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  • November 15, 2016
  • 02:56 AM
  • 328 views

Autism, ESSENCE and the question of reassessment

by Paul Whiteley in Questioning Answers

I talked about ESSENCE - Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations - only yesterday (see here) and here I am covering the topic again on this blog. There is good reason however that this concept appears once more, as I draw your attention to the paper by Anne-Katrin Kantzer and colleagues [1] and the specific observation that: "Co-existence with other conditions was the rule" when it comes to the diagnosis of autism.OK, it's nothing new to say that the l........ Read more »

  • November 14, 2016
  • 03:13 AM
  • 385 views

ESSENCE meets connective tissue disorders?

by Paul Whiteley in Questioning Answers

ESSENCE referred to in the title of this post concerns 'Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations', a concept championed by the ever-intrepid Prof. Christopher Gillberg and colleagues. Combined with some rather important discussions about the research validity of the concept of a singular 'autism' (see here) [part of the ESSENCE issues described] I'm drawn to quite a few of the proposals put forward by this research group it has to be said.It is with ESSENCE ........ Read more »

Baeza-Velasco C, Grahame R, & Bravo JF. (2016) A connective tissue disorder may underlie ESSENCE problems in childhood. Research in developmental disabilities. PMID: 27802895  

  • November 12, 2016
  • 03:34 PM
  • 321 views

More of the same...

by Craig Payne in Running Research Junkie

More of the same...... Read more »

  • November 12, 2016
  • 04:17 AM
  • 375 views

Bifidobacterium longum 1714 attenuates stress?

by Paul Whiteley in Questioning Answers

It's been quite a week hasn't it? Indeed for quite a few people it's been a stressful few days so perhaps timely that I'm talking about the 'attenuation of stress' in today's post.Despite the relatively small sample size included in the paper by by AP Allen and colleagues [1] there is something rather tantalising about their results suggesting that in healthy volunteers "consumption of B. longum [Bifidobacterium longum 1714] 1714 is associated with reduced stress and improved memo........ Read more »

  • November 11, 2016
  • 05:10 AM
  • 338 views

RCC clinical trials: positive results and new phase III clinical study

by Joana Guedes in BHD Research Blog

Renal cell carcinoma (RCC) is by far the most common type of kidney cancer and it can be caused by genetic conditions such as BHD (Randall et al., 2014). BHD patients can develop multiple kidney tumours. In most cases these tumours can be surgically removed. However, surgery and traditional chemotherapies can leave patients with reduced renal function and at risk of relapse. In addition, advanced or metastatic RCC is difficult to treat with surgery. Therefore, the development and improvement o........ Read more »

  • November 11, 2016
  • 03:04 AM
  • 373 views

"While you're here, I just want to talk about your weight"

by Paul Whiteley in Questioning Answers

The important Doctor-Patient relationshipIn a slight departure from the typical material discussed on this blog, I want to briefly direct readers to the paper by (Prof) Paul Aveyard and colleagues [1] and results suggesting that: "A behaviourally-informed, very brief, physician-delivered opportunistic intervention is acceptable to patients and an effective way to reduce population mean weight."The title of this post comes from some of the media coverage of the Aveyard study summarising how ........ Read more »

Aveyard, P., Lewis, A., Tearne, S., Hood, K., Christian-Brown, A., Adab, P., Begh, R., Jolly, K., Daley, A., Farley, A.... (2016) Screening and brief intervention for obesity in primary care: a parallel, two-arm, randomised trial. The Lancet. DOI: 10.1016/S0140-6736(16)31893-1  

  • November 10, 2016
  • 06:14 AM
  • 420 views

This Month in Blatstocystis Research (OCT 2016)

by Christen Rune Stensvold in Blastocystis Parasite Blog

Highlights of the month include a Special Issue on Blastocystis appearing in Parasitology International, a study of mitochondrial genomes, relationships between gut parasites and gut bacteria, and a announcement of an EMBO anaerobic protist conference next year in the UK.... Read more »

Dogruman-Al F, Stensvold CR, & Yoshikawa H. (2016) Editorial - PAR INT - special issue on Blastocystis. Parasitology international, 65(6 Pt B), 749. PMID: 27742000  

Iebba V, Santangelo F, Totino V, Pantanella F, Monsia A, Di Cristanziano V, Di Cave D, Schippa S, Berrilli F, & D'Alfonso R. (2016) Gut microbiota related to Giardia duodenalis, Entamoeba spp. and Blastocystis hominis infections in humans from Côte d'Ivoire. Journal of infection in developing countries, 10(9), 1035-1041. PMID: 27694739  

  • November 10, 2016
  • 03:09 AM
  • 318 views

Atopy increases vulnerability to affective and anxiety issues?

by Paul Whiteley in Questioning Answers

In a year of impossible things...I was rather interested to read the recent paper by Renee Goodwin and colleagues [1] observing that: "Atopy appears to be associated with increased vulnerability to affective and anxiety problems, compared to youth without atopy."Atopy, referring to a predisposition to developing allergic diseases such as eczema, asthma and/or hayfever, is something on the 'up' in research terms when it comes to aspects of psychiatry and/or developmental outcomes (see here f........ Read more »

  • November 9, 2016
  • 10:20 PM
  • 183 views

Dark selection and ruxolitinib resistance in myeloid neoplasms

by Artem Kaznatcheev in Evolutionary Games Group

I am weathering the US election in Tampa, Florida. For this week, I am back at the Moffitt Cancer Center to participate in the 6th annual IMO Workshop. The 2016 theme is one of the biggest challenges to current cancer treatment: therapy resistance. All five teams participating this year are comfortable with the evolutionary view […]... Read more »

  • November 9, 2016
  • 04:30 AM
  • 359 views

Wringing Out the Achilles

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Participants with rear foot valgus appear to have diminished blood flow to the Achilles in comparison to normal rear foot individuals. More research is needed to determine how we can clinically intervene.... Read more »

Karzis, K., Kalogeris, M., Mandalidis, D., Geladas, N., Karteroliotis, K., & Athanasopoulos, S. (2016) The effect of foot overpronation on Achilles tendon blood supply in healthy male subjects. Scandinavian Journal of Medicine . DOI: 10.1111/sms.12722  

  • November 9, 2016
  • 04:16 AM
  • 362 views

A 'frank' presentation of autism?

by Paul Whiteley in Questioning Answers

"Many individuals with ASD [autism spectrum disorder] have a distinctive behavioral presentation that is recognizable within moments, a phenomenon we call "frank" ASD." So said the paper by Ashley de Marchena & Judith Miller [1] who carried out an "empirical study of frank ASD" and by the looks of my Twitter feed when I initially posted about this study, there are quite a few varied opinions about the concept of 'frank' autism.Although 'frank autism' makes up a significant portion ........ Read more »

  • November 8, 2016
  • 02:57 AM
  • 332 views

"A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis"

by Paul Whiteley in Questioning Answers

Contrary to Murphy's Law - 'never repeat a successful experiment' - replication or reproducibility is a cornerstone of good science. Today, I'm blogging about a piece of research that aimed to do just that as per the findings reported by Stephen Walker and colleagues [1] (open-access).The title of this post has been borrowed from the title of the Walker paper to illustrate how moving on from the quite widely known 'fact' that functional gastrointestinal (GI) symptoms are over-represented wh........ Read more »

  • November 7, 2016
  • 03:13 AM
  • 374 views

8.6% of children with autism have epilepsy?

by Paul Whiteley in Questioning Answers

"Epilepsy was reported to co-occur in 8.6 % of ASD [autism spectrum disorder] cases."That was the headline conclusion reported by Shiny Thomas and colleagues [1] as they drew on data from "the most recent U.S. National Survey of Children's Health, 2011-2012" to add to the extensive literature looking at how common epilepsy is when it comes to autism.Including some 1600 children/young adults diagnosed with autism - equivalent to a prevalence of 1.8% of the entire 85,000-strong co........ Read more »

  • November 5, 2016
  • 04:20 AM
  • 389 views

Sensory subtypes and anxiety and autism

by Paul Whiteley in Questioning Answers

"This is the first study to identify the existence of sensory subtypes among older children and adolescents with ASD [autism spectrum disorder] and explore their association with anxiety levels."Far be it from me to question the above quote provided in the paper by Mirko Uljarević and colleagues [1] but I'm inclined to suggest that there has already been some research published on the link between sensory issues and anxiety in the context of the autism spectrum before (see here and se........ Read more »

Uljarević M, Lane A, Kelly A, & Leekam S. (2016) Sensory subtypes and anxiety in older children and adolescents with autism spectrum disorder. Autism research : official journal of the International Society for Autism Research, 9(10), 1073-1078. PMID: 26765165  

  • November 4, 2016
  • 06:12 AM
  • 347 views

Two recent case reports on BHD – Epidemiologic study of patients in Asia and new FLCN mutation

by Joana Guedes in BHD Research Blog

Furuya et al. (2016) present a new study describing genetic, epidemiologic and clinicopathologic features of 312 Asian individuals with BHD manifestations based on data from 120 probands from different families (119 Japanese and 1 Taiwanese), 36 siblingss with genetic testing and 156 siblings without genetic testing.... Read more »

Furuya M, Yao M, Tanaka R, Nagashima Y, Kuroda N, Hasumi H, Baba M, Matsushima J, Nomura F, & Nakatani Y. (2016) Genetic, epidemiologic and clinicopathologic studies of Japanese Asian patients with Birt-Hogg-Dubé syndrome. Clinical genetics, 90(5), 403-412. PMID: 27220747  

  • November 4, 2016
  • 05:00 AM
  • 378 views

Friday Fellow: Silvergreen Moss

by Piter Boll in Earthling Nature

by Piter Kehoma Boll Found throughout most of the world, you probably have encountered this fellow many times in your life, but did not pay any attention. After all, it is just a moss! Scientifically known as Bryum argenteum and popularly … Continue reading →... Read more »

  • November 4, 2016
  • 04:03 AM
  • 363 views

Hyperhomocysteinemia as a significant risk factor for autism?

by Paul Whiteley in Questioning Answers

The findings reported by Naushad Shaik Mohammad and colleagues [1] provide some blogging fodder today and the suggestion of a link between some of the genetics of the folate pathway and the finding of elevated levels of homocysteine with [some] autism in mind.OK, from the start, the genetics of folate metabolism mentioned in the context of autism typically means reference to the quite well replicated finding of issues with the gene methylenetetrahydrofolate reductase (MTHFR) (see ........ Read more »

Shaik Mohammad N, Sai Shruti P, Bharathi V, Krishna Prasad C, Hussain T, Alrokayan SA, Naik U, & Radha Rama Devi A. (2016) Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders. Psychiatric genetics. PMID: 27755291  

  • November 3, 2016
  • 04:10 AM
  • 414 views

Antibiotic brain part 3

by Paul Whiteley in Questioning Answers

"This study demonstrates an association between antibiotic use in the first year of life and subsequent neurocognitive outcomes in childhood."So said the findings reported by Slykerman and colleagues [1] who relied on data from the Auckland Birthweight Collaborative Study (an initiative set up to determine whether "internationally recognized risk factors for small-for-gestational-age (SGA) term babies were applicable in New Zealand") to examine the suggestion that early life antib........ Read more »

Slykerman RF, Thompson J, Waldie KE, Murphy R, Wall C, & Mitchell EA. (2016) Antibiotics in the first year of life and subsequent neurocognitive outcomes. Acta paediatrica (Oslo, Norway : 1992). PMID: 27701771  

  • November 2, 2016
  • 04:56 PM
  • 359 views

When I read things like this...

by Craig Payne in Running Research Junkie

When I read things like this...... Read more »

Hollander K, Heidt C, van der Zwaard B, Braumann KM, & Zech A. (2016) Long-Term Effects of Habitual Barefoot Running and Walking: A Systematic Review. Medicine and science in sports and exercise. PMID: 27801744  

  • November 2, 2016
  • 11:09 AM
  • 380 views

Weight Training Boosts Brain Size and Performance

by William Yates, M.D. in Brain Posts

Aerobic exercise increases brain blood flow and has demonstrated beneficial effects on cognition.The effects of weight training exercise on the brain is less frequently studied. Hence, we know little about the effect and mechanism of weight training on brain function and performance.A recent study provides some needed insight on this topic.A study by C Suo and colleagues from Australia examined the effects of resistance training and cognitive skills training on brain structure and function.The k........ Read more »

Suo C, Singh MF, Gates N, Wen W, Sachdev P, Brodaty H, Saigal N, Wilson GC, Meiklejohn J, Singh N.... (2016) Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise. Molecular psychiatry, 21(11), 1645. PMID: 27090304  

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