medical Research: What is the background for this study? What are the main findings? Dr. Nour: In October of 2014, results from the MR CLEAN trial were the first … Continue reading →
The post ISC 2015: Analysis of MR CLEAN Trial for Endovascular Therapy in Acute Ischemic Stroke appeared first on MedicalResearch.com Medical Research Interviews and New........ Read more »

MedicalResearch.com Interview with:, Dr. May Nour MD PhD, Neurology Fellow, & UCLA. (2015) ISC 2015: Analysis of MR CLEAN Trial for Endovascular Therapy in Acute Ischemic Stroke. MedicalResearch.com. info:/

  • February 11, 2015
  • 09:00 AM
  • 1,058 views

Thinking Skinny Thoughts Won’t Help

by Mark Lasbury in As Many Exceptions As Rules

As with so many other things, we learn biology best by studying what happens when things go wrong. You won’t believe the diseases that are being linked to this most innocuous of cell structures. Without any exaggeration, primary cilia make you smart, skinny, and happy. Let’s find out how.... Read more »

Tong, C., Han, Y., Shah, J., Obernier, K., Guinto, C., & Alvarez-Buylla, A. (2014) Primary cilia are required in a unique subpopulation of neural progenitors. Proceedings of the National Academy of Sciences, 111(34), 12438-12443. DOI: 10.1073/pnas.1321425111  

Han, Y., Kang, G., Byun, K., Ko, H., Kim, J., Shin, M., Kim, H., Gil, S., Yu, J., Lee, B.... (2014) Leptin-promoted cilia assembly is critical for normal energy balance. Journal of Clinical Investigation, 124(5), 2193-2197. DOI: 10.1172/JCI69395  

Davenport JR, Watts AJ, Roper VC, Croyle MJ, van Groen T, Wyss JM, Nagy TR, Kesterson RA, & Yoder BK. (2007) Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Current biology : CB, 17(18), 1586-94. PMID: 17825558  

Keryer, G., Pineda, J., Liot, G., Kim, J., Dietrich, P., Benstaali, C., Smith, K., Cordelières, F., Spassky, N., Ferrante, R.... (2011) Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. Journal of Clinical Investigation, 121(11), 4372-4382. DOI: 10.1172/JCI57552  

Miyoshi, K., Kasahara, K., Miyazaki, I., & Asanuma, M. (2009) Lithium treatment elongates primary cilia in the mouse brain and in cultured cells. Biochemical and Biophysical Research Communications, 388(4), 757-762. DOI: 10.1016/j.bbrc.2009.08.099  

  • February 4, 2015
  • 10:32 AM
  • 701 views

Exercise in the Elderly: BDNF and Executive Function

by William Yates, M.D. in Brain Posts

Exercise promotes cognitive function in children, adults and elderly individuals.The mechanism for this effect is unclear. Some of the effect may be due to a general improvement in vascular function and health.Another potential mechanism is via increased neuroplasticity mediated by neurotrophic factors.Brain-derived neurotrophic factor (BNDF) is a known contributor to brain neuroplasticity. Levels of BNDF can be determined with serum assays.RL Leckie and colleagues recently found support for BND........ Read more »

Leckie RL, Oberlin LE, Voss MW, Prakash RS, Szabo-Reed A, Chaddock-Heyman L, Phillips SM, Gothe NP, Mailey E, Vieira-Potter VJ.... (2014) BDNF mediates improvements in executive function following a 1-year exercise intervention. Frontiers in human neuroscience, 985. PMID: 25566019  

  • February 4, 2015
  • 09:00 AM
  • 1,280 views

An Immovable Moving Part- That’s Just Cilia!

by Mark Lasbury in As Many Exceptions As Rules

Nothing is simple, and we wouldn’t want it that way. The cilia on cells; they’re for propelling a cell forward or back, or for moving fluid past the cell. Unless they don’t move at all. Could a broken cilium be important to us? You bet, they control every part of our lives. And some aren’t even cilia; sterocilia are made completely differently, but the diseases of cilia affect sterocilia as well – they can make you blind, deaf and unbalanced.... Read more »

  • February 2, 2015
  • 04:54 PM
  • 666 views

Musical Training May Bolster Brain Plasticity Across A Lifetime

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with Gavin M. Bidelman, Ph.D. Assistant Professor Institute for Intelligent Systems School of Communication Sciences & Disorders University of Memphis Memphis, TN  38105 MedicalResearch: What is the background for this study? What are the main findings? Dr. Bidelman: … Continue reading →
The post Musical Training May Bolster Brain Plasticity Across A Lifetime appeared first on MedicalResearch........ Read more »

MedicalResearch.com Interview with, & Gavin M. Bidelman, Ph.D. (2015) Musical Training May Bolster Brain Plasticity Across A Lifetime. MedicalResearch.com. info:/

  • February 2, 2015
  • 12:39 PM
  • 966 views

Exercise in the Prevention of Alzheimer's Disease

by William Yates, M.D. in Brain Posts

Growing evidence links physical activity to improved cognitive outcome in elderly individuals.Few studies have examined effects of exercise on those at highest risk for Alzheimer's disease.J Carson Smith and colleagues recently published a prospective study of a cohort of older adults using structural magnetic resonance imaging.The key elements of the design of their study included the following elements:Participants: 97 adults between the ages of 65 and 89Physical activity level: Frequency and ........ Read more »

Smith JC, Nielson KA, Woodard JL, Seidenberg M, Durgerian S, Hazlett KE, Figueroa CM, Kandah CC, Kay CD, Matthews MA.... (2014) Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease. Frontiers in aging neuroscience, 61. PMID: 24795624  

  • February 2, 2015
  • 01:05 AM
  • 649 views

No Strict Rest for the Weary or Concussed

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

For individuals 11 to 22 years of age, strict rest after a concussion had no added benefit compared to 1-2 days of rest before the stepwise program.... Read more »

  • February 1, 2015
  • 10:15 AM
  • 379 views

An Improved Test for Creutzfeldt-Jakob Disease

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Byron Caughey, PhD Senior Investigator Rocky Mountain Laboratories National Institute for Allergy and Infectious Diseases National Institutes of Health Hamilton, Montana 59840 MedicalResearch: What is the background for this study? What are the main findings? Dr. Caughey: … Continue reading →
The post An Improved Test for Creutzfeldt-Jakob Disease appeared first on MedicalResearch.com Medica........ Read more »

MedicalResearch.com Interview with:, Byron Caughey, PhD, Senior Investigator, Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, National Institutes of Health, & Hamilton, Montana 59840. (2015) An Improved Test for Creutzfeldt-Jakob Disease. MedicalResearch.com. info:/

  • January 26, 2015
  • 11:02 AM
  • 713 views

Obesity, Inflammation and Cognitive Decline

by William Yates, M.D. in Brain Posts

The rate of cognitive decline with aging is quite variable. Identifying important components of this process is needed for developing interventions to reduce the burden of Alzheimer's and other dementias.Excess inflammation has been linked to obesity as well as aging-related cognitive decline.Archana Singh-Manoux and colleagues recently published a study of the association between blood markers of inflammation and cognitive decline.This study used data from the U.K. Whitehall II cohort, a g........ Read more »

Singh-Manoux A, Dugravot A, Brunner E, Kumari M, Shipley M, Elbaz A, & Kivimaki M. (2014) Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife. Neurology, 83(6), 486-93. PMID: 24991031  

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