All posts; Tags Include "Biomedical Engineering"
- September 1, 2010
- 02:32 PM
- 34 views
Blood Flow and Fahraeus Effect
by Arunn in Unruled Notebook
The dependence of apparent viscosity of human blood on the capillary size it is flowing through is identified as the Fahraeus-Lindqvist effect (1931). This was explained in the earlier Blood Flow in Capillaries note. There is a related but different effect called the Fahraeus effect (1929). This is the decrease in average concentration of red [...]... Read more »
Sutera, S. P., Seshadri, V., Croce, P. A. and Hochmuth, R. M. (1970) Capillary blood flow: II. Deformable model cells in tube flow. Microvascular Research, 2(4), 420-433. DOI: 10.1016/0026-2862(70)90035-X
- August 31, 2010
- 09:18 PM
- 46 views
The Wednesday Post - Frogs and Antibiotics!
by James Byrne in Disease of the Week
A meeting of the American Chemical Society last week a group of researchers from the United Arab Emirates University presented some data showing they had collected and analysed frog skin compounds that elicited an anti-microbial effects from a wide range of species.... Read more »
Blaustein, A., & Kiesecker, J. (2002) Complexity in conservation: lessons from the global decline of amphibian populations. Ecology Letters, 5(4), 597-608. DOI: 10.1046/j.1461-0248.2002.00352.x
Smet, K., & Contreras, R. (2005) Human Antimicrobial Peptides: Defensins, Cathelicidins and Histatins. Biotechnology Letters, 27(18), 1337-1347. DOI: 10.1007/s10529-005-0936-5
- August 31, 2010
- 08:33 PM
- 36 views
The Wednesday Post (1/9/10)
by James in Disease of the Week
Enough of vaccines for a moment. I want to talk about frogs, frogs and antimicrobial agents. Normally I find it hard to remain interested in anything with a central nervous system but recently two frog related stories have caught my eye. First was this little dude. Are you kidding me, that thing is tiny. Sometimes [...]... Read more »
Blaustein, A., & Kiesecker, J. (2002) Complexity in conservation: lessons from the global decline of amphibian populations. Ecology Letters, 5(4), 597-608. DOI: 10.1046/j.1461-0248.2002.00352.x
Smet, K., & Contreras, R. (2005) Human Antimicrobial Peptides: Defensins, Cathelicidins and Histatins. Biotechnology Letters, 27(18), 1337-1347. DOI: 10.1007/s10529-005-0936-5
- August 31, 2010
- 01:51 PM
- 57 views
Seeing double: perhaps is simply optical diplopia
by Pablo Artal in Optics confidential
Changes in the optics of the eye can produce double or even multiple images... a real case is explained as an example and more... ... Read more »
Pérez, G., Abenza, S., De Casas, A., Marín, J., & Artal, P. (2010) Cause of Monocular Diplopia Diagnosed by Combining Double-pass Retinal Image Assessment and Hartmann-Shack Aberrometry. Journal of Refractive Surgery, 26(4), 301-304. DOI: 10.3928/1081597X-20100218-05
- August 31, 2010
- 08:33 AM
- 35 views
Blood Viscosity in Capillaries
by Arunn in Unruled Notebook
Blood flow has its peculiarities, in particular how the viscosity depends on the size of the capillary it flows through. To appreciate this, let us begin with a preamble of what is standard textbook behavior of common liquids like water. Liquids in general adhere to the Newtonian law of dynamic viscosity. When flowing, their shear [...]... Read more »
R. Fahraeus and T. Lindqvist. (1931) The viscosity of the blood in narrow capillary tubes. American Journal of Physiology, 562-568. info:/
- August 10, 2010
- 11:00 PM
- 53 views
Ephesia: A New Approach for Cancer Diagnostics
by Michael Long in Phased
Jean-Louis Viovy (Universite Pierre et Marie Curie, France) and coworkers report a new technique that combines gentle cell sorting with rigorous microscopic imaging, and will revolutionize cancer diagnostics. This news feature was written on August 10, 2010.... Read more »
Saliba, A.-E., Saias, L., Psychari, E., Minc, N., Simon, D., Bidard, F.-C., Mathiot, C., Pierga, J.-Y., Fraisier, V., Salamero, J.... (2010) Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1001515107
- August 4, 2010
- 12:56 PM
- 86 views
I can’t hear you, the bacteria are too noisy
by Iddo Friedberg in Byte Size Biology
Much too noisy. When looking at a population of genetically identical bacteria, the number of proteins they produce varies. The picture below shows the levels of one type of protein that was fused to a green fluorescent protein (so we can see it): clearly there is a variation in how much of the protein each cell produces (“protein expression” in molbio-speak), even though the bacteria are genetically identical. Why is that? In 2006, a group of researchers at the University of Califor........ Read more »
Taniguchi, Y., Choi, P., Li, G., Chen, H., Babu, M., Hearn, J., Emili, A., & Xie, X. (2010) Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells. Science, 329(5991), 533-538. DOI: 10.1126/science.1188308
Guido, N., Wang, X., Adalsteinsson, D., McMillen, D., Hasty, J., Cantor, C., Elston, T., & Collins, J. (2006) A bottom-up approach to gene regulation. Nature, 439(7078), 856-860. DOI: 10.1038/nature04473
- July 21, 2010
- 07:39 AM
- 83 views
Ep 132: Science of Superheroes - The Hulk
by westius in Mr Science Show
The science of superheroes is taking a green and nasty turn this week as we discuss the largest superhero of them all, The Hulk. Join myself and our regular superhero expert Dr Boob as we delve into the science of how we might realise The Hulk in the lab. It was one of the more entertaining interviews I have done for the podcast.
Listen in to this show here (or press play below), and read further for more info:
The Hulk is alter-ego of Dr Bruce Banner, who allegedly bares a striking resembl........ Read more »
Shimomura, O., Johnson, F., & Saiga, Y. (1962) Extraction, Purification and Properties of Aequorin, a Bioluminescent Protein from the Luminous Hydromedusan,Aequorea. Journal of Cellular and Comparative Physiology, 59(3), 223-239. DOI: 10.1002/jcp.1030590302
Moghimi, S. (2005) Nanomedicine: current status and future prospects. The FASEB Journal, 19(3), 311-330. DOI: 10.1096/fj.04-2747rev
- June 30, 2010
- 10:13 AM
- 167 views
The exploration of the eye as an optical instrument: the last 400 years
by Pablo Artal in Optics confidential
A brief summary of how the optics of the eye was explored since Galileo's time. An exciting journey...... Read more »
Artal, P., & Tabernero, J. (2010) Optics of human eye: 400 years of exploration from Galileo’s time. Applied Optics, 49(16). DOI: 10.1364/AO.49.00D123
- June 28, 2010
- 11:37 PM
- 151 views
Regeneration of Tooth Enamel: Cavities Healed in Mice
by Reason in Fight Aging!
Dental researchers are forging ahead with their branch of tissue engineering and regenerative medicine. It hasn't been long since engineered growth in situ of replacement teeth was demonstrated in rats, and now a research group has shown they can regenerate tooth enamel in mice, thereby healing cavities: A new peptide, embedded in a soft gel or a thin, flexible film and placed next to a cavity, encourages cells inside teeth to regenerate in about a month ... The gel or thin film contains a pepti........ Read more »
Fioretti, F., Mendoza-Palomares, C., Helms, M., Al Alam, D., Richert, L., Arntz, Y., Rinckenbach, S., Garnier, F., Haïkel, Y., Gangloff, S.... (2010) Nanostructured Assemblies for Dental Application. ACS Nano, 4(6), 3277-3287. DOI: 10.1021/nn100713m
- June 24, 2010
- 02:41 AM
- 78 views
Understanding the Basic Principles of Nuclear Magnetic Resonance Imaging
by Amiya in Physiology physics woven fine
Principles of Nuclear Magnetic Resonance Imaging made simple, both for the common men and for the professionals alike.... Read more »
Ian L. Pykett, Ph.D., Jeffrey H. Newhouse, M.D., Ferdinando S. Buonanno, M.D., Thomas J. Brady, M.D., Mark R. Goldman, M.D., J. Philip Kistler, M.D., & Gerald M. Pohost, M.D. (1982) Principles of Nuclear Magnetic Resonance Imaging. Radiology. info:/
- June 10, 2010
- 10:17 PM
- 148 views
Building the Foundation of Tomorrow's Immune System
by Reason in Fight Aging!
The human immune system of tomorrow will look, conceptually, a lot like today's software defenses: Scientists are making real inroads into replicating and controlling the cells and mechanisms of our immune system. Producing immune cells, directing their actions, deciphering the biochemistry of pathogens - all these pieces are waiting to be put together as a bioartificial immune system, many times more selective, efficient and resistant to damage than the basic version we're all equipped with. .......... Read more »
Hoshino, Y., Koide, H., Urakami, T., Kanazawa, H., Kodama, T., Oku, N., & Shea, K. (2010) Recognition, Neutralization, and Clearance of Target Peptides in the Bloodstream of Living Mice by Molecularly Imprinted Polymer Nanoparticles: A Plastic Antibody. Journal of the American Chemical Society, 132(19), 6644-6645. DOI: 10.1021/ja102148f
- May 3, 2010
- 02:00 PM
- 218 views
Three-Parent Babies to Prevent Mitochondrial Diseases
by agoldstein in Beyond the Bench
Two moms and a dad could give babies the right combination of DNA to prevent mitochondrial diseases such as blindness, deafness, dementia, and diabetes.... Read more »
Tachibana, M., Sparman, M., Sritanaudomchai, H., Ma, H., Clepper, L., Woodward, J., Li, Y., Ramsey, C., Kolotushkina, O., & Mitalipov, S. (2009) Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature, 461(7262), 367-372. DOI: 10.1038/nature08368
Craven, L., Tuppen, H., Greggains, G., Harbottle, S., Murphy, J., Cree, L., Murdoch, A., Chinnery, P., Taylor, R., Lightowlers, R.... (2010) Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature. DOI: 10.1038/nature08958
TANAKA, A. (2009) Metaphase II karyoplast transfer from human in-vitro matured oocytes to enuclueated mature oocytes. Reproductive BioMedicine Online, 19(4), 514-520. DOI: 10.1016/j.rbmo.2009.06.004
- April 15, 2010
- 07:59 PM
- 148 views
I get e-mail too!
by Kristopher Hite in Tom Paine's Ghost
T. G. Dobzhansky, a prominant evolutionary biologist once said...
"Nothing in biology makes sense except in the light of evolution"
Recently, I received a request from a Tom Paine's Ghost reader to answer some questions about public perceptions of evolution. The questions, along with my responses follow.
Reader: How is evolution relevant to the lives of everyday people?
TPG: I will here talk about medicine, childhood obesity, and sex.
The first topic that springs to mind when I think ........ Read more »
Miller, J. (2006) SCIENCE COMMUNICATION: Public Acceptance of Evolution. Science, 313(5788), 765-766. DOI: 10.1126/science.1126746
Summers, R. (2005) Trichuris suis therapy in Crohn's disease. Gut, 54(1), 87-90. DOI: 10.1136/gut.2004.041749
- April 6, 2010
- 11:13 AM
- 225 views
Immortal Jellyfish
by agoldstein in Beyond the Bench
The turritopsis nutricula species of jellyfish may, in fact, be the only immortal creature in the world.... Read more »
Gray, D. (2003) Strategies for Engineered Negligible Senescence. Science of Aging Knowledge Environment, 2003(44), 30-30. DOI: 10.1126/sageke.2003.44.pe30
Piraino, S., Boero, F., Aeschbach, B., & Schmid, V. (1996) Reversing the Life Cycle: Medusae Transforming into Polyps and Cell Transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa). Biological Bulletin, 190(3), 302. DOI: 10.2307/1543022
Miglietta, M., & Lessios, H. (2008) A silent invasion. Biological Invasions, 11(4), 825-834. DOI: 10.1007/s10530-008-9296-0
- March 27, 2010
- 02:57 AM
- 319 views
a new, smarter weapon against cancer cells?
by Greg Fish in weird things
They sneak in, find and neutralize their target with a complex biological weapon, then sneak out before they’re even detected. No, they’re not a special forces squad from a spy novel. They’re actually 70 nanometer particles which could become one of the most important weapons in fighting cancers if their promise is proven in large [...]... Read more »
Davis, M., Zuckerman, J., Choi, C., Seligson, D., Tolcher, A., Alabi, C., Yen, Y., Heidel, J., & Ribas, A. (2010) Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature. DOI: 10.1038/nature08956
- March 13, 2010
- 08:08 AM
- 155 views
Cell Cycle Visualization in Development
by AndrewHires in Brain Windows
Atsushi Miyawaki’s lab has developed a series of neat tools for visualizing cell cycle progress.... Read more »
Sugiyama, M., Sakaue-Sawano, A., Iimura, T., Fukami, K., Kitaguchi, T., Kawakami, K., Okamoto, H., Higashijima, S., & Miyawaki, A. (2009) Illuminating cell-cycle progression in the developing zebrafish embryo. Proceedings of the National Academy of Sciences, 106(49), 20812-20817. DOI: 10.1073/pnas.0906464106
Kanki, H., Shimabukuro, M., Miyawaki, A., & Okano, H. (2010) "Color Timer" mice: visualization of neuronal differentiation with fluorescent proteins. Molecular Brain, 3(1), 5. DOI: 10.1186/1756-6606-3-5
- March 10, 2010
- 09:53 PM
- 149 views
CNiFERS of Acetylcholine and Attention
by AndrewHires in Brain Windows
Nguyen et al demonstrate a mammalian cell based system for optically measuring ACh levels in an intact brain. They coexpressed M1 muscarinic receptors with the genetically-encoded calcium indicator TN-XXL in HEK293 cells. ACh binding to the M1 receptor induced IP3-mediated calcium influx. This calcium rise was then picked up by the TN-XXL and reported as a change in CFP/YFP fluorescence. The crazy part is that they took this cell culture assay and implanted the cells into the brains of livin........ Read more »
Nguyen, Q., Schroeder, L., Mank, M., Muller, A., Taylor, P., Griesbeck, O., & Kleinfeld, D. (2009) An in vivo biosensor for neurotransmitter release and in situ receptor activity. Nature Neuroscience, 13(1), 127-132. DOI: 10.1038/nn.2469
- February 18, 2010
- 07:00 AM
- 334 views
Chromatic aberration of the eye: to correct or not to correct?
by Pablo Artal in Optics confidential
The human eye suffers of a very large chromatic aberration. This means that when a red object is in focus, a blue one at the same distance will be clearly out of focus. Why we are not yet routinely correcting this defect to improve vision? You will find here some new experiments, results and explanations...... Read more »
Artal, P., Manzanera, S., Piers, P., & Weeber, H. (2010) Visual effect of the combined correction of spherical and longitudinal chromatic aberrations. Optics Express, 18(2), 1637. DOI: 10.1364/OE.18.001637
- February 17, 2010
- 05:22 AM
- 354 views
“Codon” is now a four lettered word
by Iddo Friedberg in Byte Size Biology
As part of the process of manufacturing a new car, the designers will take the blueprints to the factory floor. There they will set up an experimental assembly line, tinkering with the manufacturing process of the prototype until it is ready for mass-production. Can we do the same with the machinery of life – the assembly [...]... Read more »
Neumann, H., Wang, K., Davis, L., Garcia-Alai, M., & Chin, J. (2010) Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome. Nature. DOI: 10.1038/nature08817
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