Have you ever wondered if those healthy fast food meals are really any better for you? McDonald’s has the Fruit ‘n Yogurt Parfait, Wendy’s offers Garden Sensations salads and at Burger King you can even get a veggie burger. Yogurt, salad, veggie burger … these are all healthy foods. However, new research suggests that healthy fast food meals have the same effect on your cardiovascular system as a burger, fries and a soda.... Read more »
Tanja K Rudolph, Kaike Ruempler, Edzard Schwedhelm, Jing Tan-Andresen, Ulrich Riederer, Rainer H Böger, & Renke Maas. (2007) Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial. American Journal of Clinical Nutrition, 86(2), 334-340. DOI: 17684202
Military personnel, chemical workers, and others could benefit from a new synthetic rubber material tailored with liquid crystals. The material might be used to make body suits to protect chemical-industry employees from skin exposure to toxic vapors and aerosols, as well as providing protection for military personnel and civilians in the event of a chemical-weapons [...]... Read more »
Lu, X., Nguyen, V., Zhou, M., Zeng, X., Jin, J., Elliott, B., & Gin, D. (2006) Crosslinked Bicontinuous Cubic Lyotropic Liquid-Crystal/Butyl-Rubber Composites: Highly Selective, Breathable Barrier Materials for Chemical Agent Protection. Advanced Materials, 18(24), 3294-3298. DOI: 10.1002/adma.200601156
You've probably heard it. “pull yourself under the bar”, “you’re not going down enough” “full range of motion”. Sometimes trainers seem to get aggravated and may end up ignoring masters athletes who don’t respond to their advice. For many the situation is more complex than choosing not to respond.
Coach Bob Takano (l) and Masters Athlete Scott Miller (r) at the 2011 SPLWC Championships
The two most important factors limiting weightlifting ability (here we mean simply ab........ Read more »
Fischer SL, Brenneman EC, Wells RP, & Dickerson CR. (2012) Relationships between psychophysically acceptable and maximum voluntary hand force capacity in the context of underlying biomechanical limitations. Applied ergonomics, 43(5), 813-20. PMID: 22245635
Robb A, & Pajaczkowski J. (2011) Immediate effect on pain thresholds using active release technique on adductor strains: Pilot study. Journal of bodywork and movement therapies, 15(1), 57-62. PMID: 21147419
Heart disease is the leading cause of death in the United States for both men and women, but in women in particular the disease often goes undetected. Finding ways to detect symptoms of heart disease in women can help us detect signs and risk factors early and help prevent deaths and increase the quality and [...]... Read more »
van Rooij, E., Sutherland, L., Liu, N., Williams, A., McAnally, J., Gerard, R., Richardson, J., & Olson, E. (2006) A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proceedings of the National Academy of Sciences, 103(48), 18255-18260. DOI: 10.1073/pnas.0608791103
Bhupathy, P., Haines, C., & Leinwand, L. (2010) Influence of sex hormones and phytoestrogens on heart disease in men and women. Women's Health, 6(1), 77-95. DOI: 10.2217/whe.09.80
Malik FI, Hartman JJ, Elias KA, Morgan BP, Rodriguez H, Brejc K, Anderson RL, Sueoka SH, Lee KH, Finer JT.... (2011) Cardiac myosin activation: a potential therapeutic approach for systolic heart failure. Science (New York, N.Y.), 331(6023), 1439-43. PMID: 21415352
Identifying individual amino acid residues within a GPCR and comparing these across different receptors is a routine task that’s helped by a widely accepted nomenclature system: that of Ballesteros and Weinstein.
Juan A. Ballesteros, Harel Weinstein (1995). Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors Methods in Neurosciences, 25, 366-428 DOI: 10.1016/S1043-9471(05)80049........ Read more »
Juan A. Ballesteros, Harel Weinstein. (1995) Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors. Methods in Neurosciences, 366-428. DOI: 10.1016/S1043-9471(05)80049-7
A recent study out of the University of Michigan Medical School suggests that the stomach bacterium Helicobacter pylori protects against inflammation caused by Salmonella in a mouse model of Inflammatory Bowel Disease (IBD).... Read more »
Higgins PD, Johnson LA, Luther J, Zhang M, Sauder KL, Blanco LP, & Kao JY. (2010) Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: Mucosal crosstalk between stomach and distal intestine. Inflammatory bowel diseases. PMID: 20976712
Cumulative probability models are widely used for the analysis of ordinal data. In this article the authors propose cumulative probability mixture models that allow the assumptions of the cumulative probability model to hold within subsamples of the data. The subsamples are defined in terms of latent class membership. In the case of the ordered logit mixture model, on which the authors focus here, the assumption of a logistic distribution for an underlying latent dependent variable holds within ........ Read more »
Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, authors challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination.... Read more »
Khatib, F., DiMaio, F., Cooper, S., Kazmierczyk, M., Gilski, M., Krzywda, S., Zabranska, H., Pichova, I., Thompson, J., Popović, Z.... (2011) Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nature Structural . DOI: 10.1038/nsmb.2119
European Monitoring Centre for Drugs and Drug Addiction confirms that prohibition does not appear to effect levels of cannabis use in any way... Read more »
The european monitoring centre for drugs and drug addiction. (2011) The state of the drugs problem in Europe . Annual Report. info:/
The paper describes how “in the past most stores were able to sell pseudoephedrine”, the US’s most popular decongestant but new laws require pharmacies, often with restricted opening hours to sell the medicine only to those carrying government issued ID. The paper argues that “it would be of great interest to have a simple synthesis of pseudoephedrine from reagents which can be more readily procured”. The study is published in the splendidly titled Journal of Apocry........ Read more »
Hai, O. Hakkenshit, I.B. (2012) A Simple and Convenient Synthesis of Pseudoephedrine From N-Methylamphetamine. Journal of Apocryphal Chemistry, 213-21. info:/1F.1BC9/b00000F00A
Scientists at the Society for General Microbiology’s Spring Conference, which is taking place this week in Dublin, have explained how bacteria that linger in our mouth may cause endocarditis, an inflammation of the heart that can lead to dead.
... Read more »
Petersen, H., Keane, C., Jenkinson, H., Vickerman, M., Jesionowski, A., Waterhouse, J., Cox, D., & Kerrigan, S. (2009) Human Platelets Recognize a Novel Surface Protein, PadA, on Streptococcus gordonii through a Unique Interaction Involving Fibrinogen Receptor GPIIbIIIa. Infection and Immunity, 78(1), 413-422. DOI: 10.1128/IAI.00664-09
Five years from now it may be possible to prevent breast cancer by taking a simple blood test. New research shows that the chances of developing the disease are linked to a molecular modification of the gene ATM, present on white blood cells. In the future, doctors may identify women with this molecular modification to prevent breast cancer occurrence.... Read more »
Brennan, K., Garcia-Closas, M., Orr, N., Fletcher, O., Jones, M., Ashworth, A., Swerdlow, A., Thorne, H., , ., Riboli, E.... (2012) Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk. Cancer Research, 72(9), 2304-2313. DOI: 10.1158/0008-5472.CAN-11-3157
A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »
Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887
Summary of common myths and why they are wrong.... Read more »
De Wals P, Deceuninck G, Toth E, Boulianne N, Brunet D, Boucher RM, Landry M, & De Serres G. (2012) Risk of Guillain-Barré syndrome following H1N1 influenza vaccination in Quebec. JAMA : the Journal of the American Medical Association, 308(2), 175-81. PMID: 22782419
Ten years ago, Professor Miguel Nicolelis and his team at Duke University made history. They implanted electrodes — sensors — into a monkey’s brain and trained her to control a robotic arm with her thoughts. That may sound like the stuff of science-fiction, but his latest work is even more incredible. In a paper recently published in Scientific Reports, Professor Nicolelis and his team used similar technology to enable a pair of rats to communicate — one brain to another ........ Read more »
Pais-Vieira, M., Lebedev, M., Kunicki, C., Wang, J., . (2013) A Brain-to-Brain Interface for Real-Time Sharing of Sensorimotor Information. Scientific Reports. DOI: 10.1038/srep01319
Anthrax is a deadly disease with high rates of morbidity and mortality. Because it is, thankfully, also quite rare, it is relatively easy to track its whereabouts and going-ons when an outbreak occurs. Typically, outbreaks of anthrax have been traced to groups of people involved in high-risk activities involving grazing animals and their byproducts: anthrax favors shepherds, butchers, wool-sorters, leather workers, and even the odd drum-playing hippies. In 2009, however, an outbreak upended this........ Read more »
Berger, T., Kassirer, M., & Aran, A. (2014) Injectional anthrax - new presentation of an old disease. Eurosurveillance, 19(32), 20877. DOI: 10.2807/1560-7917.ES2014.19.32.20877
The year in review: innovative discoveries and progress in all different fields of science. [Infographic]... Read more »
Qiu, X., Wong, G., Audet, J., Bello, A., Fernando, L., Alimonti, J., Fausther-Bovendo, H., Wei, H., Aviles, J., Hiatt, E.... (2014) Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature, 514(7520), 47-53. DOI: 10.1038/nature13777
Labbé, C., & Labbé, D. (2012) Duplicate and fake publications in the scientific literature: how many SCIgen papers in computer science?. Scientometrics, 94(1), 379-396. DOI: 10.1007/s11192-012-0781-y
S. W. Hawking. (2014) Information Preservation and Weather Forecasting for Black Holes. arXiv. arXiv: 1401.5761v1
Obokata, H., Wakayama, T., Sasai, Y., Kojima, K., Vacanti, M., Niwa, H., Yamato, M., & Vacanti, C. (2014) Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature, 505(7485), 641-647. DOI: 10.1038/nature12968
Bougher, S., Cravens, T., Grebowsky, J., & Luhmann, J. (2014) The Aeronomy of Mars: Characterization by MAVEN of the Upper Atmosphere Reservoir That Regulates Volatile Escape. Space Science Reviews. DOI: 10.1007/s11214-014-0053-7
Niu, Y., Shen, B., Cui, Y., Chen, Y., Wang, J., Wang, L., Kang, Y., Zhao, X., Si, W., Li, W.... (2014) Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos. Cell, 156(4), 836-843. DOI: 10.1016/j.cell.2014.01.027
Quintana, E., Barclay, T., Raymond, S., Rowe, J., Bolmont, E., Caldwell, D., Howell, S., Kane, S., Huber, D., Crepp, J.... (2014) An Earth-Sized Planet in the Habitable Zone of a Cool Star. Science, 344(6181), 277-280. DOI: 10.1126/science.1249403
Patients with Birt-Hogg-Dubé (BHD) syndrome usually develop benign hair follicle tumours (BHFTs) which appear as multiple whitish papules developing primarily on the face, neck and torso (Menko et al., 2009). BHFTs such as fibrofolliculomas and trichodiscomas (skin-coloured tumours occurring on the upper body) can be associated with various genetic conditions and their histology is often key to differential diagnosis. The morphology and histology of various BHFTs is discussed in a recent ........ Read more »
As mentioned in last week’s blog, the International Rare Lung Diseases Research Conference (RLDC) was held in Cincinnati, USA, 22nd-25th September. Clinicians, scientists, patient organizations, patients and families were brought together to discuss research and clinical trials in rare lung disease and to promote dialogue between the research community and patients.... Read more »
McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee . (2011) Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis. New England Journal of Medicine, 365(3), 271-272. DOI: 10.1056/NEJMc1106358
Obesity is often associated with decreases in the proportion of skeletal muscle slow-twitch fibers and insulin sensitivity. Slow-twitch fibers are rich in mitochondria and utilize fatty acid oxidative phosphorylation for energy production. In their new study, Zhou et al. (2017) explore the role of the FLCN/FNIP1/AMPK signalling pathway in obesity-induced reductions in slow-twitch fibers and insulin sensitivity in skeletal muscle using high-fat-diet-induced (HFD) obese mice, ob/ob mutant mice, an........ Read more »
Zhou Q, Gu Y, Lang H, Wang X, Chen K, Gong X, Zhou M, Ran L, Zhu J, & Mi M. (2017) Dihydromyricetin prevents obesity-induced slow-twitch-fiber reduction partially via FLCN/FNIP1/AMPK pathway. Biochimica et biophysica acta. PMID: 28363698
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