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  • August 20, 2014
  • 12:30 PM
  • 13 views

The DNA Signature of Lupus

by Gabriel in Lunatic Laboratories

My Uncle suffered from Lupus. The disease itself should have a more sinister sounding name, given the effect it has on the body. Lupus is a form of autoimmune disease which attacks the body and causes an incredible amount of pain. It’s not pretty and complications from the disease can make life even more unbearable for people. There is no cure and sadly there are few treatments outside of managing the pain and side effects of the disease. Thankfully medical researchers have used DNA sequencing........ Read more »

Julia I Ellyard, Rebekka Jerjen, Jaime L Martin, Adrian Lee, Matthew A Field, Simon H Jiang, Jean Cappello, Svenja K Naumann, T Daniel Andrews, Hamish S Scott.... (2014) Whole exome sequencing in early-onset cerebral SLE identifies a pathogenic variant in TREX1. Arthritis . info:/10.1002/art.38824

  • August 20, 2014
  • 10:07 AM
  • 22 views

How Humans Are Helping Ravens and Hurting Hawks

by Elizabeth Preston in Inkfish

You’ve already picked a side in the bird wars, whether or not you know it. As humans carve up formerly empty expanses of the western United States with our roads, electrical towers, and power lines, we’re inadvertently giving a boost to ravens. Meanwhile, the birds of prey that once ruled the land are being left […]The post How Humans Are Helping Ravens and Hurting Hawks appeared first on Inkfish.... Read more »

  • August 20, 2014
  • 09:38 AM
  • 27 views

Video Tip of the Week: Immune Epitope DB (IEDB)

by Mary in OpenHelix

This week’s tip was inspired by the recent NHGRI workshop of the future directions for funding and resourcing of genomics-related projects. Titled “Future Opportunities for Genome Sequencing and Beyond: A Planning Workshop for the National Human Genome Research Institute” brought together a lot of influential folks on this topic, and had them noodle on the […]... Read more »

Vita R., J. A. Greenbaum, H. Emami, I. Hoof, N. Salimi, R. Damle, A. Sette, & B. Peters. (2010) The Immune Epitope Database 2.0. Nucleic Acids Research, 38(Database). DOI: http://dx.doi.org/10.1093/nar/gkp1004  

Kim Y., Z. Zhu, D. Tamang, P. Wang, J. Greenbaum, C. Lundegaard, A. Sette, O. Lund, P. E. Bourne, & M. Nielsen. (2012) Immune epitope database analysis resource. Nucleic Acids Research, 40(W1). DOI: http://dx.doi.org/10.1093/nar/gks438  

Bhattacharya Sanchita, Linda Gomes, Patrick Dunn, Henry Schaefer, Joan Pontius, Patty Berger, Vince Desborough, Tom Smith, John Campbell, & Elizabeth Thomson. (2014) ImmPort: disseminating data to the public for the future of immunology. Immunologic Research, 58(2-3), 234-239. DOI: http://dx.doi.org/10.1007/s12026-014-8516-1  

  • August 20, 2014
  • 09:35 AM
  • 31 views

I hate you Charley, and the horse you rode in on

by Bill Sullivan in The 'Scope

The Charley Horse - why do we get these leg cramps and how can we prevent them? And why are they called a Charley Horse?!... Read more »

Garrison SR, Allan GM, Sekhon RK, Musini VM, & Khan KM. (2012) Magnesium for skeletal muscle cramps. The Cochrane database of systematic reviews. PMID: 22972143  

El-Tawil S, Al Musa T, Valli H, Lunn MP, El-Tawil T, & Weber M. (2010) Quinine for muscle cramps. The Cochrane database of systematic reviews. PMID: 21154358  

Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, & Hunter I. (2010) Three percent hypohydration does not affect threshold frequency of electrically induced cramps. Medicine and science in sports and exercise, 42(11), 2056-63. PMID: 20351595  

  • August 20, 2014
  • 09:30 AM
  • 32 views

State Fairs and Stiff Beers: Why We Can't Stop Drinking

by Aarti Chawla in The 'Scope

A look into why we drink and what alcohol does to the brain.... Read more »

Diamond I, & Messing RO. (1994) Neurologic effects of alcoholism. The Western journal of medicine, 161(3), 279-87. PMID: 7975567  

Paul CA, Au R, Fredman L, Massaro JM, Seshadri S, Decarli C, & Wolf PA. (2008) Association of alcohol consumption with brain volume in the Framingham study. Archives of neurology, 65(10), 1363-7. PMID: 18852353  

  • August 20, 2014
  • 08:00 AM
  • 21 views

Because He Is The One

by Mark Lasbury in As Many Exceptions As Rules

Swatting a fly is hard. They always seem to know you’re coming, and even if you do surprise them, they often avoid your assassination attempts. New research is showing how they do it. A 2014 paper indicates that animals with faster metabolic rates actually process information and react quicker than larger animals. This, along with recent data showing how flies can jump away from a visual stimulus before taking flight and how they can coordinate a 0.03 second banking turn with incoming visu........ Read more »

Muijres FT, Elzinga MJ, Melis JM, & Dickinson MH. (2014) Flies evade looming targets by executing rapid visually directed banked turns. Science (New York, N.Y.), 344(6180), 172-7. PMID: 24723606  

Jumpertz R, Hanson RL, Sievers ML, Bennett PH, Nelson RG, & Krakoff J. (2011) Higher energy expenditure in humans predicts natural mortality. The Journal of clinical endocrinology and metabolism, 96(6). PMID: 21450984  

  • August 20, 2014
  • 04:35 AM
  • 39 views

ADHD in DSM-5: what did you think would happen?

by Paul Whiteley in Questioning Answers

"Our results, combined with previous findings, suggest a 27% increase in the expected prevalence of ADHD [attention-deficit hyperactivity disorder] among young adults, comparing DSM-IV to DSM-5 criteria". So said the paper by Matte and colleagues [1] who as part of their study looked at "the prevalence of ADHD according to DSM-5 criteria".Europa @ Wikipedia The changes to the diagnosis of ADHD in DSM-5 can be seen here. The main difference between DSM-IV and DSM-5 diagnosis s........ Read more »

Matte, B., Anselmi, L., Salum, G., Kieling, C., Gonçalves, H., Menezes, A., Grevet, E., & Rohde, L. (2014) ADHD in DSM-5: a field trial in a large, representative sample of 18- to 19-year-old adults. Psychological Medicine, 1-13. DOI: 10.1017/S0033291714001470  

  • August 19, 2014
  • 02:17 PM
  • 51 views

Hobby Lobby and the War on Race and Women

by Gabriel in Lunatic Laboratories

There is a war going on and it's not on foreign soil. This war is the fight for the status quo, a war where you are only worth your skin color, a war where you are only worth as much as your gender. This war is all around us, we see it everyday, yet we let it quietly pass us by. We do this because, in all actuality, we are losing this war. I don't blame you if you don't believe me, you shouldn't.[…]... Read more »

  • August 19, 2014
  • 12:18 PM
  • 36 views

August 19, 2014

by Erin Campbell in HighMag Blog

Think of life without tubes for a moment. Not only would our huge bodies cease to exist, but our homes’ plumbing would be a mess and my 5-year old’s marble run would be pretty boring. The formation of tubes during development is a fascinating topic. Today’s image is from a paper describing the role of endocytosis in seamless tube formation. The trachea of the fruit fly is a simple tubular system that functions as the respiratory system of the fly. The star-shaped tracheal terminal cel........ Read more »

  • August 19, 2014
  • 04:23 AM
  • 41 views

Family processes and trajectory in autism

by Paul Whiteley in Questioning Answers

The paper by Woodman and colleagues [1] looking at trajectory and autism in adolescents and adults is the source material for today's post (another micropost). Concluding that: "Overall, autism symptoms and maladaptive behaviors were observed to improve over the study period" of about 8 years, the authors also reported that "greater improvements were associated with higher levels of maternal praise (based on maternal speech samples) and higher quality mother-child relationships". If I remember c........ Read more »

  • August 18, 2014
  • 01:21 PM
  • 48 views

We can Build it Better: The First Artificial Cell Network

by Gabriel in Lunatic Laboratories

How does the old saying go? Imitation, is the sincerest form of flattery? Well that is what we’ve been trying to do for a very long time, but mimicking the intricate networks and dynamic interactions that are inherent to living cells is difficult to achieve outside the cell. Unfortunately despite all our intelligence nature has had the upper hand on us for a long time. That has not changed… until now that is.[…]... Read more »

Karzbrun E, Tayar AM, Noireaux V, & Bar-Ziv RH. (2014) Programmable on-chip DNA compartments as artificial cells. Science (New York, N.Y.), 345(6198), 829-32. PMID: 25124443  

  • August 18, 2014
  • 01:00 PM
  • 34 views

Five Facts You Did Not Know About Eggshells

by Shefali Sabharanjak in United Academics

Don't just throw away your Sunday morning egg shell. The humble eggshell and the shell membrane – the thin paperish sheet on the inner part of the eggshell- has a large number of surprising uses. Here’s a short list of five:... Read more »

  • August 18, 2014
  • 04:10 AM
  • 46 views

ADHD in the prison population: a micropost

by Paul Whiteley in Questioning Answers

"Compared with published general population prevalence, there is a fivefold increase in prevalence of ADHD in youth prison populations (30.1%) and a 10-fold increase in adult prison populations (26.2%)"."Mianly dry" apparently @ Paul WhiteleyThat was the primary conclusion reached in the meta-analysis by Young and colleagues [1] looking at the collected peer-reviewed literature on "the variable prevalence of attention deficit hyperactivity disorder (ADHD) in incarcerated populations".There ........ Read more »

  • August 17, 2014
  • 06:18 PM
  • 69 views

Where did Ebola come from? Rooting the un-rootable

by Andrew Shaw in Virus Musings

Using molecular clocks to determine the root of the Ebola Zaire tree... Read more »

  • August 17, 2014
  • 04:30 PM
  • 49 views

Wind Turbines Pose Risk to Bats

by Denise O'Meara in Denise O'Meara

We need sustainable, affordable and clean energy production to fuel the economy, and the drive towards more environmentally friendly energy production versus coal and peat burning energy production has seen a large number of wind farms built across the countryside as an alternative. Wind turbines have had their share of negative press and many people don’t like how they disrupt the view of the countryside, while others complain of the negative psychological impact on their health. Wind turbine........ Read more »

Lehnert LS, Kramer-Schadt S, Schönborn S, Lindecke O, Niermann I, & Voigt CC. (2014) Wind farm facilities in Germany kill noctule bats from near and far. PloS one, 9(8). PMID: 25118805  

  • August 17, 2014
  • 03:01 PM
  • 51 views

DNA nets could be 'ancient defence weapon'

by This Science is Crazy! in This Science Is Crazy!

New study tests whether invertebrates produce similar DNA-based traps to neutrophil extracellular traps (NETs)to prove theory that they are an ancient immune technique... Read more »

  • August 17, 2014
  • 02:36 PM
  • 72 views

Schizophrenia and the Twilight Zone

by Gabriel in Lunatic Laboratories

You are now entering the Twilight Zone. You may remember the television show, with it’s odd twists and turns, but for people with schizophrenia it means something just a little […]... Read more »

  • August 17, 2014
  • 11:26 AM
  • 56 views

A mosaic vaccine that could potentially protect from different ebola strains

by EE Giorgi in CHIMERAS

Disclaimer: The mosaic vaccine paper discussed in this article is from my own group and overlaps with some of the research I do. I'm sure you've been following the latest news about the Ebola virus outbreak in Africa."The Ebola outbreak in West Africa is the world's deadliest to date and the World Health Organization has declared an international health emergency as more than 1,000 people have died of the virus in Guinea, Liberia, Sierra Leone and Nigeria this year." [Source: BBC News]The e........ Read more »

Friedrich BM, Trefry JC, Biggins JE, Hensley LE, Honko AN, Smith DR, & Olinger GG. (2012) Potential vaccines and post-exposure treatments for filovirus infections. Viruses, 4(9), 1619-50. PMID: 23170176  

Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, Funkhouser R, Kuiken C, Haynes B, Letvin NL, Walker BD.... (2007) Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nature medicine, 13(1), 100-6. PMID: 17187074  

  • August 16, 2014
  • 01:00 PM
  • 85 views

Is your Stomach… Controlling your Mind?

by Gabriel in Lunatic Laboratories

Close the blinds, lock the doors, and find a safe place to hide. Are you alone? No, no you aren’t and you may not even be in control of your […]... Read more »

  • August 16, 2014
  • 06:27 AM
  • 77 views

True facts about anglerfish | @GrrlScientist

by GrrlScientist in GrrlScientist

To the female anglerfish, the human male is a very loud, annoying and unnecessarily complicated pair of gonads. Continue reading...... Read more »

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