Post List

  • July 6, 2015
  • 02:45 PM
  • 2 views

Link between autoimmune diseases, medications, and a dangerous heart condition

by Dr. Jekyll in Lunatic Laboratories

Mohamed Boutjdir, PhD, professor of medicine, cell biology, and physiology and pharmacology at SUNY Downstate Medical Center, has led a study with international collaborators identifying the mechanism by which patients with various autoimmune and connective tissue disorders may be at risk for life-threatening cardiac events if they take certain anti-histamine or anti-depressant medications. Dr. Boutjdir is also director of the Cardiac Research Program at VA New York Harbor Healthcare System.... Read more »

Yue, Y., Castrichini, M., Srivastava, U., Fabris, F., Shah, K., Li, Z., Qu, Y., El-Sherif, N., Zhou, Z., January, C.... (2015) Pathogenesis of the Novel Autoimmune-Associated Long QT Syndrome. Circulation. DOI: 10.1161/CIRCULATIONAHA.115.009800  

  • July 6, 2015
  • 02:22 PM
  • 3 views

Restraint and confinement still an everyday practice in mental health settings

by Dr. Jekyll in Lunatic Laboratories

Providers of mental-health services still rely on intervention techniques such as physical restraint and confinement to control some psychiatric hospital patients, a practice which can cause harm to both patients and care facilities, according to a new study from the University of Waterloo. The study found that almost one in four psychiatric patients in Ontario hospitals are restrained using control interventions, such as chairs that prevent rising, wrist restraints, seclusion rooms or acute con........ Read more »

Mah, T., Hirdes, J., Heckman, G., & Stolee, P. (2015) Use of control interventions in adult in-patient mental health services. Healthcare Management Forum, 28(4), 139-145. DOI: 10.1177/0840470415581230  

  • July 6, 2015
  • 08:29 AM
  • 14 views

Scientists Predict A Talking Elephant, Szilamandee

by Neuroskeptic in Neuroskeptic_Discover

A talking white elephant called Slizamandee could save the world with his wisdom and "teach us with the deepest voice of history", according to an academic paper published today.

The article appeared in the journal Progress in Biophysics and Molecular Biology. The authors are led by Otto E. Rössler, a biochemist. It's called Is it Ethical to heal a young white Elephant from his physiological Autism? Many thanks to Michelle Dawson for bringing it to my attention.



Rössler et al. start ou... Read more »

Rossler, O., Theis, C., Heiter, J., Fleischer, W., & Student, A. (2015) Is it Ethical to heal a young white Elephant from his physiological Autism?. Progress in Biophysics and Molecular Biology. DOI: 10.1016/j.pbiomolbio.2015.06.020  

  • July 6, 2015
  • 08:08 AM
  • 9 views

Saving For Retirement — As Simple As Counting in Days

by Jeremiah Stanghini in Jeremiah Stanghini

A few years ago, I wrote a post about the problems with saying “I’ll be ready in 5 minutes.” It turns out, there’s now research that — in a way — supports the point I was trying to make. In this … Continue reading →... Read more »

  • July 6, 2015
  • 06:08 AM
  • 15 views

Why Radicalize? Five Motives For Becoming A Jihadist

by Sarah Boers-Goi in United Academics

Radicalization is an analyzable process, rather than the outcome of an ‘evil’ personality.... Read more »

  • July 6, 2015
  • 04:54 AM
  • 13 views

Is coeliac disease an aetiological factor in paediatric nonsyndromic intellectual disability?

by Paul Whiteley in Questioning Answers

In answer to the question posed in the title of this post on whether coeliac disease (CD) might show some connection to intellectual (learning) disability, 'probably not' is the finding reported by Taner Sezer and colleagues [1].Researchers initially looked at "serum levels of tissue transglutaminase antibody and total IgA" in over 230 children diagnosed with nonsyndromic intellectual disability compared with about the same number of asymptomatic controls. Nonsyndromic intellectual dis........ Read more »

  • July 6, 2015
  • 12:05 AM
  • 7 views

Structural Brain Changes Associated to Concussion History and Cognition

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Prior concussion that resulted in loss of consciousness is a risk factor for decreased hippocampal regions and mild cognitive impairment later in life.... Read more »

  • July 5, 2015
  • 01:50 PM
  • 18 views

Discovery points to a new path toward a universal flu vaccine

by Dr. Jekyll in Lunatic Laboratories

Flu vaccines can be something of a shot in the dark. Not only must they be given yearly, there’s no guarantee the strains against which they protect will be the ones circulating once the season arrives. New research by Rockefeller University scientists suggests it may be possible to harness a previously unknown mechanism within the immune system to create more effective and efficient vaccines against this ever-mutating virus.... Read more »

Wang, T., Maamary, J., Tan, G., Bournazos, S., Davis, C., Krammer, F., Schlesinger, S., Palese, P., Ahmed, R., & Ravetch, J. (2015) Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. Cell, 162(1), 160-169. DOI: 10.1016/j.cell.2015.06.026  

  • July 4, 2015
  • 02:50 PM
  • 32 views

Evidence of Value of Orphan Drugs Inconsistent

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Igho Onakpoya MD MSc Clarendon Scholar University of Oxford Centre for Evidence-Based Medicine Nuffield Department of Primary Care Health Sciences Oxford UK MedicalResearch: What is the background for this study? What are the main findings? Dr. Onakpoya: Several … Continue reading →
The post Evidence of Value of Orphan Drugs Inconsistent appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Igho Onakpoya MD MSc, & Clarendon Scholar. (2015) Evidence of Value of Orphan Drugs Inconsistent. medicalresearch.com. info:/

  • July 4, 2015
  • 02:26 PM
  • 40 views

Long-term memories are maintained by prion-like proteins

by Dr. Jekyll in Lunatic Laboratories

Research from Columbia University Medical Center (CUMC) has uncovered further evidence of a system in the brain that persistently maintains memories for long periods of time. And paradoxically, it works in the same way as mechanisms that cause mad cow disease, kuru, and other degenerative brain diseases.... Read more »

Fioriti, L., Myers, C., Huang, Y., Li, X., Stephan, J., Trifilieff, P., Colnaghi, L., Kosmidis, S., Drisaldi, B., Pavlopoulos, E.... (2015) The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3. Neuron, 86(6), 1433-1448. DOI: 10.1016/j.neuron.2015.05.021  

Drisaldi, B., Colnaghi, L., Fioriti, L., Rao, N., Myers, C., Snyder, A., Metzger, D., Tarasoff, J., Konstantinov, E., Fraser, P.... (2015) SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3. Cell Reports, 11(11), 1694-1702. DOI: 10.1016/j.celrep.2015.04.061  

Stephan, J., Fioriti, L., Lamba, N., Colnaghi, L., Karl, K., Derkatch, I., & Kandel, E. (2015) The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton. Cell Reports, 11(11), 1772-1785. DOI: 10.1016/j.celrep.2015.04.060  

  • July 4, 2015
  • 11:33 AM
  • 26 views

The Smile of Value Creation

by Andreas Wieland in Supply Chain Management Research

Mudambi (2008) notes that “value-added is becoming increasingly concentrated at the upstream and downstream ends of the value chain” and that “activities at both ends of the value chain are intensive in their application of knowledge and creativity”. Value-added along the value chain is, thus, represented by a “smiling curve”. Mudambi, R. (2008). Location, Control […]... Read more »

  • July 4, 2015
  • 05:19 AM
  • 39 views

A viral 'cause' of obesity?

by Paul Whiteley in Questioning Answers

I must thank Leah Hardy (@LeahFHardy) for bringing to my attention the paper by Qinglong Shang and colleagues [1] (open-access available here) reporting that: "Ad36 [Human adenovirus 36] infection is associated with an increased risk of obesity development."Based on a meta-analysis of the available research literature examining whether Ad-36 - "a nonenveloped icosahedral virus comprised of double-stranded DNA and is one of 56 serotypes in 7 subgroups of human adenoviruses" - might........ Read more »

  • July 3, 2015
  • 04:37 PM
  • 54 views

REM sleep critical for young brain development; medication interferes

by Dr. Jekyll in Lunatic Laboratories

Rapid eye movement or REM sleep actively converts waking experiences into lasting memories and abilities in young brains reports a new study. The finding broadens the understanding of children’s sleep needs and calls into question the increasing use of REM-disrupting medications such as stimulants and antidepressants.

... Read more »

Michelle C. Dumoulin Bridi, Sara J. Aton, Julie Seibt, Leslie Renouard, Tammi Coleman1, & Marcos G. Frank. (2015) Rapid eye movement sleep promotes cortical plasticity in the developing brain. Science Advances. info:/10.1126/sciadv.1500105

  • July 3, 2015
  • 04:05 PM
  • 42 views

Novel DNA repair mechanism brings new horizons

by Dr. Jekyll in Lunatic Laboratories

The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed. A group of researchers discovered a new mechanism of DNA repair, which opens up new perspectives for the treatment and prevention of neurodegenerative diseases.... Read more »

Nikolay A. Pestov, Nadezhda S. Gerasimova, Olga I. Kulaeva, & Vasily M. Studitsky. (2015) Structure of transcribed chromatin is a sensor of DNA damage. Science Advances. info:/10.1126/sciadv.1500021

  • July 3, 2015
  • 11:47 AM
  • 50 views

Smile at a party and people are more likely to remember seeing your face there

by BPS Research Digest in BPS Research Digest

When you smile at a party, your facial expression is emotionally consistent with the happy context and as a consequence other guests will in future be more likely to remember that they've seen your face before, and where you were when they saw you. That's according to a team of Italian researchers led by Stefania Righi who have explored how memory for a face is affected by the emotion shown on that face and the congruence between that emotional expression and its surrounding context.The research........ Read more »

  • July 3, 2015
  • 11:45 AM
  • 30 views

Warming Climate May Not Reduce Winter Mortality

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Prof. Patrick L Kinney Ph.D. Professor of Environmental Health Sciences and Director, Columbia Climate and Health Program Mailman School of Public Health Columbia University, New York, NY Medical Research: What is the background for this study? Dr. Kinney: … Continue reading →
The post Warming Climate May Not Reduce Winter Mortality appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Prof. Patrick L Kinney Ph.D., & Professor of Environmental Health Sciences. (2015) Warming Climate May Not Reduce Winter Mortality. MedicalResearch.com. info:/

  • July 3, 2015
  • 09:55 AM
  • 56 views

Evidence for "Unconscious Learning" Questioned

by Neuroskeptic in Neuroskeptic_Discover

Can we learn without being aware of what we're learning? Many psychologists say that 'unconscious', or implicit, learning exists.

But in a new paper, London-based psychologists Vadillo, Konstantinidis, and Shanks call the evidence for this into question.



Vadillo et al. focus on one particular example of implicit learning, the contextual cueing paradigm. This involves a series of stimulus patterns, each consisting of a number of "L" shapes and one "T" shape in various orientations. For ... Read more »

  • July 3, 2015
  • 09:13 AM
  • 35 views

Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. F. Xavier Pi–Sunyer MD Division of Endocrinology and Obesity Research Center Columbia University, New York Medical Research: What is the background for this study? What are the main findings? Dr. Pi-Sunye: In a large randomized trial, … Continue reading →
The post Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Dr. F. Xavier Pi-Sunyer MD, & Division of Endocrinology and Obesity Research Center. (2015) Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients. MedicalResearch.com. info:/

  • July 3, 2015
  • 08:54 AM
  • 34 views

Low Testosterone Linked To Obesity and Depression In Men

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Michael S. Irwig MD Division of Endocrinology Medical Faculty Associates George Washington University Medical Research: What is the background for this study? What are the main findings? Response: Many factors are associated with lower testosterone levels and … Continue reading →
The post Low Testosterone Linked To Obesity and Depression In Men appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Michael S. Irwig MD Division of Endocrinology Medical Faculty Associates. (2015) Low Testosterone Linked To Obesity and Depression In Men. MedicalResearch.com. info:/

  • July 3, 2015
  • 08:15 AM
  • 33 views

Male Kangaroos' Arms Evolved to Pound the Crap out of Each Other

by Elizabeth Preston in Inkfish



When you look at a kangaroo or a wallaby, it's obvious the animal is well built for bouncing around the outback. What may be less obvious is that its arms are built for fighting—if it's male, that is. Males of these species have disproportionately long arm bones. And the more brawling a species does, the more exaggerated the difference between the beefy-armed males and their normal-limbed mates.

To understand this evolutionary quirk, we'll need to review the rules of fighting in wallabie........ Read more »

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