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  • February 27, 2014
  • 09:10 PM
  • 1,185 views

Hydrophobically Modified Glycol Chitosan Nanoparticles and their Biocompatibility in Murine Osteosarcoma and Osteoblast-like Cells

by JNSM in JScholar Publishers

Glycol chitosan, a derivative of chitosan, can be hydrophobically modified by 5ß-cholanic acid to impart amphiphilic properties that enable the self-assembly into nanoparticles in aqueous media at neutral pH. This nanoparticle system has shown initial success as a therapeutic agent in several model cell culture systems, but little is known about its stability against enzymatic degradation. The goal of this research was therefore to investigate the physicochemical properties of hydrophobica........ Read more »

Amanda Chin, Giulia Suarato, Yizhi Meng. (2014) Evaluation of Physicochemical Characteristics of Hydrophobically Modified Glycol Chitosan Nanoparticles and their Biocompatibility in Murine Osteosarcoma and Osteoblast-like Cells. Journal of Nanotechnology and Smart Materials, 1(1), 1-7. info:/1: 104

  • February 27, 2014
  • 01:39 AM
  • 1,313 views

Nanotechnology and Smart Materials for “More than Moore” – It’s a Small World After All!

by JNSM in JScholar Publishers

Ever since Gordon Moore fore told about the future of the integrated circuit (IC) back in 1965 [1], Moore’s law was not only an accurate forecast of the achievements that microelectronics community has made, but also was a yardstick of the appropriate level of the commercial development in microelectronics for the past five decades. Such an amazing pace of the IC technology development was possible essentially because of simple two-dimensional (2D) structure of the metal-oxide-semiconducto........ Read more »

Jeong Bong Lee. (2014) Nanotechnology and Smart Materials for “More than Moore” – It’s a Small World After All!. Journal of Nanotechnology and Smart Materials, 1(1), 1-3. info:/1: 102

  • February 25, 2014
  • 11:24 PM
  • 855 views

Episode 23: Bigger IS Better!!!! (by~0.5%)

by On Your Mind in On Your Mind

  If there’s one thing we’ve learned about grad school, it’s that it’s often a humbling experience.  Well, that and never pass up an opportunity for free food.  Liam’s getting first-hand experience with all the ways to screw up a Western Blot but he’s not giving up!  Meanwhile, Kat’s taken a detour to catch up ...read moreThe post Episode 23: Bigger IS Better!!!! (by~0.5%) appeared first on On Your Mind Podcast.... Read more »

  • February 24, 2014
  • 08:00 AM
  • 1,240 views

Biomass-based Nanocomposites and Mesoporous Materials

by JNSM in JScholar Publishers

The conversion of lignocellulosic biomass into fuels and chemicals has been rigorously investigated as a response to the depletion of petroleum resources, increasing demand for in oil and secure access to energy. It has been estimated that by 2030 lignocellulosic biomass could supply a substantial portion of the international chemical and transportation fuel market. Lignocellulosic biomass is usually composed of three components: 35-50 wt% cellulose, 20-40 wt% hemicellulose, and 10-25 wt% lignin........ Read more »

Tae Jin Kim. (2014) Biomass-based Nanocomposites and Mesoporous Materials. Journal of Nanotechnology and Smart Materials, 1(1), 1-2. info:/1: 103

  • February 21, 2014
  • 09:21 AM
  • 1,116 views

Virtual Customer Service Agents: Any Help?

by Nura Rutten in United Academics

Perhaps you are able to recall this, but there was a time that if you had a question or a complaint, you could go to a building, with a desk, and there was an actual person to talk to and get annoyed with. Nowadays, you type hours of your life away writing emails or filling in contact forms, while being on hold at the customer service for days in a row. However, not long ago, the virtual customer service agent (VCSA) appeared. ... Read more »

  • February 20, 2014
  • 11:17 PM
  • 1,387 views

Smart Materials from Nanotechnology for Global Challenges

by JNSM in JScholar Publishers

There are several open challenges that our society has to address in the near future: produce sufficient amounts of clean energy from renewable sources, design new technologies that enable a sustainable economic growth, address some relevant environmental issues like quality of air and water or waste recycling, improve our standard of life via more accurate diagnostic tools and new medical treatments, just to mention a few. Most of these challenges deal with the design, synthesis, characterizati........ Read more »

Gianfranco Pacchioni. (2014) Smart Materials from Nanotechnology for Global Challenges. Journal of Nanotechnology and Smart Materials, 1(1), 1-1. info:/1: 101

  • February 20, 2014
  • 11:17 PM
  • 1,096 views

Increasing Knowledge of HIV Transmission: An Important Ingredient in HIV Risk Reduction among Young African American Women Attending Community College

by JAID in JScholar Publishers

HIV/AIDS is currently the leading cause of death for African American women ages 25-34. As heterosexual behavior is the major mode of HIV transmission among this population, it is important to further understand the factors which may influence risky sexual behaviors and promote HIV testing behaviors. The target population for this study represents the convergence of two groups disproportionately at-risk for contracting HIV: African American women and college students. Specifically, the purpose o........ Read more »

Keisha Carr Paxton*, Brandilynn Villarreal, Oku OO, Naomi M Hall. (2013) Increasing Knowledge of HIV Transmission: An Important Ingredient in HIV Risk Reduction among Young African American Women Attending Community College. Journal of HIV/AIDS , 1(2), 1-7. info:/Vol 1: 201

  • February 13, 2014
  • 01:20 AM
  • 963 views

A Putative Role of Organic Anion Transporting Polypeptides (OATPs) In Cell Survival of Hormone-Dependent Breast and Prostate Cancers

by JCRTO in JScholar Publishers

Transporter proteins classified into the solute carrier (SLC) superfamily are essential for import of nutrients for cell survival in organisms. In the last two decades, compelling evidence has accumulated that SLC transporters interact with clinically important anticancer agents and contribute to their pharmacokinetics, particularly the biopharmaceutical processes of absorption, elimination and distribution. Furthermore, many SLC transporters have been shown to be differentially upregulated in c........ Read more »

Takeo Nakanishi*, Ikumi Tamai. (2013) A Putative Role of Organic Anion Transporting Polypeptides (OATPs) In Cell Survival of Hormone-Dependent Breast and Prostate Cancers. Journal of Cancer Research and Therapeutic Oncology, 1(1), 1-6. info:other/1:101

  • February 12, 2014
  • 12:11 AM
  • 829 views

(DE) -Ubiquitination in The TGF-β Pathway

by JCRTO in JScholar Publishers

Aberrations in the enzymes that modify ubiquitin moieties have been observed to cause a myriad of diseases, including cancer. Therefore a better understanding of these enzymes and their substrates will lead to the identification of prospective druggable targets. Here we discuss the role of ubiquitin modifying enzymes in the canonical TGF-β pathway highlighting the ubiquitin regulating enzymes, which may potentially be targeted by small molecule inhibitors.

... Read more »

Prasanna Vasudevan Iyengar, Pieter Johan Adam Eichhorn*. (2013) (DE) -Ubiquitination in The TGF-ß Pathway. Journal of Cancer Research and Therapeutic Oncology, 1(1), 1-6. info:other/1:102

  • February 11, 2014
  • 12:53 AM
  • 849 views

Exploring New Strategies to Monitor Autophagy and Related Cell Death Pathways Using Raman Spectroscopy

by JCRTO in JScholar Publishers

Macroautophagy, (heretofore referred to as autophagy) is thought to play a pivotal role in tumorigenesis and tumor cell survival. Autophagy is a self-degradative cellular process that recycles intracellular components such as proteins and lipids, and may also be used to clear extraneous or damaged organelles. Through this process, metabolites such as amino acids or fatty acids can be liberated for use by the cell. While basal levels of autophagy are required for cellular homeostasis, autophagy i........ Read more »

Martin Isabelle, Vincent I Poon, Zoe V Petropoulos, Samantha J Harder, Julian J Lum*. (2013) Exploring New Strategies to Monitor Autophagy and Related Cell Death Pathways Using Raman Spectroscopy. Journal of Cancer Research and Therapeutic Oncology, 1(1), 1-5. info:other/1:103

  • February 10, 2014
  • 12:26 AM
  • 779 views

Multiple Functional Motifs Are Required for the Tumor Suppressor Activity of a Constitutively-Active ErbB4 Mutant

by JCRTO in JScholar Publishers

ErbB4 (HER4) is a member of the ErbB family of receptor tyrosine kinases, which includes the Epidermal Growth Factor Receptor (EGFR/ErbB1), ErbB2 (HER2/Neu), and ErbB3 (HER3). Mounting evidence indicates that ErbB4, unlike EGFR or ErbB2, functions as a tumor suppressor in many human malignancies. Previous analyses of the constitutively-dimerized and –active ErbB4 Q646C mutant indicate that ErbB4 kinase activity and phosphorylation of ErbB4 Tyr1056 are both required for the tumor suppressor........ Read more »

Richard M. Gallo#, Ianthe N. Bryant#, Christopher P. Mill, Steven Kaverman, David J. Riese II*. (2013) Multiple Functional Motifs Are Required for the Tumor Suppressor Activity of a Constitutively-Active ErbB4 Mutant. Journal of Cancer Research and Therapeutic Oncology, 1(1), 1-10. info:other/1:104

  • February 7, 2014
  • 08:20 AM
  • 778 views

Bone Marrow-Derived Circulating Endothelial Progenitor Cells Contribute to ENOS-Regulated Endothelial Repair and Vasodilation after Arterial Injury In Vivo

by JCVM in JScholar Publishers

Endothelial Nitric Oxide (NO) synthase (eNOS)-produced NO plays a crucial role in maintaining vascular homeostasis. Bone marrow-derived circulating Endothelial Progenitor Cells (EPCs) recently emerged as an important marker of vascular health and contribute to endothelial repair after arterial injury.

BM-derived circulating EPCs are closely involved in eNOS-regulated endothelial repair and vascular function after arterial injury. This finding enriches our understandings of the important role ........ Read more »

Junlei Chang, Dmitriy N. Atochin, Qian Li, Karen S.L. Lam, Aimin Xu, Paul L. Huang*. (2013) Bone Marrow-Derived Circulating Endothelial Progenitor Cells Contribute to ENOS-Regulated Endothelial Repair and Vasodilation after Arterial Injury In Vivo. Journal of Cardiology and Vascular Medicine, 1(1), 1-8. info:other/

  • February 6, 2014
  • 12:07 AM
  • 924 views

Identification of Cigarette Smoke Condensate-Modulated Hiv-1-Associated Host Factors Using A Targeted Transcriptomic Approach

by Journal of HIV/AIDS and Infectious Diseases in JScholar Publishers

Tobacco use has been correlated with increased HIV-1 infection. In vitro characterization of alveolar macrophages obtained from uninfected cigarette smokers showed an increased susceptibility to HIV-1 infection when compared with cell from non-smokers. We showed that Cigarette Smoke Condensate (CSC) enhances HIV-1 infection in primary CD4 cells. The underlying mechanisms of how CSC affects HIV-1 replication are unclear.

The traditional approach that studies the specific cellular processes th........ Read more »

Janaki Purushe, Mario PS Chin*. (2013) Identification of Cigarette Smoke Condensate-Modulated Hiv-1-Associated Host Factors Using A Targeted Transcriptomic Approach. Journal of HIV/AIDS , 1(1), 1-7. info:other/

  • February 4, 2014
  • 11:21 PM
  • 661 views

Morphometric Image Analysis as a Tool in the Diagnosis of Transected Squamous Neoplasms

by JScholar Publishers in JScholar Publishers

Superficial skin biopsies are common in dermatopathology specimens and can pose a diagnostic challenge especially in cosmetic sensitive areas such as the face.

When broadly transected so that the base of the lesion is not visualized, well-differentiated squamous cell carcinomas (SCC), hypertrophic actinic keratoses (HAK), irritated seborrheic keratoses (ISK), and verruca vulgaris (VV) can look quite similar on light microscopic examination.

Visit the following link for full text of the art........ Read more »

Kumaran Mudaliar , Kelli Hutchens,. (2013) Morphometric Image Analysis as a Tool in the Diagnosis of Transected Squamous Neoplasms. Journal of Clinical and Anatomic Pathology, 1(1), 1-5. info:other/

  • February 4, 2014
  • 05:06 AM
  • 787 views

Clinicopathologic Aspects of Ecthyma Gangrenosum in Pediatric Patients a Case Series and Review of the Literature

by JScholar Publishers in JScholar Publishers

Ecthyma gangrenosum (EG) is a cutaneous lesion classically associated with potentially fatal pseudomonal septicemia in immunocompromised patients. Other bacterial and fungal pathogens have also been implicated in EG. Although EG typically occurs in neutropenic or immunocompromised patients, it can occasionally affect previously healthy children.
The cutaneous findings are characteristic with small indurated papulovesicles progressing rapidly to necrotic ulcers with surrounding erythema and a ce........ Read more »

Julianna J. Weiel, Cathryn Z. Zhang, Jessica A. Smith, Wei Wang, Jason DuPont, Fangru Lian*. (2013) Clinicopathologic Aspects of Ecthyma Gangrenosum in Pediatric Patients a Case Series and Review of the Literature. Journal of Clinical and Anatomic Pathology, 1(1), 1-5. info:other/

  • January 20, 2014
  • 06:20 PM
  • 692 views

Resveratrol or Its Metabolites Modulate TNF-α And IL-13 Mediated Changes In IL-8 and Acidic Mammalian Chitinase In Cultured Human Pulmonary Artery Endothelial Cells

by JScholar Publishers in JScholar Publishers

Chronic inflammation is implicated in the etiology of Cardiovascular Disease (CVD), the leading cause of death among men and women. Accordingly, the discovery of inflammation biomarkers, identification of agents with anti-inflammation properties, and studies of their anti-CVD and cardioprotective mechanisms are of significant interest. Previously, we reported that in cultured Human Pulmonary Artery Endothelial Cells (HPAEC), treatment by grape phytochemicals resveratrol and piceatannol significa........ Read more »

Ching-Jen Yang, Tze-chen Hsieh, Susan C. Olson, Joseph M. Wu. (2013) Resveratrol or Its Metabolites Modulate TNF-α And IL-13 Mediated Changes In IL-8 and Acidic Mammalian Chitinase In Cultured Human Pulmonary Artery Endothelial Cells. Journal of Cardiology and Vascular Medicine, 1(1), 1-8. info:other/

  • December 16, 2013
  • 11:14 AM
  • 1,131 views

Genetic Factors Contribute to Being Skinny

by William Yates, M.D. in Brain Posts

An increasing body of research supports a genetic contribution to obesity.However, relatively few genetic studies of the opposite or lean phenotype have been done.The lean phenotype is important to study because being very underweight is linked to mortality risk and several clinical disorders including anorexia nervosa.Typically, I review neuroscience research manuscripts from other scientists in Brain Posts.Today I want to summarize some of my own research published recently in the journal PLOS........ Read more »

Yates WR, Johnson C, McKee P, Cannon-Albright LA. (2013) Genetic Analysis of Low BMI Phenotype in the Utah Population Database. PLOS One. info:/10.1371/journal.pone.0080287

  • November 6, 2013
  • 08:25 AM
  • 1,057 views

The Bouba/Kiki Effect: Synesthesia or Ideasthesia?

by Robert Seymour in NeuroFractal

Many researchers believed that the Bouba/Kiki effect demonstrated that we all show a little synaesthesia, where sensory inputs involuntarily activate an unrelated sensory experience. However, unlike classical synaesthesia, participants in the Bouba/Kiki experiment are associating a sensory input with a semantic label rather than two independent sensory experiences. Nikolic (2009) therefore recently introduced the idea of ideasthesia...... Read more »

Nikolic D. (2009) Is synaesthesia actually ideaesthesia? An inquiry into the nature of the phenomenon. Proceedings of the Third International Congress on Synaesthesia, Science and Art. info:/

  • September 3, 2013
  • 01:06 PM
  • 977 views

Brain Regions Involved in Immediate Reward Decisions

by William Yates, M.D. in Brain Posts

Humans make multiple decisions in the course of daily life that lead to important outcomes.Understanding the brain mechanisms involved in reward decisions has implications across consumer behavior, gambling and drug addiction.Konstanze Albrecht from Germany along with colleagues in Austria and Italy recently published an informative fMRI study of the brain regions involved in reward decision making.Their study was aimed at examining brain regions activated during decision making while varying th........ Read more »

  • August 28, 2013
  • 12:57 PM
  • 1,424 views

Effects of Testosterone Deprivation on Brain Structure

by William Yates, M.D. in Brain Posts

The evils of testosterone deficiency are trumpeted from the television, radio and internet on a daily basis. Some of this is driven by the pharmaceutical industry and the explosion of products available for testosterone replacement.I think quite a bit of this is overblown, but I did find a recent study on the effects of androgen deficiency on brain structure and function.Testosterone is the major androgen in men and this hormone contributes to risk of prostate cancer progression.  Men with ........ Read more »

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