Everyone gets angry from time to time. But there’s angry, and there’s angry - wall-punching, object-throwing, call-the-police angry. The latter type of tantrum, if it’s a recurrent problem, could be a symptom of a psychiatric condition currently known as intermittent explosive disorder, or IED. Though it has appeared in every edition of the Diagnostic and [...]... Read more »
McCloskey MS, Kleabir K, Berman ME, Chen EY, & Coccaro EF. (2010) Unhealthy aggression: intermittent explosive disorder and adverse physical health outcomes. Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 29(3), 324-32. PMID: 20496987
Coccaro, E. (2010) A family history study of intermittent explosive disorder. Journal of Psychiatric Research. DOI: 10.1016/j.jpsychires.2010.04.006
COCCARO, E., MCCLOSKEY, M., FITZGERALD, D., & PHAN, K. (2007) Amygdala and Orbitofrontal Reactivity to Social Threat in Individuals with Impulsive Aggression. Biological Psychiatry, 62(2), 168-178. DOI: 10.1016/j.biopsych.2006.08.024
On a very superficial level, the skulls of the carnivorous theropod dinosaurs might look very much the same from species to species—big jaws filled with lots of pointy teeth. If they are examined in even a little bit of detail, however, it is quickly apparent that meat-eating dinosaurs were diverse in head shape and skull [...]... Read more »
Sakamoto, M. (2010) Jaw biomechanics and the evolution of biting performance in theropod dinosaurs. Proceedings of the Royal Society B: Biological Sciences. DOI: 10.1098/rspb.2010.0794
Note: This post is a collaborative effort by Anne and guest blogger Will Dalen Rice, a graduate student in the Department of Geography and Earth Sciences at UNC Charlotte. He had the misfortune of taking a couple of courses from Anne this semester and has become a certified stream junkie, going out on rainy nights to see how high Charlotte's urban streams are running.
Most cities were started around the idea of available surface water resources. Development and misuse of our streams (ex: "di........ Read more »
Francis, R., & Hoggart, S. (2008) Waste Not, Want Not: The Need to Utilize Existing Artificial Structures for Habitat Improvement Along Urban Rivers. Restoration Ecology, 16(3), 373-381. DOI: 10.1111/j.1526-100X.2008.00434.x
Despite what many of us may believe we learned cramming for finals in college, a study published in Neuropsychopharmacology (1) suggests that your morning cup of coffee might not help you stay alert through that early morning meeting. In a study of 379 coffee drinkers, researchers found that frequent coffee drinkers developed a tolerance to both the anxiety-producing [...]... Read more »
Rogers PJ, Hohoff C, Heatherley SV, Mullings EL, Maxfield PJ, Evershed RP, Deckert J, & Nutt DJ. (2010) Association of the Anxiogenic and Alerting Effects of Caffeine with ADORA2A and ADORA1 Polymorphisms and Habitual Level of Caffeine Consumption. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. PMID: 20520601
Credit, Fir0002/Flagstaffotos. Image released under the GFDL License.... Read more »
Parsons, D., Morrison, M., & Slater, M. (2010) Responses to marine reserves: Decreased dispersion of the sparid Pagrus auratus (snapper). Biological Conservation. DOI: 10.1016/j.biocon.2010.05.009
I've decided I want to cover some recent research on social cognition in domesticated dogs. But first, we need some background. So here's a repost from the old blog.
Today I want to tell you about one of my most favorite studies, ever, of animals. Are you ready? It's a FIFTY YEAR LONG longitudinal study of captive silver foxes in Russia. Gather around, pour yourself a cup of your favorite beverage, get comfortable, and enjoy storytime.
In 1948, Soviet scientist Dmitri Belyaev lost his job at t........ Read more »
Belyaev, DK. (1969) Domestication of animals. Science, 5(1), 47-52. info:/
Trut, L. (1999) Early Canid Domestication: The Farm-Fox Experiment. American Scientist, 87(2), 160. DOI: 10.1511/1999.2.160
Have you ever wanted to know whether a mouse is in pain?Of course you have. And now you can, thanks to Langford et al's paper Coding of facial expressions of pain in the laboratory mouse.It turns out that mice, just like people, display a distinctive "Ouch!" facial expression when they're suffering acute pain. It consists of narrowing of the eyes, bulging nose and cheeks, ears pulled back, and whiskers either pulled back or forwards.With the help of a high-definition video camera and a little tr........ Read more »
Langford, D., Bailey, A., Chanda, M., Clarke, S., Drummond, T., Echols, S., Glick, S., Ingrao, J., Klassen-Ross, T., LaCroix-Fralish, M.... (2010) Coding of facial expressions of pain in the laboratory mouse. Nature Methods, 7(6), 447-449. DOI: 10.1038/nmeth.1455
by David Gorski in Science-Based Medicine
Autism and autism spectrum disorders (ASDs) actually represent a rather large continuum of conditions that range from very severe neurodevelopmental delay and abnormalities to the relatively mild. In severe cases, the child is nonverbal and displays a fairly well-characterized set of behaviors, including repetitive behaviors such as “stimming” (for example, hand flapping, making sounds, head [...]... Read more »
Pinto, D., Pagnamenta, A., Klei, L., Anney, R., Merico, D., Regan, R., Conroy, J., Magalhaes, T., Correia, C., Abrahams, B.... (2010) Functional impact of global rare copy number variation in autism spectrum disorders. Nature. DOI: 10.1038/nature09146
… except in Hollywood movies.
Let’s make this clear from the start, I don’t like the term “living fossils” at all. It’s as if we decided that certain species are second class organisms that should have gone extinct a long time ago. Unfortunately for me, the term regularly crops up in the popular scientific press. Especially [...]... Read more »
Amemiya, C., Powers, T., Prohaska, S., Grimwood, J., Schmutz, J., Dickson, M., Miyake, T., Schoenborn, M., Myers, R., Ruddle, F.... (2010) Complete HOX cluster characterization of the coelacanth provides further evidence for slow evolution of its genome. Proceedings of the National Academy of Sciences, 107(8), 3622-3627. DOI: 10.1073/pnas.0914312107
Although some have emphasized the need to breed crops for future climatic conditions, much of the world’s farming population relies on landrace populations, not formal breeding networks.
Undeniable, of course, and a good reason to not forget landraces, or farmers’ local varieties, when thinking about how agriculture will (or will not) adapt to climate change. And [...]... Read more »
Mercer, K., & Perales, H. (2010) Evolutionary response of landraces to climate change in centers of crop diversity. Evolutionary Applications. DOI: 10.1111/j.1752-4571.2010.00137.x
Today Sci is going to blog a paper that she has been meaning to blog for a long time. It's one of those papers that people who do certain kinds of science snuggle with when they go to sleep at night.
(Sci and this paper)
But the real reason that Sci loves this paper is that it's the neurobiological equivilant of a RickRoll.
And the question behind this paper is: what is the mechanism behind reward prediction?
Schultz, Dayan, and Montague. "A neural substrate of prediction and reward" ........ Read more »
An Arabidopsis stomate showing two guard cells exhibiting green fluorescent protein and native chloroplast (red) fluorescence. via Wikipedia. This image is an extreme closeup of a stomate (singular, the plural form is stomata). These two cells, called guard cells, control the plant’s respiration: how much carbon dioxide gets in and how much oxygen and water vapor gets out. The control isn’t very good, though. Most plants just have their stomata open all day Continue reading...... Read more »
Hu H, Boisson-Dernier A, Israelsson-Nordström M, Böhmer M, Xue S, Ries A, Godoski J, Kuhn JM, & Schroeder JI. (2010) Carbonic anhydrases are upstream regulators of CO2-controlled stomatal movements in guard cells. Nature cell biology, 12(1), 87. PMID: 20010812
Will we have a universal Influenza vaccine someday? Will we find something that eliminates the need of developing a new vaccine every year and ensuring that great part of the population receives it?
The annual development of flu vaccines is a very expensive way of avoiding this disease even if it is the most efficient way. [...]... Read more »
Sui, J., Hwang, W., Perez, S., Wei, G., Aird, D., Chen, L., Santelli, E., Stec, B., Cadwell, G., Ali, M.... (2009) Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nature Structural , 16(3), 265-273. DOI: 10.1038/nsmb.1566
Wang, T., & Palese, P. (2009) Universal epitopes of influenza virus hemagglutinins?. Nature Structural , 16(3), 233-234. DOI: 10.1038/nsmb.1574
Why are there no perennial grain crops? That’s the provocative question posed by a recent paper in Evolutionary Applications written by three scientists working at The Land Institute. Whose institutional mission, of course, is to breed just this sort of crop, on the assumption that they “could reduce soil erosion while maintaining production of food [...]... Read more »
Van Tassel, D., DeHaan, L., & Cox, T. (2010) Missing domesticated plant forms: can artificial selection fill the gap?. Evolutionary Applications. DOI: 10.1111/j.1752-4571.2010.00132.x
An analysis of two recent publications describing two different systems that can penetrate solid tumors and deliver/distribute anti-cancer therapeutics throughout the tumor tissue, thereby improving treatment efficacy.... Read more »
Sugahara, K., Teesalu, T., Karmali, P., Kotamraju, V., Agemy, L., Greenwald, D., & Ruoslahti, E. (2010) Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs. Science, 328(5981), 1031-1035. DOI: 10.1126/science.1183057
Davis, M., Zuckerman, J., Choi, C., Seligson, D., Tolcher, A., Alabi, C., Yen, Y., Heidel, J., & Ribas, A. (2010) Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature, 464(7291), 1067-1070. DOI: 10.1038/nature08956
I recently received an email from a graduate student in Philosophy regarding protein function. Not sure if that person wants his name advertised, so I will keep it to myself.
I am a fan of your blog, and interested in the philosophy of biology. One particularly interesting question is what makes something have a function; when [...]... Read more »
Khersonsky O, Roodveldt C, & Tawfik DS. (2006) Enzyme promiscuity: evolutionary and mechanistic aspects. Current opinion in chemical biology, 10(5), 498-508. PMID: 16939713
Jeffery, C. (2003) Moonlighting proteins: old proteins learning new tricks. Trends in Genetics, 19(8), 415-417. DOI: 10.1016/S0168-9525(03)00167-7
I’m happy and proud to tell you that Lab Rat was kind enough to write today’s blogpost. She brings you a fascinating story about little magnetic particles found in some bacteria, that may help them find their way like compasses do. Normally she writes great posts on bacteria on her own blog, which [...]... Read more »
Komeili, A. (2006) Magnetosomes Are Cell Membrane Invaginations Organized by the Actin-Like Protein MamK. Science, 311(5758), 242-245. DOI: 10.1126/science.1123231
I read a paper today (actually, more like an essay) by Peter Wangersky, a longtime chemical oceanographer. Titled “Methods of sampling and analysis and our concepts of ocean dynamics,” it is essentially a personable ramble through six decades of marine science, reflecting on the technical capabilities and sampling methods over time and the [...]... Read more »
Peter J. Wangersky. (2005) Methods of sampling and analysis and our concepts of ocean dynamics. Scientia Marina, 69(S1), 75-84. info:/10.3989/scimar.2005.69s175
As I'm sure you're all aware by now, human life expectancy for both young and old in the most developed regions of the world is slowly increasing, and this has been the case for some time. As medical technology advances and our wealth grows, we benefit in ways that lead to less biochemical damage to the complex machinery of our body accumulated over the course of a lifetime - and thus a greater likelihood of living longer. That the medical and research establishments have achieved this ongoing b........ Read more »
Rousson, V., & Paccaud, F. (2010) A set of indicators for decomposing the secular increase of life expectancy. Population Health Metrics, 8(1), 18. DOI: 10.1186/1478-7954-8-18
Our cells are dividing all the time – replacing worn-out cells and healing injuries. But cell division can be a tricky business – every time a cell divides, each one of its 46 chromosomes, and the DNA they are made of, must be copied perfectly. Time and time again the cells in our bodies divide [...]... Read more »
Lin, T., Letsolo, B., Jones, R., Rowson, J., Pratt, G., Hewamana, S., Fegan, C., Pepper, C., & Baird, D. (2010) Telomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis. Blood. DOI: 10.1182/blood-2010-02-272104
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