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  • January 27, 2017
  • 12:27 PM
  • 483 views

Impairment of neurogenesis in ZIKV infected neuronal cells: strain specific ? Asian/American v. African strains

by thelonevirologist in Virology Tidbits

uring the current Zika Virus (ZIKV) outbreaks in the Americas, an increased number of cognitive malformations including but not limited to microcephaly in foetuses and neonates of mothers who had been infected with ZIKV during pregnancy, lead to the conclusion that ZIKV might be neuroteratogenic, a hypothesis that has been supported by findings that various ZIKV strains –including isolates from Asia such ZIKV SZ 01, ZIKV FSS13025 and H/PF/2013 as well as isolates from the Americas such as........ Read more »

Li H, Saucedo-Cuevas L, Shresta S, & Gleeson JG. (2016) The Neurobiology of Zika Virus. Neuron, 92(5), 949-958. PMID: 27930910  

van den Pol AN, Mao G, Yang Y, Ornaghi S, & Davis JN. (2017) Zika virus targeting in the developing brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. PMID: 28123079  

Li H, Saucedo-Cuevas L, Regla-Nava JA, Chai G, Sheets N, Tang W, Terskikh AV, Shresta S, & Gleeson JG. (2016) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation. Cell stem cell, 19(5), 593-598. PMID: 27545505  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870  

Garcez PP, Nascimento JM, de Vasconcelos JM, Madeiro da Costa R, Delvecchio R, Trindade P, Loiola EC, Higa LM, Cassoli JS, Vitória G.... (2017) Zika virus disrupts molecular fingerprinting of human neurospheres. Scientific reports, 40780. PMID: 28112162  

Gabriel, E., Ramani, A., Karow, U., Gottardo, M., Natarajan, K., Gooi, L., Goranci-Buzhala, G., Krut, O., Peters, F., Nikolic, M.... (2017) Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. Cell Stem Cell. DOI: 10.1016/j.stem.2016.12.005  

Gromley A, Jurczyk A, Sillibourne J, Halilovic E, Mogensen M, Groisman I, Blomberg M, & Doxsey S. (2003) A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. The Journal of cell biology, 161(3), 535-45. PMID: 12732615  

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK.... (2016) 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. The Journal of cell biology, 214(2), 155-66. PMID: 27432897  

Souza BS, Sampaio GL, Pereira CS, Campos GS, Sardi SI, Freitas LA, Figueira CP, Paredes BD, Nonaka CK, Azevedo CM.... (2016) Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Scientific reports, 39775. PMID: 28008958  

  • January 17, 2017
  • 05:05 PM
  • 298 views

Axl and GAS6: apoptotic mimicry and NLRP-3 inhibition during Zika Virus infection

by thelonevirologist in Virology Tidbits

Zika Virus (ZIKV) is a positive sense RNA virus that belongs to the Flavivirus genus of the Flaviviridae family that includes other human pathogens including Hepatitis C Virus (HCV), Yellow Fever Virus (YFV), West Nile Virus, Dengue Virus (DENV), Tick Borne Encephalitis Virus (TBEV), and Japanese Encephalitis Virus (JEV).
Although being first isolated in 1947, until recently ZIKV was not associated with severe disease; following the introduction of ZIKV in the Americas however, foetal ZIKV inf........ Read more »

Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J.... (2016) Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proceedings of the National Academy of Sciences of the United States of America, 113(50), 14408-14413. PMID: 27911847  

El Costa H, Gouilly J, Mansuy JM, Chen Q, Levy C, Cartron G, Veas F, Al-Daccak R, Izopet J, & Jabrane-Ferrat N. (2016) ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy. Scientific reports, 35296. PMID: 27759009  

Quicke KM, Bowen JR, Johnson EL, McDonald CE, Ma H, O'Neal JT, Rajakumar A, Wrammert J, Rimawi BH, Pulendran B.... (2016) Zika Virus Infects Human Placental Macrophages. Cell host , 20(1), 83-90. PMID: 27247001  

Savidis, G., Perreira, J., Portmann, J., Meraner, P., Guo, Z., Green, S., & Brass, A. (2016) The IFITMs Inhibit Zika Virus Replication. Cell Reports, 15(11), 2323-2330. DOI: 10.1016/j.celrep.2016.05.074  

Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E.... (2009) The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell, 139(7), 1243-54. PMID: 20064371  

Bailey CC, Zhong G, Huang IC, & Farzan M. (2014) IFITM-Family Proteins: The Cell's First Line of Antiviral Defense. Annual review of virology, 261-283. PMID: 25599080  

Meertens L, Carnec X, Lecoin MP, Ramdasi R, Guivel-Benhassine F, Lew E, Lemke G, Schwartz O, & Amara A. (2012) The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell host , 12(4), 544-57. PMID: 23084921  

Bhattacharyya S, Zagórska A, Lew ED, Shrestha B, Rothlin CV, Naughton J, Diamond MS, Lemke G, & Young JA. (2013) Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors. Cell host , 14(2), 136-47. PMID: 23954153  

  • December 14, 2016
  • 08:40 PM
  • 339 views

ZIKV replication and the induction of p53: a tale of three places ?

by thelonevirologist in Virology Tidbits

Zika Virus (ZIKV) is a mosquitoe-borne Flavivirus (MBFV), related to other Flavivirus’ that are transmitted by mosquitoes such as Dengue Virus (DENV), Yellow Fever Virus (YFV) or Tick Borne Encephalitis Virus (TBEV) and as such the viral genome is released into the cytoplasm following viral entry and translated into a single polyprotein that is cleaved by both viral and cellular proteases into the 3 structural and 7 non-structural proteins.
Here the induction of p53 dependent apoptosis an........ Read more »

Li H, Saucedo-Cuevas L, Shresta S, & Gleeson JG. (2016) The Neurobiology of Zika Virus. Neuron, 92(5), 949-958. PMID: 27930910  

Vasilakis N, & Weaver SC. (2016) Flavivirus transmission focusing on Zika. Current opinion in virology, 30-35. PMID: 27936448  

Barreto-Vieira DF, Barth OM, Silva MA, Santos CC, Santos Ada S, F JB Filho, & Filippis AM. (2016) Ultrastructure of Zika virus particles in cell cultures. Memorias do Instituto Oswaldo Cruz, 111(8), 532-4. PMID: 27581122  

Li H, Saucedo-Cuevas L, Regla-Nava JA, Chai G, Sheets N, Tang W, Terskikh AV, Shresta S, & Gleeson JG. (2016) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation. Cell stem cell, 19(5), 593-598. PMID: 27545505  

Pingen M, Bryden SR, Pondeville E, Schnettler E, Kohl A, Merits A, Fazakerley JK, Graham GJ, & McKimmie CS. (2016) Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection. Immunity, 44(6), 1455-69. PMID: 27332734  

Agarwal A, Joshi G, Nagar DP, Sharma AK, Sukumaran D, Pant SC, Parida MM, & Dash PK. (2016) Mosquito saliva induced cutaneous events augment Chikungunya virus replication and disease progression. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 126-35. PMID: 26925703  

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA.... (2016) SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy, 12(10), 1917-1930. PMID: 27391408  

Danthi P. (2016) Viruses and the Diversity of Cell Death. Annual review of virology, 3(1), 533-553. PMID: 27501259  

Parquet MC, Kumatori A, Hasebe F, Morita K, & Igarashi A. (2001) West Nile virus-induced bax-dependent apoptosis. FEBS letters, 500(1-2), 17-24. PMID: 11434919  

Zhao P, Han T, Guo JJ, Zhu SL, Wang J, Ao F, Jing MZ, She YL, Wu ZH, & Ye LB. (2012) HCV NS4B induces apoptosis through the mitochondrial death pathway. Virus research, 169(1), 1-7. PMID: 22542667  

Netsawang J, Noisakran S, Puttikhunt C, Kasinrerk W, Wongwiwat W, Malasit P, Yenchitsomanus PT, & Limjindaporn T. (2010) Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis. Virus research, 147(2), 275-83. PMID: 19944121  

Licon Luna RM, Lee E, Müllbacher A, Blanden RV, Langman R, & Lobigs M. (2002) Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice. Journal of virology, 76(7), 3202-11. PMID: 11884544  

Tudzarova S, Mulholland P, Dey A, Stoeber K, Okorokov AL, & Williams GH. (2016) p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress. Cell cycle (Georgetown, Tex.), 15(21), 2958-2972. PMID: 27611229  

Abraham AG, & O'Neill E. (2014) PI3K/Akt-mediated regulation of p53 in cancer. Biochemical Society transactions, 42(4), 798-803. PMID: 25109960  

  • November 12, 2016
  • 05:53 PM
  • 381 views

Neutralizing and non-neutralizing antibodies: Zika Virus and antibody dependent enhancement of infection

by thelonevirologist in Virology Tidbits

the infection of both mice and non-human primates with various ZIKV strains including the original ZIKV MR766 strain as well as strains from Asia (ZIKV FSS13025), Oceania (ZIKV H/PF/2013) and the Americas (ZIKV Paraiba 2015) as well as the infection of human placenta explants (ZIKV MR766 and ZIKV Nica-1/-2 2016) suggest that ZIKV can cross the placenta probably by infecting maternal cytotrophoblast cells (CTB) and maternal decidual fibroblast cells combined with placental injury due to the relea........ Read more »

Panyasrivanit M, Greenwood MP, Murphy D, Isidoro C, Auewarakul P, & Smith DR. (2011) Induced autophagy reduces virus output in dengue infected monocytic cells. Virology, 418(1), 74-84. PMID: 21813150  

Dejnirattisai W, Supasa P, Wongwiwat W, Rouvinski A, Barba-Spaeth G, Duangchinda T, Sakuntabhai A, Cao-Lormeau VM, Malasit P, Rey FA.... (2016) Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. Nature immunology, 17(9), 1102-8. PMID: 27339099  

Sapparapu G, Fernandez E, Kose N, Cao B, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T.... (2016) Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice. Nature. PMID: 27819683  

Savidis G, Perreira JM, Portmann JM, Meraner P, Guo Z, Green S, & Brass AL. (2016) The IFITMs Inhibit Zika Virus Replication. Cell reports, 15(11), 2323-30. PMID: 27268505  

  • November 7, 2016
  • 01:57 PM
  • 406 views

Neuroteratogenic Viruses: ZIKV, the placenta and IUGR

by thelonevirologist in Virology Tidbits

In humans, the most common infectious neuroteratogenic agents are summarised by the mnemonic “TORCH(S)” (Toxoplasmosis, Others, Rubella, (Human) Cytomegalovirus, Herpes Simplex, Syphilis) with ZIKV either classified as “Others” or by expanding the mnemonic to TORCHSZ and indeed health authorities in affected countries regularly test cases of microcephaly suspected to be associated with neurological infections not only for ZIKV but also for the presence of TORCH(S). Microc........ Read more »

Yockey LJ, Varela L, Rakib T, Khoury-Hanold W, Fink SL, Stutz B, Szigeti-Buck K, Van den Pol A, Lindenbach BD, Horvath TL.... (2016) Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. Cell, 166(5), 1247-12560000. PMID: 27565347  

El Costa H, Gouilly J, Mansuy JM, Chen Q, Levy C, Cartron G, Veas F, Al-Daccak R, Izopet J, & Jabrane-Ferrat N. (2016) ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy. Scientific reports, 35296. PMID: 27759009  

Quicke KM, Bowen JR, Johnson EL, McDonald CE, Ma H, O'Neal JT, Rajakumar A, Wrammert J, Rimawi BH, Pulendran B.... (2016) Zika Virus Infects Human Placental Macrophages. Cell host , 20(1), 83-90. PMID: 27247001  

Bayer A, Lennemann NJ, Ouyang Y, Bramley JC, Morosky S, Marques ET Jr, Cherry S, Sadovsky Y, & Coyne CB. (2016) Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell host , 19(5), 705-12. PMID: 27066743  

Ning F, Liu H, & Lash GE. (2016) The Role of Decidual Macrophages During Normal and Pathological Pregnancy. American journal of reproductive immunology (New York, N.Y. : 1989), 75(3), 298-309. PMID: 26750089  

Lash GE, Pitman H, Morgan HL, Innes BA, Agwu CN, & Bulmer JN. (2016) Decidual macrophages: key regulators of vascular remodeling in human pregnancy. Journal of leukocyte biology, 100(2), 315-25. PMID: 26819320  

Olagnier D, Amatore D, Castiello L, Ferrari M, Palermo E, Diamond MS, Palamara AT, & Hiscott J. (2016) Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus. Journal of molecular biology, 428(17), 3429-48. PMID: 27130436  

  • October 18, 2016
  • 08:22 PM
  • 422 views

Autophagy in CSFV and ZIKV infected cells: persistence versus neurodegenerative disease

by thelonevirologist in Virology Tidbits

Zika Virus (ZIKV) was first isolated in 1947 from a sentinel monkey in Uganda and associated with human infection in 1954 when neutralizing antibodies were detected in the sera of residents in India, with antibodies also being found in residents from various African countries. ZIKV is mosquitoe-borne Flavivirus that is predominantly transmitted via Aedes Agypti, although sexual transmission (female to male, male to female, male to male) and transmission via blood transfusion has also been report........ Read more »

Pei J, Zhao M, Ye Z, Gou H, Wang J, Yi L, Dong X, Liu W, Luo Y, Liao M.... (2014) Autophagy enhances the replication of classical swine fever virus in vitro. Autophagy, 10(1), 93-110. PMID: 24262968  

Frankel LB, Lubas M, & Lund AH. (2016) Emerging connections between RNA and autophagy. Autophagy, 1-21. PMID: 27715443  

Zhang F, Hammack C, Ogden SC, Cheng Y, Lee EM, Wen Z, Qian X, Nguyen HN, Li Y, Yao B.... (2016) Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic acids research, 44(18), 8610-8620. PMID: 27580721  

Calvet, G., Aguiar, R., Melo, A., Sampaio, S., de Filippis, I., Fabri, A., Araujo, E., de Sequeira, P., de Mendonça, M., de Oliveira, L.... (2016) Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. The Lancet Infectious Diseases, 16(6), 653-660. DOI: 10.1016/S1473-3099(16)00095-5  

Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, Eyrolle-Guignot D, Salje H, Van Kerkhove MD, Abadie V, Garel C.... (2016) Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study. Lancet (London, England), 387(10033), 2125-32. PMID: 26993883  

Cloëtta D, Thomanetz V, Baranek C, Lustenberger RM, Lin S, Oliveri F, Atanasoski S, & Rüegg MA. (2013) Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(18), 7799-810. PMID: 23637172  

Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S.... (2016) The Brazilian Zika virus strain causes birth defects in experimental models. Nature, 534(7606), 267-71. PMID: 27279226  

De Carvalho NS, De Carvalho BF, Fugaça CA, Dóris B, & Biscaia ES. (2016) Zika virus infection during pregnancy and microcephaly occurrence: a review of literature and Brazilian data. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 20(3), 282-9. PMID: 27102780  

Arroba AI, Rodríguez-de la Rosa L, Murillo-Cuesta S, Vaquero-Villanueva L, Hurlé JM, Varela-Nieto I, & Valverde ÁM. (2016) Autophagy resolves early retinal inflammation in Igf1-deficient mice. Disease models , 9(9), 965-74. PMID: 27483352  

McLean JE, Wudzinska A, Datan E, Quaglino D, & Zakeri Z. (2011) Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication. The Journal of biological chemistry, 286(25), 22147-59. PMID: 21511946  

Barrows NJ, Campos RK, Powell ST, Prasanth KR, Schott-Lerner G, Soto-Acosta R, Galarza-Muñoz G, McGrath EL, Urrabaz-Garza R, Gao J.... (2016) A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection. Cell host , 20(2), 259-70. PMID: 27476412  

Tang, H., Hammack, C., Ogden, S., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell, 18(5), 587-590. DOI: 10.1016/j.stem.2016.02.016  

Goodfellow FT, Tesla B, Simchick G, Zhao Q, Hodge T, Brindley MA, & Stice SL. (2016) Zika Virus Induced Mortality and Microcephaly in Chicken Embryos. Stem cells and development. PMID: 27627457  

Sir D, Kuo CF, Tian Y, Liu HM, Huang EJ, Jung JU, Machida K, & Ou JH. (2012) Replication of hepatitis C virus RNA on autophagosomal membranes. The Journal of biological chemistry, 287(22), 18036-43. PMID: 22496373  

Adams Waldorf, K., Stencel-Baerenwald, J., Kapur, R., Studholme, C., Boldenow, E., Vornhagen, J., Baldessari, A., Dighe, M., Thiel, J., Merillat, S.... (2016) Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nature Medicine. DOI: 10.1038/nm.4193  

Metz P, Chiramel A, Chatel-Chaix L, Alvisi G, Bankhead P, Mora-Rodriguez R, Long G, Hamacher-Brady A, Brady NR, & Bartenschlager R. (2015) Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62. Journal of virology, 89(15), 8026-41. PMID: 26018155  

Ho HK, White CC, Fernandez C, Fausto N, Kavanagh TJ, Nelson SD, & Bruschi SA. (2005) Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity. Toxicological sciences : an official journal of the Society of Toxicology, 86(2), 354-64. PMID: 15901913  

Ravikumar, B., Sarkar, S., Davies, J., Futter, M., Garcia-Arencibia, M., Green-Thompson, Z., Jimenez-Sanchez, M., Korolchuk, V., Lichtenberg, M., Luo, S.... (2010) Regulation of Mammalian Autophagy in Physiology and Pathophysiology. Physiological Reviews, 90(4), 1383-1435. DOI: 10.1152/physrev.00030.2009  

Menzies FM, Fleming A, & Rubinsztein DC. (2015) Compromised autophagy and neurodegenerative diseases. Nature reviews. Neuroscience, 16(6), 345-57. PMID: 25991442  

Li, Y., Chen, B., Zou, W., Wang, X., Wu, Y., Zhao, D., Sun, Y., Liu, Y., Chen, L., Miao, L.... (2016) The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity. The Journal of Cell Biology. DOI: 10.1083/jcb.201602090  

De Leo MG, Staiano L, Vicinanza M, Luciani A, Carissimo A, Mutarelli M, Di Campli A, Polishchuk E, Di Tullio G, Morra V.... (2016) Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL. Nature cell biology, 18(8), 839-50. PMID: 27398910  

  • October 7, 2016
  • 04:01 PM
  • 451 views

ZIKV and ocular infections

by thelonevirologist in Virology Tidbits

Although being first isolated in 1947 from a sentinel rhesus monkey in forests of Uganda, until 2007 Zika Virus (ZIKV) outbreaks have been sporadic, being limited to tropical regions in Africa as well as Southeast Asia and only been associated with relative mild symptoms in about 20% of infected people. Autochthonous transmission of ZIKV outside these areas was only reported in 2007 in the Federal States of Micronesia (FSM), 2013 in French Polynesia, and in 2015 in South America, spreading to th........ Read more »

Ventura CV, Maia M, Travassos SB, Martins TT, Patriota F, Nunes ME, Agra C, Torres VL, van der Linden V, Ramos RC.... (2016) Risk Factors Associated With the Ophthalmoscopic Findings Identified in Infants With Presumed Zika Virus Congenital Infection. JAMA ophthalmology, 134(8), 912-8. PMID: 27228275  

Furtado JM, Espósito DL, Klein TM, Teixeira-Pinto T, & da Fonseca BA. (2016) Uveitis Associated with Zika Virus Infection. The New England journal of medicine, 375(4), 394-6. PMID: 27332784  

Grant A, Ponia SS, Tripathi S, Balasubramaniam V, Miorin L, Sourisseau M, Schwarz MC, Sánchez-Seco MP, Evans MJ, Best SM.... (2016) Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling. Cell host , 19(6), 882-90. PMID: 27212660  

Khairallah M, Chee SP, Rathinam SR, Attia S, & Nadella V. (2010) Novel infectious agents causing uveitis. International ophthalmology, 30(5), 465-83. PMID: 19711015  

Goodfellow F, Tesla B, Simchick G, Hodge T, Zhao Q, Brindley MA, & Stice SL. (2016) Zika Virus Induced Mortality and Microcephaly in Chicken Embryos. Stem cells and development. PMID: 27627457  

Miner JJ, Sene A, Richner JM, Smith AM, Santeford A, Ban N, Weger-Lucarelli J, Manzella F, Rückert C, Govero J.... (2016) Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears. Cell reports, 16(12), 3208-18. PMID: 27612415  

Lazear HM, Govero J, Smith AM, Platt DJ, Fernandez E, Miner JJ, & Diamond MS. (2016) A Mouse Model of Zika Virus Pathogenesis. Cell host , 19(5), 720-30. PMID: 27066744  

Rossi SL, Tesh RB, Azar SR, Muruato AE, Hanley KA, Auguste AJ, Langsjoen RM, Paessler S, Vasilakis N, & Weaver SC. (2016) Characterization of a Novel Murine Model to Study Zika Virus. The American journal of tropical medicine and hygiene, 94(6), 1362-9. PMID: 27022155  

Varkey JB, Shantha JG, Crozier I, Kraft CS, Lyon GM, Mehta AK, Kumar G, Smith JR, Kainulainen MH, Whitmer S.... (2015) Persistence of Ebola Virus in Ocular Fluid during Convalescence. The New England journal of medicine, 372(25), 2423-7. PMID: 25950269  

  • October 3, 2016
  • 10:03 PM
  • 427 views

ZIKV and microcephaly: African and Asian isolates and infection of the vaginal mucosa

by thelonevirologist in Virology Tidbits

The recent emergence of Zika Virus (ZIKV) in the Americas has been associated with abnormal brain development of the foetal brain leading to microcephaly, other neurological abnormalities, severe depilation of neonates and foetal or neonatal death. it should be noted however that so far in the most affected countries -Brazil and Colombia- only a subset of all reported cases of microcephaly have been shown to be tested positive for ZIKV suggesting that other factors also may play a role in the ob........ Read more »

Simonin Y, Loustalot F, Desmetz C, Foulongne V, Constant O, Fournier-Wirth C, Leon F, Molès JP, Goubaud A, Lemaitre JM.... (2016) Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells. EBioMedicine. PMID: 27688094  

de Araújo TV, Rodrigues LC, de Alencar Ximenes RA, de Barros Miranda-Filho D, Montarroyos UR, de Melo AP, Valongueiro S, de Albuquerque MF, Souza WV, Braga C.... (2016) Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. The Lancet. Infectious diseases. PMID: 27641777  

Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S.... (2016) The Brazilian Zika virus strain causes birth defects in experimental models. Nature, 534(7606), 267-71. PMID: 27279226  

Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F.... (2015) Biology of Zika Virus Infection in Human Skin Cells. Journal of virology, 89(17), 8880-96. PMID: 26085147  

Hamel R, Liégeois F, Wichit S, Pompon J, Diop F, Talignani L, Thomas F, Desprès P, Yssel H, & Missé D. (2016) Zika virus: epidemiology, clinical features and host-virus interactions. Microbes and infection, 18(7-8), 441-9. PMID: 27012221  

Miner, J., Cao, B., Govero, J., Smith, A., Fernandez, E., Cabrera, O., Garber, C., Noll, M., Klein, R., Noguchi, K.... (2016) Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell, 165(5), 1081-1091. DOI: 10.1016/j.cell.2016.05.008  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870  

Machado-Alba JE, Machado-Duque ME, Gaviria-Mendoza A, & Orozco-Giraldo V. (2016) Diagnosis of Neurological Disorders and Zika virus epidemic in Colombia 2014 -2016. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. PMID: 27637419  

Coelho, F., Durovni, B., Saraceni, V., Lemos, C., Codeco, C., Camargo, S., Carvalho, L., Bastos, L., Arduini, D., Villela, D.... (2016) Higher incidence of Zika in adult women in Rio de Janeiro suggests a significant contribution of sexual transmission from men to women. International Journal of Infectious Diseases. DOI: 10.1016/j.ijid.2016.08.023  

Li C, Xu D, Ye Q, Hong S, Jiang Y, Liu X, Zhang N, Shi L, Qin CF, & Xu Z. (2016) Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell stem cell, 19(1), 120-6. PMID: 27179424  

Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S.... (2016) Zika virus productively infects primary human placenta-specific macrophages. JCI insight, 1(13). PMID: 27595140  

Yockey LJ, Varela L, Rakib T, Khoury-Hanold W, Fink SL, Stutz B, Szigeti-Buck K, Van den Pol A, Lindenbach BD, Horvath TL.... (2016) Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. Cell, 166(5), 1247-12560000. PMID: 27565347  

Driggers RW, Ho CY, Korhonen EM, Kuivanen S, Jääskeläinen AJ, Smura T, Rosenberg A, Hill DA, DeBiasi RL, Vezina G.... (2016) Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities. The New England journal of medicine, 374(22), 2142-51. PMID: 27028667  

Quicke KM, Bowen JR, Johnson EL, McDonald CE, Ma H, O'Neal JT, Rajakumar A, Wrammert J, Rimawi BH, Pulendran B.... (2016) Zika Virus Infects Human Placental Macrophages. Cell host , 20(1), 83-90. PMID: 27247001  

  • September 14, 2016
  • 08:00 PM
  • 216 views

ZIKV: antivirals and the cell cycle, TBK-1 relocalisation and immune signalling

by thelonevirologist in Virology Tidbits

Zika Virus (ZIKV) is an emerging flavivirus that was first isolated in 1947 from a sentinel monkey in Uganda as part of study that aimed to identify novel pathogens and despite sporadic local outbreaks in countries such as Gabon, Nigeria, Cambodia, Malaysia and Indonesia followed by the first major outbreak in Yap/Federal States of Micronesia 2007 only caused mild disease in humans with up to 80% of asymptomatic cases. Here the repurposing of drugs for treating Zika as well as the effect of re........ Read more »

Bonaldo MC, Ribeiro IP, Lima NS, Dos Santos AA, Menezes LS, da Cruz SO, de Mello IS, Furtado ND, de Moura EE, Damasceno L.... (2016) Isolation of Infective Zika Virus from Urine and Saliva of Patients in Brazil. PLoS neglected tropical diseases, 10(6). PMID: 27341420  

Campos Rde M, Cirne-Santos C, Meira GL, Santos LL, de Meneses MD, Friedrich J, Jansen S, Ribeiro MS, da Cruz IC, Schmidt-Chanasit J.... (2016) Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 69-70. PMID: 26921737  

Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B.... (2016) Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses. Cell host , 20(3), 342-56. PMID: 27545046  

Costa F, Sarno M, Khouri R, de Paula Freitas B, Siqueira I, Ribeiro GS, Ribeiro HC, Campos GS, Alcântara LC, Reis MG.... (2016) Emergence of Congenital Zika Syndrome: Viewpoint From the Front Lines. Annals of internal medicine, 164(10), 689-91. PMID: 26914810  

Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S.... (2016) The Brazilian Zika virus strain causes birth defects in experimental models. Nature, 534(7606), 267-71. PMID: 27279226  

DICK GW. (1952) Zika virus. II. Pathogenicity and physical properties. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(5), 521-34. PMID: 12995441  

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Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, & Rehen SK. (2016) Zika virus impairs growth in human neurospheres and brain organoids. Science (New York, N.Y.), 352(6287), 816-8. PMID: 27064148  

Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S.... (2016) Zika virus productively infects primary human placenta-specific macrophages. JCI insight, 1(13). PMID: 27595140  

Lazear HM, Govero J, Smith AM, Platt DJ, Fernandez E, Miner JJ, & Diamond MS. (2016) A Mouse Model of Zika Virus Pathogenesis. Cell host , 19(5), 720-30. PMID: 27066744  

Li H, Saucedo-Cuevas L, Regla-Nava JA, Chai G, Sheets N, Tang W, Terskikh AV, Shresta S, & Gleeson JG. (2016) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation. Cell stem cell. PMID: 27545505  

Miner JJ, Sene A, Richner JM, Smith AM, Santeford A, Ban N, Weger-Lucarelli J, Manzella F, Rückert C, Govero J.... (2016) Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears. Cell reports, 16(12), 3208-18. PMID: 27612415  

Nowakowski TJ, Pollen AA, Di Lullo E, Sandoval-Espinosa C, Bershteyn M, & Kriegstein AR. (2016) Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells. Cell stem cell, 18(5), 591-6. PMID: 27038591  

Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, Baudouin L, Mallet H, Musso D, & Ghawche F. (2014) Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013. Euro surveillance : bulletin Europeen sur les maladies transmissibles , 19(9). PMID: 24626205  

Onorati M, Li Z, Liu F, Sousa AM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp AT.... (2016) Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell reports, 16(10), 2576-92. PMID: 27568284  

Qian X, Nguyen HN, Song MM, Hadiono C, Ogden SC, Hammack C, Yao B, Hamersky GR, Jacob F, Zhong C.... (2016) Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure. Cell, 165(5), 1238-54. PMID: 27118425  

Ribeiro LS, Marques RE, Jesus AM, Almeida RP, & Teixeira MM. (2016) Zika crisis in Brazil: challenges in research and development. Current opinion in virology, 76-81. PMID: 27179929  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870  

Weaver SC, Costa F, Garcia-Blanco MA, Ko AI, Ribeiro GS, Saade G, Shi PY, & Vasilakis N. (2016) Zika virus: History, emergence, biology, and prospects for control. Antiviral research, 69-80. PMID: 26996139  

Zhang F, Hammack C, Ogden SC, Cheng Y, Lee EM, Wen Z, Qian X, Nguyen HN, Li Y, Yao B.... (2016) Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic acids research. PMID: 27580721  

Zhu Y, Zhao L, Liu L, Gao P, Tian W, Wang X, Jin H, Xu H, & Chen Q. (2010) Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein , 1(5), 468-77. PMID: 21203962  

Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A, Williams BR, & Sen GC. (2010) Viral apoptosis is induced by IRF-3-mediated activation of Bax. The EMBO journal, 29(10), 1762-73. PMID: 20360684  

Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA.... (2016) Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proceedings of the National Academy of Sciences of the United States of America, 113(15), 4039-44. PMID: 27035970  

  • June 10, 2016
  • 01:51 PM
  • 585 views

Yellow fever virus in Africa: current situation and importance

by thelonevirologist in Virology Tidbits

Yellow haemorraghic fever (YF) is caused by Yellow Fever Virus (YFV), a prototype Flavivirus and as such as related to Japanese Encephalitis Virus (JEV), Dengue Virus (DENV) and Zika Virus (ZIKV). Similar to DENV and ZIKV, YFV is transmitted by Aedes agypti both in Africa and South America and clinical manifestations range from asymptomatic infections to multi organ failure and subsequent death.Here the current outbreak in Angola is discussed. ... Read more »

Wasserman S, Tambyah PA, & Lim PL. (2016) Yellow fever cases in Asia: primed for an epidemic. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. PMID: 27156836  

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  • June 7, 2016
  • 07:24 AM
  • 519 views

Cytopathogenesis of ZIKV: IFTM and viral entry/Hofbauer cells and the placenta

by thelonevirologist in Virology Tidbits

Zika Virus (ZIKV) is an emerging member of the Flaviviridae that in the past months spread to over 30 countries in the Americas alone that has been associated with the emergence of microcephaly, a condition associated with abnormal brain development, in Brazil and elsewhere.
Recent studies confirmed the presence of ZIKV in the amniotic fluid as well in the brain and CNS of neonates, suggesting that ZIKV can infect embryonal and foetal tissue by crossing the placental barrier. In addition, ZIKV ........ Read more »

Driggers RW, Ho CY, Korhonen EM, Kuivanen S, Jääskeläinen AJ, Smura T, Rosenberg A, Hill DA, DeBiasi RL, Vezina G.... (2016) Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities. The New England journal of medicine, 374(22), 2142-51. PMID: 27028667  

Cugola, F., Fernandes, I., Russo, F., Freitas, B., Dias, J., Guimarães, K., Benazzato, C., Almeida, N., Pignatari, G., Romero, S.... (2016) The Brazilian Zika virus strain causes birth defects in experimental models. Nature. DOI: 10.1038/nature18296  

Savidis, G., Perreira, J., Portmann, J., Meraner, P., Guo, Z., Green, S., & Brass, A. (2016) The IFITMs Inhibit Zika Virus Replication. Cell Reports. DOI: 10.1016/j.celrep.2016.05.074  

Quicke KM, Bowen JR, Johnson EL, McDonald CE, Ma H, O'Neal JT, Rajakumar A, Wrammert J, Rimawi BH, Pulendran B.... (2016) Zika Virus Infects Human Placental Macrophages. Cell host . PMID: 27247001  

Noronha Ld, Zanluca C, Azevedo ML, Luz KG, & Santos CN. (2016) Zika virus damages the human placental barrier and presents marked fetal neurotropism. Memorias do Instituto Oswaldo Cruz, 111(5), 287-93. PMID: 27143490  

Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, & Rehen SK. (2016) Zika virus impairs growth in human neurospheres and brain organoids. Science (New York, N.Y.), 352(6287), 816-8. PMID: 27064148  

Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F.... (2015) Biology of Zika Virus Infection in Human Skin Cells. Journal of virology, 89(17), 8880-96. PMID: 26085147  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870  

Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK.... (2016) Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell, 165(5), 1081-91. PMID: 27180225  

Bayer A, Lennemann NJ, Ouyang Y, Bramley JC, Morosky S, Marques ET Jr, Cherry S, Sadovsky Y, & Coyne CB. (2016) Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell host , 19(5), 705-12. PMID: 27066743  

Azari, H., & Reynolds, B. (2016) In Vitro Models for Neurogenesis. Cold Spring Harbor Perspectives in Biology, 8(6). DOI: 10.1101/cshperspect.a021279  

Young OM, Tang Z, Niven-Fairchild T, Tadesse S, Krikun G, Norwitz ER, Mor G, Abrahams VM, & Guller S. (2015) Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages. American journal of reproductive immunology (New York, N.Y. : 1989), 73(1), 22-35. PMID: 25345551  

Xu DZ, Yan YP, Zou S, Choi BC, Wang S, Liu P, Bai G, Wang X, Shi M, & Wang X. (2001) Role of placental tissues in the intrauterine transmission of hepatitis B virus. American journal of obstetrics and gynecology, 185(4), 981-7. PMID: 11641689  

Smith S, Weston S, Kellam P, & Marsh M. (2014) IFITM proteins-cellular inhibitors of viral entry. Current opinion in virology, 71-7. PMID: 24480526  

  • May 30, 2016
  • 04:21 PM
  • 594 views

ZIKV: ATM dependent signalling, VRK1, autophagy and the ER stress response in neuronal cells

by thelonevirologist in Virology Tidbits

Upon the induction of DNA damage, complex signaling pathways are activated that regulate the ability of cells to detect and repair the damage since both single and double strand DNA damage pose significant risk to cell survival and transmission of unrepaired DNA damage to progeny is associated not only with aging and cancer but also with neurodegenerative diseases. During the DNA damage response (DDR) ds and ss DNA breaks are recognised by ATM, ATR and DNA-PK kinases, which in turn activate sign........ Read more »

Kang TH, Park DY, Kim W, & Kim KT. (2008) VRK1 phosphorylates CREB and mediates CCND1 expression. Journal of cell science, 121(Pt 18), 3035-41. PMID: 18713830  

Gonzaga-Jauregui C, Lotze T, Jamal L, Penney S, Campbell IM, Pehlivan D, Hunter JV, Woodbury SL, Raymond G, Adesina AM.... (2013) Mutations in VRK1 associated with complex motor and sensory axonal neuropathy plus microcephaly. JAMA neurology, 70(12), 1491-8. PMID: 24126608  

Kang TH, Park DY, Choi YH, Kim KJ, Yoon HS, & Kim KT. (2007) Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells. Molecular and cellular biology, 27(24), 8533-46. PMID: 17938195  

Metz P, Chiramel A, Chatel-Chaix L, Alvisi G, Bankhead P, Mora-Rodriguez R, Long G, Hamacher-Brady A, Brady NR, & Bartenschlager R. (2015) Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62. Journal of virology, 89(15), 8026-41. PMID: 26018155  

Joo, J., Wang, B., Frankel, E., Ge, L., Xu, L., Iyengar, R., Li-Harms, X., Wright, C., Shaw, T., Lindsten, T.... (2016) The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis. Molecular Cell, 62(4), 491-506. DOI: 10.1016/j.molcel.2016.04.020  

  • May 24, 2016
  • 11:27 AM
  • 602 views

ZIKV infection in mice: cell cycle defects as a cause for microcephaly?

by thelonevirologist in Virology Tidbits

Zika Virus (ZIKV) was first isolated in 1947 from a sentinel monkey in Uganda and despite sporadic local outbreaks only caused mild disease in humans. The emergence of ZIKV combined with severe pathogenicity in South America as early as 2014 however raised questions about the molecular evolution of ZIKV since ZIKV was previously only associated with arthralgia and a mild febrile illness but not neuropathological disorders including abnormal foetal brain development and Guillan-Barre Syndrome (GB........ Read more »

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870  

Rodriguez-Morales AJ, Bandeira AC, & Franco-Paredes C. (2016) The expanding spectrum of modes of transmission of Zika virus: a global concern. Annals of clinical microbiology and antimicrobials, 13. PMID: 26939897  

Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK.... (2016) Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell, 165(5), 1081-91. PMID: 27180225  

Cugola, F., Fernandes, I., Russo, F., Freitas, B., Dias, J., Guimarães, K., Benazzato, C., Almeida, N., Pignatari, G., Romero, S.... (2016) The Brazilian Zika virus strain causes birth defects in experimental models. Nature. DOI: 10.1038/nature18296  

Deng YQ, Zhao H, Li XF, Zhang NN, Liu ZY, Jiang T, Gu DY, Shi L, He JA, Wang HJ.... (2016) Isolation, identification and genomic characterization of the Asian lineage Zika virus imported to China. Science China. Life sciences, 59(4), 428-30. PMID: 26993654  

Grant, A., Ponia, S., Tripathi, S., Balasubramaniam, V., Miorin, L., Sourisseau, M., Schwarz, M., Sánchez-Seco, M., Evans, M., Best, S.... (2016) Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling. Cell Host . DOI: 10.1016/j.chom.2016.05.009  

Ashour J, Laurent-Rolle M, Shi PY, & García-Sastre A. (2009) NS5 of dengue virus mediates STAT2 binding and degradation. Journal of virology, 83(11), 5408-18. PMID: 19279106  

Gelman A, Rawet-Slobodkin M, & Elazar Z. (2015) Huntingtin facilitates selective autophagy. Nature cell biology, 17(3), 214-5. PMID: 25720962  

Amaral N, Vendrell A, Funaya C, Idrissi FZ, Maier M, Kumar A, Neurohr G, Colomina N, Torres-Rosell J, Geli MI.... (2016) The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress. Nature cell biology, 18(5), 516-26. PMID: 27111841  

Schröder-Heurich B, Wieland B, Lavin MF, Schindler D, & Dörk T. (2014) Protective role of RAD50 on chromatin bridges during abnormal cytokinesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(3), 1331-41. PMID: 24344331  

Uchil, P., Kumar, A., & Satchidanandam, V. (2006) Nuclear Localization of Flavivirus RNA Synthesis in Infected Cells. Journal of Virology, 80(11), 5451-5464. DOI: 10.1128/JVI.01982-05  

  • May 16, 2016
  • 03:34 PM
  • 805 views

Novel Borrelia Species Causes Lyme Disease with High Spirochetemia

by Pranab Chatterjee in Zoonoticus

In a recent paper in the Lancet Infectious Diseases, Pritt et al  have identified a new genospecies of Borrelia which is attributed to have caused several cases of Lyme disease, marked by a high degree of spirochetemia. In their research article abstract, they state: Methods At the Mayo clinic, from 2003 to 2014, we tested […]... Read more »

  • May 11, 2016
  • 03:50 PM
  • 744 views

ZIKV infection of brain organoids: role of TLR-3 induced apoptosis due to changes in gene expression?

by thelonevirologist in Virology Tidbits

During the current outbreak of ZIKV in Brazil, ZIKV RNA was detected in amniotic fluid samples of women infected with ZIKV during pregnancy and ZIKV RNA has also been isolated from tissue (brain and CNS) of neonates born with microcephaly, suggesting that ZIKV infection of the mother might be a contributive factor in the observed increase of microcephaly cases in neonates. In addition to microcephaly, miscarriages have also been reported in ZIKV positive pregnant women, especially during the fir........ Read more »

Slavov SN, Otaguiri KK, Kashima S, & Covas DT. (2016) Overview of Zika virus (ZIKV) infection in regards to the Brazilian epidemic. Brazilian journal of medical and biological research , 49(5). PMID: 27143174  

Ribeiro GS, & Kitron U. (2016) Zika virus pandemic: a human and public health crisis. Revista da Sociedade Brasileira de Medicina Tropical, 49(1), 1-3. PMID: 27163559  

De Carvalho NS, De Carvalho BF, Fugaça CA, Dóris B, & Biscaia ES. (2016) Zika virus infection during pregnancy and microcephaly occurrence: a review of literature and Brazilian data. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. PMID: 27102780  

Lee JY, & Bowden DS. (2000) Rubella virus replication and links to teratogenicity. Clinical microbiology reviews, 13(4), 571-87. PMID: 11023958  

Duncan R, Esmaili A, Law LM, Bertholet S, Hough C, Hobman TC, & Nakhasi HL. (2000) Rubella virus capsid protein induces apoptosis in transfected RK13 cells. Virology, 275(1), 20-9. PMID: 11017784  

Qian X, Nguyen HN, Song MM, Hadiono C, Ogden SC, Hammack C, Yao B, Hamersky GR, Jacob F, Zhong C.... (2016) Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure. Cell. PMID: 27118425  

Miner, J., Cao, B., Govero, J., Smith, A., Fernandez, E., Cabrera, O., Garber, C., Noll, M., Klein, R., Noguchi, K.... (2016) Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell. DOI: 10.1016/j.cell.2016.05.008  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870  

Casrouge A, Zhang SY, Eidenschenk C, Jouanguy E, Puel A, Yang K, Alcais A, Picard C, Mahfoufi N, Nicolas N.... (2006) Herpes simplex virus encephalitis in human UNC-93B deficiency. Science (New York, N.Y.), 314(5797), 308-12. PMID: 16973841  

Lafaille FG, Pessach IM, Zhang SY, Ciancanelli MJ, Herman M, Abhyankar A, Ying SW, Keros S, Goldstein PA, Mostoslavsky G.... (2012) Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature, 491(7426), 769-73. PMID: 23103873  

Estornes Y, Toscano F, Virard F, Jacquemin G, Pierrot A, Vanbervliet B, Bonnin M, Lalaoui N, Mercier-Gouy P, Pachéco Y.... (2012) dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell death and differentiation, 19(9), 1482-94. PMID: 22421964  

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Hagberg, H., Mallard, C., Ferriero, D., Vannucci, S., Levison, S., Vexler, Z., & Gressens, P. (2015) The role of inflammation in perinatal brain injury. Nature Reviews Neurology, 11(4), 192-208. DOI: 10.1038/nrneurol.2015.13  

  • May 4, 2016
  • 06:11 PM
  • 518 views

Zika Virus pathogenesis in adult mice: comparison to SINV ?

by thelonevirologist in Virology Tidbits

Until recently, clinical manifestations of ZIKV infection ranged from asymptomatic infections to mild dengue-like symptoms characterised by mild fever, rash, muscle/joint pain and headache. Following the 2007 epidemic however neurological complications following ZIKV infection including Guillan-Barre Syndrome (GBS) have been reported and during the current outbreak, ZIKV has been implicating to cause microcephaly and ocular malformations in foetuses born to ZIKV positive mothers. In the absence ........ Read more »

Ioos, S., Mallet, H., Leparc Goffart, I., Gauthier, V., Cardoso, T., & Herida, M. (2014) Current Zika virus epidemiology and recent epidemics. Médecine et Maladies Infectieuses, 44(7), 302-307. DOI: 10.1016/j.medmal.2014.04.008  

Sarno M, Sacramento GA, Khouri R, do Rosário MS, Costa F, Archanjo G, Santos LA, Nery N Jr, Vasilakis N, Ko AI.... (2016) Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. PLoS neglected tropical diseases, 10(2). PMID: 26914330  

Hamel R, Liégeois F, Wichit S, Pompon J, Diop F, Talignani L, Thomas F, Desprès P, Yssel H, & Missé D. (2016) Zika virus: epidemiology, clinical features and host-virus interactions. Microbes and infection / Institut Pasteur. PMID: 27012221  

Hazin AN, Poretti A, Cruz DD, Tenorio M, van der Linden A, Pena LJ, Brito C, Gil LH, Miranda-Filho DB, Marques ET.... (2016) Computed Tomographic Findings in Microcephaly Associated with Zika Virus. The New England journal of medicine. PMID: 27050112  

Broutet N, Krauer F, Riesen M, Khalakdina A, Almiron M, Aldighieri S, Espinal M, Low N, & Dye C. (2016) Zika Virus as a Cause of Neurologic Disorders. The New England journal of medicine, 374(16), 1506-9. PMID: 26959308  

Lednicky J, Beau De Rochars VM, El Badry M, Loeb J, Telisma T, Chavannes S, Anilis G, Cella E, Ciccozzi M, Rashid M.... (2016) Zika Virus Outbreak in Haiti in 2014: Molecular and Clinical Data. PLoS neglected tropical diseases, 10(4). PMID: 27111294  

Faria NR, Azevedo Rdo S, Kraemer MU, Souza R, Cunha MS, Hill SC, Thézé J, Bonsall MB, Bowden TA, Rissanen I.... (2016) Zika virus in the Americas: Early epidemiological and genetic findings. Science (New York, N.Y.), 352(6283), 345-9. PMID: 27013429  

Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, & Rehen SK. (2016) Zika virus impairs growth in human neurospheres and brain organoids. Science (New York, N.Y.). PMID: 27064148  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell. PMID: 26952870  

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Adibi JJ, Marques ET Jr, Cartus A, & Beigi RH. (2016) Teratogenic effects of the Zika virus and the role of the placenta. Lancet (London, England), 387(10027), 1587-90. PMID: 26952548  

  • April 28, 2016
  • 05:33 PM
  • 691 views

MERS-CoV and antiviral singling: role of orf4b and M protein

by thelonevirologist in Virology Tidbits

Coronaviruses (CoV) are positive sense RNA viruses with a genome size of 29-32 kb with four genera (Alpha-, Beta-, Gamma- and Delta CoV) belonging to the family of the Coronaviridae within the order of Nidovirales, with the Betacoronaviruses further divided into four lineages (A-D).

Most CoV identified until now are causing severe disease only in animals including agricultural important animals such as chicken, cattle, and pigs. To date only six human CoV (HCoV) have been identified, namely ........ Read more »

Han, H., Wen, H., Zhou, C., Chen, F., Luo, L., Liu, J., & Yu, X. (2015) Bats as reservoirs of severe emerging infectious diseases. Virus Research, 1-6. DOI: 10.1016/j.virusres.2015.05.006  

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR.... (2016) SARS-like WIV1-CoV poised for human emergence. Proceedings of the National Academy of Sciences of the United States of America. PMID: 26976607  

Munster, V., Adney, D., van Doremalen, N., Brown, V., Miazgowicz, K., Milne-Price, S., Bushmaker, T., Rosenke, R., Scott, D., Hawkinson, A.... (2016) Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis). Scientific Reports, 21878. DOI: 10.1038/srep21878  

Thornbrough JM, Jha BK, Yount B, Goldstein SA, Li Y, Elliott R, Sims AC, Baric RS, Silverman RH, & Weiss SR. (2016) Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation. mBio, 7(2). PMID: 27025250  

Li Y, Banerjee S, Wang Y, Goldstein SA, Dong B, Gaughan C, Silverman RH, & Weiss SR. (2016) Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses. Proceedings of the National Academy of Sciences of the United States of America, 113(8), 2241-6. PMID: 26858407  

Castelli, J., Wood, K., & Youle, R. (1998) The 2-5A system in viral infection and apoptosis. Biomedicine , 52(9), 386-390. DOI: 10.1016/S0753-3322(99)80006-7  

  • April 28, 2016
  • 11:21 AM
  • 333 views

A flower, a craze and the tulips bubble

by Alice Breda in la-Plumeria

In the middle of what historians call the “Age of Reason”, in a solid, thrifty and Calvinist nation, not far from a busy Cartesius involved in the writing of his Principia philosophiae to lay the foundation of modern math and phylosophy, a whole country was hit by a craze that would almost lead to its financial crisis: the tulipomania.

This story begins few centuries earlier in Turkey, when tulips didn’t appear yet in any european Encyclopedia. The Ottomans admired the abili........ Read more »

Lesnaw, J., & Ghabrial, S. (2000) Tulip Breaking: Past, Present, and Future. Plant Disease, 84(10), 1052-1060. DOI: 10.1094/PDIS.2000.84.10.1052  

  • April 13, 2016
  • 06:35 PM
  • 705 views

Zika Virus and induction of apoptosis: combination of IFN-β and downregulation of gene expression?

by thelonevirologist in Virology Tidbits

As described in a previous post, Zika virus (ZIKV) infection of primary human skin fibroblasts induces the upregulation of TLR3 mRNA as well as inducing the expression of MDA-5 and RIG-1, components of the antiviral response induced not only ZIKV but by RNA viruses in general. As a result of the activation of RIG-1 and MDA-5, the expression of both Interferon-α (IFN-α) and Interferon-β (IFN-β) is increased. In mouse models such as A129, AG129 or Ifnar1 -/- mice that are def........ Read more »

Ng CT, Sullivan BM, Teijaro JR, Lee AM, Welch M, Rice S, Sheehan KC, Schreiber RD, & Oldstone MB. (2015) Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection. Cell host , 17(5), 653-61. PMID: 25974304  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell. PMID: 26952870  

Faria NR, Azevedo RD, Kraemer MU, Souza R, Cunha MS, Hill SC, Thézé J, Bonsall MB, Bowden TA, Rissanen I.... (2016) Zika virus in the Americas: Early epidemiological and genetic findings. Science (New York, N.Y.). PMID: 27013429  

Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F.... (2015) Biology of Zika Virus Infection in Human Skin Cells. Journal of virology, 89(17), 8880-96. PMID: 26085147  

Lazear, H., Govero, J., Smith, A., Platt, D., Fernandez, E., Miner, J., & Diamond, M. (2016) A Mouse Model of Zika Virus Pathogenesis. Cell Host . DOI: 10.1016/j.chom.2016.03.010  

Rossi SL, Tesh RB, Azar SR, Muruato AE, Hanley KA, Auguste AJ, Langsjoen RM, Paessler S, Vasilakis N, & Weaver SC. (2016) Characterization of a Novel Murine Model to Study Zika Virus. The American journal of tropical medicine and hygiene. PMID: 27022155  

Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, & Rehen SK. (2016) Zika virus impairs growth in human neurospheres and brain organoids. Science (New York, N.Y.). PMID: 27064148  

Kumari J, Hussain M, De S, Chandra S, Modi P, Tikoo S, Singh A, Sagar C, Sepuri NB, & Sengupta S. (2016) Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion. Journal of cell science, 129(7), 1312-8. PMID: 26906415  

Andersen J, VanScoy S, Cheng TF, Gomez D, & Reich NC. (2008) IRF-3-dependent and augmented target genes during viral infection. Genes and immunity, 9(2), 168-75. PMID: 18094709  

Aizawa S, Fujiwara Y, Contu VR, Hase K, Takahashi M, Kikuchi H, Kabuta C, Wada K, & Kabuta T. (2016) Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes. Autophagy, 12(3), 565-78. PMID: 27046251  

Kimura T, Jain A, Choi SW, Mandell MA, Johansen T, & Deretic V. (2016) TRIM-Directed Selective Autophagy Regulates Immune Activation. Autophagy. PMID: 26983397  

Suthar, M., Aguirre, S., & Fernandez-Sesma, A. (2013) Innate Immune Sensing of Flaviviruses. PLoS Pathogens, 9(9). DOI: 10.1371/journal.ppat.1003541  

Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M.... (2013) ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature cell biology, 15(5), 481-90. PMID: 23624402  

  • April 11, 2016
  • 04:19 PM
  • 604 views

ZIKV pathogenesis: development of animal models

by thelonevirologist in Virology Tidbits

Zika Virus (ZIKV) is a emerging positive strand RNA virus that belongs to the genus of Flaviviridae. Human infections are mostly asymptomatic although a causative link to microcephaly and Guillan-Barre Syndrome (GBS) have been proposed.
So far however no reliable animal model to study ZIKV associated disease has been identified but in order to test a potential vaccine and order to gain a better understanding of ZIKV pathogenesis animal models are being developed. Similar to DENV, these models ........ Read more »

Musso D, & Gubler DJ. (2016) Zika Virus. Clinical microbiology reviews, 29(3), 487-524. PMID: 27029595  

Chan KW, Watanabe S, Kavishna R, Alonso S, & Vasudevan SG. (2015) Animal models for studying dengue pathogenesis and therapy. Antiviral research, 5-14. PMID: 26304704  

DICK GW. (1952) Zika virus. II. Pathogenicity and physical properties. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(5), 521-34. PMID: 12995441  

Rossi SL, Tesh RB, Azar SR, Muruato AE, Hanley KA, Auguste AJ, Langsjoen RM, Paessler S, Vasilakis N, & Weaver SC. (2016) Characterization of a Novel Murine Model to Study Zika Virus. The American journal of tropical medicine and hygiene. PMID: 27022155  

Lazear, H., Govero, J., Smith, A., Platt, D., Fernandez, E., Miner, J., & Diamond, M. (2016) A Mouse Model of Zika Virus Pathogenesis. Cell Host . DOI: 10.1016/j.chom.2016.03.010  

Bell TM, Field EJ, & Narang HK. (1971) Zika virus infection of the central nervous system of mice. Archiv fur die gesamte Virusforschung, 35(2), 183-93. PMID: 5002906  

Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F.... (2015) Biology of Zika Virus Infection in Human Skin Cells. Journal of virology, 89(17), 8880-96. PMID: 26085147  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell. PMID: 26952870  

Lefèvre F, Guillomot M, D'Andréa S, Battegay S, & La Bonnardière C. (1998) Interferon-delta: the first member of a novel type I interferon family. Biochimie, 80(8-9), 779-88. PMID: 9865499  

Lazear HM, Daniels BP, Pinto AK, Huang AC, Vick SC, Doyle SE, Gale M Jr, Klein RS, & Diamond MS. (2015) Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier. Science translational medicine, 7(284). PMID: 25904743  

Rowland, A., Washington, C., Sheffield, J., Pardo-Villamizar, C., & Segars, J. (2016) Zika virus infection in semen: a call to action and research. Journal of Assisted Reproduction and Genetics, 33(4), 435-437. DOI: 10.1007/s10815-016-0684-6  

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