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  • June 10, 2010
  • 09:04 AM
  • 1,660 views slimes breast cancer research again

by Orac in Respectful Insolence

Let's see. Now that I'm back from Chicago, having recently attended a major cancer meeting, not to mention having already blogged about the meeting, what to do next? Sure, the whole thing about Andrew Wakefield finding himself just one step away from appearing on Jeff Rense's or Alex Jones's radio show was amusing in the extreme to me, and no doubt there will be much more blogging material to mine in that vein, but if you really want to bring home the crazy there's only one place shy of Read more »

Rituparna Mukhopadhyay, Sylvain V Costes, Alexey V Bazarov, William C Hines, Mary Helen Barcellos-Hoff, & Paul Yaswen. (2010) Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies. Breast Cancer Research, 12(1). info:/10.1186/bcr2477

  • June 10, 2010
  • 08:51 AM

Givin’ props to hybrids

by DeLene Beeland in Wild Muse

Why does the lay public tend to view hybridization in wild nature as a bastardization of the way things ought to be? Why do we favor “pure” species while rejecting hybrid crosses, or treating them like side-show freaks á la pizzlies, ligers and tiglons? I’ve been thinking a lot about hybridization lately, trying to wrap my head around [...]... Read more »

  • June 10, 2010
  • 08:00 AM

Why do urbanized watersheds lead to amphibian declines?

by Rob Goldstein in Conservation Maven

... Read more »

  • June 10, 2010
  • 08:00 AM

Mimics without models: Allopatric Batesians

by Zen Faulkes in NeuroDojo

I was imitating Jean Chrétien a while ago to tell an anecdote to one of my students.

I could have done the greatest, most perfect, most spot-on, hysterical impersonation of Chrétien ever.* It all would have been lost on this student. An American undergraduate would be unlikely to recognize a Canadian prime minister, no matter how distinctive his speaking style was. (And it was. Oh, how it was.)

That’s the problem with imitation: it only works if both parties recognize what&........ Read more »

  • June 10, 2010
  • 07:39 AM

Autism genetics, how do you copy?

by Grant Jacobs in Code for life

Subtitle: Recent research identifies many changes in copy number that may point to genes that cause or are associated with autism.
In order to verify that important information has been conveyed over radio, the sender might ask “how do you copy” or, more briefly, “how copy” asking the receiver to tell the sender the information they [...]... Read more »

Pinto, D., Pagnamenta, A., Klei, L., Anney, R., Merico, D., Regan, R., Conroy, J., Magalhaes, T., Correia, C., Abrahams, B.... (2010) Functional impact of global rare copy number variation in autism spectrum disorders. Nature. DOI: 10.1038/nature09146  

  • June 10, 2010
  • 06:29 AM

The Evolution of a Short Back

by zinjanthropus in A Primate of Modern Aspect

One of the issues raised by the recent Sarmiento comments is that of the Miocene apes and the evolution of a short back. All extant apes possess a “short back,” by which we mean a reduction in the lumbar spine combined with an upward elongation of the blades of the pelvis.  This back is a nice, [...]... Read more »

  • June 10, 2010
  • 05:37 AM

University of Toronto Scientist Driving Cell Culture Revolution

by aviwener in Canadian Biotechnologist 2.0

Dr. Aaron Wheeler from the University of Toronto has developed the first microfluidic system for “complete” cell culture (with passaging), powered by digital microfluidics. This system offers the advantage of using only a fraction of reagents usually required in cell culture and of automating and accelerating tedious manual tasks. In a review article published in [...]... Read more »

  • June 9, 2010
  • 05:59 PM

Gulf Oil Spill Disaster: Spawn of the Living Dead for Atlantic Bluefin Tuna?

by GrrlScientist in Living the Scientific Life (Scientist, Interrupted)

A recently published study suggests that the Deepwater Horizon oil leak may devastate the endangered Atlantic bluefin population, causing it to completely collapse or possibly go extinct.... Read more »

Steven L. H. Teo, & Barbara A. Block. (2010) Comparative Influence of Ocean Conditions on Yellowfin and Atlantic Bluefin Tuna Catch from Longlines in the Gulf of Mexico. PLoS ONE, 5(5). info:/10.1371/journal.pone.0010756

  • June 9, 2010
  • 05:03 PM

Southeast Asia in the Pleistocene, from grassland to rain forest

by Jeremy in Voltage Gate

I’ve been trying to keep up with the Gulf situation, so most of my reading of late has been dominated by those details, and the unread numbers in my RSS folders were a little intimidating, but I finally found some time to read some of the papers I’ve earmarked in the past month or so.

This study...

... Read more »

  • June 9, 2010
  • 12:17 PM

A new target for hepatitis C virus

by Vincent Racaniello in virology blog

When infection with hepatitis C virus goes from acute to chronic, severe liver disease may occur which requires organ transplantation. Nearly 200 million people are chronically infected with HCV, necessitating approaches to preventing and treating infections. No HCV vaccine is available, and current antiviral therapy consists of administration of interferon plus ribavirin, a combination that [...]... Read more »

Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O'Boyle DR 2nd.... (2010) Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature, 465(7294), 96-100. PMID: 20410884  

  • June 9, 2010
  • 10:05 AM

The "Big Four," part IV: Migration

by Jeremy Yoder in Denim and Tweed

This post is the last in a special series about four fundamental forces in evolution: natural selection, mutation, genetic drift, and migration.

It's the little differences. I mean, they got the same shit over there that we got here, but it's just—it's just there it's a little different.
— Vincent, Pulp FictionDifferent places are different from each other. This is a truism bordering on tautology, but it also has real implications for the ways in which life evolves and diversifies. The spec........ Read more »

Good J.M., Hird S., Reid N., Demboski J.R., Steppan S.J., Martin-Nims T.R., & Sullivan J. (2008) Ancient hybridization and mitochondrial capture between two species of chipmunks. Molecular ecology, 17(5), 1313-27. PMID: 18302691  

Wright, S.J. (1943) Isolation by distance. Genetics, 139-56. info:other/PMC1209196

  • June 9, 2010
  • 09:52 AM

The Life and TImes of a Cellular Signal

by Nachiket Vartak in Emergent Noise

A high-throughput method uses an broad specificity reagent and a specific optical signal to capture a snapshot of signaling mediated phosphorylation in living cells.... Read more »

Grecco, H., Roda-Navarro, P., Girod, A., Hou, J., Frahm, T., Truxius, D., Pepperkok, R., Squire, A., & Bastiaens, P. (2010) In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays. Nature Methods, 7(6), 467-472. DOI: 10.1038/nmeth.1458  

  • June 9, 2010
  • 09:09 AM

“As Close to a ‘Polluting Plant’ As One Can Find”

by Promega Corporation in Promega Connections

Far Eastern vines Run from the clay banks they are Supposed to keep from eroding. Up telephone poles, Which rear, half out of leafage As though they would shriek, Like things smothered by their own Green, mindless, unkillable ghosts. In Georgia, the legend says That you must close your windows At night to keep it [...]... Read more »

  • June 9, 2010
  • 08:00 AM

Why do butterflies have marginal eyespots?

by Rob Goldstein in Conservation Maven

... Read more »

  • June 9, 2010
  • 05:07 AM

Clearing up eukaryotic life histories

by Psi Wavefunction in Skeptic Wonder

I can still vaguely recall the horrid hell that was my second year "non-vascular 'plant'" course (valid contender for most polyphyletic course in existence...) - amid the poorly explained phylogenetic clusterfuck, we also had to cram life cycle diagrams from hell. Ever thought red algae looked cute? Not quite so much after realising you get three fundamental life cycle phases to plow through...the night before a final, as it always is. In hindsight, it actually makes a lot of sense, once you gra........ Read more »

  • June 9, 2010
  • 05:00 AM

Nature promotes vitality in people, study finds

by Rob Goldstein in Conservation Maven

New research shows that interaction with nature, whether actual or imagined, has a significantly positive effect on self-reported levels of mental and physical energy...... Read more »

Ryan, R., Weinstein, N., Bernstein, J., Brown, K., Mistretta, L., & Gagné, M. (2010) Vitalizing effects of being outdoors and in nature. Journal of Environmental Psychology, 30(2), 159-168. DOI: 10.1016/j.jenvp.2009.10.009  

  • June 8, 2010
  • 11:34 PM

The neuroscience of birdsong

by NeuroKüz in NeuroKüz

I’ve decided to write a couple of articles on a relatively underappreciated area of neuroscience: the study of birds. I hope to demonstrate that although the term “bird brain” is used as an insult in everyday bicker, the tiny brains of birds are more complex than they are perceived to be. Bird brains may even be able to teach us a thing or two about the brightest of human brains. In this first post, I will describe birdsong – a rare example of music production in nonhumans.You’ve proba........ Read more »

Brenowitz EA, Margoliash D, & Nordeen KW. (1997) An introduction to birdsong and the avian song system. Journal of neurobiology, 33(5), 495-500. PMID: 9369455  

Teramitsu I, Kudo LC, London SE, Geschwind DH, & White SA. (2004) Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(13), 3152-63. PMID: 15056695  

  • June 8, 2010
  • 10:22 PM

Copepod Power

by Kelsey in Mauka to Makai

It’s human nature to think of the big bad animals that eat other animals as powerful and the animals that get eaten as wimpy. Of course, humans are often wrong (see “clusterf**kery”). Copepods get eaten by lots of animals—even by critters like jellyfish and right whales, which are known for their lack of speed—but they’re [...]... Read more »

Kiørboe T, Andersen A, Langlois VJ, & Jakobsen HH. (2010) Unsteady motion: escape jumps in planktonic copepods, their kinematics and energetics. Journal of the Royal Society, Interface / the Royal Society. PMID: 20462876  

  • June 8, 2010
  • 09:39 PM

Shape Shifter

by Journal Watch Online in Journal Watch Online

Fish evolve different body shapes in reservoirs

... Read more »

Haas, T.C., Blum, M.J., & D.C. Heins. (2010) Morphological responses of a stream fish to water impoundment. Biology Letters. info:/10.1098/rsbl.2010.0401

  • June 8, 2010
  • 07:02 PM

Wake-Up Call

by Journal Watch Online in Journal Watch Online

Sedentary snake populations are dwindling

... Read more »

Reading, C.J. et al. (2010) Are snake populations in widespread decline?. Biology Letters. info:/10.1098/rsbl.2010.0373

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