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  • September 28, 2014
  • 03:37 PM
  • 149 views

The Genetic Evolutionary Arms Race

by Gabriel in Lunatic Laboratories

Genes are tricky little buggers, the stuff that makes us up has fought the test of time to make it to where we are today. It is thought that our genes changed in an attempt to outpace other life, albeit random changes.That might only be half right however, new findings suggest that there is an evolutionary arms race going on within the genome against, of all things, itself. This inherent competition of primates drove the evolution of complex regulatory networks that orchestrate the activity of ........ Read more »

Jacobs, Greenberg, Nguyen, Haeussler, Ewing, Katzman, Paten, Salama . (2014) An evolutionary arms race betweenKRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. Nature. info:/10.1038/nature13760

  • September 28, 2014
  • 12:00 PM
  • 145 views

Numbers on a scale: How bad did you say your pain was?

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

Have you ever been asked to give your pain rating on a scale of 0 – 10 (where 0 = no pain at all and 10 = most extreme pain you can imagine)? Have you ever tried to work out whether today’s pain is worse than yesterdays? What does a pain rating tell us?... Read more »

  • September 27, 2014
  • 03:50 AM
  • 160 views

Yes, people with autism do have headaches

by Paul Whiteley in Questioning Answers

I don't mean to be haughty but a sentence included in the paper by Victorio [1] led to the title of today's very quick post. Based on a chart review of patients diagnosed with an autism spectrum disorder (ASD) attending a neurology clinic, the author concluded that "ASD patients, despite being known to have indifference to pain, can experience headaches".Pain is something which has cropped up quite a bit in the autism research arena and has appeared more than once on this blog (see here and see ........ Read more »

  • September 26, 2014
  • 02:15 PM
  • 183 views

“GMO” Foods (Once Again) Proven Safe

by Gabriel in Lunatic Laboratories

GMO, I shudder every time I hear someone talk about the “dangers”. It’s one of the new buzzwords that doesn’t actually mean anything, but still manages to scare people. Well a new scientific review reports that the performance and health of food-producing animals consuming genetically engineered feed, first introduced 18 years ago, has been comparable to that of animals consuming non-GE feed. Not that this will stop people from spreading fear, but it’s a start.... Read more »

  • September 26, 2014
  • 10:30 AM
  • 166 views

Walking Really Is Just Falling and Catching Yourself

by Elizabeth Preston in Inkfish

The flailing of a gymnast who’s missed a step on the balance beam might not be far off from what the rest of us experience every day. Each step we take is really a tiny fall, a mathematical model suggests. The random-looking variation in our footfalls is actually a series of corrections. Our strides are […]The post Walking Really Is Just Falling and Catching Yourself appeared first on Inkfish.... Read more »

  • September 26, 2014
  • 05:32 AM
  • 130 views

Schizophrenia after child and adolescent psychiatric disorders

by Paul Whiteley in Questioning Answers

More of a 'bring to your attention' post today, as I bring to your attention(!) the paper by Cecilie Frejstrup Maibing and colleagues [1] who concluded: "The risk of being diagnosed with schizophrenia spectrum disorders [SSD] after a child and adolescent psychiatric disorder was significantly increased particularly in the short term but also in the long-term period"."I coulda been a contender"The findings were based on an analysis of one of those very informative Scandinavian........ Read more »

  • September 25, 2014
  • 10:37 AM
  • 180 views

A New Discovery in the Treatment of Autoimmunity and Chronic Inflammation

by Gabriel in Lunatic Laboratories

Lupus, Type 1 diabetes, and multiple sclerosis are all diseases brought on by autoimmunity — the bodies inability to tell itself apart from foreign invaders. Finding a cure, or even a suitable treatment has been to put it gently a long, painful road, with little to show for it. On the forefront of the war against the body betrayal is immunosuppressants, which with them carry their own set of side effects and in most cases only off mild to moderate relief of symptoms. But that is all changing a........ Read more »

Dubiella C, Cui H, Gersch M, Brouwer AJ, Sieber SA, Krüger A, Liskamp RM, & Groll M. (2014) Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site. Angewandte Chemie (International ed. in English). PMID: 25244435  

  • September 25, 2014
  • 05:10 AM
  • 171 views

Temporal trends in US autism prevalence: mainly real increase

by Paul Whiteley in Questioning Answers

"Diagnosed autism prevalence has risen dramatically in the U.S over the last several decades and continued to trend upward as of birth year 2005. The increase is mainly real and has occurred mostly since the late 1980s"."They call me Cha Cha because I'm the best dancer at St. Bernadette's"That was the conclusion reached in the paper by Cynthia Nevison [1] (open-access) following her analysis of temporal trends in autism diagnosis for birth years between 1970 and 2005. Based on an analysis o........ Read more »

  • September 24, 2014
  • 03:54 PM
  • 130 views

A new Medicine may help Lupus Sufferers

by Gabriel in Lunatic Laboratories

Lupus, a particularly bad hell on earth for people suffering from it. Lupus is caused by autoimmunity, in where the body attacks itself. I have a special place in my heart for people suffering from the disease because my Uncle suffered from it. There is no cure and only moderately effective treatments for the disorder, which causes, in some cases, the most excruciating pain you will ever feel. Thankfully new findings by a biomedical engineering team raise hope for a new class of drugs to treat l........ Read more »

  • September 24, 2014
  • 12:37 PM
  • 170 views

Why Women Give Better Gifts

by William Yates, M.D. in Brain Posts

Consumer spending on gifts for birthdays and holidays is a multi-billion dollar big business.Despite this large economic impact, little research examines factors associated with gift recipient satisfaction.Selecting good gifts for others involves a complex social decision-making process related to judging the value hierarchy of others.A study from the Netherlands recently published in the journal PLOS One featured three experiments on gift selection in a series of men and women.The design of the........ Read more »

Pollmann MM, & van Beest I. (2013) Women are better at selecting gifts than men. PloS one, 8(12). PMID: 24386082  

  • September 24, 2014
  • 11:42 AM
  • 141 views

Genetics "Experts" Surveyed on Returning Incidental Findings

by Daniel Koboldt in Massgenomics

In my last post, I wrote about the return of results from next-gen sequencing, specifically a recent paper in AJHG about secondary findings in ~6500 ESP exomes. Today we’ll delve into another paper in the same issue on the attitudes of genetics professionals on return of incidental findings from whole genome sequencing (WGS) and exome sequencing […]... Read more »

  • September 24, 2014
  • 09:10 AM
  • 156 views

6 Things You Need To Know About Your Microbiome

by Bill Sullivan in The 'Scope

Surprising new facts about the bacteria living on and in you.... Read more »

Lax S, Smith DP, Hampton-Marcell J, Owens SM, Handley KM, Scott NM, Gibbons SM, Larsen P, Shogan BD, Weiss S.... (2014) Longitudinal analysis of microbial interaction between humans and the indoor environment. Science (New York, N.Y.), 345(6200), 1048-52. PMID: 25170151  

Bisgaard, H., Li, N., Bonnelykke, K., Chawes, B., Skov, T., Paludan-Müller, G., Stokholm, J., Smith, B., & Krogfelt, K. (2011) Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. Journal of Allergy and Clinical Immunology, 128(3), 646-65200000. DOI: 10.1016/j.jaci.2011.04.060  

Stefka, A., Feehley, T., Tripathi, P., Qiu, J., McCoy, K., Mazmanian, S., Tjota, M., Seo, G., Cao, S., Theriault, B.... (2014) Commensal bacteria protect against food allergen sensitization. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1412008111  

Williams NT. (2010) Probiotics. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 67(6), 449-58. PMID: 20208051  

  • September 24, 2014
  • 07:20 AM
  • 59 views

Orthodontics: What would the Martian say?

by Kevin OBrien in Kevin OBrien's Orthodontic Blog

Orthodontics: What would the Martian say? This blog has a strange title and I will start by explaining this. When I was a much younger researcher, I had several in depth conversations with a now retired USA based Professor of Orthodontics, he always attempted to open my mind. A favourite of his was to ask this […]
The post Orthodontics: What would the Martian say? appeared first on Kevin O'Brien's Orthodontic Blog.
... Read more »

  • September 24, 2014
  • 06:58 AM
  • 208 views

Psychiatric effects of childhood inflammation?

by Paul Whiteley in Questioning Answers

"Higher levels of the systemic inflammatory marker IL-6 [interleukin 6] in childhood are associated with an increased risk of developing depression and psychosis in young adulthood". So said the paper by Golam Khandaker and colleagues [1] looking at the growing link between inflammation and psychiatry.The bright light of Autumn @ Wikipedia The name Khandaker has appeared before on this blog (see here and see here), most recently with research looking at a possible link between the........ Read more »

Golam M. Khandaker, Rebecca M. Pearson, Stanley Zammit, Glyn Lewis, & Peter B. Jones. (2014) Association of Serum Interleukin 6 and C-Reactive Protein in Childhood With Depression and Psychosis in Young Adult Life. JAMA Psychiatry. info:/doi:10.1001/jamapsychiatry.2014.1332

  • September 23, 2014
  • 01:55 PM
  • 169 views

Lie Detection using Brain Waves: It’s just as creepy as it sounds…

by Gabriel in Lunatic Laboratories

Currently lie detectors (polygraphs) are not admissible in court, this is because (despite what you may read) there is little proof to show that they are much better than a guess — coming in at roughly 50% accuracy. They aren’t really based in science, making them more of a toy. There might just be a new contender in the lie detection department coming soon however, researchers have found that brain activity can be used to tell whether someone recognizes details they encountered in normal, d........ Read more »

  • September 23, 2014
  • 09:38 AM
  • 144 views

Maternal iron intake and offspring autism risk

by Paul Whiteley in Questioning Answers

Much like the discussions around the paper by Rogers and colleagues (see here) on treating autism in the first year of life, the media scrum around the findings from Rebecca Schmidt and colleagues [1] talking about maternal iron supplements and offspring autism spectrum disorder (ASD) risk preceded the publication of the paper by a few days. It's getting to be a pet-hate of mine that big headlines are being generated sometimes days before your average Jane or Joe can see the data upon which they........ Read more »

Rebecca J. Schmidt, Daniel J. Tancredi, Paula Krakowiak, Robin L. Hansen, & Sally Ozonoff. (2014) Maternal Intake of Supplemental Iron and Risk of Autism Spectrum Disorder. American Journal of Epidemiology. info:/doi: 10.1093/aje/kwu208

  • September 23, 2014
  • 05:00 AM
  • 127 views

Gut issues in autism impacting on drug availability and absorption

by Paul Whiteley in Questioning Answers

As indicated in a recent post, I was really rather pleased to see the paper by Andrew Heitzer and colleagues [1] (open-access) asking the important question: Should clinical trial research of psychotropic medication in autism control for gastrointestinal symptoms? Some media about the study can also be found here."You write "Born to Kill" on your helmet and you wear a peace button".The answer is of course, yes and not just when it comes to psychotropic medicines either, given that gastroint........ Read more »

  • September 22, 2014
  • 02:55 PM
  • 167 views

Spice, Kryptonite, Black Mamba – legal high marketing

by DJMac in Recovery Review

That the market for ‘legal highs’, or more accurately, new psychoactive substances (NPS) has grown there is no doubt. What’s also growing, in terms of sophistication and technique, is the marketing of these products. With NPS, things are changing so fast that the research is well behind what’s happening in real time. Business is way [...]
The post Spice, Kryptonite, Black Mamba – legal high marketing appeared first on Recovery Review.
... Read more »

  • September 22, 2014
  • 02:17 PM
  • 140 views

Autism and the Low Iron Connection

by Gabriel in Lunatic Laboratories

The topic of autism is a charged one. Maybe it’s because it isn’t a simple diagnosis; there are many roads to autism. Most of them are probably genetic, some of them are likely environmental, and none of them are related to vaccination (sorry to burst your bubble anti vax people, it’s called science). Some new research shows another possible (environmental) cause. The new study shows that mothers of children with autism are significantly less likely to report taking iron supplements before........ Read more »

Rebecca J. Schmidt et al. (2014) Maternal intake of supplemental iron and risk for autism spectrum disorders. American Journal of Epidemiology. info:/

  • September 22, 2014
  • 03:32 AM
  • 148 views

Omega-3 fatty acids and ADHD

by Paul Whiteley in Questioning Answers

With a title like that, this post could turn out to be quite a long winded blog entry. As it happens, I'm not going to subject you, dear reader, to such a literary onslaught but rather focus my attention on the paper by Elizabeth Hawkey & Joel Nigg [1] who undertook two meta-analyses and concluded that: "Omega-3 levels are reduced in children with ADHD [attention-deficit hyperactivity disorder]" and "Dietary supplementation appears to create modest improvements in symptoms"."Maybe the 80s wi........ Read more »

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