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  • November 30, -1
  • 12:00 AM

Most important paper ever in microbiology?

by Jonathan Eisen in The Tree of Life

Discussion of papers reporting discovery of the archaea... Read more »

Woese CR, & Fox GE. (1977) Phylogenetic structure of the prokaryotic domain: the primary kingdoms. Proceedings of the National Academy of Sciences of the United States of America, 74(11), 5088-90. PMID: 270744  

Fox GE, Magrum LJ, Balch WE, Wolfe RS, & Woese CR. (1977) Classification of methanogenic bacteria by 16S ribosomal RNA characterization. Proceedings of the National Academy of Sciences of the United States of America, 74(10), 4537-4541. PMID: 16592452  

Balch WE, Magrum LJ, Fox GE, Wolfe RS, & Woese CR. (1977) An ancient divergence among the bacteria. Journal of molecular evolution, 9(4), 305-11. PMID: 408502  

  • November 30, -1
  • 12:00 AM

So, is Darwinian Natural Selection Optimal?

by Croor Singh in Learning to be Terse

Game-theoretic approaches to study whether multiple strategies are possible in the same environment.... Read more »

Daniel S. Falster, & Mark Westoby. (2003) Plant height and evolutionary games. Trends in Ecology , 18(7), 337-343. DOI: 10.1016/S0169-5347(03)00061-2  

  • November 30, -1
  • 12:00 AM

New GPCR structure: CXCR4 Chemokine Receptor (HIV and cancer target)

by Peter Nollert in Emerald BioStructures Blog

Congratulations to Ray Stevens and team to determining and publishing the crystallographic structure of the CXCR4 Chemokine receptor in Science. The diffenent binding areas for the small molecule and peptide antagonist are nicely resolved and show extensive interactions with binding pocket residues in the 2.5 – 3.1 A crystal structures... Read more »

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC.... (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.), 330(6007), 1066-71. PMID: 20929726  

  • November 30, -1
  • 12:00 AM

Cheap Cell-Phone Microscopes Might Make Distance Ed Science Labs Feasible

by Michael Windelspecht in RicochetScience

Review of recent advances in cell phone microscopes... Read more »

  • November 30, -1
  • 12:00 AM

Old School Beer

by James McElherne in ScienceLeak

A journey to bring back a 9,000 Year old beer.... Read more »

McGovern, P. (2004) Fermented beverages of pre- and proto-historic China. Proceedings of the National Academy of Sciences, 101(51), 17593-17598. DOI: 10.1073/pnas.0407921102  

  • November 30, -1
  • 12:00 AM

The Fragile Monument of Hominin Diet

by Matt Sponheimer in Originus

Hominin Diet... Read more »

  • November 30, -1
  • 12:00 AM

Using folate receptor alpha flurorescence imaging in ovarian cancer

by Sally Church in Pharma Strategy Blog

The idea behind this concept is that fluorescence technology can be used to help guide ovarian cancer surgery more effectively, since the tumors tend to be small and hard to see for surgeons performing the excision.... Read more »

van Dam, G., Themelis, G., Crane, L., Harlaar, N., Pleijhuis, R., Kelder, W., Sarantopoulos, A., de Jong, J., Arts, H., van der Zee, A.... (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nature Medicine. DOI: 10.1038/nm.2472  

  • November 30, -1
  • 12:00 AM

Is this journal for real?

by Neurobonkers in Neurobonkers

This year 134 suspect new journals have appeared from the abyss, all published by the same clandestine company “Scientific & Academic Publishing, USA“... Read more »

Morrison, Heather. (2012) Scholarly Communication in Crisis. Freedom for scholarship in the internet age. Simon Fraser University School of Communication. info:/

  • November 30, -1
  • 12:00 AM

On the brink of extinction

by sedeer in Inspiring Science

In 1994, David Noble was trekking through Wollemi National Park in the Blue Mountains, about 200km northwest of Sydney, Australia, when he came across a copse of unusual looking trees. Unable to identify them, he took specimens back with him for further study. Botanists were shocked to realize that the trees which Noble had found belonged to a lineage which they believed had been extinct for millions of years. Designated Wollemia nobilis (in honour of the place and person of discovery), this ........ Read more »

  • November 30, -1
  • 12:00 AM

Climate change causes species to move north and to higher elevations

by brettcherry in Institute of Hazard, Risk and Resilience Blog

How climate change is causing species in the temperate zone of the northern hemisphere to move on average 12.2 metres higher in elevation per decade and northwards 17.6 kilometres per decade. Species are moving the most in regions showing the highest levels of warming, but some are more influenced by climate change than others... Read more »

Chen IC, Hill JK, Ohlemüller R, Roy DB, & Thomas CD. (2011) Rapid range shifts of species associated with high levels of climate warming. Science (New York, N.Y.), 333(6045), 1024-6. PMID: 21852500  

  • November 30, -1
  • 12:00 AM

Babies Are Healthier When There Is a Dog at Home: Research

by United Academics in United Academics

New research published in Pediatrics suggests that children living with a dog are significantly healthier than those living without it. The researchers followed up 397 Finnish children, asking their parents to fill in weekly questionnaires about their health until they were 1 year old. Scientists believe that this is so because dog contact helps the babies build up their immune system.... Read more »

Eija Bergroth, Sami Remes, Juha Pekkanen, Timo Kauppila, Gisela Büchele, & Leea Keski-Nisula. (2012) Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts. Pediatrics. info:/10.1542/peds.2011-2825

  • November 30, -1
  • 12:00 AM

Detecting Gene Doping in Sports: MicroRNA biomarker sought

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

WADA funds research into developing detection methods for the emerging threat of gene doping in sports.... Read more »

Elmo W.I. Neuberger, Magdelena Jurkiewicz, Dirk A. Moser and Perikles Simon. (2012) Detection of EPO gene doping in blood. Drug Testt. Analysis. DOI: 10.1002/dta.1347  

  • November 30, -1
  • 12:00 AM

Genes Dealt Made Asians Svelte

by nooffensebut in The Unsilenced Science

Early genome-wide association studies suggest a genetic propensity to thinness in Asians. I review how these kinds of studies might be able reveal genetic racial differences in obesity and intelligence, and I address a few of the challenges to doing so.... Read more »

Belsky DW, Moffitt TE, Houts R, Bennett GG, Biddle AK, Blumenthal JA, Evans JP, Harrington H, Sugden K, Williams B.... (2012) Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. Archives of pediatrics , 166(6), 515-21. PMID: 22665028  

Hsu FC, Lenchik L, Nicklas BJ, Lohman K, Register TC, Mychaleckyj J, Langefeld CD, Freedman BI, Bowden DW, & Carr JJ. (2005) Heritability of body composition measured by DXA in the diabetes heart study. Obesity research, 13(2), 312-9. PMID: 15800289  

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L.... (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature genetics, 43(8), 753-60. PMID: 21706003  

Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R.... (2008) Proportionally more deleterious genetic variation in European than in African populations. Nature, 451(7181), 994-7. PMID: 18288194  

MacArthur DG, Balasubramanian S, Frankish A, Huang N, Morris J, Walter K, Jostins L, Habegger L, Pickrell JK, Montgomery SB.... (2012) A systematic survey of loss-of-function variants in human protein-coding genes. Science (New York, N.Y.), 335(6070), 823-8. PMID: 22344438  

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R.... (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature genetics, 42(11), 937-48. PMID: 20935630  

Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G.... (2012) Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (New York, N.Y.), 337(6090), 64-9. PMID: 22604720  

Zuk O, Hechter E, Sunyaev SR, & Lander ES. (2012) The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America, 109(4), 1193-8. PMID: 22223662  

  • November 30, -1
  • 12:00 AM

Tet1 Enzyme Based Enrichment Method for Methylome Sequencing: TamC-Seq

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

Summary of a recent Nature paper that details a new inexpensive, enzyme based enrichment method for methylome sequencing. ... Read more »

Zhang L, Szulwach KE, Hon GC, Song CX, Park B, Yu M, Lu X, Dai Q, Wang X, Street CR.... (2013) Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing. Nature communications, 1517. PMID: 23443545  

  • November 30, -1
  • 12:00 AM

Not all E.coli strains are created equal

by Dave Dilyx in Protein Solubility Blog

BL21 (DE3) strain of E.coli and its derivatives have the ability to support expression from the strong T7 promoter, traditionally used for expression vectors. However, transcription from this promoter is “leaky”, e.g. there is some level of expression even in the absence of induction. If the protein is toxic - and if you have protein aggregation this is often the case - this creates selective pressure to get rid of the protein by accumulating mutations in the vector. That’s ........ Read more »

  • November 30, -1
  • 12:00 AM

The case of the missing genitalia: copulation costs for male spiders

by Chris Buddle in Arthropod Ecology

Male spiders can be missing their organs (pedipalps) and this is clearly quite a cost for their fitness! This post explores this topic, with some original data, and with some discussion of past literature on the topic.... Read more »

  • November 30, -1
  • 12:00 AM

Middle age females are most interested in mating: Lessons from a cricket

by Sue Bertram in Lab Chirps

How age influences phonotaxis in virgin female Jamaican field crickets (Gryllus assimilis)

A new article in PeerJ written by Karen Pacheco, Jeff Dawson, Mike Jutting, and Sue Bertram... Read more »

Karen Pacheco, Jeff Dawson, Mike Jutting, and Sue Bertram. (2013) How age influences phonotaxis in virgin female Jamaican field crickets (Gryllus assimilis). PeerJ. info:/10.7717/peerj.130

  • November 30, -1
  • 12:00 AM

A field guide to whole-genome analyses

by Mauro Mandrioli in The aphid room

Genome sequencing projects have been for long time possible goals for few model organisms and required the concerted effort of large consortia, but now...... Read more »

  • November 30, -1
  • 12:00 AM

Electron-spin clue to solving general anesthesia mystery

by This Science is Crazy! in This Science Is Crazy!

New study on fruit flies suggests general anesthetics can affect electron-spin properties... Read more »

Turin Luca, Skoulakis Efthimios, & Horsfield Andrew. (2014) Electron spin changes during general anesthesia in Drosophila. PNAS, Early edition(N/A). DOI: 10.1073/pnas.1404387111  

  • November 30, -1
  • 12:00 AM

FDA officially refers consumers to Wikipedia for information on food pathogens

by Austin Bouck in Animal Science Review

I was perusing the Bad Bug Book while doing some research on the recent Blue Bell outbreak and came across a hyperlink. After hearing “do you want to know more?” in my head I clicked through on some non-L. mono species of Listeria and was…confused. I quickly doubled back, thinking that maybe I had been redirected, but there it was...... Read more »

Food and Drug Administration. (2012) Listeria Monocytogenes. Bad Bug Book, Foodborne pathogenic microorganisms and natural toxins. Second Edition, 99-100. info:/

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