The title of this post reflects the title of the paper by Marcia Datlow Smith and colleagues* which was given to me by Natasa (many thanks) a few days back. The paper is from 2012 so I don't think we can consider this a post about new research. Nevertheless the subject matter of the paper is potentially very important: "describing individuals with autism whose catastrophic illnesses were misdiagnosed due, at least partially, to their autism".@ WikipediaIt is indeed a pity that the Smith paper is........ Read more »
Marcia Datlow Smith, Patrick J. Graveline, & Jared Brian Smith. (2012) Autism and Obstacles to Medical Diagnosis and Treatment. Focus Autism Other Dev Disabl . DOI: 10.1177/1088357612450049
Superficial skin biopsies are common in dermatopathology specimens and can pose a diagnostic challenge especially in cosmetic sensitive areas such as the face.
When broadly transected so that the base of the lesion is not visualized, well-differentiated squamous cell carcinomas (SCC), hypertrophic actinic keratoses (HAK), irritated seborrheic keratoses (ISK), and verruca vulgaris (VV) can look quite similar on light microscopic examination.
Visit the following link for full text of the art........ Read more »
Kumaran Mudaliar , Kelli Hutchens,. (2013) Morphometric Image Analysis as a Tool in the Diagnosis of Transected Squamous Neoplasms. Journal of Clinical and Anatomic Pathology, 1(1), 1-5. info:other/
Achieving a healthy weight is a major goal of anorexia nervosa treatment. Indeed, a healthy weight is often seen as a prerequisite for psychological recovery. The fact that weight restoration is a crucial component of recovery is uncontroversial, the problem arises when it comes to determining what constitutes a healthy weight. How are ideal, optimal, or goal weights set? And who gets to decide?
Despite its recognized importance, there’s surprisingly little consensus on how target w........ Read more »
Roots, P., Hawker, J., & Gowers, S. (2006) The use of Target Weights in the Inpatient Treatment of Adolescent Anorexia Nervosa. European Eating Disorders Review, 323-328. DOI: 10.1002/erv.723
"I'm a labrador" does not = "I'm hungry" (source)Hey Julie,it's great to get an updated view of what's on the canine science cards for you in 2014 - looks like we're both going to be keeping busy - and wouldn't have it any other way!I can't believe we're already into February, to be honest. There are so many great new publications coming out, it's quite exciting to be able to share them with you here! You know I'm always thinking about the welfare of kennelled dogs (because PhD!) and I noticed a........ Read more »
Denham Hamish D.C., Bradshaw John W.S., & Rooney Nicola J. (2014) Repetitive behaviour in kennelled domestic dog: Stereotypical or not?. Physiology . DOI: 10.1016/j.physbeh.2014.01.007
DALLAIRE ANDRÉ. (1993) Stress and Behavior in Domestic Animals: Temperament as a Predisposing Factor to Stereotypies. Annals of the New York Academy of Sciences, 697(1 Corticotropin), 269-274. DOI: 10.1111/j.1749-6632.1993.tb49940.x
Ecthyma gangrenosum (EG) is a cutaneous lesion classically associated with potentially fatal pseudomonal septicemia in immunocompromised patients. Other bacterial and fungal pathogens have also been implicated in EG. Although EG typically occurs in neutropenic or immunocompromised patients, it can occasionally affect previously healthy children.
The cutaneous findings are characteristic with small indurated papulovesicles progressing rapidly to necrotic ulcers with surrounding erythema and a ce........ Read more »
Julianna J. Weiel, Cathryn Z. Zhang, Jessica A. Smith, Wei Wang, Jason DuPont, Fangru Lian*. (2013) Clinicopathologic Aspects of Ecthyma Gangrenosum in Pediatric Patients a Case Series and Review of the Literature. Journal of Clinical and Anatomic Pathology, 1(1), 1-5. info:other/
Next sensors will be in you, said a recent popular article. And some of them will monitor your digestive system.Accurate monitoring of digestion is hard. There are apps and high tech gadgets for that - like a fork that monitors eating speed or a watch that counts bites, but neither of them can provide a continuous and objective measures of what exactly is eaten and how it affects the digestive system.Thanks to wonders of modern technology, cows now have a device that can monitor the effects of f........ Read more »
Kiourti, Asimina. (2014) Implantable and ingestible medical devices with wireless telemetry functionalities: A review of current status and challenges. . Bioelectromagnetics, 35(1), 1-15. DOI: 10.1002/bem.21813
Hoskins, S.; Sobering, T.; Andresen, D.; Warren, S. (2009) Near-field wireless magnetic link for an ingestible cattle health monitoring pill. Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE . DOI: 10.1109/IEMBS.2009.5332812
This Month In Blastocystis Research is introducing the possible benefits of polyparasitism (!) and pulls out an example of a potentially protecting effect of Blastocystis.... Read more »
Franke MF, Del Castillo H, Pereda Y, Lecca L, Fuertes J, Cárdenas L, Becerra MC, Bayona J, & Murray M. (2013) Parasite Infection and Tuberculosis Disease among Children: A Case-Control Study. The American journal of tropical medicine and hygiene. PMID: 24379242
Archambaud C, Sismeiro O, Toedling J, Soubigou G, Bécavin C, Lechat P, Lebreton A, Ciaudo C, & Cossart P. (2013) The intestinal microbiota interferes with the microRNA response upon oral Listeria infection. mBio, 4(6). PMID: 24327339
Frosch AE, & John CC. (2012) Immunomodulation in Plasmodium falciparum malaria: experiments in nature and their conflicting implications for potential therapeutic agents. Expert review of anti-infective therapy, 10(11), 1343-56. PMID: 23241191
Poirier P, Meloni D, Nourrisson C, Wawrzyniak I, Viscogliosi E, Livrelli V, & Delbac F. (2014) Molecular subtyping of Blastocystis spp. using a new rDNA marker from the mitochondria-like organelle genome. Parasitology, 1-12. PMID: 24467909
Heger TJ, Edgcomb VP, Kim E, Lukeš J, Leander BS, & Yubuki N. (2013) A Resurgence in Field Research is Essential to Better Understand the Diversity, Ecology, and Evolution of Microbial Eukaryotes. The Journal of eukaryotic microbiology. PMID: 24325268
Righetti AA, Glinz D, Adiossan LG, Koua AY, Niamké S, Hurrell RF, Wegmüller R, N'Goran EK, & Utzinger J. (2012) Interactions and potential implications of Plasmodium falciparum-hookworm coinfection in different age groups in south-central Côte d'Ivoire. PLoS neglected tropical diseases, 6(11). PMID: 23133691
Over the next month, I will be focusing on the effects of exercise on the brain.This topic is important for several reasons. Exercise appears to play a preventive role in the effects of brain aging in normal adults.Exercise may aid in the slowing of progression of brain disorders such as Alzheimer's disease and Parkinson's disease.Exercise is a promising adjunct to treatment of a variety of other brain disorders including depression and anxiety disorder.For this post, I want to highlight wh........ Read more »
Erickson KI, Gildengers AG, & Butters MA. (2013) Physical activity and brain plasticity in late adulthood. Dialogues in clinical neuroscience, 15(1), 99-108. PMID: 23576893
The creep and sprawl of artificial urban lighting is probably the most pervasive technological innovation of the 20th century. Keeping track of how artificial light is changing Europe’s nightscape is important, since more light is typically associated with greater economic … Continue reading →... Read more »
Bennie J, Davies TW, Duffy JP, Inger R, & Gaston KJ. (2014) Contrasting trends in light pollution across Europe based on satellite observed night time lights. Scientific reports, 3789. PMID: 24445659
So we all know smoking is bad for us – we were told when we were kids, and even the packets have warning messages and gruesome pictures to try and help us kick the habit! So why do people still smoke?
As most of you will already know, it’s the nicotine in cigarettes that is the primary cause of smoking addiction. The nicotine is absorbed when cigarette smoke is inhaled and goes on to affect normal body functions, as well as mood and cognition – this is becaus........ Read more »
D'Souza MS, & Markou A. (2011) Neuronal mechanisms underlying development of nicotine dependence: implications for novel smoking-cessation treatments. Addiction science , 6(1), 4-16. PMID: 22003417
George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, & Koob GF. (2007) CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proceedings of the National Academy of Sciences of the United States of America, 104(43), 17198-203. PMID: 17921249
Increased levels of leptin in cases of autism was a primary finding described in the paper by Rodrigues and colleagues  as part of their analysis of the adipokines, the cell signalling molecules secreted by fat (adipose tissue) (see this paper by Trayhurn and colleagues  for quite a good overview). Not for the first time I might add, that elevations in levels of leptin have been talked about with autism in mind . Indeed if you want even more evidence o........ Read more »
Rodrigues D.H, Rocha N.P, Sousa L.F.C, Barbosa I.G, Kummer A, & Teixeira A.L. (2013) Changes in Adipokine Levels in Autism Spectrum Disorders. Neuropsychobiology. info:/
Thin layer chromatography, or TLC, is a technique used for the separation and analysis of molecules in a sample (Note- NOT DNA!). It can be used on amino acids1, although in my lab it has been used to analyze the degradation (or lack of!) of large polymeric sugars by whole metabolically inactivated cells or by simple enzymes. Because of this, I’ll be focusing on the analysis of saccharides (sugars).
So far, good stuff! But! How does it work, and what the HELL do these results mean!?!... Read more »
Bhawani SA, Albishri HM, Khan ZA, Mohamad Ibrahim MN, & Mohammad A. (2013) Surfactant Modified/Mediated Thin-Layer Chromatographic Systems for the Analysis of Amino Acids. Journal of analytical methods in chemistry, 973280. PMID: 24455427
Anaesthesia and Intensive Care (AIC) is an Australian medical journal. The latest issue, just published online, contains a remarkable – and possibly even unique – pair of Letters. These letters take the form of apologies for the distress caused by the publication of an article – I do not know of any similar cases in […]The post Medical Journal Apologizes “For The Distress Caused” By A Paper appeared first on Neuroskeptic.... Read more »
Simpson RS, & Van K. (2013) Fatal rhabdomyolysis following volatile induction in a six-year-old boy with Duchenne Muscular Dystrophy. Anaesthesia and intensive care, 41(6), 805-7. PMID: 24180726
Gibbs N. (2014) Apology for distress caused by the publication of recent correspondence describing fatal rhabdomyolysis in a patient with Duchenne muscular dystrophy. Anaesthesia and intensive care, 42(1), 134. PMID: 24471672
Simpson R, & Van K. (2014) Apology in relation to our recent letter describing a case of fatal rhabdomyolysis in a patient with Duchenne muscular dystrophy. Anaesthesia and intensive care, 42(1), 134. PMID: 24471673
Can exergaming help children who have migraines without aura (MoA)? According to a recent study from a group of Italian authors published in Neuropsychiatric Disease and Treatment, playing the exergame Wii Fit over three months can improve measures of balance, coordination, motor tasks in children. ... Read more »
Esposito M, Ruberto M, Gimigliano F, Marotta R, Gallai B, Parisi L, Lavano SM, Roccella M, & Carotenuto M. (2013) Effectiveness and safety of Nintendo Wii Fit Plus™ training in children with migraine without aura: a preliminary study. Neuropsychiatric disease and treatment, 1803-10. PMID: 24453490
Also known as "halfsiders" or tetragametic chimæras, these unusual birds are actually two genetically distinct individuals -- twins -- fused into one being. ... Read more »
Zhao D., McBride D., Nandi S., McQueen H. A., McGrew M. J., Hocking P. M., Lewis P. D., Sang H. M., & Clinton M. (2010) Somatic sex identity is cell autonomous in the chicken. Nature, 464(7286), 237-242. DOI: 10.1038/nature08852
Agate R. J., Grisham W., Wade J., Mann S., Wingfield J., Schanen C., Palotie A., & Arnold A. P. (2003) Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch. Proceedings of the National Academy of Sciences, 100(8), 4873-4878. DOI: 10.1073/pnas.0636925100
Arnold A. P. (2003) Minireview: Sex Chromosomes and Brain Sexual Differentiation. Endocrinology, 145(3), 1057-1062. DOI: 10.1210/en.2003-1491
Chue Justin, & Smith Craig A. (2011) Sex determination and sexual differentiation in the avian model. FEBS Journal, 278(7), 1027-1034. DOI: 10.1111/j.1742-4658.2011.08032.x
Johnson Phyllis T., & Otto Sara V. (1981) Histology of a Bilateral Gynandromorph of the Blue Crab, Callinectes sapidus Rathbun (Decapoda: Portunidae). Biological Bulletin, 161(2), 236. DOI: 10.2307/1540801
Boklage C. E. (2005) Embryogenesis of chimeras, twins and anterior midline asymmetries. Human Reproduction, 21(3), 579-591. DOI: 10.1093/humrep/dei370
Antioxidants are recommended as food supplements, because of their anticancer effects. But in fact, clinical trials yielded inconclusive results. Some studies even indicated that these molecules could promote cancer. So what is the truth about antioxidants with respect to cancer?... Read more »
Volkan I. Sayin, Mohamed X. Ibrahim, Erik Larsson, Jonas A., Nilsson, Per Lindahl, Martin O. Bergo. (2014) Antioxidants accelerate lung cancer progression in mice. Science Translational Medicine. DOI: 10.1126/scitranslmed.3007653
Evidence based de-implementation. Should we stop some of what we are doing? Over the past few months, I have made a real effort to read the general literature on evidence based care. I came across this very interesting paper concerned with the re-evaluation of the evidence underpinning established clinical practice. It was written by Vinay […]The post Evidence based de-implementation in orthodontics. Should we stop some of what we are doing? appeared first on Kevin O'Brie........ Read more »
Vinay Prasad, & John Ioannidis. (2014) Evidence based de-implementation for contradicted, unproven and aspiring healthcare practices. Implementation Science, 9(1). DOI: 10.1186/1748-5908-9-1
I am so sorry dear readers for the dreadful pun used in the title of this post. It comes from years of reading books about 'knock-knock' jokes and the ever versatile 'the boy stood on the burning deck' ditties. More so in recent times with the advent of one of my brood starting to use the old 'Dr Who' version of the knock-knock joke. Having said all that I'm sure some people might think I am joking when it comes to talking about camel milk as a potential intervention for autism (some autism........ Read more »
Bashir S, & Al-Ayadhi L. (2013) Effect of camel milk on Thymus and Activation-Regulated Chemokine (TARC) in autistic children: double blind study. Pediatric research. PMID: 24375082
Heart disease is the most common cause of death in older adults. Heart disease kills about 600,000 Americans annually. Heart disease is the most common cause of death for women.The post Resistance and Aerobic Training: New research says both together is better for heart health appeared first on WODMasters.... Read more »
Sousa N, Mendes R, Abrantes C, Sampaio J, & Oliveira J. (2013) Long-term effects of aerobic training versus combined aerobic and resistance training in modifying cardiovascular disease risk factors in healthy elderly men. Geriatrics , 13(4), 928-35. PMID: 23441809
Drug that destroy HIV carrying lymphocytes; can impart complete treatment so that patient will not have to take antiretroviral drugs through out life as after certain period after attaining nill HIV count discontinuation of antiretroviral drug therapy there will be no hidden HIV virus in human body cells lymphocytes that relapse HIV infection and reproduce HIV count. ... Read more »
B V Waghmare. (2014) Drug that destroy HIV carrying lymphocytes; will result in complete treatment that will not require to taking antiretroviral drugs through out life. . http://bvwaghmare.blogspot.com. info:/
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