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  • November 30, 1999
  • 12:00 AM
  • 2,561 views

Cheap Cell-Phone Microscopes Might Make Distance Ed Science Labs Feasible

by Michael Windelspecht in RicochetScience

Review of recent advances in cell phone microscopes... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,223 views

Dr. A H Bandivdekar finds the inhibitor for sexual transmission of HIV virus.

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

Dr. A H Bandivdekar Indian scientist found the exact way by which HIV virus gains entry in to human blood in sexual transmission of HIV virus, which is one of the biggest reason for HIV virus infections and AIDS.
There are certain individuals who are tested positive and do not develop symptoms of AIDS or AIDS this is because there is diffrerance in their genetic constitution.
In latancy period there is a resistance for replication of HIV virus in lymphocytes in these infected individuals. The........ Read more »

B V Waghmare. (2011) Dr. A H Bandivdekar finds the inhibitor for sexual transmission of HIV virus. . http://bvwaghmare.blogspot.com/. info:/bvwaghmare

  • November 30, 1999
  • 12:00 AM
  • 2,398 views

genetically engineered stem cell treatment, gen therapy for HIV virus infection, AIDS.

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

Scientists have collected stem cells from patients own body , and engineered them , and induced in to them gens which expresses three RNA-based anti-HIV moieties as follows .
1.tat/rev short hairpin RNA,
2.TAR decoy,
3.CCR5 ribozyme.
Amongst these anti HIV moieties CCR5 ribozyme is capable of hampering production of CCR5 protein a essential protein which is responsible for HIV virus entry in to new host cell , there it can lower a viral load , in to patient and help anti retroviral drugs t........ Read more »

B V Waghmare. (2010) Information on genetically engineered stem cell treatment, gen therapy for HIV virus infection, AIDS. . bvwaghmare.blogspot.com. info:/

  • November 30, 1999
  • 12:00 AM
  • 2,115 views

Novel Approach for anti AIDS drug development.

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

HIV virus when it incorporates its DNA in human T-Lymphocytes , it integrates in a very controlled manner so that it takes care that our T-Lymphocytes cells do not get destroyed before they code and generate HIV virus proteins and genetic material and form enough new HIV viruses.
Professors Abraham Loyter, Assaf Friedler and their colleagues have reported that they have developed a peptide called as “MIX”

Peptide “MIX” is able to increase activity of HIV virus enzyme ........ Read more »

B V Waghmare. (2010) Developing a peptide that kills HIV virus. bvwaghmare.blogspot.com. info:/

  • November 30, 1999
  • 12:00 AM
  • 2,825 views

2011: The Year in Drugs Deaths and data fraud

by Neurobonkers in Neurobonkers

A look at the biggest drugs news stories of the year and a statistical analysis of drugs deaths this year.... Read more »

Measham,F. Moore, K. Østergaard, J. (2011) Mephedrone, ‘‘Bubble’’ and unidentified white powders: the contested identities of synthetic ‘‘legal highs". DRUGS AND ALCOHOL TODAY, 137-146. info:/

Editorial team. (2010) The EMCDDA annual report 2010: the state of the drugs problem in Europe. The European Monitoring Centre for Drugs and Drug Addiction, also published in Euro surveillance :European communicable disease bulletin, 15(46). PMID: 21144426  

  • November 30, 1999
  • 12:00 AM
  • 2,514 views

Copyright vs Medicine: If this topic isn’t covered in your newspaper this weekend, get a new newspaper

by Neurobonkers in Neurobonkers

After thirty years of silence, authors of a standard clinical psychiatric bedside test have issued take down orders of new medical research. Doctors who use copies of the bedside test which will have been printed in some of their oldest medical textbooks are liable to be sued for up to $150,000.... Read more »

Newman, J., & Feldman, R. (2011) Copyright and Open Access at the Bedside. New England Journal of Medicine, 365(26), 2447-2449. DOI: 10.1056/NEJMp1110652  

  • November 30, 1999
  • 12:00 AM
  • 2,223 views

Many Vegetarians Consume Animal-Derived Products in Medicines

by United Academics in United Academics

What should vegetarians do when medicines contain animal products? The answer seems an easy one: to refuse them or to act according to their conscience. But what if the consumers are not appropriately informed about the medicine components, or the doctors not even know that it contains animal products?... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,993 views

“Beware of Exercise” is a Sexy Headline

by nooffensebut in The Unsilenced Science

A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »

Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887

  • November 30, 1999
  • 12:00 AM
  • 2,196 views

Genes Dealt Made Asians Svelte

by nooffensebut in The Unsilenced Science

Early genome-wide association studies suggest a genetic propensity to thinness in Asians. I review how these kinds of studies might be able reveal genetic racial differences in obesity and intelligence, and I address a few of the challenges to doing so.... Read more »

Belsky DW, Moffitt TE, Houts R, Bennett GG, Biddle AK, Blumenthal JA, Evans JP, Harrington H, Sugden K, Williams B.... (2012) Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. Archives of pediatrics , 166(6), 515-21. PMID: 22665028  

Hsu FC, Lenchik L, Nicklas BJ, Lohman K, Register TC, Mychaleckyj J, Langefeld CD, Freedman BI, Bowden DW, & Carr JJ. (2005) Heritability of body composition measured by DXA in the diabetes heart study. Obesity research, 13(2), 312-9. PMID: 15800289  

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L.... (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature genetics, 43(8), 753-60. PMID: 21706003  

Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R.... (2008) Proportionally more deleterious genetic variation in European than in African populations. Nature, 451(7181), 994-7. PMID: 18288194  

MacArthur DG, Balasubramanian S, Frankish A, Huang N, Morris J, Walter K, Jostins L, Habegger L, Pickrell JK, Montgomery SB.... (2012) A systematic survey of loss-of-function variants in human protein-coding genes. Science (New York, N.Y.), 335(6070), 823-8. PMID: 22344438  

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R.... (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature genetics, 42(11), 937-48. PMID: 20935630  

Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G.... (2012) Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (New York, N.Y.), 337(6090), 64-9. PMID: 22604720  

Zuk O, Hechter E, Sunyaev SR, & Lander ES. (2012) The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America, 109(4), 1193-8. PMID: 22223662  

  • November 30, 1999
  • 12:00 AM
  • 1,313 views

More evidence that antibiotics are over-prescribed - How should that change?

by Rogue Medic in Rogue Medic

Today Lancet Infectious Diseases posted an early release of an article that shows that the antibiotic amoxicillin still does not work on viruses.

Many doctors still routinely prescribe antibiotics for viral infections.

Bias, perhaps the biggest confounder in medical research, is controlled for very well.

What does the study show?... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,435 views

Testing Hair Can Detect Heart Disease

by Andrew Porterfield in United Academics

Usually, doctors take a blood test to determine levels of cortisol, a hormone that’s elevated by stress and is linked to a number of cardiovascular disorders. But a blood test just takes a cross-section “snapshot” of blood cortisol levels, and can’t tell how long these levels have been high.... Read more »

Manenschijn, L., Schaap, L., van Schoor, N., van der Pas, S., Peeters, G., Lips, P., Koper, J., & van Rossum, E. (2013) High Long-Term Cortisol Levels, Measured in Scalp Hair, Are Associated With a History of Cardiovascular Disease. Journal of Clinical Endocrinology , 98(5), 2078-2083. DOI: 10.1210/jc.2012-3663  

  • November 30, 1999
  • 12:00 AM
  • 1,529 views

Ibrutinib leads the race to CLL 17p deletion market

by Pieter Droppert in Biotech Strategy Blog

Earlier this month, Janssen/Pharmacyclics announced they had submitted a New Drug Application (NDA) for FDA approval of ibrutinib, an oral Bruton’s tyrosine kinase inhibitor (BTK) in chronic lymphocytic leukemia (CLL) for the treatment of patients with a deletion of the short arm of chromosome 17 (del17p).

The company have requested Priority review; approval later this year or in early 2014 is highly likely given that the agent also has Breakthrough designation status.

This is grea........ Read more »

Hartmut Döhner, M.D., Stephan Stilgenbauer, M.D., Axel Benner, M.Sc., Elke Leupolt, M.D., Alexander Kröber, M.D., Lars Bullinger, M.D., Konstanze Döhner, M.D., Martin Bentz, M.D., & Peter Lichter, Ph.D. (2000) Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia. The New England Journal of Medicine, 1910-1916. info:/10.1056/NEJM200012283432602

  • November 30, 1999
  • 12:00 AM
  • 1,796 views

When chronic pain is there before surgery

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

People with chronic pain present a special risk for surgeons, anaesthetists, nurses and the rehabilitation team working with them after surgery. Surgery is, after all, “planned trauma”, and a sensitive nervous system is going to be even more sensitive after a surgical insult – even when that surgery is intended to reduce pain.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,246 views

Supercomputers, The Human Brain and the Advent of Computational Biology

by JB Sheppard in Antisense Science

Recent developments in computational neuroscience and the modelling of biological systems prompted a look at how advanced our simulations of living systems are today. ... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,162 views

2014: The Year in Science

by Viputheshwar Sitaraman in Draw Science

The year in review: innovative discoveries and progress in all different fields of science. [Infographic]... Read more »

Qiu, X., Wong, G., Audet, J., Bello, A., Fernando, L., Alimonti, J., Fausther-Bovendo, H., Wei, H., Aviles, J., Hiatt, E.... (2014) Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature, 514(7520), 47-53. DOI: 10.1038/nature13777  

Obokata, H., Wakayama, T., Sasai, Y., Kojima, K., Vacanti, M., Niwa, H., Yamato, M., & Vacanti, C. (2014) Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature, 505(7485), 641-647. DOI: 10.1038/nature12968  

Quintana, E., Barclay, T., Raymond, S., Rowe, J., Bolmont, E., Caldwell, D., Howell, S., Kane, S., Huber, D., Crepp, J.... (2014) An Earth-Sized Planet in the Habitable Zone of a Cool Star. Science, 344(6181), 277-280. DOI: 10.1126/science.1249403  

A.K. Geim, & K. S. Novoselov. (2010) The rise and rise of graphene. Nature Nanotechnology, 5(11), 755-755. DOI: 10.1038/nnano.2010.224  

  • November 30, 1999
  • 12:00 AM
  • 673 views

The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR

by Rogue Medic in Rogue Medic

This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.

Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »

Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139  

Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521  

  • November 30, 1999
  • 12:00 AM
  • 1,364 views

The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR

by Rogue Medic in Rogue Medic

This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.

Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »

Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139  

Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521  

  • November 30, 1999
  • 12:00 AM
  • 1,190 views

The PROCAMIO Trial – IV Procainamide vs IV Amiodarone for the Acute Treatment of Stable Wide Complex Tachycardia

by Rogue Medic in Rogue Medic

This is a very interesting trial that may surprise the many outspoken amiodarone advocates, but it should not surprise anyone who pays attention to research.

ALPS showed that we should stop giving amiodarone for unwitnessed shockable cardiac arrest. The lead researcher is still trying to spin amiodarone for witnessed shockable cardiac arrest, even though the results do not show improvement in the one outcome that matters – leaving the hospital with a brain that still works.[1],[2],[3]... Read more »

Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. The New England journal of medicine, 374(18), 1711-22. PMID: 27043165  

Marill KA, deSouza IS, Nishijima DK, Senecal EL, Setnik GS, Stair TO, Ruskin JN, & Ellinor PT. (2010) Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(3), 297-306. PMID: 20370763  

Marill KA, deSouza IS, Nishijima DK, Stair TO, Setnik GS, & Ruskin JN. (2006) Amiodarone is poorly effective for the acute termination of ventricular tachycardia. Annals of emergency medicine, 47(3), 217-24. PMID: 16492484  

Kułakowski P, Karczmarewicz S, Karpiński G, Soszyńska M, & Ceremuzyński L. (2000) Effects of intravenous amiodarone on ventricular refractoriness, intraventricular conduction, and ventricular tachycardia induction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2(3), 207-15. PMID: 11227590  

Bonny A, De Sisti A, Márquez MF, Megbemado R, Hidden-Lucet F, & Fontaine G. (2012) Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia. World journal of cardiology, 4(10), 296-301. PMID: 23110246  

Kowey PR. (1988) The calamity of cardioversion of conscious patients. The American journal of cardiology, 61(13), 1106-7. PMID: 3364364  

  • November 30, 1999
  • 12:00 AM
  • 591 views

Zebrafish model of early stage human ccRCC

by Joana Guedes in BHD Research Blog

Von Hippel–Lindau (VHL) disease is caused by a germline mutation in the VHL gene that leads to the development of several tumors including clear cell renal cell carcinoma (ccRCC) (Maher and Kaelin, 1997). ‘Clear cell’ tumors are characterized by large, proliferating epithelial cells with clear cytoplasm, and a reduced number of cilia. VHL inactivation leads to the stabilization of hypoxia inducible factors 1a and 2a (HIF1a and HIF2a) that leads to up-regulation of genes involve........ Read more »

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