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  • March 13, 2017
  • 11:38 AM
  • 136 views

Earliest Brain Changes in Alzheimer's Disease

by William Yates, M.D. in Brain Posts

Amyloid brain plaques are well-known pathological changes associated with Alzheimer's disease. Changes preceding amyloid plaque build up are less well studied and understood. Some of this relates to limitations to current imaging technology.Klementieva and colleagues from Sweden and Spain recently published an important reserach topic in this area.Their studied used a rat model of Alzheimer's disease and imaging techniques that included infrared microspectroscopy and gel electrophoresis.The........ Read more »

Klementieva, O., Willén, K., Martinsson, I., Israelsson, B., Engdahl, A., Cladera, J., Uvdal, P., & Gouras, G. (2017) Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP. Nature Communications, 14726. DOI: 10.1038/ncomms14726  

  • March 2, 2017
  • 12:19 PM
  • 159 views

Improving Hearing-Aid Access in Older Adults

by William Yates, M.D. in Brain Posts

There are significant barriers to widespread use of hearing-aids in older adults with age-related hearing loss.Sensitivity to the stigma of wearing a hearing-aid is one barrier.Cost is another significant barrier. In the U.S., bilateral hearing-aid purchase amounts to a cost of $2400 to $5800. This cost is typically not covered by Medicare or other health insurance plans.I ran into a interesting manuscript on looking at an alternative less costlier approach to hearing-aid selection and purchase......... Read more »

  • February 13, 2017
  • 04:30 AM
  • 206 views

Blood Test Could Help Provide Information on Prolonged Concussion Recovery

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Elevated plasma tau concentrations within 6 hours of sport-related concussion was associated with prolonged return to play.... Read more »

Gill, J., Merchant-Borna, K., Jeromin, A., Livingston, W., & Bazarian, J. (2017) Acute plasma tau relates to prolonged return to play after concussion. Neurology, 88(6), 595-602. DOI: 10.1212/WNL.0000000000003587  

  • February 8, 2017
  • 04:30 AM
  • 208 views

Physical Activity Within 7 Days May Lead to Better Long-Term Outcomes After a Concussion

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Among children and adolescents with acute concussion, participation in physical activity within 7 days of acute injury compared with no physical activity was associated with lower risk of persistent postconcussion symptoms at 28 days post injury.... Read more »

  • January 18, 2017
  • 04:30 AM
  • 260 views

Alterations in Leg Stiffness Following A Concussion May Lead to Changes in Return-to-Play Protocol

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

An athlete with a recent concussion has altered lower extremity stiffness at the leg, hip, and knee, which could increase their risk for musculoskeletal injury.... Read more »

Dubose DF, Herman DC, Jones DL, Tillman SM, Clugston JR, Pass A, Hernandez JA, Vasilopoulos T, Horodyski M, & Chmielewski TL. (2017) Lower Extremity Stiffness Changes after Concussion in Collegiate Football Players. Medicine and science in sports and exercise, 49(1), 167-172. PMID: 27501359  

  • December 23, 2016
  • 05:13 AM
  • 364 views

Bad news for DARPA's RAM program: Electrical Stimulation of Entorhinal Region Impairs Memory

by The Neurocritic in The Neurocritic





The neural machinery that forms new memories is fragile and vulnerable to insults arising from brain injuries, cerebral anoxia, and neurodegenerative diseases such as Alzheimer's. Unlike language, which shows a great deal of plasticity after strokes and other injuries, episodic memory – memory for autobiographical events and contextual details of past experiences – doesn't recover after

... Read more »

  • December 23, 2016
  • 04:30 AM
  • 331 views

Do Low Neurocognitive Scores Increase the Risk of Injury?

by Stephan Bodkin in Sports Medicine Research (SMR): In the Lab & In the Field

An athlete with low baseline neurocognitive scores is likely to produce knee movement patterns that are associated to anterior cruciate ligament (ACL) injury.... Read more »

  • December 18, 2016
  • 12:41 AM
  • 319 views

On the Interpretation of Neuroscientific Findings

by Justin A. Sattin in The Ghost of Charcot

A review of classic "split brain" research and critique of a new paper regarding "functional" splits in brain function.... Read more »

Sasai, S., Boly, M., Mensen, A., & Tononi, G. (2016) Functional split brain in a driving/listening paradigm. Proceedings of the National Academy of Sciences, 113(50), 14444-14449. DOI: 10.1073/pnas.1613200113  

  • December 16, 2016
  • 04:30 AM
  • 298 views

Frequency and Location of Head Impacts in Division 1 Men’s Lacrosse Players

by Patricia Kelshaw, MS, LAT, ATC in Sports Medicine Research (SMR): In the Lab & In the Field

Player position and session type such as practice or game are the main factors that influence head impact frequencies and magnitudes for lacrosse athletes.... Read more »

  • December 5, 2016
  • 04:30 AM
  • 304 views

Is Normative Data the New Normal?

by Sam Walton in Sports Medicine Research (SMR): In the Lab & In the Field

Individual differences may be seen in baseline SCAT3 data between sex, history of concussion, and history of comorbidities. Therefore, using the patient’s personal medical history may add value to the SCAT3 sideline screening.... Read more »

  • November 29, 2016
  • 11:24 AM
  • 398 views

Your Brain On God: Reward and Motivation

by William Yates, M.D. in Brain Posts

William James authored a seminal book titled The Varieties of Religious Experience: A Study in Human Nature that was published in 1902.In this work, James reviewed the nature of religious experiences and noted a lack of scientific inquiry into this human phenomenon.James would have been extremely interested in a recent scientific inquiry into the religious experience from brain researchers at the University of Utah and Harvard University.In this study, functional magnetic resonance imaging (fMRI........ Read more »

Ferguson MA, Nielsen JA, King JB, Dai L, Giangrasso DM, Holman R, Korenberg JR, & Anderson JS. (2016) Reward, Salience, and Attentional Networks are Activated by Religious Experience in Devout Mormons. Social neuroscience. PMID: 27834117  

  • November 28, 2016
  • 04:51 AM
  • 376 views

Airplane Headache II: The Sequel

by The Neurocritic in The Neurocritic




Airline travel during the holidays is one big headache. But for some people, “airplane headache” is a truly painful experience. The headache occurs during take-off and landing, is unique to plane travel, and is not associated with other conditions. The pain is severe, with a jabbing or stabbing quality, and located on one side of the head (usually around the eye sockets or forehead).



... Read more »

Bui, S., Petersen, T., Poulsen, J., & Gazerani, P. (2016) Headaches attributed to airplane travel: a Danish survey. The Journal of Headache and Pain, 17(1). DOI: 10.1186/s10194-016-0628-7  

Headache Classification Committee of the International Headache Society (IHS). (2013) The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia, 33(9), 629-808. DOI: 10.1177/0333102413485658  

  • November 21, 2016
  • 11:10 AM
  • 401 views

Benefits of Physical Activity in Parkison's Disease

by William Yates, M.D. in Brain Posts

Parkinson's disease (PD) is a progressive neurodegerative disorder estimated to affect 7 to 10 million individual worldwide.The primary mechanism for Parkinson's disease is a reduction in the neurotransmitter dopamine in the midbrain region of the substantia nigra highlighted in red in the figure.PD impairs motor and cognitive functions and leads to significant decline in psychosocial functioning.Drugs for PD can be effective in reversing and slowing the progression of the illness. However, resp........ Read more »

Lauzé M, Daneault JF, & Duval C. (2016) The Effects of Physical Activity in Parkinson's Disease: A Review. Journal of Parkinson's disease, 6(4), 685-698. PMID: 27567884  

  • November 17, 2016
  • 11:00 AM
  • 452 views

Missed Opportunities in Stroke Prevention

by William Yates, M.D. in Brain Posts

Rates of myocardial infarction and stroke have been declining over the last decade in the U.S. and Europe. However, a recent manuscript suggests there are still significant missed opportunities to prevent stroke.This manuscript presents results of review of electronic primary care records in the United Kingdom.The authors examines a group of over 29,000 subjects with a diagnosis of stroke or transient ischemic attack over a 10 year period.Records were reviewed to assess for compliance with guide........ Read more »

  • November 2, 2016
  • 04:30 AM
  • 372 views

What Came First the Concussion Or the Lower Extremity Musculoskeletal Injury?

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Athletes who reported sustaining a concussion were 1.6 to 2.9 times more likely to have also sustained a lower extremity musculoskeletal injury at the end of their intercollegiate athletic careers.... Read more »

Gilbert, F., Burdette, G., Joyner, A., Llewellyn, T., & Buckley, T. (2016) Association Between Concussion and Lower Extremity Injuries in Collegiate Athletes. Sports Health: A Multidisciplinary Approach, 8(6), 561-567. DOI: 10.1177/1941738116666509  

  • October 31, 2016
  • 04:30 AM
  • 342 views

Repetitive Head Impacts in Mice Suggest Cumulative Affliction

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Mild repetitive blows resulted in Alzheimer’s disease and chronic traumatic encephalopathy (CTE) like conditions in mice. Additionally, as number of head impacts increased balance coordination declined, and depressive symptoms progressed.... Read more »

  • October 17, 2016
  • 04:30 AM
  • 376 views

Comprehensive Services Improve Care for Adolescents with Persistent Postconcussive Symptoms

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Adolescents with persistent postconcussive symptoms experienced greater improvements in symptoms and quality of life after receiving a collaborative care treatment compared with adolescents who received the standard of care.... Read more »

McCarty CA, Zatzick D, Stein E, Wang J, Hilt R, Rivara FP, & Seattle Sports Concussion Research Collaborative. (2016) Collaborative Care for Adolescents With Persistent Postconcussive Symptoms: A Randomized Trial. Pediatrics. PMID: 27624513  

  • October 14, 2016
  • 06:20 AM
  • 464 views

Forgetting Earth, forgetting Mars: Dementia, pollution, and space travel

by gdw in FictionalFieldwork

Forgetting Earth Dementia. Few words inspire greater fear in those of us who value (quasi-?) independent thought. The term ‘dementia’ encompasses various brain disorders that all share some scary traits: general decline in cognitive function, decreased ability to speak, and in later stages, being unable to take care of oneself. Unfortunately, as human lifespan increases […]... Read more »

Killin LO, Starr JM, Shiue IJ, & Russ TC. (2016) Environmental risk factors for dementia: a systematic review. BMC geriatrics, 16(1), 175. PMID: 27729011  

Parihar VK, Allen BD, Caressi C, Kwok S, Chu E, Tran KK, Chmielewski NN, Giedzinski E, Acharya MM, Britten RA.... (2016) Cosmic radiation exposure and persistent cognitive dysfunction. Scientific reports, 34774. PMID: 27721383  

  • October 10, 2016
  • 11:54 AM
  • 417 views

Alzheimer's Disease: Atrophy Pattern and Symptoms

by William Yates, M.D. in Brain Posts

Memory impairment is a key symptom of Alzheimer's dementia common to patients with the condition.However, additional cognitive and behavioral symptoms vary between patients with a clinical and pathological diagnosis of Alzheimer's disease.A key area of research is focused on understanding factors that contribute to symptom variability in Alzheimer's disease.A team of researchers from Singapore and Harvard Medical School recently published an important study on this topic.They analyzed structural........ Read more »

Zhang X, Mormino EC, Sun N, Sperling RA, Sabuncu MR, Yeo BT, & Alzheimer’s Disease Neuroimaging Initiative. (2016) Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID: 27702899  

  • October 10, 2016
  • 04:30 AM
  • 366 views

Therapist-Directed Cognitive Rehabilitation Improved Functional Cognitive Outcomes

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Four treatment strategies for chronic symptoms after a mild traumatic brain injury (mTBI) improved symptoms; however, those with therapist-directed cognitive rehabilitation demonstrated superior improvements in functional cognitive scores compared with standard of care and computer-based rehabilitation.... Read more »

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