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  • November 26, 2014
  • 03:20 PM
  • 11 views

Need to turn off the pain? Well now we can!

by Gabriel in Lunatic Laboratories

My sister suffers from chronic pain issues. I’ve written several posts about how her autoimmune disease is a special brand of pain that you will thankfully (almost certainly) never have to feel. While great strides have been made in pain management, there are still relatively few options that do not carry the risk of being extremely addictive. Well thankfully there is some new research and it offers hope, not just for my sister, but for the millions of people suffering from chronic pain that ........ Read more »

Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S.... (2014) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a journal of neurology. PMID: 25414036  

  • November 26, 2014
  • 02:35 PM
  • 9 views

Tryptophan vs. The NFL Fan

by Mark Lasbury in The 'Scope

What is tryptophan, and is it indeed responsible for the snoring that follows Thanksgiving dinner? ... Read more »

  • November 26, 2014
  • 11:06 AM
  • 13 views

Treatment Resistance in Eating Disorders

by William Yates, M.D. in Brain Posts

Clinicians treating patients with eating disorders find the challenge great with many treatment-resistant cases.To some extent, this is true of any clinical disorder. Outpatient treatment rolls and inpatient samples are over-represented by those failing to respond to initial interventions.A medical example is helpful here. Endocrinologists specializing in diabetes see more complicated cases where glucose control is difficult and diabetic complications are common.Diabetics with easy glucose contr........ Read more »

  • November 26, 2014
  • 04:54 AM
  • 24 views

The gut microbiome in Down Syndrome

by Paul Whiteley in Questioning Answers

The recent preliminary findings from Elena Biagi and colleagues [1] (open-access) reporting on the constitution of the gut microbiome - the collected bacteria which reside in the deepest, darkest recesses of our gastrointestinal (GI) tract - in a small number of cases of Down's syndrome caught my eye recently.It's a funny feeling being taken under the wing of a dragonPerhaps a little bit unusually looking at the gut microbiome because of the link between premature ageing in Down's syndrome ........ Read more »

Biagi E, Candela M, Centanni M, Consolandi C, Rampelli S, Turroni S, Severgnini M, Peano C, Ghezzo A, Scurti M.... (2014) Gut Microbiome in Down Syndrome. PloS one, 9(11). PMID: 25386941  

  • November 26, 2014
  • 12:05 AM
  • 17 views

Self-Reported Knee Outcomes Can Be Used to Help Determine Functional Assessment Readiness after an ACL Reconstruction

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

The subjective IKDC-2000 form can be used to determine when a participant may be ready to be functionally assessed for a possible return to play. The participants who have IKDC-2000 scores that are lower than normative data have a high likelihood of failing a battery of functional tests. ... Read more »

  • November 25, 2014
  • 01:18 PM
  • 38 views

Oy. I worry about this with cell line studies a lot. Mis-IDed contaminated.

by Mary in OpenHelix

Via NCBI Announce mailing list: NCBI BioSample includes curated list of over 400 known misidentified and contaminated cell lines The NCBI BioSample database now includes a curated list of over 400 known misidentified and contaminated cell lines. Scientists should check this list before they start working with a new cell line to see if that cell line […]... Read more »

American Type Culture Collection Standards Development Organization Workgroup ASN-0002. (2010) Cell line misidentification: the beginning of the end. Nature Reviews Cancer, 10(6), 441-448. DOI: http://dx.doi.org/10.1038/nrc2852  

  • November 25, 2014
  • 03:20 AM
  • 37 views

Serotonin - melatonin (and the in-betweeners) linked to autism

by Paul Whiteley in Questioning Answers

The paper by Pagan and colleagues [1] (open-access) looking at "serotonin, melatonin and the intermediate N-acetylserotonin (NAS) in a large cohort of patients with ASD [autism spectrum disorder] and their relatives" set the old grey-pink matter into action recently. Not only because I have some real interest in the starting material for these compounds - the aromatic amino acid known as tryptophan - but because this research group included some quite important analysis of the enz........ Read more »

Pagan C, Delorme R, Callebert J, Goubran-Botros H, Amsellem F, Drouot X, Boudebesse C, Le Dudal K, Ngo-Nguyen N, Laouamri H.... (2014) The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders. Translational psychiatry. PMID: 25386956  

  • November 25, 2014
  • 12:05 AM
  • 38 views

Kinesiotaping with Exercise Versus Manual Therapy with Exercise in Patients with Subacromial Impingement Syndrome

by Lauren Hankle, Kayla Green in Sports Medicine Research (SMR): In the Lab & In the Field

Kinesiotaping with exercise and manual therapy with exercise are both effective in decreasing pain and disability in patients with subacromial impingement syndrome. The kinesiotaping with exercise intervention was more effective in decreasing pain at night than the manual therapy with exercise treatment group. ... Read more »

  • November 24, 2014
  • 03:26 PM
  • 39 views

Hiding cells to prevent HIV transmission

by Gabriel in Lunatic Laboratories

The fight against HIV is ongoing and despite our rapid progression against the disease we still lack a cure or even adequate treatment for people infected. However, new research suggests that cloaking immune cells with antibodies that block T cell trafficking to the gut can substantially reduce the risk of viral transmission, at least in a non-human primate model of HIV infection. If it works out, this could help slow down the spread of HIV and give people a better shot at a normal life.... Read more »

  • November 24, 2014
  • 05:15 AM
  • 45 views

Helicobacter pylori and stem cells in the gastric crypt

by Artem Kaznatcheev in Evolutionary Games Group

Last Friday, the 4th Integrated Mathematical Oncology Workshop finished here at Moffitt. The event drew a variety of internal and external participants — you can see a blurry photo of many of them above — and was structured as a competition between four teams specializing in four different domains: Microbiome, Hepatitis C, Human papillomavirus, and […]... Read more »

Houghton, J., Stoicov, C., Nomura, S., Rogers, A.B., Carlson, J., Li, H., Cai, X., Fox, J.G., Goldenring, J.R., & Wang, T.C. (2004) Gastric cancer originating from bone marrow-derived cells. Science, 306(5701), 1568-71. PMID: 15567866  

  • November 24, 2014
  • 04:29 AM
  • 43 views

Finland, parental migration and offspring Asperger syndrome

by Paul Whiteley in Questioning Answers

A quote from the paper by Venla Lehti and colleagues [1] to start things off: "The study showed that children whose parents are both immigrants have a significantly lower likelihood of being diagnosed with Asperger's syndrome than those with two Finnish parents."Can I cook, or can't I?Based on an analysis of data derived from "the Finnish Hospital Discharge Register" and "the Finnish Medical Birth Register", researchers looked at the records of children with a diagnosis of Asperger syndrome (AS)........ Read more »

Lehti V, Cheslack-Postava K, Gissler M, Hinkka-Yli-Salomäki S, Brown AS, & Sourander A. (2014) Parental migration and Asperger's syndrome. European child . PMID: 25381114  

  • November 24, 2014
  • 12:05 AM
  • 39 views

Experiences With Workplace Bullying Among Athletic Trainers in the Collegiate Setting

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Among athletic trainers working in a college setting 14% reported that they were bullied, and 20% reported that they witnessed bullying. There were no differences between who experienced bullying, but most of the bullying perpetrators were males with the majority being coaches.... Read more »

  • November 22, 2014
  • 02:45 PM
  • 54 views

Mental Health- The invisible barrier for women’s care

by Gabriel in Lunatic Laboratories

A while back I wrote a post about mental health and jail sentences, it seems like no one takes mental health seriously and that leads to lack of care for the individual. Well a new study offers even more bad news on the mental health front. Women with symptoms of serious mental illness are significantly less likely to receive three routine cancer screenings – Pap tests, mammograms and clinical breast exams – than women in the general population, despite being at elevated risk for medical com........ Read more »

  • November 22, 2014
  • 03:26 AM
  • 55 views

Children as research participants: assessing competence

by Paul Whiteley in Questioning Answers

I was brought to writing about this topic after reading an interesting post by Virginia Hughes titled: Personhood Week: Do Kids Count? Among the various points raised in that article was some discussion about minors having medical autonomy and how this might impinge on areas outside of just medical decision-making. It also reminded me about something which was raised on more than one occasion when I undertook a stint on a University Ethics committee...Most people involved in the medica........ Read more »

  • November 21, 2014
  • 06:39 PM
  • 74 views

Dogtober = Canine science in October

by Cobb & Hecht in Do You Believe In Dog?

What a BOOMING month for dogs and science October was! We've captured the links to all the latest blogs, research and news that caught out attention throughout Dog-tober.Thanks to Storify (click here if the you can't see the collection of links below) you can make sure you didn't miss out too.[View the story "Do You Believe in Dog? [01-31 October 2014]" on Storify] Further reading:Bradshaw J.W.S. & Nicola J. Rooney (2014). Why do adult dogs ‘play’?, Behavioural Processes, DOI: http:/........ Read more »

Bozkurt Alper, Barbara Sherman, Rita Brugarolas, Sean Mealin, John Majikes, Pu Yang, & Robert Loftin. (2014) Towards Cyber-Enhanced Working Dogs for Search and Rescue. IEEE Intelligent Systems, 1-1. DOI: http://dx.doi.org/10.1109/mis.2014.77  

  • November 21, 2014
  • 04:54 PM
  • 65 views

The impact of powered prosthetic failures on the user

by Gabriel in Lunatic Laboratories

Prosthetics have come a long way in a relatively short amount of time. With the ongoing wars in the middle east the need for better prosthetics technologies has become more apparent, to this end we now have prosthetics that will allow a person to "feel", we even have motorized prosthetics that will help allow a more fluid walk, but while powered lower limb prosthetics hold promise for improving the mobility of amputees, errors in the technology may also cause some users to stumble or fall. Becau........ Read more »

  • November 21, 2014
  • 03:02 PM
  • 55 views

Injecting a Placebo to Run Faster!

by Craig Payne in Running Research Junkie

Injecting a Placebo to Run Faster!... Read more »

  • November 21, 2014
  • 05:58 AM
  • 64 views

Genomic instability not linked to autism?

by Paul Whiteley in Questioning Answers

An eyebrow was raised upon reading the findings reported by Penelope Main and colleagues [1] concluding that: "it appears unlikely that genomic instability is a feature of the aetiology of autism." Based on results derived in part from "the cytokinesis-block micronucleus cytome (CBMN-cyt) assay" [2] looking at markers of DNA damage, authors reported very little to see in their small cohort of children with autism (n=35) compared with siblings (n=27) and asymptomatic controls (n=25) although with........ Read more »

Main PA, Thomas P, Angley MT, Young R, Esterman A, King CE, & Fenech MF. (2014) Lack of Evidence for Genomic Instability in Autistic Children as Measured by the Cytokinesis-Block Micronucleus Cytome Assay. Autism research : official journal of the International Society for Autism Research. PMID: 25371234  

  • November 21, 2014
  • 04:41 AM
  • 56 views

Non-Sticky Nano Bullets Targeting Cancer

by Agnese Mariotti in United Academics

Researchers describe the use of traceable nanoparticles constructed to specifically target tumors. These drug loaded nano particles could function as ‘intelligent’ bullets, leaving body in 72 hours.... Read more »

Phillips E, Penate-Medina O, Zanzonico PB, Carvajal RD, Mohan P, Ye Y, Humm J, Gönen M, Kalaigian H, Schöder H.... (2014) Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe. Science translational medicine, 6(260). PMID: 25355699  

  • November 21, 2014
  • 12:05 AM
  • 54 views

Can Low Back Pain in Young Athletes be Treated and Prevented?

by Adam Scott and Jan Bruins in Sports Medicine Research (SMR): In the Lab & In the Field

Increased training time in sports that require a forward lean posture can predispose young athletes to low back pain.... Read more »

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