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  • November 30, 1999
  • 12:00 AM
  • 3,246 views

Nicotine and the Humphrey Bogart Gene

by Dirk Hanson in Addiction Inbox

You can lead a fish to water, but can you make it smoke?

... Read more »

Petzold AM, Balciunas D, Sivasubbu S, Clark KJ, Bedell VM, Westcot SE, Myers SR, Moulder GL, Thomas MJ, & Ekker SC. (2009) Nicotine response genetics in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America, 106(44), 18662-7. PMID: 19858493  

  • November 30, 1999
  • 12:00 AM
  • 2,020 views

Let’s Get Cellular: Meth Metabolism

by Dirk Hanson in Addiction Inbox

We know from the work of Nora Volkow and others that meth abusers have chronically low levels of dopamine D2 receptors in their brains. But what is going on in the rest of the body when methamphetamine addiction is running full force?... Read more »

Sun, L., Li, H., Seufferheld, M., Walters, K., Margam, V., Jannasch, A., Diaz, N., Riley, C., Sun, W., Li, Y.... (2011) Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0018215  

  • November 30, 1999
  • 12:00 AM
  • 2,262 views

Let’s Get Cellular: Meth Metabolism

by Dirk Hanson in Addiction Inbox

We know from the work of Nora Volkow and others that meth abusers have chronically low levels of dopamine D2 receptors in their brains. But what is going on in the rest of the body when methamphetamine addiction is running full force?... Read more »

Sun, L., Li, H., Seufferheld, M., Walters, K., Margam, V., Jannasch, A., Diaz, N., Riley, C., Sun, W., Li, Y.... (2011) Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0018215  

  • November 30, 1999
  • 12:00 AM
  • 2,838 views

The neural correlates of romantic love

by DJ in Neuropoly

Examining a recent study that attempts to answer whether intense, romantic love of the kind commonly associated with young couples exists for long-term married couples as well.... ... Read more »

Acevedo BP, Aron A, Fisher HE, & Brown LL. (2011) Neural correlates of long-term intense romantic love. Social cognitive and affective neuroscience. PMID: 21208991  

DEGRECK, M., ROTTE, M., PAUS, R., MORITZ, D., THIEMANN, R., PROESCH, U., BRUER, U., MOERTH, S., TEMPELMANN, C., & BOGERTS, B. (2008) Is our self based on reward? Self-relatedness recruits neural activity in the reward system. NeuroImage, 39(4), 2066-2075. DOI: 10.1016/j.neuroimage.2007.11.006  

  • November 30, 1999
  • 12:00 AM
  • 2,857 views

2011: The Year in Drugs Deaths and data fraud

by Neurobonkers in Neurobonkers

A look at the biggest drugs news stories of the year and a statistical analysis of drugs deaths this year.... Read more »

Measham,F. Moore, K. Østergaard, J. (2011) Mephedrone, ‘‘Bubble’’ and unidentified white powders: the contested identities of synthetic ‘‘legal highs". DRUGS AND ALCOHOL TODAY, 137-146. info:/

Editorial team. (2010) The EMCDDA annual report 2010: the state of the drugs problem in Europe. The European Monitoring Centre for Drugs and Drug Addiction, also published in Euro surveillance :European communicable disease bulletin, 15(46). PMID: 21144426  

  • November 30, 1999
  • 12:00 AM
  • 2,543 views

Copyright vs Medicine: If this topic isn’t covered in your newspaper this weekend, get a new newspaper

by Neurobonkers in Neurobonkers

After thirty years of silence, authors of a standard clinical psychiatric bedside test have issued take down orders of new medical research. Doctors who use copies of the bedside test which will have been printed in some of their oldest medical textbooks are liable to be sued for up to $150,000.... Read more »

Newman, J., & Feldman, R. (2011) Copyright and Open Access at the Bedside. New England Journal of Medicine, 365(26), 2447-2449. DOI: 10.1056/NEJMp1110652  

  • November 30, 1999
  • 12:00 AM
  • 1,932 views

Parody: How to Synthesise Pseudoephedrine From N-Methylamphetamine

by Neurobonkers in Neurobonkers

Over in the US it has apparently become so difficult to get hold of pseudoephedrine (Sudafed), that one researcher has published a satirical paper explaining how to manufacture it out of crystal meth (PDF). The paper describes how “in the past most stores were able to sell pseudoephedrine”, the US’s most popular decongestant but new laws require only pharmacies, often with restricted opening hours to sell the medicine only to those carrying government issued ID. The paper argue........ Read more »

Hai, O. Hakkenshit, I.B. (2012) A Simple and Convenient Synthesis of Pseudoephedrine From N-Methylamphetamine. Journal of Apocryphal Chemistry. info:/

  • November 30, 1999
  • 12:00 AM
  • 2,675 views

Coffee: a caffeinated chronicle

by Jordan Gaines in Gaines, on Brains

Because I like to understand what I'm putting in my body, I decided to explore coffee: its history, its neurological mechanism, and—what I'm sure everyone's dying to know—why it is so easy to become addicted and dependent on it.... Read more »

Cocker PJ, Hosking JG, Benoit J, & Winstanley CA. (2012) Sensitivity to Cognitive Effort Mediates Psychostimulant Effects on a Novel Rodent Cost/Benefit Decision-Making Task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. PMID: 22453140  

  • November 30, 1999
  • 12:00 AM
  • 1,717 views

Your Good Side Is the Left Side, According to Science

by United Academics in United Academics

Don’t give it any more thought: according to scientists, left side of the face usually looks better, mainly because it’s more expressive than the right side. Researchers at the Wake Forest University showed a series of photographs to 37 people, some of them mirror-reversed, so the viewers wouldn’t know which side they were looking at. In most cases, they chose the left side no matter where it was in the picture.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,796 views

“Beware of Exercise” is a Sexy Headline

by nooffensebut in The Unsilenced Science

A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »

Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887

  • November 30, 1999
  • 12:00 AM
  • 2,023 views

“Beware of Exercise” is a Sexy Headline

by nooffensebut in The Unsilenced Science

A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »

Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887

  • November 30, 1999
  • 12:00 AM
  • 2,238 views

The Role of Feedback Is Overemphasized, Says Researcher

by United Academics in United Academics

No matter if it’s good or bad; when it comes to difficult decision-making tasks, feedback may make things even more confusing, according to new research published in the journal Frontiers in Neuroscience.... Read more »

Osman, M. (2012) The role of feedback in dynamic decision making. Frontiers in Decision Neuroscience. info:/

  • November 30, 1999
  • 12:00 AM
  • 2,236 views

Genes Dealt Made Asians Svelte

by nooffensebut in The Unsilenced Science

Early genome-wide association studies suggest a genetic propensity to thinness in Asians. I review how these kinds of studies might be able reveal genetic racial differences in obesity and intelligence, and I address a few of the challenges to doing so.... Read more »

Belsky DW, Moffitt TE, Houts R, Bennett GG, Biddle AK, Blumenthal JA, Evans JP, Harrington H, Sugden K, Williams B.... (2012) Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. Archives of pediatrics , 166(6), 515-21. PMID: 22665028  

Hsu FC, Lenchik L, Nicklas BJ, Lohman K, Register TC, Mychaleckyj J, Langefeld CD, Freedman BI, Bowden DW, & Carr JJ. (2005) Heritability of body composition measured by DXA in the diabetes heart study. Obesity research, 13(2), 312-9. PMID: 15800289  

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L.... (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature genetics, 43(8), 753-60. PMID: 21706003  

Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R.... (2008) Proportionally more deleterious genetic variation in European than in African populations. Nature, 451(7181), 994-7. PMID: 18288194  

MacArthur DG, Balasubramanian S, Frankish A, Huang N, Morris J, Walter K, Jostins L, Habegger L, Pickrell JK, Montgomery SB.... (2012) A systematic survey of loss-of-function variants in human protein-coding genes. Science (New York, N.Y.), 335(6070), 823-8. PMID: 22344438  

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R.... (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature genetics, 42(11), 937-48. PMID: 20935630  

Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G.... (2012) Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (New York, N.Y.), 337(6090), 64-9. PMID: 22604720  

Zuk O, Hechter E, Sunyaev SR, & Lander ES. (2012) The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America, 109(4), 1193-8. PMID: 22223662  

  • November 30, 1999
  • 12:00 AM
  • 1,346 views

Early Human Diet Went Grassy, Early

by Andrew Porterfield in United Academics

A series of studies from the University of Utah found that our ancestors expanded their culinary tastes to grasses and grains, as much as 3.5 million years ago.... Read more »

Cerling TE, Manthi FK, Mbua EN, Leakey LN, Leakey MG, Leakey RE, Brown FH, Grine FE, Hart JA, Kaleme P.... (2013) Stable isotope-based diet reconstructions of Turkana Basin hominins. Proceedings of the National Academy of Sciences of the United States of America. PMID: 23733966  

Wynn JG, Sponheimer M, Kimbel WH, Alemseged Z, Reed K, Bedaso ZK, & Wilson JN. (2013) Diet of Australopithecus afarensis from the Pliocene Hadar Formation, Ethiopia. Proceedings of the National Academy of Sciences of the United States of America. PMID: 23733965  

Sponheimer M, Alemseged Z, Cerling TE, Grine FE, Kimbel WH, Leakey MG, Lee-Thorp JA, Manthi FK, Reed KE, Wood BA.... (2013) Isotopic evidence of early hominin diets. Proceedings of the National Academy of Sciences of the United States of America. PMID: 23733964  

  • November 30, 1999
  • 12:00 AM
  • 1,659 views

Stress Leaves Its Mark on Dad’s Sperm

by Anouk Vleugels in United Academics

For the first time, researchers have found that stress can leave an epigenetic mark on sperm, which then alters the offspring’s hypothalamic-pituitary-adrenal (HPA) axis, a part of the brain that deals with responding to stress. The study was published in the Journal of Neuroscience.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,210 views

I WILL FEAR NO EVIL: THE FIRST HEAD TRANSPLANT ON HUMAN

by Eugenio Maria Battaglia in Science to Grok

In 2008, doctor Sergio Canavero, an italian neurosurgeon based in Turin, IT, have awakened a 20 years old lady from a permanent post-traumatic vegetative state, by means of a bifocal extradural cortical electro-stimulation. Today, while Science still find it hard to explain consciousness and embodied cognition – the world-class neurosurgeon made a shock announcement: “I’m ready for the first head transplant on a man.”

In the manuscript published on Surgical Neurology I........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,199 views

How Reliable Are Neuroimages?

by Tonya Sudiono in United Academics

Because of neuroscience, we are confronted with more and more pictures of brains in the newspapers and other media. But how reliable are these neuroimages? Here's what you didn’t know about neuroimaging techniques yet.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,308 views

The Science of Sleep

by Amy Swanston in Antisense Science

Feeling tired? I know I am. But what is it that makes us feel like we need to sleep? And what keeps us awake?
Within our bodies, a lot of systems work antagonistically to maintain homeostasis - that is, one action opposes another, keeping balance. There are two important forces that we use to control sleep: our sleep drive and our alerting signal. As the day goes on, the drive to sleep becomes greater and greater, so our alerting signal has to increase at the same rate to keep us awake. S........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,102 views

Tit for tet: Tet3 regulates neuron activity through epigenetic changes

by Betty Zou in Eat, Read, Science

Tet3 regulates neuronal activity through epigenetic changes in the cells' DNA. It alters the speed and ease with which neurons communicate by altering the number of receptors at the synapse.... Read more »

Yu H, Su Y, Shin J, Zhong C, Guo JU, Weng YL, Gao F, Geschwind DH, Coppola G, Ming GL.... (2015) Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nature neuroscience, 18(6), 836-43. PMID: 25915473  

  • November 30, 1999
  • 12:00 AM
  • 815 views

The geometry of consciousness is a multi-dimensional math trip

by amanda alvarez in It Ain't Magic

Amanda Alvarez writes about how neuroscientists are studying consciousness with mathematics.... Read more »

Oizumi M, Tsuchiya N, & Amari SI. (2016) Unified framework for information integration based on information geometry. Proceedings of the National Academy of Sciences of the United States of America, 113(51), 14817-14822. PMID: 27930289  

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