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All posts; Tags Include "Psychopharmacology"

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  • January 28, 2017
  • 09:42 AM

Distortions of Reality

by The Neurocritic in The Neurocritic

President Trump this week repeated an assertion he made shortly after his election: that millions of ballots cast illegally by undocumented immigrants cost him the popular vote. If true, this would suggest the wholesale corruption of American democracy.

Not to worry: As far as anyone knows, the president’s assertion is akin to saying that millions of unicorns also voted illegally.

- In a

... Read more »

Preller, K., Herdener, M., Pokorny, T., Planzer, A., Kraehenmann, R., Stämpfli, P., Liechti, M., Seifritz, E., & Vollenweider, F. (2017) The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation. Current Biology. DOI: 10.1016/j.cub.2016.12.030  

Wacker, D., Wang, S., McCorvy, J., Betz, R., Venkatakrishnan, A., Levit, A., Lansu, K., Schools, Z., Che, T., Nichols, D.... (2017) Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell, 168(3), 377-2147483647. DOI: 10.1016/j.cell.2016.12.033  

  • January 8, 2016
  • 08:47 AM

Opioid Drugs for Mental Anguish: Basic Research and Clinical Trials

by The Neurocritic in The Neurocritic

The prescription opioid crisis of overdosing and overprescribing has reached epic proportions, according to the North American media. Just last week, we learned that 91% of patients who survive opioid overdose are prescribed more opioids! The CDC calls it an epidemic, and notes there's been “a 200% increase in the rate of overdose deaths involving opioid pain relievers and heroin.” A recent paper in the Annual Review of Public Health labels it a “public health crisis” and proposes “int........ Read more »

  • December 29, 2015
  • 08:04 AM

Social Pain Revisited: Opioids for Severe Suicidal Ideation

by The Neurocritic in The Neurocritic

Does the pain of mental anguish rely on the same neural machinery as physical pain? Can we treat these dreaded ailments with the same medications? These issues have come to the fore in the field of social/cognitive/affective neuroscience.As many readers know, Lieberman and Eisenberger (2015) recently published a controversial paper claiming that a brain region called the dorsal anterior cingulate cortex (dACC, shown above) is “selective” for pain.1 This finding fits with their long-time narr........ Read more »

  • October 26, 2015
  • 02:47 AM

On the Long Way Down: The Neurophenomenology of Ketamine

by The Neurocritic in The Neurocritic

Is ketamine a destructive club drug that damages the brain and bladder? With psychosis-like effects widely used as a model of schizophrenia? Or is ketamine an exciting new antidepressant, the “most important discovery in half a century”?For years, I've been utterly fascinated by these separate strands of research that rarely (if ever) intersect. Why is that? Because there's no such thing as “one receptor, one behavior.” And because like most scientific endeavors, neuro-pharmacology/psyc........ Read more »

  • July 23, 2011
  • 08:37 PM

Neuro Bliss and Neuro Codeine

by The Neurocritic in The Neurocritic

Lindsay Lohan drinking Neuro Bliss.NEUROBRANDS®, LLC is a company that markets a series of colorful and attractively designed "nutritional drinks", known as Neuro® Drinks.Neuro Gasm Is Part Of The New Neuro CultureFor a company that has great product placement (with many celebrity endorsements), carefully crafted packaging, and regularly issued press releases, they sure are modest about their marketing efforts:"Neuro Drinks® offer consumers an alternative to products that perpetuate our self........ Read more »

  • February 17, 2011
  • 04:18 PM

A Decade of Penn Medicine Research Translates into a New Drug for Depression

by Kim Menard in Penn Medicine News Blog

Tucked away in two separate labs at the Department of Psychiatry at Penn Medicine, researchers have spent more than a decade researching and testing a new treatment for depression. The drug became the first new medicine to treat depression in more than a decade when it received FDA approval in January.... Read more »

  • November 23, 2010
  • 04:40 PM

Drug Development for Cognitive Enhancement

by William Yates, M.D. in Brain Posts

AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate)Cognitive enhancement seeks to improve cognitive function in healthy adults.  Although medicine typically focuses on treatment of medical disorders, a significant effort is underway to explore the mechanism of human attention, concentration, memory and other cognitive functions.  Cognitive enhancement does not replace other methods of cognitive performance.  There is no substitute for repetitive practice and learning conten........ Read more »

  • August 31, 2010
  • 04:58 PM

The Clinical Neuroscience iPad Library

by William Yates, M.D. in Brain Posts

Carrying around a library of pdf files has now become easy with the introduction of the iPad and net book computers.  It is now possible to keep a library of key references that can be accessed at the patient bedside for reference use.  This brings up the question of what pdf files are most valuable for clinicians.   I have spent some time thinking about this and elected to come up with a dozen suggestions.  The criteria for selection included:Valuable for clinicians caring ........ Read more »

Davies P, & Koppel J. (2009) Mechanism-based treatments for Alzheimer's disease. Dialogues in clinical neuroscience, 11(2), 159-69. PMID: 19585951  

  • August 30, 2010
  • 01:58 PM

Ketamine for Depression: Yay or Neigh?

by The Neurocritic in The Neurocritic

Venn diagram of psychoactive drugs [click for larger image]This post is part of a Nature Blog Focus on hallucinogenic drugs in medicine and mental health, inspired by a recent Nature Reviews Neuroscience paper, The neurobiology of psychedelic drugs: implications for the treatment of mood disorders, by Franz Vollenweider & Michael Kometer. This article will be available, open-access, until September 23. For more information on this Blog Focus, including a Table of Contents, please visit Th........ Read more »

  • August 30, 2010
  • 12:32 PM

Neuroscience of Murder and Aggression: Pharmacotherapy

by William Yates, M.D. in Brain Posts

Davis Love--2010 PGA ChampionshipThis is the final post in the series titled: Neuroscience of Murder and Aggression. The other four posts can be found in the links below:Overview and TED video of Dr. FallonEpidemiologyGeneticsBrain ImagingThe treatment of antisocial personality disorder, aggressive behavior and violence receives a limited amount of research attention.  Despite the public health implications of this problem, the therapeutic treatment options are limited.  Clinicians are........ Read more »

Gibbon S, Duggan C, Stoffers J, Huband N, Völlm BA, Ferriter M, & Lieb K. (2010) Psychological interventions for antisocial personality disorder. Cochrane database of systematic reviews (Online). PMID: 20556783  

Khalifa N, Duggan C, Stoffers J, Huband N, Völlm BA, Ferriter M, & Lieb K. (2010) Pharmacological interventions for antisocial personality disorder. Cochrane database of systematic reviews (Online). PMID: 20687091  

Pappadopulos E, Woolston S, Chait A, Perkins M, Connor DF, & Jensen PS. (2006) Pharmacotherapy of aggression in children and adolescents: efficacy and effect size. Journal of the Canadian Academy of Child and Adolescent Psychiatry , 15(1), 27-39. PMID: 18392193  

  • October 7, 2009
  • 11:29 AM

Longitudinal analysis of street Ecstasy content

by DrugMonkey in DrugMonkey

A topic that arises every now and again, particularly when I am discussing Ecstasy-related medical emergency and death, is the nature of the psychoactive ingredients in Ecstasy tablets. For definitional purposes, I consider 3,4-methylenedioxymethamphetamine (MDMA) to be what is considered by the vast majority of consumers to be canonical "Ecstasy".

It is reasonably well-established in the peer reviewed literature and the harm reduction effort that some fraction of Ecstasy that ........ Read more »

Vogels, N., Brunt, T., Rigter, S., van Dijk, P., Vervaeke, H., & Niesink, R. (2009) Content of ecstasy in the Netherlands: 1993-2008. Addiction. DOI: 10.1111/j.1360-0443.2009.02707.x  

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