MedicalResearch.com Interview with: Susanna C. Larsson PhD, Associate Professor Associate professor, Nutritional Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm, Sweden Medical Research: What are the main findings? Dr. Larsson: A high dietary cholesterol intake has been postulated to increase the … Continue reading →
The post Eggs Not Linked To Heart Attack or Stroke appeared first on MedicalResearch.com.
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Susanna C. Larsson. (2015) Eggs Not Linked To Heart Attack or Stroke. MedicalResearch.com. info:/
A team including the scientist who first harnessed the revolutionary CRISPR-Cas9 system for mammalian genome editing has now identified a different CRISPR system with the potential for even simpler and more precise genome engineering. In the study researchers describe the unexpected biological features of this new system and demonstrate that it can be engineered to edit the genomes of human cells.... Read more »
Zetsche, B., Gootenberg, J., Abudayyeh, O., Slaymaker, I., Makarova, K., Essletzbichler, P., Volz, S., Joung, J., van der Oost, J., Regev, A.... (2015) Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System. Cell. DOI: 10.1016/j.cell.2015.09.038
I was interested to read the paper by Joseph Prandota and colleagues  who observed that: "latent chronic T. gondii [Toxoplasma gondii] infection have an important impact on triggering and development of ASD [autism spectrum disorders], at least in a subset of autistic children, and this requires some modification(s) of its diagnostic procedures and treatment regimens." Big words, I'm sure you'll agree.From the start I'll indicate that I'm interested in T. gondii on this bl........ Read more »
Joseph Prandota, Noha Abdel Fattah Elleboudy, Khadiga Ahmed Ismail, Osama Kamal Zaki, & Hanan Hussein Shehata. (2015) Increased Seroprevalence of Chronic Toxoplasmosis in Autistic Children: Special Reference to the Pathophysiology of IFN-γ and NO Overproduction. International Journal of Neurology Research, 1(3), 102-122. info:/10.17554/j.issn.2313-5611.2015.01.30
Classifying something as living isn’t as easy as it sounds, after all we are all atoms, so when do atoms go from nonliving to living? Despite the complexities of viruses, we have historically deemed them nonliving. However, a new analysis supports the hypothesis that viruses are living entities that share a long evolutionary history with cells. The study offers the first reliable method for tracing viral evolution back to a time when neither viruses nor cells existed in the forms recognized to........ Read more »
Arshan Nasir, & Gustavo Caetano-Anollés. (2015) A phylogenomic data-driven exploration of viral origins and evolution. Science Advances. info:/10.1126/sciadv.1500527
MedicalResearch.com Interview with: Philip J. Peters MD DTM&H (Diploma in Tropical Medicine & Hygiene) Medical Officer, Division of HIV/AIDS Prevention US Centers for Disease Control and Prevention Atlanta Georgia Medical Research: What is the background for this study? What are … Continue reading →
The post Newly Diagnosed HIV+ Men Underreport Male Sexual Encounters appeared first on MedicalResearch.com.
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Philip J. Peters MD DTM. (2015) Newly Diagnosed HIV Men Underreport Male Sexual Encounters. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Ramon C. Hermida Dominguez, Ph.D. Director, Bioengineering & Chronobiology Labs. Campus Universitario Vigo, Pontevedra Medical Research: What is the background for this study? What are the main findings? Dr. Hermida Dominguez: Independent studies have shown that the … Continue reading →
The post Taking Blood Pressure Meds At Night Decreases Diabetes Risk appeared first on MedicalResearch.com.
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Ramon C. Hermida Dominguez, Ph.D. (2015) Taking Blood Pressure Meds At Night Decreases Diabetes Risk. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Meng-Yun Lin, MPH PhD candidate Department of Health Policy & Management Boston University School of Public Health Boston MA 02118 Medical Research: What is the background for this study? What are the main findings? Response: Racial and ethnic … Continue reading →
The post Physician Communication Needs To Vary By Patient Background appeared first on MedicalResearch.com.
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Meng-Yun Lin, MPH PhD. (2015) Physician Communication Needs To Vary By Patient Background. MedicalResearch.com. info:/
"This report provides evidence that teeth can be useful biomarkers of early life exposure for use in epidemiologic case-control studies seeking to identify differential unbiased exposures during development between those with and without specific disorders such as autism."That was one of the conclusions reached in the paper by Raymond Palmer and colleagues  (open-access available here) who played science tooth fairy with 71 deciduous teeth (baby teeth) provided by children with autism fr........ Read more »
Palmer, R., Heilbrun, L., Camann, D., Yau, A., Schultz, S., Elisco, V., Tapia, B., Garza, N., & Miller, C. (2015) Organic Compounds Detected in Deciduous Teeth: A Replication Study from Children with Autism in Two Samples. Journal of Environmental and Public Health, 1-9. DOI: 10.1155/2015/862414
MedicalResearch.com Interview with: Dr. Sanda Dolcos PhD Post-doc Fellow University of Illinois Medical Research: What are the main findings? Dr. Dolcos : With its high prevalence rate, anxiety is a pressing concern in our society. Identifying psychological and neural markers … Continue reading →
The post Where Does Optimism Reside in the Brain? appeared first on MedicalResearch.com.
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Dr. Sanda Dolcos PhD. (2015) Where Does Optimism Reside in the Brain?. MedicalResearch.com. info:/
A new study by researchers heightens concerns over the detrimental impact of air pollution on hippocampal metabolites as early markers of neurodegeneration in young urbanites carrying an allele 4 of the apolipoprotein E gene (APOE). This is associated with the risk for Alzheimer disease (AD) and a susceptibility marker for poor outcome in traumatic brain injury (TBI) recovery.... Read more »
Dr. Lilian Calderón-Garcidueñas et. al. (2015) Mexico City's air pollution has detrimental impact on Alzheimer's disease gene . Journal of Alzheimer's Disease. DOI: http://dx.org/10.3233/JAD-150415
My stark lack of knowledge in the area of genetics and specifically that linked to the human endogenous retroviruses (HERVs) that litter the genome is likely to shine through in this post so be ready with that pinch of salt.The starting point for today's post is the paper by Ines Quintela and colleagues  detailing a case report of "a 9-year-old female patient with autistic disorder, total absence of language, intellectual disability, anxiety disorder and disruptive, and compulsive e........ Read more »
Quintela I, Gomez-Guerrero L, Fernandez-Prieto M, Resches M, Barros F, & Carracedo A. (2015) Female patient with autistic disorder, intellectual disability, and co-morbid anxiety disorder: Expanding the phenotype associated with the recurrent 3q13.2-q13.31 microdeletion. American journal of medical genetics. Part A. PMID: 26332054
Social networking makes it easy to monitor the status and activities of a former romantic partner, an often unhealthy use of social media known as interpersonal electronic surveillance (IES) or, more commonly, “Facebook stalking.” Psychological and relationship factors and how individuals cope with the termination of a romantic relationship can help predict their use of online surveillance, according to a new study.... Read more »
Fox, J., & Tokunaga, R. (2015) Romantic Partner Monitoring After Breakups: Attachment, Dependence, Distress, and Post-Dissolution Online Surveillance via Social Networking Sites. Cyberpsychology, Behavior, and Social Networking, 18(9), 491-498. DOI: 10.1089/cyber.2015.0123
What makes two babies twins? Do they have to look similar; be born at the same time; be conceived at the same time? Twins of different races give us idea just how genetics can play out in siblings and how complex the control of skin pigmentation, hair and eye color and hair texture can be.... Read more »
Sturm, R., Duffy, D., Zhao, Z., Leite, F., Stark, M., Hayward, N., Martin, N., & Montgomery, G. (2008) A Single SNP in an Evolutionary Conserved Region within Intron 86 of the HERC2 Gene Determines Human Blue-Brown Eye Color. The American Journal of Human Genetics, 82(2), 424-431. DOI: 10.1016/j.ajhg.2007.11.005
Duffy DL, Montgomery GW, Chen W, Zhao ZZ, Le L, James MR, Hayward NK, Martin NG, & Sturm RA. (2007) A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation. American journal of human genetics, 80(2), 241-52. PMID: 17236130
Maroñas, O., Phillips, C., Söchtig, J., Gomez-Tato, A., Cruz, R., Alvarez-Dios, J., de Cal, M., Ruiz, Y., Fondevila, M., Carracedo, �.... (2014) Development of a forensic skin colour predictive test. Forensic Science International: Genetics, 34-44. DOI: 10.1016/j.fsigen.2014.06.017
Gerstenblith MR, Goldstein AM, Fargnoli MC, Peris K, & Landi MT. (2007) Comprehensive evaluation of allele frequency differences of MC1R variants across populations. Human mutation, 28(5), 495-505. PMID: 17279550
Here we go again."A positive association between maternal autoimmune diseases and the risk of ASD [autism spectrum disorder] in offspring was identified assuming a fixed effect model." Further: "Maternal autoimmune disease is likely to be an independent risk factor of ASD in offspring."Those were the findings and conclusions published by Shao-wei Chen and colleagues  as part of their systematic review and meta-analysis of the available peer-reviewed literature looking at how ma........ Read more »
Chen SW, Zhong XS, Jiang LN, Zheng XY, Xiong YQ, Ma SJ, Qiu M, Huo ST, Ge J, & Chen Q. (2015) Maternal autoimmune diseases and the risk of autism spectrum disorders in offspring: a systematic review and meta-analysis. Behavioural brain research. PMID: 26327239
A team led by researchers at Cold Spring Harbor Laboratory (CSHL) has published a new analysis of data on the genetics of autism spectrum disorder (ASD). One commonly held theory is that autism results from the chance combinations of commonly occurring gene mutations, which are otherwise harmless. But the authors’ work provides support for a different theory.... Read more »
Ivan Iossifov, Dan Levy, Jeremy Allen, Kenny Ye, Michael Ronemus, Yoon-ha Lee, Boris Yamrom, & Michael Wigler. (2015) Low load for disruptive mutations in autism genes and their biased transmission. Proceedings of the National Academy of Sciences in the United States of America. info:/
Today I'm bringing the paper by Kamila Castro and colleagues  to the blogging table and their systematic review of the available peer-reviewed literature on the use of a ketogenic diet (KD) when it comes to real life autism and various mouse models trying to map the label.Drawing on data derived from 8 studies - "three studies with animals and five studies with humans" - that met the relevant inclusion criteria for study, authors concluded that although the evidence looks promising for t........ Read more »
Kamila Castro, Larissa Slongo Faccioli, Diego Baronio, Carmem Gottfried, Ingrid Schweigert Perry, & Rudimar dos Santos Riesgo. (2015) Effect of a ketogenic diet on autism spectrum disorder: A systematic review. Research in Autism Spectrum Disorders, 31-38. info:/10.1016/j.rasd.2015.08.005
For adults, memories tend to fade with time. But a new study has shown that there are circumstances under which the opposite is true for small children: they can remember a piece of information better days later than they can on the day they first learned it. While playing a video game that asked them to remember associations between objects, 4- and 5-year-olds who re-played the game after a two-day delay scored more than 20 percent higher than kids who re-played it later the same day.... Read more »
Kevin Darby. (20115) ‘Delayed remembering’: kids can remember tomorrow what they forgot today. Psychological Science. info:/
"Autism spectrum disorder (ASD) phenomenology is reported to be more common in individuals with some genetic syndromes than in the general population."That was the starting point for the systematic review and meta-analysis published by Caroline Richards and colleagues  who set about 'synthesising' the various peer-reviewed data "to provide accurate estimates about ASD phenomenology in genetic and metabolic syndromes." A scan of the cumulative literature in this area ("168 papers reportin........ Read more »
Caroline Richards, Christopher Jones, Laura Groves, Jo Moss, & Chris Oliver. (2015) Prevalence of autism spectrum disorder phenomenology in genetic disorders: a systematic review and meta-analysis. The Lancet Psychiatry. info:/
Neural stem cells generate new neurons throughout life in the mammalian brain. However, with advancing age the potential for regeneration in the brain dramatically declines. Scientists now identified a novel mechanism of how neural stem cells stay relatively free of aging-induced damage. A diffusion barrier regulates the sorting of damaged proteins during cell division.... Read more »
Moore, D., Pilz, G., Arauzo-Bravo, M., Barral, Y., & Jessberger, S. (2015) A mechanism for the segregation of age in mammalian neural stem cells. Science, 349(6254), 1334-1338. DOI: 10.1126/science.aac9868
Research led by scientists from Duke-NUS Graduate Medical School Singapore (Duke-NUS) has linked the abnormal behaviour of two genes (BDNF and DTNBP1) to the underlying cause of schizophrenia. These findings have provided a new target for schizophrenia treatment.... Read more »
Yuan, Q., Yang, F., Xiao, Y., Tan, S., Husain, N., Ren, M., Hu, Z., Martinowich, K., Ng, J., Kim, P.... (2015) Regulation of Brain-Derived Neurotrophic Factor Exocytosis and Gamma-Aminobutyric Acidergic Interneuron Synapse by the Schizophrenia Susceptibility Gene Dysbindin-1. Biological Psychiatry. DOI: 10.1016/j.biopsych.2015.08.019
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