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  • November 26, 2014
  • 03:35 PM
  • 959 views

Tryptophan vs. The NFL Fan

by Mark Lasbury in The 'Scope

What is tryptophan, and is it indeed responsible for the snoring that follows Thanksgiving dinner? ... Read more »

  • November 26, 2014
  • 12:06 PM
  • 1,047 views

Treatment Resistance in Eating Disorders

by William Yates, M.D. in Brain Posts

Clinicians treating patients with eating disorders find the challenge great with many treatment-resistant cases.To some extent, this is true of any clinical disorder. Outpatient treatment rolls and inpatient samples are over-represented by those failing to respond to initial interventions.A medical example is helpful here. Endocrinologists specializing in diabetes see more complicated cases where glucose control is difficult and diabetic complications are common.Diabetics with easy glucose contr........ Read more »

  • November 19, 2014
  • 10:25 AM
  • 758 views

A Meal More Powerful Than The NFL

by Mark Lasbury in As Many Exceptions As Rules

Tryptophan supposedly puts you to sleep at Thanksgiving, but research shows that turkey isn’t really that high in this amino acid. On the other hand, tryptophan can save lives. In several old cultures, human sacrifices increased during periods of the year when tryptophan levels in the diet were low. ... Read more »

  • November 18, 2014
  • 09:00 AM
  • 1,265 views

This Is Your TV On Drugs

by Mark E. Lasbury in The 'Scope

There are more than 100 drug commercials on TV every hour of every day. Why? Because they work. Research shows that advertised drugs are prescribed 9x more than comparable drugs that aren’t advertised. And all those side effect notices? The drug companies like them because research says that all you remember is that they were “honest” with you.... Read more »

  • November 12, 2014
  • 09:00 AM
  • 1,018 views

A Goat For Thanksgiving

by Mark Lasbury in As Many Exceptions As Rules

The cornucopia is a symbol for unending bounty, and has become a synonym for Thanksgiving in the US. But what if we investigate this further; the goat should be the real symbol for Thanksgiving. It spawned the horn of plenty in Greek mythology, it represents a dairy and meat source that the pilgrims made use of. And as far as a sustainable source of red meat, its tops. Goat – the other green meat!... Read more »

Liu YT, Sun J, Luo ZY, Rao SQ, Su YJ, Xu RR, & Yang YJ. (2012) Chemical composition of five wild edible mushrooms collected from Southwest China and their antihyperglycemic and antioxidant activity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(5), 1238-44. PMID: 22300772  

  • November 5, 2014
  • 09:00 AM
  • 1,162 views

Doing More With Less

by Mark Lasbury in As Many Exceptions As Rules

Animal-like protists are similar to animal cells, but they do many things in their single cell that we have a hard time competing with. New research shows that they may be useful in medicine, as well as lethal in some cases. N. fowleri is a brain eating amoeba, but calcium tests of foraminifera may be helpful in bone grafts and repairing skull fractures.... Read more »

Sifuentes LY, Choate BL, Gerba CP, & Bright KR. (2014) The occurrence of Naegleria fowleri in recreational waters in Arizona. Journal of environmental science and health. Part A, Toxic/hazardous substances , 49(11), 1322-30. PMID: 24967566  

  • October 29, 2014
  • 02:45 PM
  • 1,344 views

This Month in Blastocystis Research (OCT 2014) - Trick or Treat Edition

by Christen Rune Stensvold in Blastocystis Parasite Blog

October was mostly about conferences and funding. And why is no one studying endosymbiosis in Blastocystis?... Read more »

Fletcher S, Caprarelli G, Merif J, Andresen D, Hal SV, Stark D, & Ellis J. (2014) Epidemiology and geographical distribution of enteric protozoan infections in sydney, australia. Journal of public health research, 3(2), 298. PMID: 25343139  

Nowack EC, & Melkonian M. (2010) Endosymbiotic associations within protists. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 365(1541), 699-712. PMID: 20124339  

Prodeus TV, Zelia OP, Khlebnikova TA, & Pikul' DA. (2014) [Extraenteric infection caused by Blastocystis spp. in a female patient with liver abscess]. Meditsinskaia parazitologiia i parazitarnye bolezni, 6-9. PMID: 25296418  

  • October 15, 2014
  • 09:00 AM
  • 1,408 views

Frankenstein Meets Genetic Modification

by Mark Lasbury in As Many Exceptions As Rules

Halloween conjures up monsters, like Mary Shelly’s Frankenstein. Her story is just as applicable for us today – the story of science being responsible for what it creates. The so-called Frankenfoods are called dangerous – but why? Studies that label them dangerous have been retracted or are merely correlative. New studies have shown that genetically modified crops are safe for livestock and humans. However, there are valid concerns, so every GMO must be tested rigorously.... Read more »

Snell C, Bernheim A, Bergé JB, Kuntz M, Pascal G, Paris A, & Ricroch AE. (2012) Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4), 1134-48. PMID: 22155268  

McCall WV, Andrade C, & Sienaert P. (2014) Searching for the mechanism(s) of ECT's therapeutic effect. The journal of ECT, 30(2), 87-9. PMID: 24755719  

  • September 17, 2014
  • 12:28 PM
  • 762 views

Antidepressants Modulate Memory in the Healthy Brain

by William Yates, M.D. in Brain Posts

The mechanism of antidepressant drug response is not well understood.One theory posits antidepressant effects are only seen in those with clinical depression leaving the healthy brain unchanged.In a previous post, I outlined a study demonstrating effects of antidepressants on brain connectivity measures in the healthy brain.A recent fMRI study extends our understanding of the potential mechanisms for antidepressant drugs.CT Cerqueira and colleagues from Brazil studied the effects of the antidepr........ Read more »

  • September 17, 2014
  • 09:05 AM
  • 1,172 views

Should I Stay Or Should I Go

by Mark Lasbury in As Many Exceptions As Rules

Bacteria can swarm to conquer new territory or settle into structured biofilms, not unlike tribes that are nomadic versus those that build cities. New research indicates has shed light on the mechanics of swarming and biofilm production, including the function of extracellular DNA and secreted polysaccharides. Both biofilms and swarming depend on quorum sensing, and several new papers have identified chemicals that can interrupt quorum sensing in pathogenic bacteria and therefore prevent disease........ Read more »

Gloag ES, Turnbull L, Huang A, Vallotton P, Wang H, Nolan LM, Mililli L, Hunt C, Lu J, Osvath SR.... (2013) Self-organization of bacterial biofilms is facilitated by extracellular DNA. Proceedings of the National Academy of Sciences of the United States of America, 110(28), 11541-6. PMID: 23798445  

Alteri CJ, Himpsl SD, Pickens SR, Lindner JR, Zora JS, Miller JE, Arno PD, Straight SW, & Mobley HL. (2013) Multicellular bacteria deploy the type VI secretion system to preemptively strike neighboring cells. PLoS pathogens, 9(9). PMID: 24039579  

  • September 10, 2014
  • 07:00 PM
  • 113,482 views

Anecdotes and the Appearance of Improvement

by Rogue Medic in Rogue Medic

We like to give treatments that produce results that we can see and logically attribute to the treatments we gave.

We like to give IV (IntaVenous) furosemide (Lasix – frusemide in Commonwealth countries) for CHF (Congestive Heart Failure).

1. The patient had CHF.
2. I gave IV furosemide.
3. The patient produced urine.... Read more »

  • September 8, 2014
  • 09:00 AM
  • 1,261 views

I’ll Wager That You Bet On Football, Or Maybe Football

by Mark E. Lasbury in The 'Scope

Betting on American football and football proper is a trillion dollar a year industry. Why do only 4% of gamblers become addicted. Some of it is actually due to the games themselves. New research is showing that a belief in your knowledge of the game and the “near miss” wherein you almost win your bet, are strong factors in dopamine signaling in the reward centers of the brain.... Read more »

Anselme P, & Robinson MJ. (2013) What motivates gambling behavior? Insight into dopamine's role. Frontiers in behavioral neuroscience, 182. PMID: 24348355  

Huberfeld R, Gersner R, Rosenberg O, Kotler M, & Dannon PN. (2013) Football gambling three arm-controlled study: gamblers, amateurs and laypersons. Psychopathology, 46(1), 28-33. PMID: 22890307  

Khazaal Y, Chatton A, Billieux J, Bizzini L, Monney G, Fresard E, Thorens G, Bondolfi G, El-Guebaly N, Zullino D.... (2012) Effects of expertise on football betting. Substance abuse treatment, prevention, and policy, 18. PMID: 22578101  

Zhou K, Tang H, Sun Y, Huang GH, Rao LL, Liang ZY, & Li S. (2012) Belief in luck or in skill: which locks people into gambling?. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming, 28(3), 379-91. PMID: 21894576  

Grötsch P, Lange C, Wiesbeck GA, & Lang U. (2013) Pathological Gambling Induced by Dopamine Antagonists: A Case Report. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming. PMID: 24356928  

  • September 8, 2014
  • 03:41 AM
  • 985 views

A Dangerous New Dish

by The Neurocritic in The Neurocritic

Bibimbop Brugmansia ** Do NOT try this at home.Edible flowers can make for a beautiful garnish on salads and trendy Brooklyn cocktails, but those decorative flourishes can be a disaster for the oblivious amateur. An unusual case report in BMC Research Notes summarizes what happens when you sprinkle toxic flower petals on your bibimbop (Kim et al., 2014).A 64 year old Koren woman came to the emergency room with incoherent speech and fluctuations in attention, orientation and comprehension. She ha........ Read more »

Evans Schultes, R., & Plowman, T. (1979) The ethnobotany of Brugmansia. Journal of Ethnopharmacology, 1(2), 147-164. DOI: 10.1016/0378-8741(79)90004-7  

  • September 2, 2014
  • 09:00 AM
  • 1,340 views

The Anti-Vaccine Movement Is A Preventable Disease

by Mark E. Lasbury in The 'Scope

Yet another study that attempts to make a link between vaccines and autism has been withdrawn by the publishers. Data from the CDC was re-analysed, and low and behold, a link between vaccine timing and autism was drawn, but only for African-American boys. The problems with this paper and the anti-vaccine movement in general are discussed.... Read more »

  • August 19, 2014
  • 11:15 PM
  • 1,712 views

Dextrose 10% in the Treatment of Out-of-Hospital Hypoglycemia

by Rogue Medic in Rogue Medic

Is 50% dextrose as good as 10% dextrose for treating symptomatic hypoglycemia?

If the patient is disoriented, but becomes oriented before the full dose of dextrose is given, is it appropriate to continue to treat the patient as if the patient were still disoriented? If your protocols require you to keep giving dextrose, do the same protocols require you to keep giving opioids after the pain is relieved? Is there really any difference?

50% dextrose has problems.... Read more »

Kiefer MV, Gene Hern H, Alter HJ, & Barger JB. (2014) Dextrose 10% in the treatment of out-of-hospital hypoglycemia. Prehospital and disaster medicine, 29(2), 190-4. PMID: 24735872  

  • August 18, 2014
  • 11:16 AM
  • 841 views

Guidelines for Treatment of Problem Gambling

by William Yates, M.D. in Brain Posts

Despite the prevalence and impact of problem gambling, few summaries or guidelines address treatment.Searching the guideline.gov website shows no recent additions to the guideline literature.A guideline was published by the Singapore Ministry of Health in 2011. This guideline is still relevant and highlights some of the key elements of a problem gambling treatment program.I will summarize some of these key elements from this source titled: "Management of gambling disorders".  In their summa........ Read more »

Lee KM, Chan HN, Cheah B, Gentica GF, Guo S, Lim HK, Lim YC, Noorul F, Tan HS, Teo P.... (2011) Ministry of Health clinical practice guidelines: management of gambling disorders. Singapore medical journal, 52(6), 456. PMID: 21732000  

  • August 14, 2014
  • 12:17 PM
  • 1,043 views

FDA Approves Novel Insomnia Drug Suvorexant (Belsomra)

by William Yates, M.D. in Brain Posts

Regular readers of this blog had a heads up last year on the development of orexin receptor antagonists for the treatment of insomnia.I posted a review of an Italian clinical drug trial in humans with insomnia paired with polysomnography. This study used three different doses of a orexin receptor antagonist (10 mg 30 mg and 60 mg).In a second post, I reviewed a sleep lab study of the effects of an orexin antagonist drug compared to zolpidem (Ambien) on sleep architecture.This second study found ........ Read more »

  • August 14, 2014
  • 12:35 AM
  • 1,304 views

The Controversy of Admitting 'We Do Not Know What Works'

by Rogue Medic in Rogue Medic

There are several news articles today criticizing a study because the patients might be deprived of a drug that has not been adequately studied in humans. This criticism is coming from journalists – the people who publicized the fraudulent vaccines research by Andrew Wakefield, who was trying to sell his competing vaccine and was being paid to produce negative research by lawyers suing the vaccine companies.[1]

The real controversy is that this untested drug became the standard of care ........ Read more »

Larabee TM, Liu KY, Campbell JA, & Little CM. (2012) Vasopressors in cardiac arrest: a systematic review. Resuscitation, 83(8), 932-9. PMID: 22425731  

Herlitz J, Ekström L, Wennerblom B, Axelsson A, Bång A, & Holmberg S. (1995) Adrenaline in out-of-hospital ventricular fibrillation. Does it make any difference?. Resuscitation, 29(3), 195-201. PMID: 7667549  

Olasveengen, T., Sunde, K., Brunborg, C., Thowsen, J., Steen, P., & Wik, L. (2009) Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest: A Randomized Trial. JAMA: The Journal of the American Medical Association, 302(20), 2222-2229. DOI: 10.1001/jama.2009.1729  

Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, & Miyazaki S. (2012) Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA : the journal of the American Medical Association, 307(11), 1161-8. PMID: 22436956  

Hayashi Y, Iwami T, Kitamura T, Nishiuchi T, Kajino K, Sakai T, Nishiyama C, Nitta M, Hiraide A, & Kai T. (2012) Impact of early intravenous epinephrine administration on outcomes following out-of-hospital cardiac arrest. Circulation journal : official journal of the Japanese Circulation Society, 76(7), 1639-45. PMID: 22481099  

Glover BM, Brown SP, Morrison L, Davis D, Kudenchuk PJ, Van Ottingham L, Vaillancourt C, Cheskes S, Atkins DL, Dorian P.... (2012) Wide variability in drug use in out-of-hospital cardiac arrest: A report from the resuscitation outcomes consortium. Resuscitation. PMID: 22858552  

Stiell IG, Hebert PC, Weitzman BN, Wells GA, Raman S, Stark RM, Higginson LA, Ahuja J, & Dickinson GE. (1992) High-dose epinephrine in adult cardiac arrest. The New England journal of medicine, 327(15), 1045-50. PMID: 1522840  

Callaway, C. (2012) Questioning the Use of Epinephrine to Treat Cardiac Arrest. JAMA: The Journal of the American Medical Association, 307(11), 1198. DOI: 10.1001/jama.2012.313  

  • August 3, 2014
  • 06:00 PM
  • 1,690 views

Resuscitation characteristics and outcomes in suspected drug overdose-related out-of-hospital cardiac arrest

by Rogue Medic in Rogue Medic

This study is interesting for several reasons.

In a system that claims excellence, the most consistent way to identify the study group is by documentation of a protocol violation - but it is not intended as a study of protocol violations.

This may hint at some benefit from epinephrine (Adrenaline in Commonwealth countries), but that would require some study and we just don't study epinephrine. We only make excuses for not studying epinephrine.

The atropine results suggest that the ........ Read more »

  • July 29, 2014
  • 08:01 PM
  • 1,503 views

Gabapentin and pregabalin misuse

by DJMac in Recovery Review

  Gabapentin and pregabalin misuse are problems that are not going to go away. My post on gabapentin is one of the most-read on this site. While these are useful medicines, workers in drug treatment and support see patients regularly on gabapentin or pregabalin who have misused the drugs or who are misusing them. Guidance is [...]
The post Gabapentin and pregabalin misuse appeared first on Recovery Review.
... Read more »

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