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  • June 29, 2013
  • 09:00 AM

Lack of Association of Guillain-Barré Syndrome With Vaccinations

by Rogue Medic in Rogue Medic

Don’t expect the self-proclaimed vaccine safety organizations to write about this, unless they are claiming that it is a part of some sort of international conspiracy of governments, universities, private companies, and other research organizations.

They are not interested in safety.

They are interested in creating fear and making money off of the fear they create.... Read more »

Baxter R, Bakshi N, Fireman B, Lewis E, Ray P, Vellozzi C, & Klein NP. (2013) Lack of association of guillain-barre syndrome with vaccinations. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 57(2), 197-204. PMID: 23580737  

  • June 27, 2013
  • 03:45 PM

Looks Like Anaphylaxis, But Isn't

by Rogue Medic in Rogue Medic

Half an hour after lunch, a 67 year old man passes out.

He regains consciousness, as often happens with syncope.

He is not quite back to normal, blood pressure is 80/60 mm Hg, heart rate is 110, respiratory rate is 25, oxygen saturation is 99% on room air, with a temperature of 96.8° Fahrenheit.

If we tilt him, we will probably get a worsening of his vital signs, but there is no need to actually obtain the numbers if the assessment is causing deterioration.... Read more »

Bourcier S, Mongardon N, Daviaud F, Moachon L, Arnould MA, Perruche F, Pène F, & Cariou A. (2013) Disulfiram ethanol reaction mimicking anaphylactic, cardiogenic, and septic shock. The American journal of emergency medicine, 31(1), 2700-3. PMID: 22809767  

Senthilkumaran S, Menezes RG, Ravindra G, Jena NN, & Thirumalaikolundusubramanian P. (2013) Antabuse reaction due to occupational exposure-an another road on the map?. The American journal of emergency medicine. PMID: 23791458  

Ehrlich RI, Woolf DC, Kibel DA. (2012) Disulfiram reaction in an artist exposed to solvents. Occup Med (Lond)., 62(1), 64-66. DOI: 10.1093/occmed/kqr172  

  • June 19, 2013
  • 09:45 PM

Epinephrine for V Tach - Instant Death or Effective Treatment?

by Rogue Medic in Rogue Medic

The patient has V Tach (Ventricular Tachycardia) with a pulse. After amiodarone is given the patient's blood pressure drops and the patient becomes unstable. The patient is still awake, so cardioversion would be very painful and these physicians would need to get anesthesia to sedate the patient. I know - that anesthesia requirement is a bad policy and completely unnecessary for the safety of the patient, but it is politics in that facility. However, sedation for emergency cardioversion is ........ Read more »

  • June 17, 2013
  • 01:03 PM

Brain Insula Signals Response to Depression Treatment

by William Yates, M.D. in Brain Posts

In a previous post, I reviewed a research summary of the potential for brain imaging to be a clinical tool in the diagnosis of brain disorders in the mood disorders domain.One of the key points in that review is the value of finding brain biomarkers for response to specific treatments.To follow up on this point, a recent research study has been published that proposes the brain insular cortex region may be key to determining specific treatment response in major depressive disorder.Helen Mayberg ........ Read more »

McGrath CL, Kelley ME, Holtzheimer PE, Dunlop BW, Craighead WE, Franco AR, Craddock RC, & Mayberg HS. (2013) Toward a Neuroimaging Treatment Selection Biomarker for Major Depressive Disorder. JAMA psychiatry (Chicago, Ill.), 1-9. PMID: 23760393  

  • June 12, 2013
  • 12:25 PM

Brain Imaging for Diagnosis of Mood Disorders

by William Yates, M.D. in Brain Posts

Brain imaging holds promise for improving the accuracy of diagnosis in brain disorders falling under the psychiatric domain.No reliable and valid brain imaging techniques currently exist for the diagnosis of depression or bipolar disorder.  However, research progress has been rapid.Jonathan Savitz from the Laureate Institute for Brain Research and colleagues at Harvard University and Johnson and Johnson Research and Development recently summarized the current state of knowledge in........ Read more »

  • June 12, 2013
  • 12:30 AM

Publication Bias - The Lit Whisperers

by Rogue Medic in Rogue Medic

The Lit Whisperers raise an important point about publication bias and the validity of published studies that show benefit from a drug company study of a treatment that still has patent exclusivity.[1]

There are many problems with science. Science will never be perfect, but only people who do not understand science claim that it should be perfect.

One of the problems with science is publication bias. A paper that has a positive results about a brand name drug is twice as likely to be publi........ Read more »

Kudenchuk, P., Cobb, L., Copass, M., Cummins, R., Doherty, A., Fahrenbruch, C., Hallstrom, A., Murray, W., Olsufka, M., & Walsh, T. (1999) Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation. New England Journal of Medicine, 341(12), 871-878. DOI: 10.1056/NEJM199909163411203  

  • June 11, 2013
  • 11:54 AM

Sleep Effects of Orexin Receptor Drugs in Insomnia

by William Yates, M.D. in Brain Posts

In a previous post, I reviewed a recently clinical trial studying the effect of an orexin receptor blocking agent in the treatment of insomnia.Orexin appears to be a neurochemical involved in arousability and motor activity.  Preliminary studies suggest the orexin receptor may provide a novel target for hypnotics in the treatment of insomnia.An important question in the effects of orexin is whether the hypnotic effect of orexin simulates the same sleep effects as seen by the more studied be........ Read more »

  • June 3, 2013
  • 04:48 AM

Cancer Vaccines from a Blue-Blooded Mollusk

by Andrew Porterfield in United Academics

Along about 1,000 miles of coastline between Monterey, California, and Isla Asuncion, Mexico, a large mollusk lives just under the breaking waves of the Pacific Ocean.

Megathura crenulata, or the giant keyhole limpet, runs up to 10 inches in size, and uses an unusual molecule for breathing: hemocyanin. Instead of its red-blooded terrestrial oxygen carrier hemoglobin, hemocyanin is blue in color, carries a copper molecule instead of iron, and is used by marine snails and mollusks for gill-base........ Read more »

Kantele, A., Häkkinen, M., Zivny, J., Elson, C., Mestecky, J., & Kantele, J. (2011) Humoral Immune Response to Keyhole Limpet Haemocyanin, the Protein Carrier in Cancer Vaccines. Clinical and Developmental Immunology, 1-6. DOI: 10.1155/2011/614383  

Lieb, B., Gebauer, W., Gatsogiannis, C., Depoix, F., Hellmann, N., Harasewych, M., Strong, E., & Markl, J. (2010) Molluscan mega-hemocyanin: an ancient oxygen carrier tuned by a ~550 kDa polypeptide. Frontiers in Zoology, 7(1), 14. DOI: 10.1186/1742-9994-7-14  

  • May 29, 2013
  • 09:25 AM

Gas, Knuckles, And The Little Blue Pill

by Mark Lasbury in As Many Exceptions As Rules

Recent studies have shed a little more light on the state of gas in your body. Besides the obvious, gas bubbles play a role in cracking your knuckles and in decompression sickness after scuba diving. A 2013 study indicates that drugs that regulate nitric oxide generation for vasodilation have a tendency to increase the chances of decompression sickness. This means you might want to skip the Viagra if you plan on diving. In terms of joint manipulation, a study shows that despite the annoying soun........ Read more »

Blatteau, J., Brubakk, A., Gempp, E., Castagna, O., Risso, J., & Vallée, N. (2013) Sidenafil Pre-Treatment Promotes Decompression Sickness in Rats. PLoS ONE, 8(4). DOI: 10.1371/journal.pone.0060639  

deWeber, K., Olszewski, M., & Ortolano, R. (2011) Knuckle Cracking and Hand Osteoarthritis. The Journal of the American Board of Family Medicine, 24(2), 169-174. DOI: 10.3122/jabfm.2011.02.100156  

  • May 28, 2013
  • 10:30 AM

Examples of Ventricular Tachycardia Caused by Amiodarone - Part I

by Rogue Medic in Rogue Medic

How much worse could the patient get if we give amiodarone?

But amiodarone doesn’t cause V Tach (Ventricular Tachycardia). Amiodarone stops V Tach.


If amiodarone can cause V Tach, shouldn’t someone have told us?... Read more »

Marill, K., deSouza, I., Nishijima, D., Stair, T., Setnik, G., & Ruskin, J. (2006) Amiodarone Is Poorly Effective for the Acute Termination of Ventricular Tachycardia. Annals of Emergency Medicine, 47(3), 217-224. DOI: 10.1016/j.annemergmed.2005.08.022  

Helmy, I., Herre, J., Gee, G., Sharkey, H., Malone, P., Sauve, M., Griffin, J., & Scheinman, M. (1988) Use of intravenous amiodarone for emergency treatment of life-threatening ventricular arrhythmias. Journal of the American College of Cardiology, 12(4), 1015-1022. DOI: 10.1016/0735-1097(88)90470-6  

  • May 16, 2013
  • 03:54 PM

Why not use human material for medical research?

by Professor Gareth Sanger in NC3Rs Blog

Using human tissue in medical research throws up a number of different challenges. In our third 2012 NC3Rs 3Rs Prize post, Professor Gareth Sanger from Queen Mary, University of London, discusses how tissue removed from the stomach and intestine can actually help overcome some of these challenges. Is this a viable alternative to using animals for gastrointestinal research? Professor Sanger’s research suggests it could be.... Read more »

  • May 15, 2013
  • 05:50 PM

What RDoC Research Might Look Like

by The Neurocritic in The Neurocritic

The month of May is a violent thingIn the city their hearts start to singWell, some people sing, it sounds like they're screamingI used to doubt it, but now I believe itMonth Of May   ------The Arcade FireToday is Mental Health Month Blog Day, sponsored by the American Psychological Association (APA). It's designed to:...educate the public about mental health, decrease stigma about mental illness, and discuss strategies for making lasting lifestyle and behavior changes that pro........ Read more »

  • May 6, 2013
  • 08:38 AM

It’s Not the Sugar That Rots Teeth

by Andrew Porterfield in United Academics

You’ve been hearing it for years; don’t eat too much sugar, because sugar rots your teeth. It turns out that sugar isn’t the real culprit behind tooth decay. Researchers, looking at the bacteria responsible for dental cavities, had found a molecule that can stop these common dental problems.

Jose Cordova, a Yale University researcher, and Erich Astudillo, from the University of Chile, identified the new molecule, called Keep32, that kills the Streptococcus Mutans bacteria an........ Read more »

Pacey, L. (2012) Chile creates cavity killer. BDJ, 213(5), 202-202. DOI: 10.1038/sj.bdj.2012.793  

  • May 5, 2013
  • 06:57 AM

More on 'Bugs as Drugs'

by Christen Rune Stensvold in Blastocystis Parasite Blog

A follow-up on Carl Zimmer's post in "Phenomena" (National Geographic) on 'Bugs as Drugs'.... Read more »

van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JF, Tijssen JG.... (2013) Duodenal infusion of donor feces for recurrent Clostridium difficile. The New England journal of medicine, 368(5), 407-15. PMID: 23323867  

Weinstock JV. (2012) Autoimmunity: The worm returns. Nature, 491(7423), 183-5. PMID: 23135449  

  • May 2, 2013
  • 11:38 AM

Redefining Mental Disorders as Brain Disorders: TED Talk of Thomas Insel

by William Yates, M.D. in Brain Posts

Components of Brain Limbic SystemAdvances in the diagnosis and treatment of brain disorders like bipolar disorder, schizophrenia and autism are a public health priority.Dr. Thomas Insel, director at NIMH recently presented a TED talk that emphasized the need to rethink how we conceptualize and study these types of disorders.  He argues for a need to redefine mental disorders as brain disorders.  Advances in brain research tools are likely to provide improvements in early diagnosis and ........ Read more »

  • May 2, 2013
  • 09:27 AM

Bodyweight loss – a new industry benchmark to improve animal welfare in preclinical safety assessment

by Dr Fiona Sewell in NC3Rs Blog

Evidence from a multinational pharmaceutical industry collaboration shows this week that upper limits of bodyweight loss of 10 per cent in rats and dogs are sufficient for setting the maximum-tolerated dose in short-term toxicity studies. Where there has been no previously accepted evidence-based assessment criteria before now, Dr Fiona Sewell, NC3Rs, describes how the new recommendations were developed to improve the welfare of thousands of animals used in regulatory studies each year.... Read more »

  • May 1, 2013
  • 12:54 PM

Advances In Parkinson's Disease Treatment: Part II

by William Yates, M.D. in Brain Posts

Globus Pallidus Region of Brain Targeted in DBS in YellowIn a previous post, I summarized some of the highlights of a recent review of Parkinson's disease management by the German neurologists Pedrosa and Timmerman.The first post can be located here and was limited to the drug treatment of the motor symptoms of Parkinson's disease.In part II, I want to focus on deep brain stimulation and the treatment of non-motor symptoms.The authors of the review note the following key points regarding deep br........ Read more »

Pedrosa, D., & Timmermann, . (2013) Review: management of Parkinson's disease. Neuropsychiatric Disease and Treatment, 321. DOI: 10.2147/NDT.S32302  

  • May 1, 2013
  • 09:10 AM

Venomous Plants – A Hairy Situation

by Mark Lasbury in As Many Exceptions As Rules

There are many thousands of poison plants, but not too many are venomous. The nettles and the dendrocnidaes have hollow spines that deliver neurotoxins when they stab you. Recent research has shown that nettle toxin is beneficial in liver regeneration. It stimulates cell proliferation and reduces apoptosis. In an opposite effect, the dendrocnidae toxin called moroidin is a mitotic spindle inhibitor. It may prove useful as an anticancer drug.... Read more »

Hammond-Tooke, G., Taylor, P., Punchihewa, S., & Beasley, M. (2007) Urtica ferox neuropathy. Muscle , 35(6), 804-807. DOI: 10.1002/mus.20730  

  • April 30, 2013
  • 12:31 PM

Treatment Advances in Parkinson's Disease: Part I

by William Yates, M.D. in Brain Posts

3D Molecular Model of L-DopaDrug treatment of Parkinson's disease is a complex clinical problem.  This complexity relates to several factors including incomplete response, multiple symptom domains and adverse effects of commonly used drugs.David Pedrosa and Lars Timmerman from the Department of Neurology at University Hospital Cologne in Germany have recently published an excellent review of Parkinson's disease management.The review is packed with comprehensive tables with specific drug inf........ Read more »

Pedrosa, D., & Timmermann, . (2013) Review: management of Parkinson's disease. Neuropsychiatric Disease and Treatment, 321. DOI: 10.2147/NDT.S32302  

  • April 29, 2013
  • 11:37 AM

Essential Tremor as a Risk Factor for Parkinson's Disease

by William Yates, M.D. in Brain Posts

The number people suffereing from Parkison's disease in the United States is estimated to be between 500,000 and 1,000,000.The key symptoms of Parkinson's disease include tremor and slowed movement or bradykinesia.Known risk factors for Parkinson's disease include advanced age, male gender, family history of Parkinson's disease and exposure to pesticides.Of note, smokers appear to have a reduced risk of Parkinson's disease although the mechanism for this protective effect is unknown.Romero and c........ Read more »

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