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  • September 8, 2014
  • 03:41 AM

A Dangerous New Dish

by The Neurocritic in The Neurocritic

Bibimbop Brugmansia ** Do NOT try this at home.Edible flowers can make for a beautiful garnish on salads and trendy Brooklyn cocktails, but those decorative flourishes can be a disaster for the oblivious amateur. An unusual case report in BMC Research Notes summarizes what happens when you sprinkle toxic flower petals on your bibimbop (Kim et al., 2014).A 64 year old Koren woman came to the emergency room with incoherent speech and fluctuations in attention, orientation and comprehension. She ha........ Read more »

Evans Schultes, R., & Plowman, T. (1979) The ethnobotany of Brugmansia. Journal of Ethnopharmacology, 1(2), 147-164. DOI: 10.1016/0378-8741(79)90004-7  

  • August 25, 2014
  • 12:11 PM

E-cigs Aren't Safe

by Viputheshwar Sitaraman in Draw Science

Vaping through e-cigs brings out the harms in components of nicotine that are considered nanoparticles that can clog the smaller airways in our lungs [Infographic].... Read more »

Grana, R., Benowitz, N., & Glantz, S. (2014) E-Cigarettes: A Scientific Review. Circulation, 129(19), 1972-1986. DOI: 10.1161/​CIRCULATIONAHA.114.007667  

  • August 19, 2014
  • 11:15 PM

Dextrose 10% in the Treatment of Out-of-Hospital Hypoglycemia

by Rogue Medic in Rogue Medic

Is 50% dextrose as good as 10% dextrose for treating symptomatic hypoglycemia?

If the patient is disoriented, but becomes oriented before the full dose of dextrose is given, is it appropriate to continue to treat the patient as if the patient were still disoriented? If your protocols require you to keep giving dextrose, do the same protocols require you to keep giving opioids after the pain is relieved? Is there really any difference?

50% dextrose has problems.... Read more »

Kiefer MV, Gene Hern H, Alter HJ, & Barger JB. (2014) Dextrose 10% in the treatment of out-of-hospital hypoglycemia. Prehospital and disaster medicine, 29(2), 190-4. PMID: 24735872  

  • August 14, 2014
  • 12:35 AM

The Controversy of Admitting 'We Do Not Know What Works'

by Rogue Medic in Rogue Medic

There are several news articles today criticizing a study because the patients might be deprived of a drug that has not been adequately studied in humans. This criticism is coming from journalists – the people who publicized the fraudulent vaccines research by Andrew Wakefield, who was trying to sell his competing vaccine and was being paid to produce negative research by lawyers suing the vaccine companies.[1]

The real controversy is that this untested drug became the standard of care ........ Read more »

Larabee TM, Liu KY, Campbell JA, & Little CM. (2012) Vasopressors in cardiac arrest: a systematic review. Resuscitation, 83(8), 932-9. PMID: 22425731  

Herlitz J, Ekström L, Wennerblom B, Axelsson A, Bång A, & Holmberg S. (1995) Adrenaline in out-of-hospital ventricular fibrillation. Does it make any difference?. Resuscitation, 29(3), 195-201. PMID: 7667549  

Olasveengen, T., Sunde, K., Brunborg, C., Thowsen, J., Steen, P., & Wik, L. (2009) Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest: A Randomized Trial. JAMA: The Journal of the American Medical Association, 302(20), 2222-2229. DOI: 10.1001/jama.2009.1729  

Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, & Miyazaki S. (2012) Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA : the journal of the American Medical Association, 307(11), 1161-8. PMID: 22436956  

Hayashi Y, Iwami T, Kitamura T, Nishiuchi T, Kajino K, Sakai T, Nishiyama C, Nitta M, Hiraide A, & Kai T. (2012) Impact of early intravenous epinephrine administration on outcomes following out-of-hospital cardiac arrest. Circulation journal : official journal of the Japanese Circulation Society, 76(7), 1639-45. PMID: 22481099  

Glover BM, Brown SP, Morrison L, Davis D, Kudenchuk PJ, Van Ottingham L, Vaillancourt C, Cheskes S, Atkins DL, Dorian P.... (2012) Wide variability in drug use in out-of-hospital cardiac arrest: A report from the resuscitation outcomes consortium. Resuscitation. PMID: 22858552  

Stiell IG, Hebert PC, Weitzman BN, Wells GA, Raman S, Stark RM, Higginson LA, Ahuja J, & Dickinson GE. (1992) High-dose epinephrine in adult cardiac arrest. The New England journal of medicine, 327(15), 1045-50. PMID: 1522840  

Callaway, C. (2012) Questioning the Use of Epinephrine to Treat Cardiac Arrest. JAMA: The Journal of the American Medical Association, 307(11), 1198. DOI: 10.1001/jama.2012.313  

  • August 3, 2014
  • 06:00 PM

Resuscitation characteristics and outcomes in suspected drug overdose-related out-of-hospital cardiac arrest

by Rogue Medic in Rogue Medic

This study is interesting for several reasons.

In a system that claims excellence, the most consistent way to identify the study group is by documentation of a protocol violation - but it is not intended as a study of protocol violations.

This may hint at some benefit from epinephrine (Adrenaline in Commonwealth countries), but that would require some study and we just don't study epinephrine. We only make excuses for not studying epinephrine.

The atropine results suggest that the ........ Read more »

  • July 29, 2014
  • 08:01 PM

Gabapentin and pregabalin misuse

by DJMac in Recovery Review

  Gabapentin and pregabalin misuse are problems that are not going to go away. My post on gabapentin is one of the most-read on this site. While these are useful medicines, workers in drug treatment and support see patients regularly on gabapentin or pregabalin who have misused the drugs or who are misusing them. Guidance is [...]
The post Gabapentin and pregabalin misuse appeared first on Recovery Review.
... Read more »

  • June 27, 2014
  • 04:03 PM

Constructed Wetlands: A promising system

by Ruth Garcia de la Calle in ADVOCATE Marie Curie Network

Pathways of ammonium (NH4+) removal using the stable isotope approach in constructed wetlands (CWs)... Read more »

  • May 26, 2014
  • 04:00 AM

Legal high problems – time to wake up

by DJMac in Recovery Review

Legal high problems Legal highs, or novel psychoactive substances (NPS), have been causing unusual presentations at A&E (Emergency Room) departments in European cities. Because these are relatively new drugs, doctors and other healthcare professionals are not always familiar with them. They are not easy to test for either, requiring specialist forensic laboratories in the main. [...]
The post Legal high problems – time to wake up appeared first on Recovery Review.
... Read more »

  • February 12, 2014
  • 10:54 PM

Fun with Fundulus: The Evolution of Pollution Resistance in Killifish

by Melissa Chernick in Science Storiented

In honor of Mr. Charlie Darwin’s birthday I thought I would read an evolution paper. Put that together with the turn my career has taken into ecotoxicology (and the associated steep learning curve), I was steered towards a study about adapting to pollution.Let me start by introducing you to today’s study organism: The mummichog (Fundulus heteroclitus) is a species of non-migratory killifish found along the Atlantic coast of North America. They can be found in the brackish waters of tidal cre........ Read more »

  • February 12, 2014
  • 08:50 AM

Tasting With Every Part Of Your Body

by Mark Lasbury in As Many Exceptions As Rules

Lots of recent evidence is demonstrating that lingual taste buds are just the tip of the iceberg. Taste receptors have been identified in parts of the respiratory, gastrointestinal, renal, and nervous systems. Taste receptor functions in non-gustatory tissues are related to feeding and hunger, nutrient sensing, and protective responses.

Studies have shown that the pancreas has umami and sweet receptors that work in insulin release. The gut has receptors for fat, umami, sweet and bitter. The........ Read more »

Sundaresan S, Shahid R, Riehl TE, Chandra R, Nassir F, Stenson WF, Liddle RA, & Abumrad NA. (2013) CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(3), 1191-202. PMID: 23233532  

Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, Bookout AL, Chambers CP, Jivan A, McGlynn K, Hutchison MR, Deberardinis RJ, Cobb MH. (2012) The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol Cell., 47(6), 851-862. DOI: 10.1016/j.molcel.2012.08.001  

Dehkordi O, Rose JE, Fatemi M, Allard JS, Balan KV, Young JK, Fatima S, Millis RM, & Jayam-Trouth A. (2012) Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem. Brain research, 1-10. PMID: 22836012  

  • January 28, 2014
  • 07:38 AM

Geneticaly developed toxin destroy HIV carrying lymphocytes

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

Drug that destroy HIV carrying lymphocytes; can impart complete treatment so that patient will not have to take antiretroviral drugs through out life as after certain period after attaining nill HIV count discontinuation of antiretroviral drug therapy there will be no hidden HIV virus in human body cells lymphocytes that relapse HIV infection and reproduce HIV count. ... Read more »

B V Waghmare. (2014) Drug that destroy HIV carrying lymphocytes; will result in complete treatment that will not require to taking antiretroviral drugs through out life. . info:/

  • December 27, 2013
  • 02:14 PM

The Facts & Figures on Substance Abuse in the United States

by Imtiaz Ibne Alam in Medical-Reference - A Pioneer in Medical Blogging

Substance abuse is a serious problem throughout the world; in the United States, an estimated 23.5 million people are affected. However, out of these millions of addicted people, only an estimated 11.2 percent ever receives treatment in care facilities. Unfortunately, this means that the remaining men, women, and children 12 and up included in the statistics have to live with their addiction. ... Read more »

Nutt DJ, King LA, Phillips LD, & Independent Scientific Committee on Drugs. (2010) Drug harms in the UK: a multicriteria decision analysis. Lancet, 376(9752), 1558-65. PMID: 21036393  

  • October 30, 2013
  • 09:25 AM

Free Will Ain’t Free

by Mark Lasbury in As Many Exceptions As Rules

Nature is rife with examples of how one organism can rob another of its free will, turning them into zombies so to say. New evidence is showing that in the case of the Jewel Wasp and the American Cockroach, the wasp is very careful to sting the victim in a certain part of the brain, that which controls the roach’s ability to initiate walking. This is based on the neurotransmitter octopamine, but additional research shows that the change is not due to alterations in octopamine production le........ Read more »

Herzner G, Schlecht A, Dollhofer V, Parzefall C, Harrar K, Kreuzer A, Pilsl L, & Ruther J. (2013) Larvae of the parasitoid wasp Ampulex compressa sanitize their host, the American cockroach, with a blend of antimicrobials. Proceedings of the National Academy of Sciences of the United States of America, 110(4), 1369-74. PMID: 23297195  

  • October 29, 2013
  • 08:02 PM

Bridging Study in Clinical Trials: Definition, History, and Importance

by Imtiaz Ibne Alam in Medical-Reference - A Pioneer in Medical Blogging

In today’s economic environment, globalization of pharmaceutical products has turned into the key to success for drug manufacturers. Investors in new drug development are therefore required to do more at less cost and faster rate now. However, sponsors are facing a new challenge due to ethnic factors, as the pharmacodynamic or clinical data in the original population could vary with the population in the new region. ... Read more »

Liu JP, & Chow SC. (2002) Bridging studies in clinical development. Journal of biopharmaceutical statistics, 12(3), 359-67. PMID: 12448577  

  • August 7, 2013
  • 02:48 PM

Cannabis Smoking and Driving Performance Skills

by William Yates, M.D. in Brain Posts

A trend of increasing liberalization of laws related to cannabis use is emerging in the United States.  As cannabis becomes more available it will be important to monitor for any adverse effects of increased cannabis use.One area of concern is the potential for cannabis to influence driving performance.  I have previously posted a review of two studies of cannabis and motor vehicle accident risk.   A Belgium study estimated cannabis use increased accident risk to about the le........ Read more »

  • August 6, 2013
  • 01:56 PM

Prescription Opiates, Heroin and Overdose

by William Yates, M.D. in Brain Posts

I have previously reviewed research related to prescription opiate drug overdose including:EpidemiologyRisk FactorsToxicologyThese research studies documented the increased rates of prescription opiate drug overdose.  Risk appears increased in those with other substance abuse problems and in those with significant affective disorders, PTSD or schizophrenia.Now a recent research study has been published in PLOS One examining the interrelationship between opiate overdoses and heroin overdoses........ Read more »

  • August 1, 2013
  • 06:08 PM

Heavy Metals in Fish: Toxicity and Tolerance

by Melissa Chernick in Science Storiented

Today I found an interesting paper that fits right in to my new job in the field of aquatic ecotoxicology. As the name suggests, this field is a combination of ecology and toxicology that deals with the nature, effects, and interactions of harmful substances in the environment. In my case, it is aquatic, freshwater systems in particular. The paper I came across looks at the effects of metal contamination and tolerance in freshwater fish.Metal contamination is something that occurs worldwide. A n........ Read more »

  • July 31, 2013
  • 10:45 PM

Dilaudid – Start With 2 mg or Start With 1 mg?

by Rogue Medic in Rogue Medic

What is the proper interval before we should give another dose of opioid to patients who still have significant pain?

This study suggests that 3 to 5 minutes would be ideal, but that the ED (Emergency Department) is not a setting where that is practical. ... Read more »

  • June 29, 2013
  • 09:00 AM

Lack of Association of Guillain-Barré Syndrome With Vaccinations

by Rogue Medic in Rogue Medic

Don’t expect the self-proclaimed vaccine safety organizations to write about this, unless they are claiming that it is a part of some sort of international conspiracy of governments, universities, private companies, and other research organizations.

They are not interested in safety.

They are interested in creating fear and making money off of the fear they create.... Read more »

Baxter R, Bakshi N, Fireman B, Lewis E, Ray P, Vellozzi C, & Klein NP. (2013) Lack of association of guillain-barre syndrome with vaccinations. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 57(2), 197-204. PMID: 23580737  

  • June 27, 2013
  • 03:45 PM

Looks Like Anaphylaxis, But Isn't

by Rogue Medic in Rogue Medic

Half an hour after lunch, a 67 year old man passes out.

He regains consciousness, as often happens with syncope.

He is not quite back to normal, blood pressure is 80/60 mm Hg, heart rate is 110, respiratory rate is 25, oxygen saturation is 99% on room air, with a temperature of 96.8° Fahrenheit.

If we tilt him, we will probably get a worsening of his vital signs, but there is no need to actually obtain the numbers if the assessment is causing deterioration.... Read more »

Bourcier S, Mongardon N, Daviaud F, Moachon L, Arnould MA, Perruche F, Pène F, & Cariou A. (2013) Disulfiram ethanol reaction mimicking anaphylactic, cardiogenic, and septic shock. The American journal of emergency medicine, 31(1), 2700-3. PMID: 22809767  

Senthilkumaran S, Menezes RG, Ravindra G, Jena NN, & Thirumalaikolundusubramanian P. (2013) Antabuse reaction due to occupational exposure-an another road on the map?. The American journal of emergency medicine. PMID: 23791458  

Ehrlich RI, Woolf DC, Kibel DA. (2012) Disulfiram reaction in an artist exposed to solvents. Occup Med (Lond)., 62(1), 64-66. DOI: 10.1093/occmed/kqr172  

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