"However, patients admitted on five day/number combinations were 20-30% more likely to survive at 13 years. These findings could be explained by subgroup analysis inflation of the type I error, although supernatural causes merit further investigation."
No. Supernatural causes do not merit further investigation, at least, not based on anything in this paper.
The authors used Friday the 13th as their "normal" date for comparison with every other date, but the outcomes ........ Read more »
Protty, M., Jaafar, M., Hannoodee, S., & Freeman, P. (2016) Acute coronary syndrome on Friday the 13th: a case for re-organising services?. The Medical Journal of Australia, 205(11), 523-525. DOI: 10.5694/mja16.00870
A recent 30-page manuscript provides an exhaustive review of the evidence for the efficacy and safety of statin therapy.The authors of this excellent review provide some context for the relative value of statins.The note that putting 10000 individuals with a history of a vascular event on a statin drug for 5 years would prevent 1,000 subsequent events. This is an example of secondary prevention--preventing another adverse outcome in those already experiencing an adverse event.But the statin drug........ Read more »
Collins, Rory, Reith, Christina, & Emberson, Jonathan. (2016) Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet. info:/http://dx.doi.org/10.1016/S0140-6736(16)31357-5
After the stroke The human brain is complicated. Very complicated. And like any piece of complex machinery that relies on the smooth functioning of many components, it’s not immune to malfunction. When a part of the brain doesn’t get proper nutrition through a nice and smooth blood flow, things go awry and a stroke occurs. […]... Read more »
Chowdhury R, Stevens S, Gorman D, Pan A, Warnakula S, Chowdhury S, Ward H, Johnson L, Crowe F, Hu FB.... (2012) Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease: systematic review and meta-analysis. BMJ (Clinical research ed.). PMID: 23112118
Hurst K, Lee R, Sideso E, Giles M, & Handa A. (2016) Delays in the presentation to stroke services of patients with transient ischaemic attack and minor stroke. The British journal of surgery. PMID: 27529453
Mayurasakorn K, Niatsetskaya ZV, Sosunov SA, Williams JJ, Zirpoli H, Vlasakov I, Deckelbaum RJ, & Ten VS. (2016) DHA but Not EPA Emulsions Preserve Neurological and Mitochondrial Function after Brain Hypoxia-Ischemia in Neonatal Mice. PloS one, 11(8). PMID: 27513579
Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, & Zlokovic BV. (2016) 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nature medicine. PMID: 27548576
This is a very interesting trial that may surprise the many outspoken amiodarone advocates, but it should not surprise anyone who pays attention to research.
ALPS showed that we should stop giving amiodarone for unwitnessed shockable cardiac arrest. The lead researcher is still trying to spin amiodarone for witnessed shockable cardiac arrest, even though the results do not show improvement in the one outcome that matters – leaving the hospital with a brain that still works.,,... Read more »
Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. The New England journal of medicine, 374(18), 1711-22. PMID: 27043165
Ortiz M, Martín A, Arribas F, Coll-Vinent B, Del Arco C, Peinado R, Almendral J, & PROCAMIO Study Investigators. (2016) Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. European heart journal. PMID: 27354046
Marill KA, deSouza IS, Nishijima DK, Senecal EL, Setnik GS, Stair TO, Ruskin JN, & Ellinor PT. (2010) Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(3), 297-306. PMID: 20370763
Marill KA, deSouza IS, Nishijima DK, Stair TO, Setnik GS, & Ruskin JN. (2006) Amiodarone is poorly effective for the acute termination of ventricular tachycardia. Annals of emergency medicine, 47(3), 217-24. PMID: 16492484
Tomlinson DR, Cherian P, Betts TR, & Bashir Y. (2008) Intravenous amiodarone for the pharmacological termination of haemodynamically-tolerated sustained ventricular tachycardia: is bolus dose amiodarone an appropriate first-line treatment?. Emergency medicine journal : EMJ, 25(1), 15-8. PMID: 18156531
Kułakowski P, Karczmarewicz S, Karpiński G, Soszyńska M, & Ceremuzyński L. (2000) Effects of intravenous amiodarone on ventricular refractoriness, intraventricular conduction, and ventricular tachycardia induction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2(3), 207-15. PMID: 11227590
Bonny A, De Sisti A, Márquez MF, Megbemado R, Hidden-Lucet F, & Fontaine G. (2012) Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia. World journal of cardiology, 4(10), 296-301. PMID: 23110246
Kowey PR. (1988) The calamity of cardioversion of conscious patients. The American journal of cardiology, 61(13), 1106-7. PMID: 3364364
There is only her and the track. The people standing on her left and right do not matter now. She has only one adversary: time. In her head she plays how the future might…will unfold. Forty seven strides. That’s all she needs. All things on the periphery disappear. Her world, her universe becomes a single […]... Read more »
Savulescu J, Foddy B, & Clayton M. (2004) Why we should allow performance enhancing drugs in sport. British journal of sports medicine, 38(6), 666-70. PMID: 15562155
Gaviglio CM, Osborne M, Kelly VG, Kilduff LP, & Cook CJ. (2015) Salivary testosterone and cortisol responses to four different rugby training exercise protocols. European journal of sport science, 15(6), 497-504. PMID: 25743223
Park HY, Hwang H, Park J, Lee S, & Lim K. (2016) The effects of altitude/hypoxic training on oxygen delivery capacity of the blood and aerobic exercise capacity in elite athletes - a meta-analysis. Journal of exercise nutrition , 20(1), 15-22. PMID: 27298808
Sudden cardiac death among athletes most often occurred in African-American/Minorities and male athletes. Hypertrophic cardiomyopathy was the most common cause of sudden cardiac death.... Read more »
Maron BJ, Haas TS, Ahluwalia A, Murphy CJ, & Garberich RF. (2016) Demographics and Epidemiology of Sudden Deaths in Young Competitive Athletes: From the U.S. National Registry. The American Journal of Medicine. PMID: 27039955
In my daily review of neuroscience news I ran across an article flu vaccination and dementia risk in heart failure.This study was reported at the 3rd World Congress on Acute Heart Failure by Dr. Ju-Chi Liu from Taipei Medical University.So how might influenza vaccination be related to dementia risk? We do know acute influenza infection reaches the brain causing headache and increasing brain inflammation, at least temporarily. We also know brain inflammation may be involved in the mechanism........ Read more »
Liu JC, Hsu YP, Kao PF, Hao WR, Liu SH, Lin CF, Sung LC, & Wu SY. (2016) Influenza Vaccination Reduces Dementia Risk in Chronic Kidney Disease Patients: A Population-Based Cohort Study. Medicine, 95(9). PMID: 26945371
A free full-text commentary in the Lancet summarizes recent evidence of the benefit of aspirin in stroke prevention.This commentary focused on what is called secondary prevention. Secondary prevention is defined as prevention following events related to the disease in question.So secondary prevention in stroke would be reduction in stroke risk in those who have had a stroke or pre-stroke syndromes such as transient ischemic attacks (TIA).The key take-home message from the commentary by Graeme Ha........ Read more »
Hankey, G. (2016) The benefits of aspirin in early secondary stroke prevention. The Lancet. DOI: 10.1016/S0140-6736(16)30511-6
Delirium is an acute confusional state that is common in elderly hospitalized patients.I think of it light a sign of acute brain failure requiring aggressive attentional for detection and treatment of any reversible underlying causes.Delirium in elderly hospitalized patients is a marker for poor outcome in a variety of medical and surgical subjects.A recent study published by a Norwegian team found effects on outcome for delirium following surgical aortic valve replacement. The key findings from........ Read more »
Eide LS, Ranhoff AH, Fridlund B, Haaverstad R, Hufthammer KO, Kuiper KK, Nordrehaug JE, Norekvål TM, & Delirium in Octogenarians Undergoing Cardiac Surgery or Intervention-CARDELIR Investigators. (2016) Delirium as a Predictor of Physical and Cognitive Function in Individuals Aged 80 and Older After Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement. Journal of the American Geriatrics Society. PMID: 27106745
We know that diet, exercise and low-stress life will keep the heart healthy. But sometimes things happen that are beyond our control. Thanks to more coordinated, faster emergency response and improved treatment, heart attacks aren't as deadly as they used to be. But survivors still face a substantial risk of further cardiovascular events. How to restore after a heart attack and prevent another one? What to do besides obvious things such as taking medications, reducing stress, calories, avoidin........ Read more »
Li S, Flint A, Pai JK, Forman JP, Hu FB, Willett WC, Rexrode KM, Mukamal KJ, & Rimm EB. (2014) Low carbohydrate diet from plant or animal sources and mortality among myocardial infarction survivors. Journal of the American Heart Association, 3(5). PMID: 25246449
Li S, Flint A, Pai JK, Forman JP, Hu FB, Willett WC, Rexrode KM, Mukamal KJ, & Rimm EB. (2014) Dietary fiber intake and mortality among survivors of myocardial infarction: prospective cohort study. BMJ (Clinical research ed.). PMID: 24782515
This study was very well done, but it was not designed to provide valid information about the effects of amiodarone or lidocaine on witnessed arrests or on EMS Witnessed arrests. Maybe the authors were overconfident.
In resuscitation research, we have abundant evidence that overconfidence is much more common than improvements in outcomes.... Read more »
Kudenchuk, P., Brown, S., Daya, M., Rea, T., Nichol, G., Morrison, L., Leroux, B., Vaillancourt, C., Wittwer, L., Callaway, C.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. New England Journal of Medicine. DOI: 10.1056/NEJMoa1514204
Glover BM, Brown SP, Morrison L, Davis D, Kudenchuk PJ, Van Ottingham L, Vaillancourt C, Cheskes S, Atkins DL, Dorian P.... (2012) Wide variability in drug use in out-of-hospital cardiac arrest: A report from the resuscitation outcomes consortium. Resuscitation. PMID: 22858552
Patients who suffered sudden cardiac death reported experiencing more cardiac symptoms prior to death compared with control patients.... Read more »
Glinge C, Jabbari R, Risgaard B, Lynge TH, Engstrøm T, Albert CM, Haunsø S, Winkel BG, & Tfelt-Hansen J. (2015) Symptoms Before Sudden Arrhythmic Death Syndrome: A Nationwide Study Among the Young in Denmark. Journal of cardiovascular electrophysiology, 26(7), 761-7. PMID: 25807988
Lynge TH, Risgaard B, Jabbari R, Glinge C, Bundgaard H, Maron B, Haunsø S, Winkel BG, & Tfelt-Hansen J. (2016) Cardiac symptoms before sudden cardiac death caused by hypertrophic cardiomyopathy: a nationwide study among the young in Denmark. Europace. PMID: 26823388
The return of consciousness without the return of a pulse is still rare, but may be more common with our increased focus on high quality chest compressions. There is still no evidence that interrupting chest compressions, for anything other than defibrillation, improves outcomes.
Is this due to the consistency of the machine? Maybe. Maybe not. We do not have enough evidence to draw that conclusion.
Is this growing population really growing? Maybe. Maybe not. We do not have enough evidence ........ Read more »
Rice, D., Nudell, N., Habrat, D., Smith, J., & Ernest, E. (2016) CPR induced consciousness: It's time for sedation protocols for this growing population. Resuscitation. DOI: 10.1016/j.resuscitation.2016.02.013
Olaussen A, Shepherd M, Nehme Z, Smith K, Bernard S, & Mitra B. (2015) Return of consciousness during ongoing cardiopulmonary resuscitation: A systematic review. Resuscitation, 44-8. PMID: 25447435
Lilja G, Nilsson G, Nielsen N, Friberg H, Hassager C, Koopmans M, Kuiper M, Martini A, Mellinghoff J, Pelosi P.... (2015) Anxiety and depression among out-of-hospital cardiac arrest survivors. Resuscitation, 68-75. PMID: 26433116
Guacamole, while delicious, is actually fairly destructive. This is thanks in part to a compound called persin, which is present in the fruit and leaves of the avocado tree (Persea americana). Persin is an acetogenin (a type of polyketide) made via the same biochemical pathways the avocado plant uses to make its delicious fatty acids. In fact, it closely resembles linoleic acid, an essential omega-6 fatty acid.Avocado fruits in their natural setting (Source)For some reason, persin is usuall........ Read more »
McCloy RA, Shelley EJ, Roberts CG, Boslem E, Biden TJ, Nicholson RI, Gee JM, Sutherland RL, Musgrove EA, Burgess A.... (2013) Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells. British Journal of Cancer, 109(12), 3034-3041. PMID: 24178758
Rodriguez-Sanchez DG, Flores-García M, Silva-Platas C, Rizzo S, Torre-Amione G, De la Peña-Diaz A, Hernández-Brenes C, & García-Rivas G. (2015) Isolation and chemical identification of lipid derivatives from avocado (Persea americana) pulp with antiplatelet and antithrombotic activities. Food , 6(1), 193-203. PMID: 25319210
Let's talk about hearts and how they get broken. Literally, with drugs. When we swallow a pill, it's often to help address a problem we're experiencing with a particular body part. An aching head or a sore throat, for example. The pill breaks down in our guts and we absorb the drug into our bloodstream. It travels around our body and eventually ends up at the hurting locale where it works to fix the problem. Unfortunately, sometimes the drug will end up somewhere else and act there to cause an u........ Read more »
Wu A. (2008) Cardiotoxic drugs: Clinical monitoring and decision making. Heart, 94(11), 1503-1509. DOI: 10.1136/hrt.2007.133876
Compared with Whites, Black Americans have high levels of an important stress hormone called cortisol circulating in their bloodstream. No-one really knows why this is, but the differences remain even after you take into account social and psychological factors. It seems likely that simply being black exposes you to a cumulative effect of increased lifetime [Read More...]... Read more »
Assari, S., Moghani Lankarani, M., Malekahmadi, M., Caldwell, C., & Zimmerman, M. (2015) Baseline Religion Involvement Predicts Subsequent Salivary Cortisol Levels Among Male But not Female Black Youth. International Journal of Endocrinology and Metabolism, 13(4). DOI: 10.5812/ijem.31790
More on Heart Disease on MedicalResearch.com MedicalResearch.com Interview with: Professor Ian C K Wong Fellow of Royal Pharmaceutical Society Fellow of Royal College of Paediatrics and Child Health (Honorary) Fellow of the Higher Education Academy Chair in Pharmacy Practice Head … Continue reading →
The post Increased Short Term Risk of Adverse Cardiac Effects With Antibiotic Clarithromycin appeared first on MedicalResearch.com.
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Prof. Ian CK Wong. (2016) Increased Short Term Risk of Adverse Cardiac Effects With Antibiotic Clarithromycin. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Frank J. Rybicki, MD, PhD Professor, Chair and Chief, Department of Radiology The University of Ottawa, Faculty of Medicine and The Ottawa Hospital Editor-in-Chief, 3D Printing in Medicine Medical Research: What is the background for this document? Dr. … Continue reading →
The post Cardiac Groups Outline Appropriate Imaging For Chest Pain in ER appeared first on MedicalResearch.com.
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Frank J. Rybicki, MD, PhD. (2016) Cardiac Groups Outline Appropriate Imaging For Chest Pain in ER. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Jimmy T. Efird, PhD, MSc Director Center for Epidemiology and Outcomes Research East Carolina Heart Institute Brody School of Medicine East Carolina University NC Medical Research: What is the background for this study? What are the main … Continue reading →
The post Obesity Increases Atrial Fibrillation Risk For Blacks After Bypass Surgery appeared first on MedicalResearch.com.
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Jimmy T. Efird, PhD. (2016) Obesity Increases Atrial Fibrillation Risk For Blacks After Bypass Surgery. MedicalResearch.com. info:/
MedicalResearch.com Interview with: François Delahaye, MD, PhD Department of Cardiology Hôpital Louis Pradel, Hospices Civils de Lyon Université Claude Bernard Lyon, France Medical Research: What is the background for this study? Response: Infective endocarditis (IE) is a severe disease, with … Continue reading →
The post Infectious Endocarditis: Skin, Mouth Are Most Frequent Portals of Entry appeared first on MedicalResearch.com.
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François Delahaye, MD, PhD. (2016) Infectious Endocarditis: Skin, Mouth Are Most Frequent Portals of Entry. MedicalResearch.com. info:/
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