Ah, nature and nurture, those eternal enemies. What once used to be the domain of philosophy and English classes has migrated over the past century to the sphere of science, culminating in the completion of The Human Genome Project in 2003. But far from settling this age-old battle, the HGP may have reinvigorated it. Now [...]... Read more »
Zhang, D., Cheng, L., Badner, J., Chen, C., Chen, Q., Luo, W., Craig, D., Redman, M., Gershon, E., & Liu, C. (2010) Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain. The American Journal of Human Genetics, 86(3), 411-419. DOI: 10.1016/j.ajhg.2010.02.005
In today’s tip I want to make you aware of a tool that I think will help researchers to present their own data and publications in an accurate and universally searchable way. I learned of the resource (UCSDBioLit) through an article in one of my recent BioMed Central article alert emails. This resource allows authors to mark-up their own publications with XML tags AS THEY WRITE their papers. This will allow faster and more accurate semantic searching of their research.
A huge problem in ........ Read more »
Fink, J., Fernicola, P., Chandran, R., Parastatidis, S., Wade, A., Naim, O., Quinn, G., & Bourne, P. (2010) Word add-in for ontology recognition: semantic enrichment of scientific literature. BMC Bioinformatics, 11(1), 103. DOI: 10.1186/1471-2105-11-103
SUMMARY: Sexual identity is genetically imposed on male and female chicken cells at fertilization and is the major factor in determining the adult sexual phenotype -- gonads have limited effects on the avian sexual phenotype... Read more »
Zhao, D., McBride, D., Nandi, S., McQueen, H., McGrew, M., Hocking, P., Lewis, P., Sang, H., & Clinton, M. (2010) Somatic sex identity is cell autonomous in the chicken. Nature, 464(7286), 237-242. DOI: 10.1038/nature08852
Cartoonist and engineer Tim Hunkin is probably best known for his exhibits at the Science Museum in London and his Under The Pier Show “a mad arcade of home-made slot machines & simulator rides on Southwold Pier, Suffolk”. His website is a treasure trove of weird and wonderful things.
Tim has an interesting proposition, let’s call [...]... Read more »
Frances Evans. (1998) Two legs, thing using and talking: The origins of the creative engineering mind. AI , 12(3), 185-213. DOI: 10.1007/BF01206195
This is part III of Measles week. In Part II (“Emerging disease”) I talked about the origin of measles; in Part I (“Introduction”), I posed the question of why measles case-fatality rates dropped so dramatically over the first half of the 20th century (example chart of death rates here). Today I’m going to quickly [...]... Read more »
Condran, G. (2008) The Elusive Role of Scientific Medicine in Mortality Decline: Diphtheria in Nineteenth- and Early Twentieth-Century Philadelphia. Journal of the History of Medicine and Allied Sciences, 63(4), 484-522. DOI: 10.1093/jhmas/jrn039
In a tasty new paper, British neurologists Kate El Bouzidi et al report on the case of a woman who suffered epileptic seizures whenever she saw, or tasted, food:A 44-year-old right-handed woman was walking in the Scottish highlands. Upon unwrapping her lunch, she had a focal seizure with witnessed onset on the right side of the face and secondary generalization... She was airlifted to hospital. Three weeks later, the smell of food triggered another seizure and she was admitted to the neurology u........ Read more »
El Bouzidi K, Duncan S, Whittle IR, & Butler CR. (2010) Lesional reflex epilepsy associated with the thought of food. Neurology, 74(7), 610-2. PMID: 20157165
Proponents for drilling in the Arctic National Wildlife Refuge in Alaska and government regulators have generally assumed that conducting seismic activities in the winter would avoid damaging the sensitive tundra ecosystem. A new study throws this assumption into doubt...... Read more »
Jorgenson, J., Hoef, J., & Jorgenson, M. (2010) Long-term recovery patterns of arctic tundra after winter seismic exploration. Ecological Applications, 20(1), 205-221. DOI: 10.1890/08-1856.1
This post is the third in a series on the origin and history of HeLa S3 cells. The first post details how I came about to ask this question when launching my independent research laboratory. The second post details the life and careers of the legendary physician-scientist pioneer, Dr. Florence Rena Sabin.
Today, we take up a discussion where we will finally learn the origin of HeLa S3 cells, complete with original literature citations.
We left our previous discussion with the final ........ Read more »
Puck TT and Marcus PI. (1955) A rapid method for viable cell titration and clone production with HeLa cells in tissue culture: the use of X-irradiated cells to supply conditioning factors. Proceedings of the National Academy of Sciences, 41(7), 432-437. DOI: 10.1073/pnas.41.7.432
Puck TT, Marcus PI, and Cieciura SJ. (1956) Clonal growth of mammalian cells in vitro: growth characteristics of colonies from single HeLa cells with and without a "feeder" layer. Journal of Experimental Medicine, 103(2), 273-284. DOI: 10.1084/jem.103.2.273
Puck TT, & Fisher HW. (1956) Genetics of somatic mammalian cells: I. Demonstration of the existence of mutants with different growth requirements in a human cancer cell strain HeLa. Journal of Experimental Medicine, 104(3), 427-434. PMID: 19867118
Sato G, Fisher HW, and Puck TT. (1957) Molecular growth requirements of single mammalian cells. Science, 126(3280), 961-964. DOI: 10.1126/science.126.3280.961
Just when you think you’ve seen it all, you learn about something completely unexpected. In this case, it’s a new way to get nitrogen, an important nutrient for all living things. Where the soil is poor in nitrogen, various plants have developed ways to trap insects and the like, among them the pitcher plants. Now [...]... Read more »
Chin, L., Moran, J., & Clarke, C. (2010) Trap geometry in three giant montane pitcher plant species from Borneo is a function of tree shrew body size. New Phytologist. DOI: 10.1111/j.1469-8137.2009.03166.x
To review: I love ecological stoichiometry (ES). I find it a fascinating subject and a useful framework for understanding ecological phenomena. However, ES is still relatively new, with a lot of the empirical work restricted to plankton (esp. Daphnia and algae). So it is always interesting to see theories developed predominantly in the pelagic system examined in other habitats.One of the more... Read more »
Hill, W., Smith, J., & Stewart, A. (2010) Light, nutrients, and herbivore growth in oligotrophic streams. Ecology, 91(2), 518-527. DOI: 10.1890/09-0703.1
Urabe, J., & Sterner, RW. (1996) Regulation of herbivore growth by the balance of light and nutrients. Proceedings of the National Academy of Sciences, 93(16), 8465-8469. DOI: 10.1073/pnas.93.16.8465
Iron fertilization could increase toxin production in ocean
... Read more »
Trick, C.G. et al. (2010) Iron enrichment stimulates toxic diatom production in high-nitrate, low-chlorophyll areas. Proceedings of the National Academy of Sciences. info:/10.1073/pnas.0910579107
As is well-known, peptides helices can be right or left handed. Many details of structure, amino acid identity and orientation can control this screw sense, and sometimes the controlling factors can be quite subtle. In a JACS communication, Jonathan Clayden (yes, the co-author of the amazing organic chemistry textbook) and his group uncover a surprising factor that controls the helical screw sense and also incorporate a neat "reporter group" to monitor the screw sense.But this reporter group is ........ Read more »
Solà, J., Helliwell, M., & Clayden, J. (2010) N- versus C-Terminal Control over the Screw-Sense Preference of the Configurationally Achiral, Conformationally Helical Peptide Motif Aib GlyAib . Journal of the American Chemical Society, 2147483647. DOI: 10.1021/ja100662d
Understanding how blood cells are formed is not only important for developing treatments against numerous diseases, but also teaches us more about the fascinating process of turning stem cells into their specialized descendants. Recent work suggests that the initial stem cell that produces all of our blood’s formed elements (cells) comes in two flavors. But [...]... Read more »
Bertrand, J., Chi, N., Santoso, B., Teng, S., Stainier, D., & Traver, D. (2010) Haematopoietic stem cells derive directly from aortic endothelium during development. Nature, 464(7285), 108-111. DOI: 10.1038/nature08738
Kissa, K., & Herbomel, P. (2010) Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature, 464(7285), 112-115. DOI: 10.1038/nature08761
Two new articles in the journal Frontiers in Ecology and the Environment show that dramatic expansion of biofuel agriculture may reduce biodiversity and promote the spread of invasive species. The articles also make a number of recommendations for reducing the ecological impact from biofuel production. ... Read more »
Davis, A., Cousens, R., Hill, J., Mack, R., Simberloff, D., & Raghu, S. (2010) Screening bioenergy feedstock crops to mitigate invasion risk. Frontiers in Ecology and the Environment, 2147483647. DOI: 10.1890/090030
Symptoms of small pox, scarlet fever, measles, miliary fever, petechiae, rank itch and watery itch.
from Domestic medicine. Or, a treatise on the prevention and cure of diseases, by regimen and simple medicines.
by William Buchan (T. Nelson,London. 1846)
This is part II of “Measles Week”; see Part I for an explanation of what this is about, [...]... Read more »
Grenfell, B., Bjørnstad, O., & Kappey, J. (2001) Travelling waves and spatial hierarchies in measles epidemics. Nature, 414(6865), 716-723. DOI: 10.1038/414716a
Furuse, Y., Suzuki, A., & Oshitani, H. (2010) Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries. Virology Journal, 7(1), 52. DOI: 10.1186/1743-422X-7-52
Sometimes the well-intentioned efforts of land managers can have unintended negative consequences for threatened species. In a new case study, researchers from Israel show how efforts by the national forestry agency to improve scrubland habitat in the Negev desert actually created an ecological trap for a highly endangered, endemic lizard...... Read more »
HAWLENA, D., SALTZ, D., ABRAMSKY, Z., & BOUSKILA, A. (2010) Ecological Trap for Desert Lizards Caused by Anthropogenic Changes in Habitat Structure that Favor Predator Activity. Conservation Biology. DOI: 10.1111/j.1523-1739.2010.01477.x
What factors predominate in evolution? In daily life, the constant evolution of our lives is influenced by our conditions and by external factors. If I want to build a house with my own hands, I have to consider my abilities, some of which are genetic (I am small, thin and I am not strong, so [...]... Read more »
Benton MJ. (2009) The Red Queen and the Court Jester: species diversity and the role of biotic and abiotic factors through time. Science (New York, N.Y.), 323(5915), 728-32. PMID: 19197051
Paterson S, Vogwill T, Buckling A, Benmayor R, Spiers AJ, Thomson NR, Quail M, Smith F, Walker D, Libberton B.... (2010) Antagonistic coevolution accelerates molecular evolution. Nature, 464(7286), 275-8. PMID: 20182425
Falush D. (2009) Toward the use of genomics to study microevolutionary change in bacteria. PLoS genetics, 5(10). PMID: 19855823
Where last we left our heroes of the Tunisian salt pans, we found that desert ants (Cataglyphis fortis) represent direction by using the sun as a compass in combination with a mental clock to correct for the changing position of the sun. Ants represent distance by counting its steps in 3D space, in [...]... Read more »
Steck, K., Hansson, B., & Knaden, M. (2009) Smells like home: Desert ants, Cataglyphis fortis, use olfactory landmarks to pinpoint the nest. Frontiers in Zoology, 6(1), 5. DOI: 10.1186/1742-9994-6-5
Octopuses* and their cephalopod relatives are some of the smartest animals on the planet. Accordingly, many scientists want to understand how their mind works. To gain insights into the complex minds of cephalopods, researchers have been studying behavior in individual animals for years by presenting different animals with various visual stimuli. But many of the methods have downsides - for example, if you want to see how an octopus reacts to another octopus, you can add an octopus to the tank, ........ Read more »
Pronk, R., Wilson, D., & Harcourt, R. (2010) Video playback demonstrates episodic personality in the gloomy octopus. Journal of Experimental Biology, 213(7), 1035-1041. DOI: 10.1242/jeb.040675
You might recall the accidental discovery of unusually potent regeneration in MRL mice by Ellen Heber-Katz's team some years ago: Our laboratory has determined that the MRL mouse strain is unique in its capacity for regenerative wound healing, as shown by the closure of ear punches with normal tissue architecture and cartilage replacement reminiscent of amphibian regeneration as opposed to scarring. One line of research into regenerative medicine is based on understanding and then recreating in ........ Read more »
Khamilia Bedelbaeva, Andrew Snyder, Dmitri Gourevitch, Lise Clark, Xiang-Ming Zhang, John Leferovich, James M. Cheverud, Paul Lieberman, & Ellen Heber-Katz. (2010) Lack of p21 expression links cell cycle control and appendage regeneration in mice. PNAS. info:/10.1073/pnas.1000830107
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.