Post List

All posts; Tags Include "Clinical Research"

(Modify Search »)

  • October 12, 2014
  • 10:55 AM
  • 875 views

Is EV-D68 causing mysterious polio-like symptoms in children?

by EE Giorgi in CHIMERAS

Bubble fun at the Santa Fe Renaissance Fair © EEG One of the twists in my latest book, Gene Cards, is an unknown pathogen threatening the fictional city of Liasis. I confess that when I came up with the idea I was a little nervous. My story is set in the future, and with all the state-of-the-art technology we already have, is it feasible to think that we will still deal with diseases without a known causative agent? The thing is, new viruses and new pathogens arise all the time. Take the f........ Read more »

Zangwill KM, Yeh SH, Wong EJ, Marcy SM, Eriksen E, Huff KR, Lee M, Lewis EM, Black SB, & Ward JI. (2010) Paralytic syndromes in children: epidemiology and relationship to vaccination. Pediatric neurology, 42(3), 206-12. PMID: 20159431  

  • October 7, 2014
  • 04:21 PM
  • 754 views

Personality, Emotion and Psychopathology: David Watson Lecture Notes

by William Yates, M.D. in Brain Posts

I had the privilege to attend today the William K Warren Frontiers in Neuroscience Conference in Tulsa, OK by Dr. David Watson from Notre Dame University.Dr. Watson's lecture was titled: An integrative model of personality, emotion and psychopathology. This lecture summarized a body of research examining personality, psychological symptoms and a variety of brain disorders.Here are my lecture notes and links to relevant research citations. The first two citations have links to a free full-te........ Read more »

Stasik SM, Naragon-Gainey K, Chmielewski M, & Watson D. (2012) Core OCD symptoms: exploration of specificity and relations with psychopathology. Journal of anxiety disorders, 26(8), 859-70. PMID: 23026094  

  • October 2, 2014
  • 11:01 AM
  • 705 views

Parenting: Genetics and Environmental Effects

by William Yates, M.D. in Brain Posts

Effective parenting is a key element in child development.Both genetic and environmental factors appear to contribute to the cognitive, emotional and behavioral aspects of parenting.Childhood temperament also influences the process of parenting. A well-behaved, emotionally stable and loving child is obviously much easier to parent than a child with behavioral and emotional problems.Bonamy Oliver and colleagues from the United Kingdom have recently published an informative twin study of pare........ Read more »

Oliver BR, Trzaskowski M, & Plomin R. (2014) Genetics of parenting: The power of the dark side. Developmental psychology, 50(4), 1233-40. PMID: 24364831  

  • September 30, 2014
  • 12:34 PM
  • 1,370 views

This Month in Blastocystis Research (SEP 2014)

by Christen Rune Stensvold in Blastocystis Parasite Blog

Do companion animals contribute to human Blastocystis? Do IBS patients have a higher prevalence of Blastocystis and Dientamoeba fragilis than healthy invididuals? Check out this issue of 'This Month in Blastocystis Research'.... Read more »

Krogsgaard LR, Engsbro AL, Stensvold CR, Vedel Nielsen H, & Bytzer P. (2014) The Prevalence of Intestinal Parasites is not Greater Among Individuals with IBS: a Population-Based Case-Control Study. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. PMID: 25229421  

Wang W, Cuttell L, Bielefeldt-Ohmann H, Inpankaew T, Owen H, & Traub RJ. (2013) Diversity of Blastocystis subtypes in dogs in different geographical settings. Parasites , 215. PMID: 23883734  

Wawrzyniak I, Poirier P, Viscogliosi E, Dionigia M, Texier C, Delbac F, & Alaoui HE. (2013) Blastocystis, an unrecognized parasite: an overview of pathogenesis and diagnosis. Therapeutic advances in infectious disease, 1(5), 167-78. PMID: 25165551  

  • September 29, 2014
  • 10:32 AM
  • 970 views

Family Attachment and the Brain Cingulate Cortex

by William Yates, M.D. in Brain Posts

Healthy family attachment provides a key element for social support and successful interpersonal relationships.Several brain regions as well as hormonal factors appear to modulate positive emotional responses to family members.I have previously reviewed several studies involving the prosocial effects of the hormone oxytocin and the related hormone vasopressin.Nicolas Rusch from the Department of Psychiatry at Ulm University in Germany along with colleagues in Brazil and London recently published........ Read more »

  • September 24, 2014
  • 12:37 PM
  • 733 views

Why Women Give Better Gifts

by William Yates, M.D. in Brain Posts

Consumer spending on gifts for birthdays and holidays is a multi-billion dollar big business.Despite this large economic impact, little research examines factors associated with gift recipient satisfaction.Selecting good gifts for others involves a complex social decision-making process related to judging the value hierarchy of others.A study from the Netherlands recently published in the journal PLOS One featured three experiments on gift selection in a series of men and women.The design of the........ Read more »

Pollmann MM, & van Beest I. (2013) Women are better at selecting gifts than men. PloS one, 8(12). PMID: 24386082  

  • September 24, 2014
  • 11:42 AM
  • 1,023 views

Genetics "Experts" Surveyed on Returning Incidental Findings

by Daniel Koboldt in Massgenomics

In my last post, I wrote about the return of results from next-gen sequencing, specifically a recent paper in AJHG about secondary findings in ~6500 ESP exomes. Today we’ll delve into another paper in the same issue on the attitudes of genetics professionals on return of incidental findings from whole genome sequencing (WGS) and exome sequencing […]... Read more »

  • September 18, 2014
  • 11:11 AM
  • 889 views

Genetics of Social Skills: Oxytocin Receptor Gene

by William Yates, M.D. in Brain Posts

Social neuroscience is an emerging emphasis in the field of neuroscience research.Social cognition is the subset of cognitive functions related to social processes and includes factors such as facial recognition, social memory and ability to form friendships and other social bonds.Impairment in social cognition is a known feature in autism, schizophrenia and other mental disorders. This type of impairment can produce significant problems in life adjustment, employment and human attachment.Geneti........ Read more »

Skuse DH, Lori A, Cubells JF, Lee I, Conneely KN, Puura K, Lehtimäki T, Binder EB, & Young LJ. (2014) Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. Proceedings of the National Academy of Sciences of the United States of America, 111(5), 1987-92. PMID: 24367110  

  • September 17, 2014
  • 11:28 AM
  • 683 views

Antidepressants Modulate Memory in the Healthy Brain

by William Yates, M.D. in Brain Posts

The mechanism of antidepressant drug response is not well understood.One theory posits antidepressant effects are only seen in those with clinical depression leaving the healthy brain unchanged.In a previous post, I outlined a study demonstrating effects of antidepressants on brain connectivity measures in the healthy brain.A recent fMRI study extends our understanding of the potential mechanisms for antidepressant drugs.CT Cerqueira and colleagues from Brazil studied the effects of the antidepr........ Read more »

  • September 16, 2014
  • 11:01 AM
  • 706 views

Cannabis-induced Paranoia: Cognitive Mechanisms

by William Yates, M.D. in Brain Posts

Some individuals appear vulnerable to paranoia induced by exposure to tetrahydrocannabinol (THC) in cannabis.The mechanism for this effect is poorly understood.Daniel Freeman from University of Oxford along with colleagues in England and Switzerland recently conducted an interventional research study on this issue.In this study, 121 subjects were recruited to receive injections of THC in a laboratory setting.These subjects were required to have taken cannabis at least once before participation i........ Read more »

  • September 10, 2014
  • 06:00 PM
  • 110,774 views

Anecdotes and the Appearance of Improvement

by Rogue Medic in Rogue Medic

We like to give treatments that produce results that we can see and logically attribute to the treatments we gave.

We like to give IV (IntaVenous) furosemide (Lasix – frusemide in Commonwealth countries) for CHF (Congestive Heart Failure).

1. The patient had CHF.
2. I gave IV furosemide.
3. The patient produced urine.... Read more »

  • September 10, 2014
  • 08:00 AM
  • 975 views

Return of Results from Next-gen Sequencing

by Daniel Koboldt in Massgenomics

The rapid adoption of next-gen exome and genome sequencing for clinical use (i.e. with patient DNA) raises some difficult questions about the return of results to patients and their families. In contrast to traditional genetic testing, which usually checks for variants in specific genes, high-throughput sequencing has the potential to reveal a number of secondary […]... Read more »

  • September 1, 2014
  • 08:28 AM
  • 1,105 views

Tracking the Daily Microbiome

by Stephanie Swift in mmmbitesizescience

Humans are essentially 90% bacteria. These bacteria pepper our skin and hang out in our digestive tracts, helping to break down complex carbohydrates and keeping bad bugs in check. We know how the human microbiome (our collection of bacteria) gets … Continue reading →... Read more »

David LA, Materna AC, Friedman J, Campos-Baptista MI, Blackburn MC, Perrotta A, Erdman SE, & Alm EJ. (2014) Host lifestyle affects human microbiota on daily timescales. Genome biology, 15(7). PMID: 25146375  

  • August 28, 2014
  • 11:40 AM
  • 859 views

Gambler Sub-types: Three Distinct Profiles

by William Yates, M.D. in Brain Posts

One method to advance understanding of a disorder is to use statistical modeling for sub-type or class analysis.Lia Nower and colleagues recently published the results of such an analysis from the large general population data-set known as the U.S. National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).In this sample, 851 adults 18 years and older were identified with disordered gambling.This group then underwent a type of latent class statistical analysis known as the Pathways........ Read more »

  • August 27, 2014
  • 10:58 AM
  • 782 views

Diagnostic Profile in Pathological Gamblers

by William Yates, M.D. in Brain Posts

Behavioral disorders like pathological gambling (PG) rarely occur alone as a single uncomplicated disorder.In a previous post, I noted the overlap of PG with personality disorder, anxiety disorder, depression, bipolar disorder and substance abuse.A recent study from Germany adds to our knowledge of the general diagnostic profile in the PG population.Erbas and Buchner reviewed German national data sources and other German studies to come up with a series of findings:Twelve month prevalence rates ........ Read more »

  • August 24, 2014
  • 09:38 AM
  • 1,168 views

This Month in Blastocystis Research (AUG 2014)

by Christen Rune Stensvold in Blastocystis Parasite Blog

August 2014 saw interesting data emerging on Blastocystis in the background population, mRNA polyadnylation in the Blastocystis nuclear genome which calls for genome reannotation, and a large focus on Blastocystis in the ICOPA 2014 Congress in Mexico City.... Read more »

Fayer R, Elsasser T, Gould R, Solano G, Urban J Jr, & Santin M. (2014) Blastocystis tropism in the pig intestine. Parasitology research, 113(4), 1465-72. PMID: 24535732  

  • August 19, 2014
  • 10:15 PM
  • 1,500 views

Dextrose 10% in the Treatment of Out-of-Hospital Hypoglycemia

by Rogue Medic in Rogue Medic

Is 50% dextrose as good as 10% dextrose for treating symptomatic hypoglycemia?

If the patient is disoriented, but becomes oriented before the full dose of dextrose is given, is it appropriate to continue to treat the patient as if the patient were still disoriented? If your protocols require you to keep giving dextrose, do the same protocols require you to keep giving opioids after the pain is relieved? Is there really any difference?

50% dextrose has problems.... Read more »

Kiefer MV, Gene Hern H, Alter HJ, & Barger JB. (2014) Dextrose 10% in the treatment of out-of-hospital hypoglycemia. Prehospital and disaster medicine, 29(2), 190-4. PMID: 24735872  

  • August 18, 2014
  • 10:16 AM
  • 752 views

Guidelines for Treatment of Problem Gambling

by William Yates, M.D. in Brain Posts

Despite the prevalence and impact of problem gambling, few summaries or guidelines address treatment.Searching the guideline.gov website shows no recent additions to the guideline literature.A guideline was published by the Singapore Ministry of Health in 2011. This guideline is still relevant and highlights some of the key elements of a problem gambling treatment program.I will summarize some of these key elements from this source titled: "Management of gambling disorders".  In their summa........ Read more »

Lee KM, Chan HN, Cheah B, Gentica GF, Guo S, Lim HK, Lim YC, Noorul F, Tan HS, Teo P.... (2011) Ministry of Health clinical practice guidelines: management of gambling disorders. Singapore medical journal, 52(6), 456. PMID: 21732000  

  • August 14, 2014
  • 11:17 AM
  • 947 views

FDA Approves Novel Insomnia Drug Suvorexant (Belsomra)

by William Yates, M.D. in Brain Posts

Regular readers of this blog had a heads up last year on the development of orexin receptor antagonists for the treatment of insomnia.I posted a review of an Italian clinical drug trial in humans with insomnia paired with polysomnography. This study used three different doses of a orexin receptor antagonist (10 mg 30 mg and 60 mg).In a second post, I reviewed a sleep lab study of the effects of an orexin antagonist drug compared to zolpidem (Ambien) on sleep architecture.This second study found ........ Read more »

  • August 13, 2014
  • 11:35 PM
  • 1,091 views

The Controversy of Admitting 'We Do Not Know What Works'

by Rogue Medic in Rogue Medic

There are several news articles today criticizing a study because the patients might be deprived of a drug that has not been adequately studied in humans. This criticism is coming from journalists – the people who publicized the fraudulent vaccines research by Andrew Wakefield, who was trying to sell his competing vaccine and was being paid to produce negative research by lawyers suing the vaccine companies.[1]

The real controversy is that this untested drug became the standard of care ........ Read more »

Larabee TM, Liu KY, Campbell JA, & Little CM. (2012) Vasopressors in cardiac arrest: a systematic review. Resuscitation, 83(8), 932-9. PMID: 22425731  

Herlitz J, Ekström L, Wennerblom B, Axelsson A, Bång A, & Holmberg S. (1995) Adrenaline in out-of-hospital ventricular fibrillation. Does it make any difference?. Resuscitation, 29(3), 195-201. PMID: 7667549  

Olasveengen, T., Sunde, K., Brunborg, C., Thowsen, J., Steen, P., & Wik, L. (2009) Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest: A Randomized Trial. JAMA: The Journal of the American Medical Association, 302(20), 2222-2229. DOI: 10.1001/jama.2009.1729  

Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, & Miyazaki S. (2012) Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA : the journal of the American Medical Association, 307(11), 1161-8. PMID: 22436956  

Hayashi Y, Iwami T, Kitamura T, Nishiuchi T, Kajino K, Sakai T, Nishiyama C, Nitta M, Hiraide A, & Kai T. (2012) Impact of early intravenous epinephrine administration on outcomes following out-of-hospital cardiac arrest. Circulation journal : official journal of the Japanese Circulation Society, 76(7), 1639-45. PMID: 22481099  

Glover BM, Brown SP, Morrison L, Davis D, Kudenchuk PJ, Van Ottingham L, Vaillancourt C, Cheskes S, Atkins DL, Dorian P.... (2012) Wide variability in drug use in out-of-hospital cardiac arrest: A report from the resuscitation outcomes consortium. Resuscitation. PMID: 22858552  

Stiell IG, Hebert PC, Weitzman BN, Wells GA, Raman S, Stark RM, Higginson LA, Ahuja J, & Dickinson GE. (1992) High-dose epinephrine in adult cardiac arrest. The New England journal of medicine, 327(15), 1045-50. PMID: 1522840  

Callaway, C. (2012) Questioning the Use of Epinephrine to Treat Cardiac Arrest. JAMA: The Journal of the American Medical Association, 307(11), 1198. DOI: 10.1001/jama.2012.313  

join us!

Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.

If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.

Register Now

Research Blogging is powered by SMG Technology.

To learn more, visit seedmediagroup.com.