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  • March 5, 2014
  • 03:15 PM

Drug resistance evolves in inbred parasites

by sedeer in Inspiring Science

It all starts with a mosquito bite. When a hungry mosquito pierces someone’s skin to gorge herself, she also pumps …Continue reading →... Read more »

Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S, Rockett KA, Amaratunga C, Lim P, Suon S, Sreng S.... (2013) Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nature genetics, 45(6), 648-55. PMID: 23624527  

  • March 5, 2014
  • 03:00 PM

The Failure of LUCAS to Improve Outcomes in the LINC Trial

by Rogue Medic in Rogue Medic

We love gadgets in EMS.

Dr. Bryan Bledsoe tells us that if we paint it orange and put a star of life on it, we can sell any product for a lot more money.

How much would you pay to not improve outcomes?





$50,000.00?... Read more »

  • March 5, 2014
  • 05:02 AM

Drug-refractory aggression and SIB

by Paul Whiteley in Questioning Answers

At the time of writing this post, the media is awash with two stories with an autism research slant to them. So we have the paper by Brian D’Onofrio and colleagues [1] talking about older, sorry, advancing paternal age and the risk of various conditions for offspring, including autism, and the paper by Sébastien Jacquemont and colleagues [2] on a female protective model for autism. Y'know these are serious pieces of research when the good old BBC (Auntie) puts it........ Read more »

  • March 3, 2014
  • 11:58 PM

Pulmonary Hypertension in the RASopathies

by JCVM in JScholar Publishers

The RASopathies are a class of developmental disorders caused by a genetic mutation in the Ras signaling pathway and associated mitogen-activated protein kinases that control the cell cycle, differentiation and senescence. These diseases encompass a diverse set of clinical syndromes including neurofibromatosis type 1 and Noonan syndrome. Although the pathophysiological manifestations of these conditions are diverse, they share some common phenotypic features. The prevalence of pulmonary hyperten........ Read more »

Krishna S. Vyas, Jacqueline A. Noonan. (2014) Pulmonary Hypertension in the RASopathies. Journal of Cardiology and Vascular Medicine, 2(1), 1-6. info:/2: 101

  • March 3, 2014
  • 09:14 AM

Behavioral Weight-Loss in Serious Mental Illness

by William Yates, M.D. in Brain Posts

Individuals with schizophrenia or bipolar disorder are at higher risk for obesity.This risk may be related to physical inactivity, diet or the weight gain commonly associated with psychotropic drug use.Few clinical trials for weight loss have targeted individuals with serious mental illness (SMI). This population may pose specific challenges in recruitment, adherence and outcome.Gail Daumit and colleagues recently published a randomized clinical trial of behavioral weight loss in a cohort with S........ Read more »

Daumit GL, Dickerson FB, Wang NY, Dalcin A, Jerome GJ, Anderson CA, Young DR, Frick KD, Yu A, Gennusa JV 3rd.... (2013) A behavioral weight-loss intervention in persons with serious mental illness. The New England journal of medicine, 368(17), 1594-602. PMID: 23517118  

  • March 3, 2014
  • 09:00 AM

Life (for a mouse) sucks without Bmal1

by Allison in Dormivigilia

Scientists have uncovered a host of pathological consequences in liver- and mitochondrial-pathways in the absence of Bmal1. These studies lend further credence to Bmal1 being important for rhythms of metabolism. These critters are certainly no star athletes. ... Read more »

Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C.... (2013) Circadian clock NAD cycle drives mitochondrial oxidative metabolism in mice. Science (New York, N.Y.), 342(6158), 1243417. PMID: 24051248  

  • March 3, 2014
  • 09:00 AM

Creatine: Guest Post from Beauty by the Geeks

by Alex Giffen in Antisense Science

Creatine. A molecular gem that you’ve probably heard of in the context of exercise and working out in the gym. Creatine is used as a supplement by gym-goers and sporty folk when they want to get more out of their workout. It comes from both endogenous and exogenous sources, being produced in the liver and coming from dietary meat and fish.

It’s a compound which can give a runner that extra bit of explosive energy or a weight-lifter a little more strength. This nitrogenous organic........ Read more »

Bemben MG, & Lamont HS. (2005) Creatine supplementation and exercise performance: recent findings. Sports medicine (Auckland, N.Z.), 35(2), 107-25. PMID: 15707376  

Brosnan JT, da Silva RP, & Brosnan ME. (2011) The metabolic burden of creatine synthesis. Amino acids, 40(5), 1325-31. PMID: 21387089  

Cooper R, Naclerio F, Allgrove J, & Jimenez A. (2012) Creatine supplementation with specific view to exercise/sports performance: an update. Journal of the International Society of Sports Nutrition, 9(1), 33. PMID: 22817979  

  • March 3, 2014
  • 04:53 AM

Vitamin D and autism: a continuing saga

by Paul Whiteley in Questioning Answers

The "sunshine vitamin" that is vitamin D has cropped up quite a few times on this blog for all manner of reasons. The suggestion of a link (whatever that means) between vitamin D and the autism spectrum conditions has received the lion's share of coverage, be that in relation to measured levels of vitamin D (see here and see here) or more speculatively, the possible impact of something like deficiency of vitamin D to symptoms or physiology (see here and see here). I've also not been adverse to t........ Read more »

  • March 3, 2014
  • 01:50 AM

The Impenetrable Bulwark of Vaccination Lies

by Eric Horowitz in peer-reviewed by my neurons

America has a problem. Some people are spouting the lie that vaccines can cause autism and other people are believing them. This has led to some unfortunate false-equivalence when the issue is discussed, and wouldn’t you know it, that false equivalence makes people less likely to believe the truth. Sometimes there’s no false equivalence; people […]... Read more »

Nyhan, B., Reifler, J., Richey, S., & Freed, G.L. (2014) Effective Messages in Vaccine Promotion: A Randomized Trial. Pediatrics. info:/

  • February 28, 2014
  • 02:39 PM

This Month In Blastocystis Research (FEB 2014) - The Protease Edition

by Christen Rune Stensvold in Blastocystis Parasite Blog

The February issue of This Month In Blastocystis Research is mostly about Blastocystis proteases and their potential clinical significance. ... Read more »

Fayer R, Elsasser T, Gould R, Solano G, Urban J Jr, & Santin M. (2014) Blastocystis tropism in the pig intestine. Parasitology research. PMID: 24535732  

Denoeud F, Roussel M, Noel B, Wawrzyniak I, Da Silva C, Diogon M, Viscogliosi E, Brochier-Armanet C, Couloux A, Poulain J.... (2011) Genome sequence of the stramenopile Blastocystis, a human anaerobic parasite. Genome biology, 12(3). PMID: 21439036  

Olivo-Diaz A, Romero-Valdovinos M, Gudiño-Ramirez A, Reyes-Gordillo J, Jimenez-Gonzalez DE, Ramirez-Miranda ME, Martinez-Flores WA, Martinez-Hernandez F, Flisser A, & Maravilla P. (2012) Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis. Parasitology research, 111(1), 487-91. PMID: 22287022  

Puthia MK, Vaithilingam A, Lu J, & Tan KS. (2005) Degradation of human secretory immunoglobulin A by Blastocystis. Parasitology research, 97(5), 386-9. PMID: 16151742  

Wawrzyniak I, Texier C, Poirier P, Viscogliosi E, Tan KS, Delbac F, & El Alaoui H. (2012) Characterization of two cysteine proteases secreted by Blastocystis ST7, a human intestinal parasite. Parasitology international, 61(3), 437-42. PMID: 22402106  

Sio SW, Puthia MK, Lee AS, Lu J, & Tan KS. (2006) Protease activity of Blastocystis hominis. Parasitology research, 99(2), 126-30. PMID: 16518611  

  • February 28, 2014
  • 08:01 AM


by Amy Swanston in Antisense Science

You might remember back in 2008 reading about how scientists had made a breakthrough in regenerative medicine by engineering a human trachea. Since then people have been wondering if the same principles could be applied to more complex body parts. The answer? Yes. Scientists in Texas have grown functioning lungs by using damaged ones as a scaffold to grow new tissue.... Read more »

Nichols JE, Niles JA, & Cortiella J. (2012) Production and utilization of acellular lung scaffolds in tissue engineering. Journal of cellular biochemistry, 113(7), 2185-92. PMID: 22573544  

  • February 28, 2014
  • 04:21 AM

Asthma as a risk factor for autism?

by Paul Whiteley in Questioning Answers

I start with a quote from the paper by Po-Hsin Tsai and colleagues [1]: "This prospective study indicated a temporal relation between asthma and subsequent ASD [autism spectrum disorder] diagnosis, supporting the immune hypothesis of ASD pathogenesis". Based on a familiar collaboration residing in Taiwan (see here and see here for some discussions on previous data), yet more evidence is emerging of a correlation between immune function, physiology and behavioural / developmental c........ Read more »

  • February 26, 2014
  • 08:10 AM

Strange Insects Taste

by Mark Lasbury in As Many Exceptions As Rules

New research is describing the ways that arthropods use gustatory receptors. Drosophila use a muscular reflex to extend or retract the proboscis, based on the sweet or bitter taste they experience. In silica studies are showing that female behaviors are driving gene duplication and evolution of taste receptor genes, while specific taste receptors are responsible for male female interactions in fruit fly courtship rituals.
... Read more »

Briscoe AD, Macias-Muñoz A, Kozak KM, Walters JR, Yuan F, Jamie GA, Martin SH, Dasmahapatra KK, Ferguson LC, Mallet J.... (2013) Female behaviour drives expression and evolution of gustatory receptors in butterflies. PLoS genetics, 9(7). PMID: 23950722  

  • February 26, 2014
  • 04:48 AM

Pregnancy paracetamol use and offspring ADHD traits?

by Paul Whiteley in Questioning Answers

Poor old paracetamol (acetaminophen if you wish).Tablets (before tablets again) @ WikipediaFirst it was the Brandlistuen correlation [1] suggesting that sustained exposure in-utero may impact on childhood developmental outcome (see here for my take). Now another swipe has been taken at this pharmaceutical stalwart of pain relief / fever reduction with the publication of results by Zeyan Liew and colleagues [2] suggesting that: "Maternal acetaminophen use during preg........ Read more »

  • February 26, 2014
  • 12:32 AM

Here’s Why Adults Think Teenagers Sleep Too Much

by Eric Horowitz in peer-reviewed by my neurons

The teenage ability to sleep past noon is one of the great joys of adolescence. It’s also one of the great headaches of parenthood. On weekends parents are up bright and early, but try as they might, they can’t get their teenage children to make use of the morning hours. A simple explanation for why […]... Read more »

  • February 25, 2014
  • 11:47 PM

Drug and Alcohol Consumption and Trade and HIV in the Caribbean: A Review of the Literature

by JAID in JScholar Publishers

This consultancy was granted by the Caribbean Health Research Council (CHRC) to assess the state of the literature on possible links between HIV spread and prevalence of drug and alcohol abuse and trade in the region. The methodology was that of a thematic search of existing literature in databases and books or journal publications. Online materials and UN agency reports of relevance were also consulted. Regular meetings were held with CHRC staff to review progress and edit drafts while staff of........ Read more »

Biko Agozino. (2013) Drug and Alcohol Consumption and Trade and HIV in the Caribbean: A Review of the Literature. Journal of HIV/AIDS , 1(2), 1-12. info:/Vol 1: 203

  • February 24, 2014
  • 03:34 PM

Taking a Transdiagnostic Approach to Understanding Self-Injury

by amikulak in Daily Observations

Millions of people are affected by self-injury, especially adolescents and young adults.  Non-suicidal self-injury (NSSI) has been the focus of numerous studies and, yet, there is still a lot to […]... Read more »

  • February 24, 2014
  • 08:17 AM

Fish Consumption and Brain Health

by William Yates, M.D. in Brain Posts

I have previously examined outcomes for MRI changes known as brain white matter hyperintensities (WMHI).WMHIs are noted in a minority of adults and are not completely understood. The changes are considered subclinical in nature, meaning  they do not reach a threshold for medical significance.However, these subclinical WMHI are linked to higher rates of premature cognitive decline. Absence of WMHI is seen by some as one marker of brain health.Jyrki Virtanen and colleagues from Finl........ Read more »

  • February 24, 2014
  • 07:00 AM

Newly-found antibodies predict joint damage in Rheumatoid Arthritis

by Pieter Carrière in United Academics

Promising Rheumatoid Arthritis (RA) research is done about the involvement of anti-CarP antibodies. These antibodies seem to be an important cause of RA. Moreover, they are associated with more severe joint destruction in RA patients.... Read more »

6. Peters M.J.L., Symmons D.P.M., McCarey D., Dijkmans B.A.C., Nicola P., Kvien T.K., McInnes I.B., Haentzschel H., Gonzalez-Gay M.A., Provan S., Semb A., Sidiropoulos P., Kitas G., Smulders Y.M., Soubrier M., Szekanecz Z., Sattar N. and Nurmohamed M.T. (2010) EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. . Annals of Rheumatic Diseases. DOI: 10.1136/ard.2009.113696  

Wang Z, Nicholls SJ, Rodriguez ER, Kummu O, Hörkkö S, Barnard J, Reynolds WF, Topol EJ, DiDonato JA, & Hazen SL. (2007) Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nature medicine, 13(10), 1176-84. PMID: 17828273  

Mydel P, Wang Z, Brisslert M, Hellvard A, Dahlberg LE, Hazen SL, & Bokarewa M. (2010) Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis. Journal of immunology (Baltimore, Md. : 1950), 184(12), 6882-90. PMID: 20488785  

  • February 24, 2014
  • 04:39 AM

The [universal] early identification of autism or not?

by Paul Whiteley in Questioning Answers

As I might have already intimated, whilst I'm all in favour of the very early identification of autism and the potential effects this might bring to a child in terms of something like benefiting from early intervention, I'm not overly enthused by the collected evidence which has been amassed so far in this area despite some promising data.Under my umbrellas @ Wikipedia Most people with some knowledge of autism will know that it is an extremely heterogeneous condition, with presentation........ Read more »

Samango-Sprouse CA, Stapleton EJ, Aliabadi F, Graw R, Vickers R, Haskell K, Sadeghin T, Jameson R, Parmele CL, & Gropman AL. (2014) Identification of infants at risk for autism spectrum disorder and developmental language delay prior to 12 months. Autism : the international journal of research and practice. PMID: 24550549  

Stenberg N, Bresnahan M, Gunnes N, Hirtz D, Hornig M, Lie KK, Lipkin WI, Lord C, Magnus P, Reichborn-Kjennerud T.... (2014) Identifying Children with Autism Spectrum Disorder at 18 Months in a General Population Sample. Paediatr Perinat Epidemiol. DOI: 10.1111/ppe.12114  

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