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  • January 30, 2013
  • 02:12 AM

Dr. David H. Barlow and Aversion Therapy for Gays

by The Neurocritic in The Neurocritic

Should a professional society honor a highly accomplished investigator who conducted studies in the past that would now be considered unethical? Distinguished professor and clinical psychologist Dr. David H. Barlow was recognized for his achievements by the Association for Psychological Science (APS) last year as the recipient of the 2012 James McKeen Cattell Fellow Award:David H. Barlow has made enormous theoretical and empirical contributions in many areas of clinical psychology. He is best........ Read more »

  • January 28, 2013
  • 10:09 AM

Identifying Samples from Genomic Data

by Daniel Koboldt in Massgenomics

In last week's issue of Science, Melissa Gymrek and colleagues from the lab of Yaniv Erlich (Whitehead) report a method for the triangulation the identity of a sample donor using genomic data and public databases.

As a proof-of-principle, they uncovered the identities of about 50 sample donors from the CEPH Utah collection, perhaps the best-studied collection of "anonymous" samples to date. Their approach exploits several facts of this "information age" we live in.... Read more »

Gymrek M, McGuire AL, Golan D, Halperin E, & Erlich Y. (2013) Identifying personal genomes by surname inference. Science (New York, N.Y.), 339(6117), 321-4. PMID: 23329047  

  • January 25, 2013
  • 08:20 AM

Are we incentivizing hype in science? A case study

by Björn Brembs in

There is a lively discussion going on right now in various forums on the incentives for scientists to publish their work in this venue or another. Some of these discussions cite our manuscript on the pernicious consequences of journal rank, others don't. In our manuscript, we speculate that the scientific community may be facing a deluge of fraud and misconduct, because of the incentives to publish in high-ranking journals, a central point of contention in the discussions lnked to above. An exam........ Read more »

Wasserman, S., Salomon, A., & Frye, M. (2013) Drosophila Tracks Carbon Dioxide in Flight. Current Biology. DOI: 10.1016/j.cub.2012.12.038  

  • January 17, 2013
  • 05:42 PM

Now You’re Just A Moral Rule I Used To Know

by Jesse Marczyk in Pop Psychology

At one point in my academic career I found myself facing something resembling an ethical dilemma: I had, what I felt was, a fantastic idea for a research project, hindered only by the fact that someone had conducted a very … Continue reading →... Read more »

  • January 11, 2013
  • 12:08 PM

On Selling and Over-Selling Science

by TheCellularScale in The Cellular Scale

Science!!! (source)Science communication is a persistent topic of ... well communication. Who is responsible for communicating science? How can science be best communicated to the public? What can we to do stop sensationalist and misleading articles from controlling what findings are generally accepted in the public sphere?All these questions rise up in science blogs and on twitter and then fade back into the background. Then something happens and a flurry of posts about communicating science fl........ Read more »

  • January 8, 2013
  • 12:37 PM

The USA Dream for IMGs: Coming to an end? Analysing the 2012 Match

by Pranab Chatterjee in Scepticemia

My attention was drawn to an article in the JAMA today (1) by one of my friends who is actively pursuing the USMLE route. And after reading this, I guess I have to admit that one now has to make haste in order to prevent waste. Now I have long been wanting to write about [...]... Read more »

Traverso G, & McMahon GT. (2012) Residency training and international medical graduates: coming to America no more. JAMA : the journal of the American Medical Association, 308(21), 2193-4. PMID: 23212494  

  • January 4, 2013
  • 11:44 AM

Cellular Recap of 2012 #2: favorites

by TheCellularScale in The Cellular Scale

As promised, here are my favorite posts from each month.January: The Human Neuron" not so special after all?Butti C, Santos M, Uppal N, & Hof PR (2011). Von Economo neurons: Clinical and evolutionary perspectives. Cortex; a journal devoted to the study of the nervous system and behavior PMID: 22130090February: If you give a mouse a placebo...Wise RA, Wang B, & You ZB (2008). Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release. P........ Read more »

Butti C, Santos M, Uppal N, & Hof PR. (2011) Von Economo neurons: Clinical and evolutionary perspectives. Cortex; a journal devoted to the study of the nervous system and behavior. PMID: 22130090  

Benolken RM, & Jacobson SL. (1970) Response properties of a sensory hair excised from Venus's flytrap. The Journal of general physiology, 56(1), 64-82. PMID: 5514161  

Forterre Y, Skotheim JM, Dumais J, & Mahadevan L. (2005) How the Venus flytrap snaps. Nature, 433(7024), 421-5. PMID: 15674293  

Kay JN, De la Huerta I, Kim IJ, Zhang Y, Yamagata M, Chu MW, Meister M, & Sanes JR. (2011) Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(21), 7753-62. PMID: 21613488  

Casile A, Caggiano V, & Ferrari PF. (2011) The mirror neuron system: a fresh view. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 17(5), 524-38. PMID: 21467305  

Marx M, Günter RH, Hucko W, Radnikow G, & Feldmeyer D. (2012) Improved biocytin labeling and neuronal 3D reconstruction. Nature protocols, 7(2), 394-407. PMID: 22301777  

Finger TE, & Kinnamon SC. (2011) Taste isn't just for taste buds anymore. F1000 biology reports, 20. PMID: 21941599  

Triana-Del Rio R, Montero-Domínguez F, Cibrian-Llanderal T, Tecamachaltzi-Silvaran MB, Garcia LI, Manzo J, Hernandez ME, & Coria-Avila GA. (2011) Same-sex cohabitation under the effects of quinpirole induces a conditioned socio-sexual partner preference in males, but not in female rats. Pharmacology, biochemistry, and behavior, 99(4), 604-13. PMID: 21704064  

Labour MN, Banc A, Tourrette A, Cunin F, Verdier JM, Devoisselle JM, Marcilhac A, & Belamie E. (2012) Thick collagen-based 3D matrices including growth factors to induce neurite outgrowth. Acta biomaterialia, 8(9), 3302-12. PMID: 22617741  

  • January 1, 2013
  • 06:28 AM

What’s wrong with citation analysis?

by Hadas Shema in Information Culture

What’s wrong with citation analysis? Other than your papers not being cited enough, what’s wrong with measuring scientific influence based on citation count? Citation analysis-based decisions concerning grants, promotions, etc. have become popular because, among other things, they’re considered “unbiased.” After all, such analysis gives numbers even non-professionals can understand, helping them make the best [...]

... Read more »

MacRoberts, M., & MacRoberts, B. (1996) Problems of citation analysis. Scientometrics, 36(3), 435-444. DOI: 10.1007/BF02129604  

MacRoberts, M., & MacRoberts, B. (2010) Problems of citation analysis: A study of uncited and seldom-cited influences. Journal of the American Society for Information Science and Technology, 61(1), 1-12. DOI: 10.1002/asi.21228  

Priem, J., Taraborelli, D., Groth, P., & Neylon, C. (2010) altmetrics: a manifesto. info:/

  • December 31, 2012
  • 10:33 AM

Ethical Challenges for Clinical Genome Sequencing

by Daniel Koboldt in Massgenomics

Clinical genome sequencing holds great promise for the diagnosis and treatment of human disease, but also brings many ethical challenges. What if key variants are found in the genome of a patient who died? Should those results be returned to the family, and if so, how? [...]... Read more »

  • December 29, 2012
  • 09:22 AM

Crowdfunding Science

by GDW in The Beast, the Bard and the Bot

Scientific research costs money. And in times where the economy isn’t exactly booming, it’s an area where, wrongfully I believe, budget cuts are quite likely to occur. When austerity reigns, governments and funding agencies alike allocate less and less capital to scientific research. Time to consider alternative routes of funding. One of these relies on [...]... Read more »

  • December 27, 2012
  • 10:00 PM

If the patient is asleep, does that mean that the pain is gone?

by Rogue Medic in Rogue Medic

Is it appropriate to stop giving pain medicine just because the patient is asleep?

My little burned patient was probably not expressing relief from pain with her periods of unresponsiveness – especially since she had not received anything for her severe pain. Each time that she woke up screaming, that was also a clue. the medical command doctor’s orders were to give no pain medicine.[1]

Is propofol effective at putting patients to sleep without relieving their pain?

Sleep do........ Read more »

Paqueron X, Lumbroso A, Mergoni P, Aubrun F, Langeron O, Coriat P, & Riou B. (2002) Is morphine-induced sedation synonymous with analgesia during intravenous morphine titration?. British journal of anaesthesia, 89(5), 697-701. PMID: 12393765  

  • December 19, 2012
  • 05:15 PM

More evidence that antibiotics are over-prescribed - How should that change?

by Rogue Medic in Rogue Medic

Today Lancet Infectious Diseases posted an early release of an article that shows that the antibiotic amoxicillin still does not work on viruses.

Many doctors still routinely prescribe antibiotics for viral infections.

Bias, perhaps the biggest confounder in medical research, is controlled for very well.

What does the study show?... Read more »

  • December 16, 2012
  • 06:57 AM

Premature Babies Poll Results

by GDW in The Beast, the Bard and the Bot

Ten days ago, I asked you all a question in a poll and I promised to let you know the results. To recapitulate: Studies had shown that the survival of extremely premature (~22 weeks) babies has increased over the past decade, but also that the risk these babies run to develop severe disabilities hadn’t changed [...]... Read more »

  • December 14, 2012
  • 12:45 AM

How do we measure the QT segment when there are prominent U waves?

by Rogue Medic in Rogue Medic

This ECG has large T waves, U waves, and P waves, but where does one end and the other begin?

When measuring the QT segment, where do we measure the end of the QT segment and why?... Read more »

Omar, H. (2012) Amiodarone-induced T-U fusion. The American Journal of Emergency Medicine, 30(9), 20810-208100. DOI: 10.1016/j.ajem.2011.10.024  

  • December 6, 2012
  • 08:53 AM

POLL: Very premature babies

by GDW in The Beast, the Bard and the Bot

Preterm birth is risky. And, not surprisingly, the earlier a baby is born, the greater the risks. Two new studies (part of EPICure) address the survival and further development of babies born way too soon (after between 22 and 26 weeks of gestation). The studies found that survival has increased, when comparing premature babies born [...]... Read more »

  • November 29, 2012
  • 09:30 PM

Is Digoxin a Killer?

by Rogue Medic in Rogue Medic

Digoxin (Lanoxin) is an antiarrhythmic drug, which means that it is also a proarrhythmic drug. Any drug that affects the heart’s conduction system can produced changes that are bad, good, or a combination of the two. Digoxin has been associated with a higher death rate, but is that because it is prescribed to sicker patients?... Read more »

Whitbeck, M., Charnigo, R., Khairy, P., Ziada, K., Bailey, A., Zegarra, M., Shah, J., Morales, G., Macaulay, T., Sorrell, V.... (2012) Increased mortality among patients taking digoxin-analysis from the AFFIRM study. European Heart Journal. DOI: 10.1093/eurheartj/ehs348  

  • November 15, 2012
  • 05:30 PM

Extreme Spinal Injury With Preservation of Neurologic Function

by Rogue Medic in Rogue Medic

How bad can spinal injuries be without causing paralysis?

The spine is supposed to be continuous.

The spine should not zig, zig, or take any other detours.

The red line over the spine should be drawn as a roughly straight line, with slight curvature, which can be extreme with kyphosis, scoliosis, or other diseases affecting the spine.... Read more »

  • November 14, 2012
  • 09:00 PM

Is a clot-busting drug safe for 6 hours after stroke symptom onset – or only for an hour and a half? – Part II

by Rogue Medic in Rogue Medic

It has been a couple of months since I wrote Part I and I have not been that motivated to write this part, but Dr. Jerome R Hoffman and Dr. Richelle J Cooper have been busy with the topic. Their paper appears in the current Emergency Medicine Australasia.

"Just before the release of the results of the third inter-national stroke trial (IST-3),1 the largest trial of thrombolysis in acute ischaemic stroke (AIS), the journal Stroke published a remarkable pre-emptive strike – a comm........ Read more »

  • November 12, 2012
  • 10:29 AM

Whole genome sequencing and everyone [with video]

by Mary in OpenHelix

Increasingly people will have the option to learn more about their genetic makeup with new sequencing technologies. These strategies are really moving to the clinic now–and also to the general public in what has been called “recreational genomics”–so more people will be confronted with what to do about the data. For some families there are [...]... Read more »

Presidential Commission for the Study of Bioethical Issues. (2012) PRIVACY and PROGRESS in Whole Genome Sequencing. Presidential Commission for the Study of Bioethical Issues. info:other/

  • October 30, 2012
  • 01:00 AM

Fluid Replacement in the vomiting child - IV, IO, or NG?

by Rogue Medic in Rogue Medic

Annals of Emergency Medicine has some Systematic Review Snapshots that are free and useful for getting a quick look at the evidence on various topics. In the current issue, there is a review of the evidence on fluid replacement for the child unable to take fluids orally, or unable to keep those fluids down.

Which is the best route to give fluids?



... Read more »

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