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  • November 30, -1
  • 12:00 AM
  • 2,078 views

Let’s Get Cellular: Meth Metabolism

by Dirk Hanson in Addiction Inbox

We know from the work of Nora Volkow and others that meth abusers have chronically low levels of dopamine D2 receptors in their brains. But what is going on in the rest of the body when methamphetamine addiction is running full force?... Read more »

Sun, L., Li, H., Seufferheld, M., Walters, K., Margam, V., Jannasch, A., Diaz, N., Riley, C., Sun, W., Li, Y.... (2011) Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0018215  

  • November 30, -1
  • 12:00 AM
  • 1,974 views

HIV vaccine research: Protein which train B cells for production of antibodies against HIV which successfully neutralize HIV

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

HIV virus rapidly undergoes mutation, which is main hurdle in developing vaccine against HIV.There is a region on HIV virus which shows less variations, called as Cd4 binding site ,therefore a protein which stimulate antibody formation against this region can be developed and used as a vaccine.
Researchers at Vaccine Research Center (VRC) and the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health have studied genes which code for such proteins which can........ Read more »

B V Waghmare. (2011) HIV vaccine development : Proteins which trains B Cells for production of antibodies which successfully neutralize HIV by binding with it . http://bvwaghmare.blogspot.com. info:/(DOI/arXiv/etc.)

  • November 30, -1
  • 12:00 AM
  • 2,247 views

Crystal structure solved by protein folding game players

by Olexandr Isayev in olexandrisayev.com

Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, authors challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination.... Read more »

Khatib, F., DiMaio, F., Cooper, S., Kazmierczyk, M., Gilski, M., Krzywda, S., Zabranska, H., Pichova, I., Thompson, J., Popović, Z.... (2011) Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nature Structural . DOI: 10.1038/nsmb.2119  

  • November 30, -1
  • 12:00 AM
  • 1,871 views

Using folate receptor alpha flurorescence imaging in ovarian cancer

by Sally Church in Pharma Strategy Blog

The idea behind this concept is that fluorescence technology can be used to help guide ovarian cancer surgery more effectively, since the tumors tend to be small and hard to see for surgeons performing the excision.... Read more »

van Dam, G., Themelis, G., Crane, L., Harlaar, N., Pleijhuis, R., Kelder, W., Sarantopoulos, A., de Jong, J., Arts, H., van der Zee, A.... (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nature Medicine. DOI: 10.1038/nm.2472  

  • November 30, -1
  • 12:00 AM
  • 2,925 views

2011: The Year in Drugs Deaths and data fraud

by Neurobonkers in Neurobonkers

A look at the biggest drugs news stories of the year and a statistical analysis of drugs deaths this year.... Read more »

Measham,F. Moore, K. Østergaard, J. (2011) Mephedrone, ‘‘Bubble’’ and unidentified white powders: the contested identities of synthetic ‘‘legal highs". DRUGS AND ALCOHOL TODAY, 137-146. info:/

Editorial team. (2010) The EMCDDA annual report 2010: the state of the drugs problem in Europe. The European Monitoring Centre for Drugs and Drug Addiction, also published in Euro surveillance :European communicable disease bulletin, 15(46). PMID: 21144426  

  • November 30, -1
  • 12:00 AM
  • 2,297 views

Many Vegetarians Consume Animal-Derived Products in Medicines

by United Academics in United Academics

What should vegetarians do when medicines contain animal products? The answer seems an easy one: to refuse them or to act according to their conscience. But what if the consumers are not appropriately informed about the medicine components, or the doctors not even know that it contains animal products?... Read more »

  • November 30, -1
  • 12:00 AM
  • 1,421 views

Making sense of a small worm from big data

by Michael Hsieh in Hsieh Lab Blog

We recently published a gene expression microarray-based paper in PLOS Neglected Tropical Diseases. As a "reductionist", it was challenging for me to deal with the massive amount of data associated with the paper. ... Read more »

  • November 30, -1
  • 12:00 AM
  • 1,395 views

More evidence that antibiotics are over-prescribed - How should that change?

by Rogue Medic in Rogue Medic

Today Lancet Infectious Diseases posted an early release of an article that shows that the antibiotic amoxicillin still does not work on viruses.

Many doctors still routinely prescribe antibiotics for viral infections.

Bias, perhaps the biggest confounder in medical research, is controlled for very well.

What does the study show?... Read more »

  • November 30, -1
  • 12:00 AM
  • 1,450 views

...How to Fix Science

by Viputheshwar Sitaraman in Draw Science

(Part 2/2) However, we can fix science. [Infographic]... Read more »

Alberts, B., Kirschner, M., Tilghman, S., & Varmus, H. (2014) Rescuing US biomedical research from its systemic flaws. Proceedings of the National Academy of Sciences, 111(16), 5773-5777. DOI: 10.1073/pnas.1404402111  

  • November 30, -1
  • 12:00 AM
  • 400 views

H255Y and K508R missense mutations in FLCN promote kidney neoplasia

by Joana Guedes in BHD Research Blog

The germline FLCN missense mutations H255Y (Hasumi et al., 2009) and K508R (Toro et al., 2008) have been identified in patients with bilateral multifocal (BMF) kidney tumours and other clinical symptoms of Birt-Hogg-Dube (BHD) syndrome, or with BMF kidney tumours as the only manifestation. Building on their previous work identifying the H255Y mutation in human BHD kidney tumour, Hasumi et al. (2016) investigated whether these mutations have an impact on FLCN function. The authors evaluated the F........ Read more »

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