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  • January 5, 2016
  • 11:37 AM
  • 779 views

Stroke Risk Following Mental Disorders

by William Yates, M.D. in Brain Posts

An important recent manuscript published in JAMA Psychiatry looked at medical illnesses rates following diagnosis of a brain (mental) disorder.This very large international study examined over 47,000 subjects followed between 2001 and 2011.Baseline psychiatric assessment was completed using the Composite International Diagnostic Interview. Physical illness was assessed using a self-report of physician's diagnosis.The manuscript is not free but I was able to obtain a professional courtesy copy of........ Read more »

  • January 4, 2016
  • 01:59 PM
  • 606 views

Meta-Research: Getting the Most Out of Research

by Roli Roberts in PLOS Biologue

Scientific research, often portrayed as the acme of human rigorous thought, is actually an activity that’s grown rather organically over the centuries from Aristotle, via Bacon, to an endeavour that now involves millions of people... Read more »

  • December 29, 2015
  • 04:30 PM
  • 1,003 views

This Month in Blastocystis Research (DEC 2015)

by Christen Rune Stensvold in Blastocystis Parasite Blog

Practically all Blastocystis research has focussed on identifying a role for the parasite in disease. Meanwhile, no one has really tried to looked into what Blastocystis may tell us about human health. Together with partner labs, our lab has produced data suggesting that Blastocystis carriage is extremely common, and probably also extremely long lasting. We have also shown that the parasite is associated with certain gut microbial communities and that it is more common in healthy individuals tha........ Read more »

  • December 23, 2015
  • 10:27 AM
  • 534 views

Paid Sick Leave May Help Cancer Patient Retain Jobs

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Christine Veenstra MD Clinical Lecturer, Internal Medicine Medical Oncology University of Michigan Ann Arbor, MI  48109-5343 MedicalResearch: What is the background for this study? What are the main findings? Dr. Veenstra: Patients with cancer face many costs … Continue reading →
The post Paid Sick Leave May Help Cancer Patient Retain Jobs appeared first on MedicalResearch.com.
... Read more »

Christine Veenstra MD. (2015) Paid Sick Leave May Help Cancer Patient Retain Jobs. MedicalResearch.com. info:/

  • December 11, 2015
  • 12:41 AM
  • 1,454 views

The Apocalypse is HERE: Transmissible Resistance to Last Resort Antibiotic (Colistin)

by Pranab Chatterjee in Scepticemia

Polymyxins are a group of bacterial origin cyclic polypeptides with antibacterial properties. It was isolated by a Japanese researcher in 1949 from a jar of fermenting bacteria. Colistin, also known as Polymyxin E, which is produced by the bacteria Paenibacillus polymyxa var. colistinus, is a polypeptide antibiotic, which is effective against almost all gram-negative bacilli. Owing to its nephrotoxocity and…... Read more »

  • December 8, 2015
  • 01:50 PM
  • 709 views

Why is progress so slow in resuscitation research?

by Rogue Medic in Rogue Medic

Why is progress so slow in resuscitation research? A lot of money and time went in to finding out which type of blood-letting ventilation works best – ignoring the absence of valid evidence that ventilation is better than no ventilation. Why not gamble with our patients?

In response to The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR,[1],[2] Kenny commented that –

there are many things in your blog that are not correct.[1]... Read more »

Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139  

  • December 3, 2015
  • 09:21 AM
  • 566 views

What’s the Answer? (Dare we edit the human race?) #GeneEditSummit

by Mary in OpenHelix

This week’s question is a biggie. And there’s no answer yet. But that is the topic of the National Academies big event this week, International Summit on Human Gene Editing. I have been glued to this for the whole time and didn’t spend much time looking for questions this week. And I’ll be watching the final […]... Read more »

  • December 2, 2015
  • 11:37 AM
  • 464 views

Treatment Guidelines for Problem Gambling

by William Yates, M.D. in Brain Posts

Basal ganglia may be involving in gambling disorderProblem gambling effects a number of individuals who engage in gambling behavior.Gambling behavior that meets criteria as a Gambling Disorder according to the criteria of DSM-5 includes four or more of the following over a consecutive 12 month period of time:Increased quantity of money gambled to achieve excitementRestlessness/irritability when attempting to cut down gambling behaviorRepeated unsuccessful attempts to cut down or stop gamblingPre........ Read more »

Lee KM, Chan HN, Cheah B, Gentica GF, Guo S, Lim HK, Lim YC, Noorul F, Tan HS, Teo P.... (2011) Ministry of Health clinical practice guidelines: management of gambling disorders. Singapore medical journal, 52(6), 456. PMID: 21732000  

  • November 29, 2015
  • 01:41 PM
  • 759 views

It is possible to develop successful HIV vaccine

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

Antibodies developed in HIV infected individuals do not protect them against further proliferation of HIV, but protect proliferation of HIV in animals.
That means it is possible to develop a vaccine which will completely protect human from HIV infection.... Read more »

B V Waghmare. (2015) HIV Vaccine heading toward success. Combination of HIV neutralizing antibodies and Nanoparticle protien eOD-GT8 60mer are good hope for getting a effective anti HIV vaccine. http://bvwaghmare.blogspot.com. info:/

  • November 25, 2015
  • 10:15 AM
  • 909 views

The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR

by Rogue Medic in Rogue Medic

This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.

Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »

Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139  

Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521  

  • November 20, 2015
  • 08:37 AM
  • 666 views

Summary of recent kidney cancer clinical trials

by Joana Guedes in BHD Research Blog

Kidney tumours, if detected early enough, can often be removed surgically without the need for further drug treatments. However, if the primary tumour metastasises traditional chemotherapies and radiotherapies become ineffective and patient survival is limited. In recent years there have been great advances in treatments for metastatic renal cell carcinoma (mRCC) with several targeted treatments now available. However, these targeted treatments show variable response rates and efficacy. This blo........ Read more »

Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER.... (2015) Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. The New England journal of medicine, 373(19), 1803-13. PMID: 26406148  

  • November 18, 2015
  • 01:00 PM
  • 935 views

Predictors of Poor Outcome After Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

The outcome following traumatic brain injury (TBI) is often unpredictable and variable.Two individuals with similar types of TBI can have quite different outcomes ranging from total disability to functional employment.Torun Finnanger and colleagues from Norway and Australia recently reported on a study that examined a number of predictor variables on self-reported outcome following TBI.In this study, 67 adolescents and adults with moderate to severe TBI completed baseline assessments and were fo........ Read more »

  • November 16, 2015
  • 11:40 AM
  • 912 views

Smell Test in Screening for Parkinson's Disease Risk

by William Yates, M.D. in Brain Posts

Molecular model of polypeptide parkinIdentification of early or prodromal stages of the diseases of neuroscience medicine is an important clinical and research goal.Identification of prodromal illness allows for enhanced surveillance and initiation of secondary prevention interventions.Impairment of smell or olfactory sensation is a key early clue for Parkinson's disease (PD).Danna Jennings and colleagues recently published an important study of the role of smell impairment in prodromal PD.This ........ Read more »

Jennings D, Siderowf A, Stern M, Seibyl J, Eberly S, Oakes D, Marek K, & PARS Investigators. (2014) Imaging prodromal Parkinson disease: the Parkinson Associated Risk Syndrome Study. Neurology, 83(19), 1739-46. PMID: 25298306  

  • November 12, 2015
  • 11:51 AM
  • 737 views

Screening for Cognitive Impairment in Parkinson's Disease

by William Yates, M.D. in Brain Posts

Sunset in Blanchard, OK courtesy of Dr. Tim YatesThere is a significant need for improvement in the tools available for screening for cognitive impairment in a variety of disorders in neuroscience medicine.The Mini-Mental State Examination Score (MMSE) is a widely used 30-item scale for screening dementia and other neurological conditions.However, the MMSE has some significant weaknesses for use in the clinical setting.Jin Qiao and colleagues from China recently published a study testing th........ Read more »

  • November 10, 2015
  • 11:35 AM
  • 734 views

Brain Inflammation in Dementia with Lewy Bodies

by William Yates, M.D. in Brain Posts

The role of inflammation in the brain is receiving increased attention in dementia and other disorders in neuroscience medicine.Dementia with Lewy bodies (DLB) is the third leading cause of dementia. This disorder has received increased attention with the finding of the condition in the autopsy of comedian and actor Robin Williams.Patrick Ejlerskov and colleagues from Denmark, Sweden, Germany and the United Kingdom recently published an informative study in the journal Cell on this topic.Cytokin........ Read more »

Ejlerskov P, Hultberg JG, Wang J, Carlsson R, Ambjørn M, Kuss M, Liu Y, Porcu G, Kolkova K, Friis Rundsten C.... (2015) Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia. Cell, 163(2), 324-39. PMID: 26451483  

  • November 4, 2015
  • 01:50 PM
  • 850 views

Brain Imaging in Diagnosis of Lewy Body Dementia

by William Yates, M.D. in Brain Posts

Brain image highlighting right insula implicated in DLBRecent information has emerged concerning the suicide death of the comedian/actor Robin Williams.Autopsy results have demonstrated that Robin Williams suffered from dementia with Lewy bodies (DLB).This public case demonstrates the difficulty in making a correct diagnosis of DLB prior to the findings at autopsy.In a previous post I reported on a screening tool for clinicians that appears to have some promise for screening for high-risk DLB pa........ Read more »

  • October 30, 2015
  • 11:06 AM
  • 1,048 views

Wii Fit Games for Children with Coordination Problems

by William Yates, M.D. in Brain Posts

Among the types of development problems of childhood is developmental coordination disorder or DCD.In DCD, children show delay and subnormal performance in coordinated motor skills.This may be noted as a general tendency of clumsiness with difficulties in activities such as catching a ball, using scissors, handwriting or riding a bike.Computer games such as the Nintendo Wii platform provide a method to improve a variety of motor and coordination skills in a fun environment.A South African team r........ Read more »

  • October 22, 2015
  • 11:27 AM
  • 642 views

Early Birds, Night Owls and Working Memory

by William Yates, M.D. in Brain Posts

There is a growing body of research showing the individual preference for mornings or evenings influences human performance and disease.Early birds is common term for individuals who arise early and prefer activity in mornings. Night owls often stay up late at night and find they are more productive in the evenings.This day time preference pattern is known scientifically as chronotype.Christina Schmidt and colleagues from Belgium recently published an interesting study of the effect of chronotyp........ Read more »

  • October 20, 2015
  • 12:50 PM
  • 695 views

Hopelessness as Risk Factor for Alzheimer's Disease

by William Yates, M.D. in Brain Posts

Original figure from Hakansson K et al. (citation below)I have been reviewing advances in neuropsychology in neuroscience medicine.One important relevant topic is the art of neuropsychological testing for the early diagnosis and monitoring of Alzheimer's and other dementias.Another important focus is finding neuropsychological risk factors for later development of cognitive impairment.Mid-life depression has been identified as a risk factor for later life cognitive impairment and Alzheimer's dis........ Read more »

  • October 15, 2015
  • 11:54 AM
  • 768 views

Tools for Alzheimer's Screening: BrainCheck

by William Yates, M.D. in Brain Posts

Screening for cognitive decline and early Alzheimer's disease presents a clinical challenge for primary care providers.A variety of tests and tools are available for use but limited research has focused on testing in primary care settings.Michael Ehrensperger and colleagues recently published a study of a brief tool for screening for cognitive decline called BrainCheck.This tool combines a patient interview, an informant interview and the Clock Drawing Test administered in combination.The import........ Read more »

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