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All posts; Tags Include "Toxicology"

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  • January 24, 2011
  • 11:19 PM
  • 919 views

Selenium, Brazil Nuts and The Strange Things Men Do.

by ABK in Environment and Health

We all know of men's warm, protective feelings for nuts, but why all the male interest in Brazil nuts? It might be the shape, if not the texture, but I think the answer lies in the Brazil nut's high concentration of selenium. Selenium is protective against prostate cancer, and good for testicular development (fetal period . . . sorry guys) and possibly protective against other oxidative-stress-induced ailments, testicular or not. On the other hand, selenium, at high concentrations can res........ Read more »

  • January 22, 2011
  • 05:38 PM
  • 1,175 views

Weekend Short Stories

by Matthew DiLeo in The Scientist Gardener

Some pretty cool links for your weekend:

Jurassic Park beer:

Fossil Fuels Brewing Co. makes beer with an Eocene-era yeast, formerly encased in a 45 million year old chunk of amber! Incredible, but apparently true. Viable Bacillus spores were discovered first in 25-40 million year old amber by Raul Cano (these spores are so tough you can't kill them with an autoclave). He then founded a startup (Ambergene) with the hopes of discovering ancient antibiotics (this was back during the natural ........ Read more »

  • January 22, 2011
  • 05:22 PM
  • 1,865 views

Did Intestinal parasites and poor hygiene protect us from autoimmune diseases?

by ABK in Environment and Health

Autoimmune diseases are troubling, and often frustrating and painful for health care practitioners and patients. As far as I know, celiac disease is the only autoimmune disorder with a specific and identified trigger: the protein gluten. It has also been pointed out that the incidence of Celiac Disease, the formal name for gluten-triggered autoimmune reactions in the bowel, appears to have been increasing. Some have claimed that humans are not adapted to consumption of plant proteins like glu........ Read more »

  • January 20, 2011
  • 09:00 AM
  • 1,853 views

The risks of CAM: How much do we know?

by Scott in Science-Based Pharmacy

Working in pharmacies where supplements are sold alongside traditional (over-the-counter) medications, I’m regularly astonished at the different perceptions consumers can have about the relative efficacy and safety of different types of products. Once, speaking with a customer about a medical condition she wanted to treat, I indicated that there were no effective non-prescription therapies — [...]... Read more »

  • January 20, 2011
  • 08:45 AM
  • 2,198 views

The risks of CAM: How much do we know?

by Scott Gavura in Science-Based Medicine

Working in pharmacies where supplements are sold alongside traditional (over-the-counter) medications, I’m regularly astonished at the different perceptions consumers can have about the relative efficacy and safety of different types of products. Once, speaking with a customer about a medical condition she wanted to treat, I indicated that there were no effective non-prescription therapies — [...]... Read more »

  • January 19, 2011
  • 11:55 PM
  • 778 views

Elaborating Upon Titanium Dioxide Nanoparticle Pulmonary Toxicity

by Michael Long in Phased

Titanium dioxide nanoparticles interfere with intracellular calcium signaling and promote mucin protein secretion, directly implicating such nanoparticles in pulmonary toxicity (blocked airways).... Read more »

Chen, E. Y. T., Garnica, M., Wang, Y.-C., Chen, C.-S., & Chin, W.-C. (2011) Mucin Secretion Induced by Titanium Dioxide Nanoparticles. PLoS ONE, 6(1). DOI: 10.1371/journal.pone.0016198  

  • January 15, 2011
  • 04:26 PM
  • 1,163 views

Ketogenic Diets

by ABK in Environment and Health

To my friends whom I love dearly and whom are trying to follow ketogenic diets in order to lose weight:I would advocate moderation in just about everything, except for fun and other adrenaline release-provoking activities. Ketogenic diets have proven helpful to people with uncontrolled epilepsy and may be of benefit to epileptics in general, to victims of stroke and other forms of brain injury and possibly cancer. They come with other effects that may not be worth the discomfort or unintended ri........ Read more »

Kossoff, E., Zupec-Kania, B., & Rho, J. (2009) Ketogenic Diets: An Update for Child Neurologists. Journal of Child Neurology, 24(8), 979-988. DOI: 10.1177/0883073809337162  

  • January 7, 2011
  • 11:40 PM
  • 1,125 views

Role of Hormones, Genes, Hybrid Cars and Environmental Factors in Human Cryptorchidism

by ABK in Environment and Health

Undescended testicles (Cryptorchidism) appear to be of complex origin . . . one of those cases where there are genetic and environmental components, and therefore more difficult to tease out (very unintended possible pun there). You can consider genetics, exposures to environmental estrogens and anti-androgens and the relations among risk factors. You will not be bored trying to figure this one out. Added to this mix is a previously unconsidered variable: Hybrid Cars.I teach a course called "........ Read more »

Foresta, C., Zuccarello, D., Garolla, A., & Ferlin, A. (2008) Role of Hormones, Genes, and Environment in Human Cryptorchidism. Endocrine Reviews, 29(5), 560-580. DOI: 10.1210/er.2007-0042  

  • January 6, 2011
  • 01:09 PM
  • 851 views

Hearing, Reading Disabilities and PCB exposures

by ABK in Environment and Health

I found this article very exciting. Serum PCB Concentrations and Cochlear Function in 12-Year-Old Children. by Trnovec et al. 2010, in which they describe associations between hearing function and PCB exposures in Slovakian kids. (In regular terms: PCB exposure in children probably causes hearing deficits). My forebears were deaf, graduated from the American School for the Deaf, were members of Deaf Baseball and Football teams, and from all the old pictures we have, seem to have had absolute........ Read more »

Trnovec, T., Šovčíková, E., Pavlovčinová, G., Jakubíková, J., Jusko, T., Husťák, M., Jurečková, D., Palkovičová, L., Kočan, A., Drobná, B.... (2010) Serum PCB Concentrations and Cochlear Function in 12-Year-Old Children. Environmental Science , 44(8), 2884-2889. DOI: 10.1021/es901918h  

  • January 6, 2011
  • 09:00 AM
  • 2,251 views

Energy Drinks

by Scott in Science-Based Pharmacy

My stimulant of choice is coffee. I started drinking it in first-year university, and never looked back. A tiny four-cup coffee maker became my reliable companion right through graduate school. But since I stopped needing to drink a pot at a time, an entirely new category of products has appeared — the energy drink. Targeting [...]... Read more »

  • January 6, 2011
  • 07:00 AM
  • 2,943 views

Energy Drinks

by Scott Gavura in Science-Based Medicine

My stimulant of choice is coffee. I started drinking it in first-year university, and never looked back. A tiny four-cup coffee maker became my reliable companion right through graduate school. But since I stopped needing to drink a pot at a time, an entirely new category of products has appeared — the energy drink. Targeting [...]... Read more »

  • December 30, 2010
  • 09:41 PM
  • 1,203 views

Triclosan induces hypothyroidism and is transfered to infants during lactation.

by ABK in Environment and Health

Triclosan is used in many personal care products as an anti-bacterial agent. You can find it in soaps, toothpaste etc. It is also an endocrine disruptor that effects at least two different (albeit interrelated) systems. Triclosan has some estrogenic effects, Paul et al. (Dec 2010) and has also been shown to alter thyroid hormone levels early in lactation. Thyroid hormones are especially important during fetal and infant development because they play crucial roles in brain development. Early........ Read more »

Paul KB, Hedge JM, Devito MJ, & Crofton KM. (2010) Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats. Environmental toxicology and chemistry / SETAC, 29(12), 2840-4. PMID: 20954233  

  • December 29, 2010
  • 06:48 PM
  • 1,263 views

Fluoride and IQ

by Ashartus in exposure/effect

One effect that has been claimed for fluoridation of drinking water that I didn’t really examine in my previous examination of fluoride toxicity is reduced IQ. The major regulatory reviews have previously concluded there is no evidence for any such link at relevant concentrations, but a new study published ahead of print in Environmental Health [...]... Read more »

  • December 24, 2010
  • 08:47 AM
  • 928 views

Fried food may cause diabetes in thin people too.

by ABK in Environment and Health

A Taiwanese research group published on the effects of high oxidized frying oil on insulin secretion (reduces insulin secretion)in 2007. In this study they (Chiang et al. 2010) attempt to determine the cause by experimenting with mice. They used three treatment groups: Low Fat DietHigh Fat DietHigh Oxidized Frying Oil Diet. The mice fed high oxidized frying oil exhibited reduced insulin secretion and high blood glucose levels. Very important here: their islets of langerhans (the tissue that ........ Read more »

Ya-Fan Chiang, Huey-Mei Shaw, Mei-Fang Yang, Chih-Yang Huang, Cheng-Hsien Hsieh and Pei-Min Chao. (2010) Dietary oxidised frying oil causes oxidative damage of pancreatic islets and impairment of insulin secretion, effects associated with vitamin E deficiency. British Journal of Nutrition. info:/10.1017/S0007114510005039

  • December 23, 2010
  • 09:10 AM
  • 954 views

Autoimmune disease and inhalation of particulates

by ABK in Environment and Health

Airborne particulate matter appears to increase risk of diabetes, as discussed a few posts down and diabetics appear to have altered immune function according to a number of parameters. Diabetics have now been observed to have stronger indicators of immune response when air pollution levels (particulate matter in this case) are high. Schneider and Alexis (2010 . . . two first authors, congratulations all) observed increased blood levels of endogenous promotors of Activated Protein C Resistanc........ Read more »

  • December 20, 2010
  • 12:26 PM
  • 1,025 views

Inflammation, autoimmune disease, diabetes and gum disease

by ABK in Environment and Health

The other day I wrote about environmental agents increasing risk of obesity, diabetes and insulin resistance and mentioned an article associating exposure to particulate matter with increased incidence of diabetes and wondered about it. If, as the authors suggest, exposure to particulates results in low-level chronic inflammation, then other causes of chronic inflammation (like gum disease) should also be associated with increased risk of diabetes, insulin resistance or similar. A little pokin........ Read more »

Nesse W, Dijkstra PU, Abbas F, Spijkervet FK, Stijger A, Tromp JA, van Dijk JL, & Vissink A. (2010) Increased prevalence of cardiovascular and autoimmune diseases in periodontitis patients: a cross-sectional study. Journal of periodontology, 81(11), 1622-8. PMID: 20583916  

  • December 17, 2010
  • 02:50 PM
  • 848 views

A Little More on Lipophilic Chemicals, Diabetes and Obesity

by ABK in Environment and Health

This is just a little continuation of the post made yesterday in which I wondered if associations between intake of animal protein (vs. vegetable protein) and waist circumference had anything to do with increased exposure of consumers of animal products to environmental contaminants. This is not my area of research . . . but it is an area of research for a lot of other people. Diabetes and/or Insulin Resistance is associated with exposure to Brominated Flame Retardants, Persistent Organic Poll........ Read more »

  • December 13, 2010
  • 05:28 PM
  • 602 views

Atrazine

by ABK in Environment and Health

Congratulations to Walid D. Fakhouri, Joseph L. Nuñez, and Frances Trail for their recently published work on reduction of growth hormone production by the herbicide Atrazine.  Growth hormone is important, as will sound obvious, because it plays a key role in growth (cell proliferation) but also because it influences production of many other hormones including those important in sexual development and reproduction. Changes in growth hormone produce a range of effects that extend far b........ Read more »

  • December 9, 2010
  • 07:41 AM
  • 821 views

Nutritional Stuff, Protein and Vegetarianism

by ABK in Environment and Health

I don't want to get into why I find the whole paleo diet thing so aggravating.  I do find some of the assumptions funny and a little naive, but I think its mainly the hype and messianic tone that make it hard for me to listen too.  However, late at night, when I can't sleep, I sometimes look at articles dealing with nutrition and here are two that piqued my curiosity.One is that high protein maternal diets may predispose infants (at least rats anyway) to greater risk of obesity later i........ Read more »

  • November 24, 2010
  • 11:28 PM
  • 1,253 views

San Antonio Statement on Brominated and Chlorinated Flame Retardants

by Ashartus in exposure/effect

A group of nearly 150 scientists has signed a statement about brominated and chlorinated flame retardants (BFRs and CFRs), essentially asking for some serious thought to be given about whether we really need to be using them the way we are. BFRs and CFRs have been used in a wide range of products due to [...]... Read more »

DiGangi, J., Blum, A., Bergman, �., de Wit, C., Lucas, D., Mortimer, D., Schecter, A., Scheringer, M., Shaw, S., & Webster, T. (2010) San Antonio Statement on Brominated and Chlorinated Flame Retardants. Environmental Health Perspectives, 118(12). DOI: 10.1289/ehp.1003089  

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