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  • November 16, 2010
  • 09:39 PM
  • 1,416 views

A Brush with Madness

by Kristopher Hite in Tom Paine's Ghost







I'm giving myself ten minutes to do this. To write whatever storms into my mind then hit post.

I think the archaic revival might run into some barriers. Like starvation, no communication, and other electrical difficulties if it embraces the Abbey-esque Luddite philosophy entirely.

As much as I want to get onto that other boat I think I will just slip between the hulls and end up swimming by myself among the sea-monsters, bullets whizzing past my head with bubbles trailing behind in dark ........ Read more »

Sedel F, Baumann N, Turpin JC, Lyon-Caen O, Saudubray JM, & Cohen D. (2007) Psychiatric manifestations revealing inborn errors of metabolism in adolescents and adults. Journal of inherited metabolic disease, 30(5), 631-41. PMID: 17694356  

Rose FC. (2006) Van Gogh's madness. International review of neurobiology, 253-69. PMID: 16730519  

Altintoprak AE, Ersel M, & Bayrakci A. (2009) An unusual suicide attempt: a case with psychosis during an acute porphyric attack. European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 16(2), 106-8. PMID: 19262206  

Mandoki MW, & Sumner GS. (1994) Psychiatric manifestations of hereditary coproporphyria in a child. The Journal of nervous and mental disease, 182(2), 117-8. PMID: 8308532  

  • November 16, 2010
  • 10:50 AM
  • 1,204 views

Sometimes in cancer research there really is hope

by Sally Church in Pharma Strategy Blog

It’s easy to forget that oncologists (whether medical, radiation or surgical) and hematologists deal with death and dying every single day, it’s sadly an integral part of the daily job.  Sometimes though, something comes along that offers hope or perhaps … Continue reading →... Read more »

  • November 15, 2010
  • 01:04 PM
  • 1,561 views

Can obesity surgery for mothers prevent obesity in their children?

by Travis Saunders, MSc in Obesity Panacea

…And we’re back! After a month in exile from the blogging world my comprehensive exams are done!… for now. Assuming that my committee finds my answers satisfactory I will move on to an oral exam sometime between now and the holiday season. The good news is that I have read a ton of papers in the past few months (probably somewhere north of 200) so I’ve found plenty of interesting things to blog about well into the new year!... Read more »

  • November 10, 2010
  • 10:28 PM
  • 1,647 views

Glucosamine and Chondroitin Found to be Ineffective for Relief of Arthritis Pain

by Walter Jessen in Highlight HEALTH

A recent meta-analysis in the British Journal of Medicine (BMJ) concludes that chondroitin, glucosamine and their combination do not reduce joint pain or have an impact on narrowing of joint space.... Read more »

  • November 4, 2010
  • 10:45 AM
  • 1,186 views

Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

by Sally Church in Pharma Strategy Blog

This morning I was delighted to see that one of my favourite medical doctors on Twitter, Dr Anas Younes from MD Anderson, has published a paper in the New England Journal of Medicine on a clinical trial of a promising … Continue reading →... Read more »

Younes, A., Bartlett, N., Leonard, J., Kennedy, D., Lynch, C., Sievers, E., & Forero-Torres, A. (2010) Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas. New England Journal of Medicine, 363(19), 1812-1821. DOI: 10.1056/NEJMoa1002965  

  • November 3, 2010
  • 12:11 PM
  • 1,148 views

Metastatic melanoma – what’s new on the horizon?

by Sally Church in Pharma Strategy Blog

Metastatic melanoma is quite a hot topic right now with a rich pipeline of products in development after a decade of little or no progress.  Of course, it is a bit like three London buses coming along at once after … Continue reading →... Read more »

  • November 3, 2010
  • 08:08 AM
  • 1,344 views

How To Form A Habit

by Lorimer Moseley in BodyInMind

We’ve all wondered how to get our patients to change their life habits (to the better of course…in our minds). In fact, the behavioural and physical therapies depend on us being able to convince patients to develop new habits – to  bend and straighten their knees a few times before getting up from prolonged sitting [...]... Read more »

Lally, P., van Jaarsveld, C., Potts, H., & Wardle, J. (2009) How are habits formed: Modelling habit formation in the real world. European Journal of Social Psychology. DOI: 10.1002/ejsp.674  

  • November 2, 2010
  • 08:13 AM
  • 1,024 views

Dendritic Polyglycerol Sulfates for Inflammatory Diseases

by Michael Long in Phased

Rainer Haag (Freie Universitat Berlin) and coworkers have synthesized a branched polymer that potently inhibits L and P selectin activity in mice, and thus shows promise as a treatment for inflammatory diseases.... Read more »

Dernedde, J., Rausch, A., Weinhart, M., Enders, S., Tauber, R., Licha, K., Schirner, M., Zugel, U., von Bonin, A., & Haag, R. (2010) Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1003103107  

  • November 1, 2010
  • 01:42 PM
  • 1,171 views

Crizotinib in ALK-rearranged cancer mutations

by Sally Church in Pharma Strategy Blog






While reading the latest New England Journal of Medicine, it was hard not to notice the focus on ALK mutations and crizotinib (Pfizer), with four articles in all on the topic, including a full original article, two brief reports and [...]... Read more »

Morris, S., Kirstein, M., Valentine, M., Dittmer, K., Shapiro, D., Saltman, D., & Look, A. (1994) Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science, 263(5151), 1281-1284. DOI: 10.1126/science.8122112  

Soda, M., Choi, Y., Enomoto, M., Takada, S., Yamashita, Y., Ishikawa, S., Fujiwara, S., Watanabe, H., Kurashina, K., Hatanaka, H.... (2007) Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer. Nature, 448(7153), 561-566. DOI: 10.1038/nature05945  

Kwak, E., Bang, Y., Camidge, D., Shaw, A., Solomon, B., Maki, R., Ou, S., Dezube, B., Jänne, P., Costa, D.... (2010) Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer. New England Journal of Medicine, 363(18), 1693-1703. DOI: 10.1056/NEJMoa1006448  

Hallberg, B., & Palmer, R. (2010) Crizotinib — Latest Champion in the Cancer Wars?. New England Journal of Medicine, 363(18), 1760-1762. DOI: 10.1056/NEJMe1010404  

Butrynski, J., D'Adamo, D., Hornick, J., Dal Cin, P., Antonescu, C., Jhanwar, S., Ladanyi, M., Capelletti, M., Rodig, S., Ramaiya, N.... (2010) Crizotinib in -Rearranged Inflammatory Myofibroblastic Tumor . New England Journal of Medicine, 363(18), 1727-1733. DOI: 10.1056/NEJMoa1007056  

  • October 29, 2010
  • 09:00 AM
  • 913 views

What's in a placebo? Mike Adams certainly doesn't know. [Respectful Insolence]

by Orac none@example.com in Food Matters

If there's one thing that confounds advocates of so-called "complementary and alternative medicine" (CAM), it's the placebo effect. That's because, whenever most such remedies are studied using rigorous clinical trial design using properly constituted placebo controls, they almost always end up showing effects no greater than placebo effects. That's the main reason why they frequently suggest that, you know, all those rigorous, carefully constructed randomized placebo-controlled clinical trials ........ Read more »

Golomb BA, Erickson LC, Koperski S, Sack D, Enkin M, & Howick J. (2010) What's in placebos: who knows? Analysis of randomized, controlled trials. Annals of internal medicine, 153(8), 532-5. PMID: 20956710  

  • October 29, 2010
  • 08:44 AM
  • 2,201 views

Weight-loss variability in response to the same diet

by Peter Janiszewski, Ph.D. in Obesity Panacea

Whoever said weight loss was a straightforward process has probably never tried to go from a BMI of 40 down to 24 kg/m2. I must admit that only a few years back, in the early stages of my graduate training, I was equally naive. I thought: it’s a case of simple math – once your energy expenditure exceeds your energy intake, you lose weight.
It certainly sounds simple, and yet it rarely is that simple in practice.
Take for example a recent study published in the November issue of Obesi........ Read more »

  • October 29, 2010
  • 08:31 AM
  • 2,095 views

What's in a placebo? Mike Adams certainly doesn't know.

by Orac in Respectful Insolence

If there's one thing that confounds advocates of so-called "complementary and alternative medicine" (CAM), it's the placebo effect. That's because, whenever most such remedies are studied using rigorous clinical trial design using properly constituted placebo controls, they almost always end up showing effects no greater than placebo effects. That's the main reason why they frequently suggest that, you know, all those rigorous, carefully constructed randomized placebo-controlled clinical trials ........ Read more »

Golomb BA, Erickson LC, Koperski S, Sack D, Enkin M, & Howick J. (2010) What's in placebos: who knows? Analysis of randomized, controlled trials. Annals of internal medicine, 153(8), 532-5. PMID: 20956710  

  • July 9, 2010
  • 01:37 AM
  • 930 views

Friday Weird Science: The Human Penis Bone

by Evil Monkey in Neurotopia

Today's post is some seriously OLD science. Old science and WEIRD science, coming to you courtesy of Mt. Sinai hospital in NYC, 1913.

And it's also the WEIRDEST conjunction of this:



And this:



That Sci has ever seen.

Gerster AG, Mandlebaum FS. "XI. On the Formation of Bone in the Human Penis." Annals of Surgery, 1913.

The pictures below are curiously safe for work. I suppose that picture up there wasn't. oops. Read the rest of this post... | Read the comments on this post...... Read more »

GERSTER, A., & MANDLEBAUM, F. (1913) ON THE FORMATION OF BONE IN THE HUMAN PENIS. Annals of Surgery, 57(6), 896-901. DOI: 10.1097/00000658-191306000-00012  

  • November 2, 2009
  • 08:37 PM
  • 2,193 views

Hot News: Curry, Curcumin, Cancer & Cure

by Laika in Laika's Medliblog

*Hot* News via Twitter and various news media a few days ago. Big headlines tell the following in respectively The Sun, Herald, Ireland, BBC News / NHS Health and Reuters:
Curry is a ‘cure for cancer‘
Spices in curry may help cure cancer
Curry spice ‘kills cancer cells‘
Scientists say curry compound kills cancer cells
The message of these headlines [...]... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,619 views

Cheap Cell-Phone Microscopes Might Make Distance Ed Science Labs Feasible

by Michael Windelspecht in RicochetScience

Review of recent advances in cell phone microscopes... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,252 views

Interlukin 32 biomarker which predict relapse of mycobacterium tuberculosis

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

Interlukin 32 a protien which is found in people which do test positie for mycobacterium tuberculosis infection but do not develop pulmonary disease, it is found that interlukin is important in killing micobacterium, thereby protect them from TB disease, this interleukin 32 can be used therapeutically in patients suffering with TB along with chemotherapy, which will enhance efficacy of anti tuberculosis chemo therapy... Read more »

B V Waghmare. (2014) Interlukin 32 biomarker that will predict relapse of tuberculosis infection and will be used in treatment of TB. http://www.medicalwebsite.org/2014/09/protein-that-protect-from-tb-infection.html. info:/

  • November 30, 1999
  • 12:00 AM
  • 722 views

The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR

by Rogue Medic in Rogue Medic

This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.

Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »

Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139  

Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521  

  • November 30, 1999
  • 12:00 AM
  • 1,414 views

The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR

by Rogue Medic in Rogue Medic

This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.

Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »

Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139  

Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521  

  • November 30, 1999
  • 12:00 AM
  • 1,125 views

‘Hotspots’ for DNA breakage in neurons may promote brain genetic diversity, disease

by Tom Ulrich in Vector, a Boston Children's Hospital blog

As organs go, the brain seems to harbor an abundance of somatic mutations — genetic variants that arise after conception and affect only some of our neurons. In one recent study, researchers found about 1,500 variants in each of neurons they sampled.

New research revealing the propensity of DNA to break in certain spots backs up the idea of a genetically diverse brain. Reported in Cell last month, it also suggests a new avenue for thinking about brain development, brain tumors and neuro........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,239 views

The PROCAMIO Trial – IV Procainamide vs IV Amiodarone for the Acute Treatment of Stable Wide Complex Tachycardia

by Rogue Medic in Rogue Medic

This is a very interesting trial that may surprise the many outspoken amiodarone advocates, but it should not surprise anyone who pays attention to research.

ALPS showed that we should stop giving amiodarone for unwitnessed shockable cardiac arrest. The lead researcher is still trying to spin amiodarone for witnessed shockable cardiac arrest, even though the results do not show improvement in the one outcome that matters – leaving the hospital with a brain that still works.[1],[2],[3]... Read more »

Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. The New England journal of medicine, 374(18), 1711-22. PMID: 27043165  

Marill KA, deSouza IS, Nishijima DK, Senecal EL, Setnik GS, Stair TO, Ruskin JN, & Ellinor PT. (2010) Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(3), 297-306. PMID: 20370763  

Marill KA, deSouza IS, Nishijima DK, Stair TO, Setnik GS, & Ruskin JN. (2006) Amiodarone is poorly effective for the acute termination of ventricular tachycardia. Annals of emergency medicine, 47(3), 217-24. PMID: 16492484  

Kułakowski P, Karczmarewicz S, Karpiński G, Soszyńska M, & Ceremuzyński L. (2000) Effects of intravenous amiodarone on ventricular refractoriness, intraventricular conduction, and ventricular tachycardia induction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2(3), 207-15. PMID: 11227590  

Bonny A, De Sisti A, Márquez MF, Megbemado R, Hidden-Lucet F, & Fontaine G. (2012) Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia. World journal of cardiology, 4(10), 296-301. PMID: 23110246  

Kowey PR. (1988) The calamity of cardioversion of conscious patients. The American journal of cardiology, 61(13), 1106-7. PMID: 3364364  

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