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  • May 8, 2017
  • 05:45 PM
  • 189 views

Let those who never smelled bad cast the first stone

by Aurametrix team in Aurametrix Blog

Analysis of our metabolism is crucial to comprehending the responses of our genes and microbes to the stresses of daily life, and to elucidating the causes and consequences of health and disease. And measurement of urinary metabolites - small molecules produced from foods, drinks, drugs, environmental contaminants, bodily waste products and bacterial by-products - is key to the analysis. We applied this approach to an elusive condition that has always evaded diagnosis: s........ Read more »

Bouatra, S., Aziat, F., Mandal, R., Guo, A., Wilson, M., Knox, C., Bjorndahl, T., Krishnamurthy, R., Saleem, F., Liu, P.... (2013) The Human Urine Metabolome. PLoS ONE, 8(9). DOI: 10.1371/journal.pone.0073076  

Irene S. Gabashvili. (2017) Raw Data from Clinical Trial NCT02692495. Mendeley Data. info:/DOI: 10.17632/8bk6h6bmkr.1

  • January 13, 2017
  • 02:40 AM
  • 362 views

Acute coronary syndrome on Friday the 13th: a case for re-organising services?

by Rogue Medic in Rogue Medic

"However, patients admitted on five day/number combinations were 20-30% more likely to survive at 13 years. These findings could be explained by subgroup analysis inflation of the type I error, although supernatural causes merit further investigation.[1]"

No. Supernatural causes do not merit further investigation, at least, not based on anything in this paper.

The authors used Friday the 13th as their "normal" date for comparison with every other date, but the outcomes ........ Read more »

Protty, M., Jaafar, M., Hannoodee, S., & Freeman, P. (2016) Acute coronary syndrome on Friday the 13th: a case for re-organising services?. The Medical Journal of Australia, 205(11), 523-525. DOI: 10.5694/mja16.00870  

  • September 9, 2016
  • 12:10 PM
  • 721 views

Statin Therapy: Rethinking Benefits and Risks

by William Yates, M.D. in Brain Posts

A recent 30-page manuscript provides an exhaustive review of the evidence for the efficacy and safety of statin therapy.The authors of this excellent review provide some context for the relative value of statins.The note that putting 10000 individuals with a history of a vascular event on a statin drug for 5 years would prevent 1,000 subsequent events. This is an example of secondary prevention--preventing another adverse outcome in those already experiencing an adverse event.But the statin drug........ Read more »

Collins, Rory, Reith, Christina, & Emberson, Jonathan. (2016) Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet. info:/http://dx.doi.org/10.1016/S0140-6736(16)31357-5

  • August 25, 2016
  • 09:40 AM
  • 724 views

How to rebuild a brain

by gdw in FictionalFieldwork

After the stroke The human brain is complicated. Very complicated. And like any piece of complex machinery that relies on the smooth functioning of many components, it’s not immune to malfunction. When a part of the brain doesn’t get proper nutrition through a nice and smooth blood flow, things go awry and a stroke occurs. […]... Read more »

  • August 17, 2016
  • 01:30 PM
  • 611 views

The PROCAMIO Trial – IV Procainamide vs IV Amiodarone for the Acute Treatment of Stable Wide Complex Tachycardia

by Rogue Medic in Rogue Medic

This is a very interesting trial that may surprise the many outspoken amiodarone advocates, but it should not surprise anyone who pays attention to research.

ALPS showed that we should stop giving amiodarone for unwitnessed shockable cardiac arrest. The lead researcher is still trying to spin amiodarone for witnessed shockable cardiac arrest, even though the results do not show improvement in the one outcome that matters – leaving the hospital with a brain that still works.[1],[2],[3]... Read more »

Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. The New England journal of medicine, 374(18), 1711-22. PMID: 27043165  

Marill KA, deSouza IS, Nishijima DK, Senecal EL, Setnik GS, Stair TO, Ruskin JN, & Ellinor PT. (2010) Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(3), 297-306. PMID: 20370763  

Marill KA, deSouza IS, Nishijima DK, Stair TO, Setnik GS, & Ruskin JN. (2006) Amiodarone is poorly effective for the acute termination of ventricular tachycardia. Annals of emergency medicine, 47(3), 217-24. PMID: 16492484  

Kułakowski P, Karczmarewicz S, Karpiński G, Soszyńska M, & Ceremuzyński L. (2000) Effects of intravenous amiodarone on ventricular refractoriness, intraventricular conduction, and ventricular tachycardia induction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2(3), 207-15. PMID: 11227590  

Bonny A, De Sisti A, Márquez MF, Megbemado R, Hidden-Lucet F, & Fontaine G. (2012) Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia. World journal of cardiology, 4(10), 296-301. PMID: 23110246  

Kowey PR. (1988) The calamity of cardioversion of conscious patients. The American journal of cardiology, 61(13), 1106-7. PMID: 3364364  

  • August 3, 2016
  • 09:13 AM
  • 768 views

Do we need a doping Olympics? The ethics of doping in sports

by gdw in FictionalFieldwork

There is only her and the track. The people standing on her left and right do not matter now. She has only one adversary: time. In her head she plays how the future might…will unfold. Forty seven strides. That’s all she needs. All things on the periphery disappear. Her world, her universe becomes a single […]... Read more »

  • June 1, 2016
  • 04:30 AM
  • 574 views

African-American/Minority Males are at High Risk of Sudden Death

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Sudden cardiac death among athletes most often occurred in African-American/Minorities and male athletes. Hypertrophic cardiomyopathy was the most common cause of sudden cardiac death.... Read more »

  • May 24, 2016
  • 10:44 AM
  • 611 views

Does Flu Vaccination Reduce Dementia Risk?

by William Yates, M.D. in Brain Posts

In my daily review of neuroscience news I ran across an article flu vaccination and dementia risk in heart failure.This study was reported at the 3rd World Congress on Acute Heart Failure by Dr. Ju-Chi Liu from Taipei Medical University.So how might influenza vaccination be related to dementia risk?  We do know acute influenza infection reaches the brain causing headache and increasing brain inflammation, at least temporarily. We also know brain inflammation may be involved in the mechanism........ Read more »

  • May 21, 2016
  • 10:21 AM
  • 683 views

Quick Aspirin Use Reduces Stroke Risk in TIA

by William Yates, M.D. in Brain Posts

A free full-text commentary in the Lancet summarizes recent evidence of the benefit of aspirin in stroke prevention.This commentary focused on what is called secondary prevention. Secondary prevention is defined as prevention following events related to the disease in question.So secondary prevention in stroke would be reduction in stroke risk in those who have had a stroke or pre-stroke syndromes such as transient ischemic attacks (TIA).The key take-home message from the commentary by Graeme Ha........ Read more »

  • May 3, 2016
  • 11:36 AM
  • 407 views

Delirium and Aortic Valve Surgery Outcome

by William Yates, M.D. in Brain Posts

Delirium is an acute confusional state that is common in elderly hospitalized patients.I think of it light a sign of acute brain failure requiring aggressive attentional for detection and treatment of any reversible underlying causes.Delirium in elderly hospitalized patients is a marker for poor outcome in a variety of medical and surgical subjects.A recent study published by a Norwegian team found effects on outcome for delirium following surgical aortic valve replacement. The key findings from........ Read more »

Eide LS, Ranhoff AH, Fridlund B, Haaverstad R, Hufthammer KO, Kuiper KK, Nordrehaug JE, Norekvål TM, & Delirium in Octogenarians Undergoing Cardiac Surgery or Intervention-CARDELIR Investigators. (2016) Delirium as a Predictor of Physical and Cognitive Function in Individuals Aged 80 and Older After Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement. Journal of the American Geriatrics Society. PMID: 27106745  

  • April 27, 2016
  • 10:35 AM
  • 714 views

Food to Restore a Heart

by Aurametrix team in Health Technologies

We know that diet, exercise and low-stress life will keep the heart healthy. But sometimes things happen that are beyond our control. Thanks to more coordinated, faster emergency response and improved treatment, heart attacks aren't as deadly as they used to be. But survivors still face a substantial risk of further cardiovascular events. How to restore after a heart attack and prevent another one? What to do besides obvious things such as taking medications, reducing stress, calories, avoidin........ Read more »

Li S, Flint A, Pai JK, Forman JP, Hu FB, Willett WC, Rexrode KM, Mukamal KJ, & Rimm EB. (2014) Low carbohydrate diet from plant or animal sources and mortality among myocardial infarction survivors. Journal of the American Heart Association, 3(5). PMID: 25246449  

  • April 12, 2016
  • 05:00 PM
  • 774 views

Dr. Kudenchuk is Misrepresenting ALPS as 'Significant'

by Rogue Medic in Rogue Medic

This study was very well done, but it was not designed to provide valid information about the effects of amiodarone or lidocaine on witnessed arrests or on EMS Witnessed arrests. Maybe the authors were overconfident.

In resuscitation research, we have abundant evidence that overconfidence is much more common than improvements in outcomes.... Read more »

Kudenchuk, P., Brown, S., Daya, M., Rea, T., Nichol, G., Morrison, L., Leroux, B., Vaillancourt, C., Wittwer, L., Callaway, C.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. New England Journal of Medicine. DOI: 10.1056/NEJMoa1514204  

Glover BM, Brown SP, Morrison L, Davis D, Kudenchuk PJ, Van Ottingham L, Vaillancourt C, Cheskes S, Atkins DL, Dorian P.... (2012) Wide variability in drug use in out-of-hospital cardiac arrest: A report from the resuscitation outcomes consortium. Resuscitation. PMID: 22858552  

  • March 9, 2016
  • 04:30 AM
  • 653 views

Knowing the Symptoms of Sudden Cardiac Death May be the First Step in the Right Direction

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Patients who suffered sudden cardiac death reported experiencing more cardiac symptoms prior to death compared with control patients.... Read more »

Glinge C, Jabbari R, Risgaard B, Lynge TH, Engstrøm T, Albert CM, Haunsø S, Winkel BG, & Tfelt-Hansen J. (2015) Symptoms Before Sudden Arrhythmic Death Syndrome: A Nationwide Study Among the Young in Denmark. Journal of cardiovascular electrophysiology, 26(7), 761-7. PMID: 25807988  

  • March 8, 2016
  • 04:15 PM
  • 833 views

What do you do when a patient wakes up during CPR?

by Rogue Medic in Rogue Medic

The return of consciousness without the return of a pulse is still rare, but may be more common with our increased focus on high quality chest compressions. There is still no evidence that interrupting chest compressions, for anything other than defibrillation, improves outcomes.

Is this due to the consistency of the machine? Maybe. Maybe not. We do not have enough evidence to draw that conclusion.

Is this growing population really growing? Maybe. Maybe not. We do not have enough evidence ........ Read more »

  • February 18, 2016
  • 10:52 AM
  • 962 views

The secret pharmacological life of the humble avocado

by Rosin Cerate in Rosin Cerate

Guacamole, while delicious, is actually fairly destructive. This is thanks in part to a compound called persin, which is present in the fruit and leaves of the avocado tree (Persea americana). Persin is an acetogenin (a type of polyketide) made via the same biochemical pathways the avocado plant uses to make its delicious fatty acids. In fact, it closely resembles linoleic acid, an essential omega-6 fatty acid.Avocado fruits in their natural setting (Source)For some reason, persin is usuall........ Read more »

  • February 12, 2016
  • 08:48 AM
  • 868 views

Heartbreaking drugs: A Valentine's Day special

by Rosin Cerate in Rosin Cerate

Let's talk about hearts and how they get broken. Literally, with drugs. When we swallow a pill, it's often to help address a problem we're experiencing with a particular body part. An aching head or a sore throat, for example. The pill breaks down in our guts and we absorb the drug into our bloodstream. It travels around our body and eventually ends up at the hurting locale where it works to fix the problem. Unfortunately, sometimes the drug will end up somewhere else and act there to cause an u........ Read more »

  • February 11, 2016
  • 03:26 PM
  • 1,029 views

Religion linked to reduced levels of stress hormones in young American Blacks

by Tom Rees in Epiphenom

Compared with Whites, Black Americans have  high levels of an important stress hormone called cortisol circulating in their bloodstream. No-one really knows why this is, but the differences remain even after you take into account social and psychological factors. It seems likely that simply being black exposes you to a cumulative effect of increased lifetime [Read More...]... Read more »

Assari, S., Moghani Lankarani, M., Malekahmadi, M., Caldwell, C., & Zimmerman, M. (2015) Baseline Religion Involvement Predicts Subsequent Salivary Cortisol Levels Among Male But not Female Black Youth. International Journal of Endocrinology and Metabolism, 13(4). DOI: 10.5812/ijem.31790  

  • January 24, 2016
  • 10:01 AM
  • 551 views

Increased Short Term Risk of Adverse Cardiac Effects With Antibiotic Clarithromycin

by Marie Benz in MedicalResearch.com

More on Heart Disease on MedicalResearch.com MedicalResearch.com Interview with: Professor Ian C K Wong Fellow of Royal Pharmaceutical Society Fellow of Royal College of Paediatrics and Child Health (Honorary) Fellow of the Higher Education Academy Chair in Pharmacy Practice Head … Continue reading →
The post Increased Short Term Risk of Adverse Cardiac Effects With Antibiotic Clarithromycin appeared first on MedicalResearch.com.
... Read more »

Prof. Ian CK Wong. (2016) Increased Short Term Risk of Adverse Cardiac Effects With Antibiotic Clarithromycin. MedicalResearch.com. info:/

  • January 23, 2016
  • 10:15 AM
  • 793 views

Cardiac Groups Outline Appropriate Imaging For Chest Pain in ER

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Frank J. Rybicki, MD, PhD Professor, Chair and Chief, Department of Radiology The University of Ottawa, Faculty of Medicine and The Ottawa Hospital Editor-in-Chief, 3D Printing in Medicine Medical Research: What is the background for this document? Dr. … Continue reading →
The post Cardiac Groups Outline Appropriate Imaging For Chest Pain in ER appeared first on MedicalResearch.com.
... Read more »

Frank J. Rybicki, MD, PhD. (2016) Cardiac Groups Outline Appropriate Imaging For Chest Pain in ER. MedicalResearch.com. info:/

  • January 21, 2016
  • 07:38 PM
  • 435 views

Obesity Increases Atrial Fibrillation Risk For Blacks After Bypass Surgery

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Jimmy T. Efird, PhD, MSc Director Center for Epidemiology and Outcomes Research East Carolina Heart Institute Brody School of Medicine East Carolina University NC Medical Research: What is the background for this study? What are the main … Continue reading →
The post Obesity Increases Atrial Fibrillation Risk For Blacks After Bypass Surgery appeared first on MedicalResearch.com.
... Read more »

Jimmy T. Efird, PhD. (2016) Obesity Increases Atrial Fibrillation Risk For Blacks After Bypass Surgery. MedicalResearch.com. info:/

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