Post List

All posts; Tags Include "Clinical Research"

(Modify Search »)

  • March 20, 2017
  • 11:25 AM
  • 114 views

Opioids, Benzos and Risk for Overdose

by William Yates, M.D. in Brain Posts

The evolving epidemic of opioid overdose and overdose deaths is receiving increased public and research attention.Opioids overdoses and overdose deaths are often unintentional or accidental. It has been known that concurrent use of opioids with alcohol or benzodiazepines (i.e. Valium or Xanax) increases risk for overdose toxicity.A recent study published in the British Medical Journal confirmed the association of concurrent benzodiazepine prescription with opioid overdose.This research team exam........ Read more »

  • March 15, 2017
  • 12:57 PM
  • 153 views

Emotional Intelligence and the Physician

by William Yates, M.D. in Brain Posts

Emotional intelligence (EI) is characterized by the ability to recognize emotional states in self and in others.This emotional recognition may be helpful in guiding behavior and in improving interpersonal relationships.It seems logical on a face validity level to assume that higher levels of EI would be good in the selection of students for medical school.However, there are few studies assessing EI in physicians. There are fewer studies that examine whether EI influences physician behavior, pati........ Read more »

  • March 10, 2017
  • 06:05 AM
  • 145 views

Spontaneous Pneumothorax and air travel in BHD Syndrome

by Joana Guedes in BHD Research Blog

Previous studies show that BHD syndrome causes spontaneous pneumothorax (SP) in 24-38% of patients, with a recurrence rate of up to 75% (Toro et al., 2007; Toro et al., 2008; Houweling et al., 2011). A common preventative strategy used following an initial SP in patients with BHD is pleurodesis, however, its efficacy in preventing recurrent episodes is not well known. Due to the pressure changes during air travel, cystic air spaces expand and compress in the thorax possibly leading to cyst ruptu........ Read more »

Gupta N, Kopras EJ, Henske EP, James LE, El-Chemaly S, Veeraraghavan S, Drake MG, & McCormack FX. (2017) Spontaneous Pneumothoraces in Patients with Birt-Hogg-Dubé Syndrome. Annals of the American Thoracic Society. PMID: 28248571  

  • March 7, 2017
  • 11:01 AM
  • 148 views

Can Older Drivers Benefit From Training?

by William Yates, M.D. in Brain Posts

Older drivers are over-represented in motor-vehicle driving accidents.The lowest rate of fatal vehicle crashes per 100 million miles driven is found in drivers between the ages of 30-69 years of age.Fatal vehicle driving rates per miles driven is 4 to 5 times higher in drivers over 80 years of age. (IIHS.org data)So can older drivers be trained or educated to improve their safety (and the safety o those around them)?A recent randomized controlled trial examined an educational intervention in dri........ Read more »

  • March 2, 2017
  • 12:19 PM
  • 161 views

Improving Hearing-Aid Access in Older Adults

by William Yates, M.D. in Brain Posts

There are significant barriers to widespread use of hearing-aids in older adults with age-related hearing loss.Sensitivity to the stigma of wearing a hearing-aid is one barrier.Cost is another significant barrier. In the U.S., bilateral hearing-aid purchase amounts to a cost of $2400 to $5800. This cost is typically not covered by Medicare or other health insurance plans.I ran into a interesting manuscript on looking at an alternative less costlier approach to hearing-aid selection and purchase......... Read more »

  • February 28, 2017
  • 10:43 AM
  • 162 views

Outcome in Early Education Interventions (Educare)

by William Yates, M.D. in Brain Posts

Despite centuries of experience in education, the best time to start formal education is still under debate. Is five years of age too old? Is three years of age too early?One issue with early education interventions is the potential for catch-up in children starting school later. In other words, early gains with younger children may evaporate overtime.One recent research study examines effectiveness of a child development intervention known as Educare. Educare seeks to reduce the achievement gap........ Read more »

Yazejian, N., Bryant, D., Hans, S., Horm, D., St. Clair, L., File, N., & Burchinal, M. (2017) Child and Parenting Outcomes After 1 Year of Educare. Child Development. DOI: 10.1111/cdev.12688  

  • February 10, 2017
  • 07:19 AM
  • 201 views

BHD in patients undergoing chest CT and characteristics of BHD in Korea.

by Joana Guedes in BHD Research Blog

To date, there have been no prospective studies attempting to diagnose BHD syndrome or literature reviews on BHD in Korea. Park et al. (2017) address this in their new study that aims to detect BHD prospectively in patients undergoing chest computed tomography (CT) scans and to classify the characteristics of BHD in Korea.... Read more »

  • February 3, 2017
  • 11:22 AM
  • 93 views

Brain Shape and Personality Type

by William Yates, M.D. in Brain Posts

Personality has often been conceptualized a a human feature shaped largely by nurture and environment.Unlike major neuroscience medicine disorders, personality features have been considered less influenced by brain structure and genetic influences.A recent brain structure (morphology) study puts these assumptions at risk.Roberta Riccelli along with colleagues in Italy and Florida State University studied brain structural features across 507 participants in the Human Connectome Project.All subjec........ Read more »

  • January 27, 2017
  • 05:13 AM
  • 452 views

TSC1 expression is affected by VHL alterations and HIF-1α production in clear-cell RCC

by Joana Guedes in BHD Research Blog

VHL genetic alterations do not affect the production of HIF-α in clear-cell renal cell carcinoma (ccRCC). However, their effects on tuberous sclerosis proteins (TSC1/2) and heat shock protein 90 (Hsp90) expression are currently unknown. In a recent study, Damjanovic et al. (2016) evaluated the impact of VHL genetic alterations and HIF-α production on the expression of TSC proteins and Hsp90 in 47 sporadic ccRCCs and corresponding normal tissues.... Read more »

  • January 25, 2017
  • 12:06 PM
  • 284 views

Jet Lag and Baseball (MLB) Performance

by William Yates, M.D. in Brain Posts

Abrupt changes in the biological clock or circadian rhythm are noted to contribute to significant cognitive and psychomotor impairments.One practical area for this effect to potentially be important is in the area of sports performance.Alex Song and colleagues recently completed an interesting study of major league baseball (MLB) performance related to team travel patterns.The major leagues are divided into regional divisions (western, central and eastern) to minimize length of travel to and fro........ Read more »

Song A, Severini T, & Allada R. (2017) How jet lag impairs Major League Baseball performance. Proceedings of the National Academy of Sciences of the United States of America. PMID: 28115724  

  • January 23, 2017
  • 10:59 AM
  • 260 views

Processing Speed Cognition in Elderly: Clinical Trial

by William Yates, M.D. in Brain Posts

Processing speed declines significantly with age and contributes to impairment and disability in old age.There is little known about whether age-related processing speed decline can be slowed with interventionA recent clinical trial by a Japanese group targeted processing speed training in a group of 72 elderly.This study found significant effects for a daily 15 minute processing speed training game over 4 weeks.In contrast to a control group, the intervention group found specific improvement in........ Read more »

  • January 20, 2017
  • 05:19 AM
  • 242 views

RCC: Updates on Guidelines for Adjuvant Therapy and new drug combination

by Joana Guedes in BHD Research Blog

The European Association of Urology (EAU) Renal Cell Carcinoma (RCC) guidelines panel has recently updated its recommendation on adjuvant therapy with sunitinib in non-metastatic RCC after surgical tumour removal (Bex et al., 2016). These clinical guidelines provide urologists with evidence-based information and recommendations for the management of RCC and the panel includes urological surgeons, oncologists, pathologists, radiologists and patient advocates. Based on the conflicting results of t........ Read more »

  • January 13, 2017
  • 05:11 AM
  • 263 views

Nutrient-dependent FNIP degradation regulates FLCN localization and promotes renal cancer progression

by Joana Guedes in BHD Research Blog

Birt-Hogg-Dubé (BHD) syndrome is a rare disorder caused by mutations in FLCN and associated with increased risk of kidney cancer. It has been shown that FLCN-interacting protein 1 and 2 (FNIP1 and FNIP2) double knockout mice, like the FLCN knockout mice, develop renal carcinoma (Hasumi et al., 2015). However, the molecular mechanisms linking FNIP and FLCN remain unknown. In their new study, Nagashima et al. (2016) show that FNIP2 undergoes proteasome-dependent degradation via β-TRCP ........ Read more »

  • December 16, 2016
  • 05:25 AM
  • 333 views

Patient participation in clinical trials

by Joana Guedes in BHD Research Blog

Clinical trials are crucial to help doctors and scientists understand how to safely treat a particular condition, to evaluate new treatments and to test drug safety and efficacy. They have an important role in every step of managing a condition with different clinical trials helping with prevention, diagnosis, treatments and follow-up support.... Read more »

  • December 6, 2016
  • 12:07 PM
  • 391 views

Online Insomnia Therapy Effective in Clinical Trial

by William Yates, M.D. in Brain Posts

Insomnia of sufficient severity to meet clinical significance is estimated to affect up to 20% of the general population.This makes insomnia an important public health challenge.Effective, inexpensive and accessible programs to treat insomnia are needed.One recent controlled clinical trial supports the promise of an online intervention that incorporates key elements of cognitive behavioral therapy (CBT).Lee Ritterband and colleagues at the University of Virginia recently published a controlled c........ Read more »

  • November 29, 2016
  • 11:24 AM
  • 401 views

Your Brain On God: Reward and Motivation

by William Yates, M.D. in Brain Posts

William James authored a seminal book titled The Varieties of Religious Experience: A Study in Human Nature that was published in 1902.In this work, James reviewed the nature of religious experiences and noted a lack of scientific inquiry into this human phenomenon.James would have been extremely interested in a recent scientific inquiry into the religious experience from brain researchers at the University of Utah and Harvard University.In this study, functional magnetic resonance imaging (fMRI........ Read more »

Ferguson MA, Nielsen JA, King JB, Dai L, Giangrasso DM, Holman R, Korenberg JR, & Anderson JS. (2016) Reward, Salience, and Attentional Networks are Activated by Religious Experience in Devout Mormons. Social neuroscience. PMID: 27834117  

  • November 21, 2016
  • 11:10 AM
  • 403 views

Benefits of Physical Activity in Parkison's Disease

by William Yates, M.D. in Brain Posts

Parkinson's disease (PD) is a progressive neurodegerative disorder estimated to affect 7 to 10 million individual worldwide.The primary mechanism for Parkinson's disease is a reduction in the neurotransmitter dopamine in the midbrain region of the substantia nigra highlighted in red in the figure.PD impairs motor and cognitive functions and leads to significant decline in psychosocial functioning.Drugs for PD can be effective in reversing and slowing the progression of the illness. However, resp........ Read more »

Lauzé M, Daneault JF, & Duval C. (2016) The Effects of Physical Activity in Parkinson's Disease: A Review. Journal of Parkinson's disease, 6(4), 685-698. PMID: 27567884  

  • November 18, 2016
  • 07:25 AM
  • 347 views

Mutated mTOR regulator RRAGC proteins decrease interactions with FLCN

by Joana Guedes in BHD Research Blog

Follicular lymphoma is a B-cell lymphoma that remains incurable with conventional therapies. Ying et al. (2016) present a new study exploring the biological and genetic features of follicular lymphoma and identifying potential new therapeutic targets. The authors identified recurrent mutations in the mTOR regulator RRAGC, a small G-protein, in approximately 10% of follicular lymphoma cases. Mutations in RRAGC localized to one protein surface area surrounding the GTP/GDP–binding sites. In s........ Read more »

Ying ZX, Jin M, Peterson LF, Bernard D, Saiya-Cork K, Yildiz M, Wang S, Kaminski MS, Chang AE, Klionsky DJ.... (2016) Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 22(21), 5383-5393. PMID: 27267853  

  • November 17, 2016
  • 11:00 AM
  • 453 views

Missed Opportunities in Stroke Prevention

by William Yates, M.D. in Brain Posts

Rates of myocardial infarction and stroke have been declining over the last decade in the U.S. and Europe. However, a recent manuscript suggests there are still significant missed opportunities to prevent stroke.This manuscript presents results of review of electronic primary care records in the United Kingdom.The authors examines a group of over 29,000 subjects with a diagnosis of stroke or transient ischemic attack over a 10 year period.Records were reviewed to assess for compliance with guide........ Read more »

  • November 15, 2016
  • 11:38 AM
  • 413 views

Celebrex Boosts Antidepressant Response

by William Yates, M.D. in Brain Posts

I ran into an interesting article at ScienceDaily providing data on a small sample size study of the anti-inflammatory drug celecoxib (Celebrex) in depression.Access the ScienceDaily report on this study by clicking HERE.This study focused on subjects with bipolar depression. All subjects were in a depressed phase and received the antidepressant drug escitalopram (Lexapro).Although only 55 subjects participated in this study, the results were significant and large. Adding Celebrex to escitalopra........ Read more »

join us!

Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.

If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.

Register Now

Research Blogging is powered by SMG Technology.

To learn more, visit seedmediagroup.com.