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  • September 30, 2014
  • 09:28 AM
  • 117 views

The Playing Ground Part One

by Rodney Steadman in Gravity's Pull

How parent and peer support in preadolescent and adolescent girls influences their engagement in physical activity across ages nine to 15 years.... Read more »

  • September 30, 2014
  • 08:21 AM
  • 21 views

Heart Changes One Year Post-Kidney Donation

by Cristy at Living Donor 101 in Living Donors Are People Too

Unfortunately, I can’t get access to the entire article ($$$) so this is from the abstract. 38 living kidney donors were included in the study.   “The mean serum interleukin-6 levels, both at 3 months and 12 months, were significantly increased as compared to the baseline (P=0.007 and P<0.001, respectively).”   Interleukin-6 stimulates inflammatory and …
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The post Heart Changes One Year Post-Kidney Donation appeared first on Living Do........ Read more »

Yilmaz BA, Caliskan Y, Yilmaz A, Ozkok A, Bilge AK, Deniz G, Sariyar M, & Yildiz A. (2014) Cardiovascular-Renal Changes After Kidney Donation: One-Year Follow-Up Study. Transplantation. PMID: 25226174  

  • September 30, 2014
  • 05:06 AM
  • 123 views

Autoimmune thyroiditis and depressive disorder

by Paul Whiteley in Questioning Answers

"Our study demonstrates a strong association between anti-TPO levels, which are considered to be of diagnostic value for autoimmune thyroiditis... with uni- or bipolar depression.""Beware the bad cat bearing a grudge"So said the study published by Detlef Degner and colleagues [1]. Anti-TPO antibodies by the way, refers to anti-thyroid peroxidase antibodies which, as the name suggests, are antibodies against thyroid peroxidase, an important step in the production of thyroid hormone........ Read more »

Degner D, Haust M, Meller J, Rüther E, & Reulbach U. (2014) Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients. European archives of psychiatry and clinical neuroscience. PMID: 25193677  

  • September 29, 2014
  • 06:07 PM
  • 149 views

Cat and Dogs: seeking solutions with sniffing canines and science

by Cobb & Hecht in Do You Believe In Dog?

Hi Mia and Julie,  First of all, I LOVE your blog! After meeting at SPARCS this past summer (summer for us in North America.. I take it summer is just beginning in Australia!), I’ve followed it closely.  You do amazing things for the promotion of  canine science. Serious love. A bit of background for the readers: I’m currently doing my PhD at Dalhousie University in Halifax, Nova Scotia in Canada, under the supervision of Dr. Simon Gadbois. Dr. Gadbois........ Read more »

  • September 29, 2014
  • 05:12 PM
  • 131 views

New Protein Implicated in Alzheimer’s

by Gabriel in Lunatic Laboratories

Alzheimer's prevention has made some strides in recent years. We've even identified some new causes, and in some cases we can do both. In fact, researchers have now shown that low levels of the protein progranulin in the brain can increase the formation of amyloid-beta plaques (a hallmark of Alzheimer's disease). These plaques can cause neuroinflammation, and worsen memory deficits in a mouse model of this condition. Conversely, by using a gene therapy approach to elevate progranulin levels, sci........ Read more »

Minami, S., Min, S., Krabbe, G., Wang, C., Zhou, Y., Asgarov, R., Li, Y., Martens, L., Elia, L., Ward, M.... (2014) Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. Nature Medicine. DOI: 10.1038/nm.3672  

  • September 29, 2014
  • 10:32 AM
  • 132 views

Family Attachment and the Brain Cingulate Cortex

by William Yates, M.D. in Brain Posts

Healthy family attachment provides a key element for social support and successful interpersonal relationships.Several brain regions as well as hormonal factors appear to modulate positive emotional responses to family members.I have previously reviewed several studies involving the prosocial effects of the hormone oxytocin and the related hormone vasopressin.Nicolas Rusch from the Department of Psychiatry at Ulm University in Germany along with colleagues in Brazil and London recently published........ Read more »

  • September 29, 2014
  • 04:35 AM
  • 132 views

Term vs. preterm birth and the presentation of autism

by Paul Whiteley in Questioning Answers

The paper by Katherine Bowers and colleagues [1] continues the interest in the concept of 'the autisms' with their observations on the presentation of autism (and its comorbidities) when looking at those "born preterm versus those born at term".We'd better get back, 'cause it'll be dark soon, and they mostly come at night... mostlyBased on an analysis of quite a healthy participant number heading up to 900 "males and females with autism spectrum disorder", authors reported on several phenotypic ........ Read more »

  • September 28, 2014
  • 03:37 PM
  • 149 views

The Genetic Evolutionary Arms Race

by Gabriel in Lunatic Laboratories

Genes are tricky little buggers, the stuff that makes us up has fought the test of time to make it to where we are today. It is thought that our genes changed in an attempt to outpace other life, albeit random changes.That might only be half right however, new findings suggest that there is an evolutionary arms race going on within the genome against, of all things, itself. This inherent competition of primates drove the evolution of complex regulatory networks that orchestrate the activity of ........ Read more »

Jacobs, Greenberg, Nguyen, Haeussler, Ewing, Katzman, Paten, Salama . (2014) An evolutionary arms race betweenKRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. Nature. info:/10.1038/nature13760

  • September 28, 2014
  • 12:00 PM
  • 147 views

Numbers on a scale: How bad did you say your pain was?

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

Have you ever been asked to give your pain rating on a scale of 0 – 10 (where 0 = no pain at all and 10 = most extreme pain you can imagine)? Have you ever tried to work out whether today’s pain is worse than yesterdays? What does a pain rating tell us?... Read more »

  • September 27, 2014
  • 03:50 AM
  • 160 views

Yes, people with autism do have headaches

by Paul Whiteley in Questioning Answers

I don't mean to be haughty but a sentence included in the paper by Victorio [1] led to the title of today's very quick post. Based on a chart review of patients diagnosed with an autism spectrum disorder (ASD) attending a neurology clinic, the author concluded that "ASD patients, despite being known to have indifference to pain, can experience headaches".Pain is something which has cropped up quite a bit in the autism research arena and has appeared more than once on this blog (see here and see ........ Read more »

  • September 26, 2014
  • 02:15 PM
  • 187 views

“GMO” Foods (Once Again) Proven Safe

by Gabriel in Lunatic Laboratories

GMO, I shudder every time I hear someone talk about the “dangers”. It’s one of the new buzzwords that doesn’t actually mean anything, but still manages to scare people. Well a new scientific review reports that the performance and health of food-producing animals consuming genetically engineered feed, first introduced 18 years ago, has been comparable to that of animals consuming non-GE feed. Not that this will stop people from spreading fear, but it’s a start.... Read more »

  • September 26, 2014
  • 10:30 AM
  • 173 views

Walking Really Is Just Falling and Catching Yourself

by Elizabeth Preston in Inkfish

The flailing of a gymnast who’s missed a step on the balance beam might not be far off from what the rest of us experience every day. Each step we take is really a tiny fall, a mathematical model suggests. The random-looking variation in our footfalls is actually a series of corrections. Our strides are […]The post Walking Really Is Just Falling and Catching Yourself appeared first on Inkfish.... Read more »

  • September 26, 2014
  • 05:32 AM
  • 131 views

Schizophrenia after child and adolescent psychiatric disorders

by Paul Whiteley in Questioning Answers

More of a 'bring to your attention' post today, as I bring to your attention(!) the paper by Cecilie Frejstrup Maibing and colleagues [1] who concluded: "The risk of being diagnosed with schizophrenia spectrum disorders [SSD] after a child and adolescent psychiatric disorder was significantly increased particularly in the short term but also in the long-term period"."I coulda been a contender"The findings were based on an analysis of one of those very informative Scandinavian........ Read more »

  • September 25, 2014
  • 10:37 AM
  • 180 views

A New Discovery in the Treatment of Autoimmunity and Chronic Inflammation

by Gabriel in Lunatic Laboratories

Lupus, Type 1 diabetes, and multiple sclerosis are all diseases brought on by autoimmunity — the bodies inability to tell itself apart from foreign invaders. Finding a cure, or even a suitable treatment has been to put it gently a long, painful road, with little to show for it. On the forefront of the war against the body betrayal is immunosuppressants, which with them carry their own set of side effects and in most cases only off mild to moderate relief of symptoms. But that is all changing a........ Read more »

Dubiella C, Cui H, Gersch M, Brouwer AJ, Sieber SA, Krüger A, Liskamp RM, & Groll M. (2014) Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site. Angewandte Chemie (International ed. in English). PMID: 25244435  

  • September 25, 2014
  • 05:10 AM
  • 172 views

Temporal trends in US autism prevalence: mainly real increase

by Paul Whiteley in Questioning Answers

"Diagnosed autism prevalence has risen dramatically in the U.S over the last several decades and continued to trend upward as of birth year 2005. The increase is mainly real and has occurred mostly since the late 1980s"."They call me Cha Cha because I'm the best dancer at St. Bernadette's"That was the conclusion reached in the paper by Cynthia Nevison [1] (open-access) following her analysis of temporal trends in autism diagnosis for birth years between 1970 and 2005. Based on an analysis o........ Read more »

  • September 24, 2014
  • 03:54 PM
  • 130 views

A new Medicine may help Lupus Sufferers

by Gabriel in Lunatic Laboratories

Lupus, a particularly bad hell on earth for people suffering from it. Lupus is caused by autoimmunity, in where the body attacks itself. I have a special place in my heart for people suffering from the disease because my Uncle suffered from it. There is no cure and only moderately effective treatments for the disorder, which causes, in some cases, the most excruciating pain you will ever feel. Thankfully new findings by a biomedical engineering team raise hope for a new class of drugs to treat l........ Read more »

  • September 24, 2014
  • 12:37 PM
  • 172 views

Why Women Give Better Gifts

by William Yates, M.D. in Brain Posts

Consumer spending on gifts for birthdays and holidays is a multi-billion dollar big business.Despite this large economic impact, little research examines factors associated with gift recipient satisfaction.Selecting good gifts for others involves a complex social decision-making process related to judging the value hierarchy of others.A study from the Netherlands recently published in the journal PLOS One featured three experiments on gift selection in a series of men and women.The design of the........ Read more »

Pollmann MM, & van Beest I. (2013) Women are better at selecting gifts than men. PloS one, 8(12). PMID: 24386082  

  • September 24, 2014
  • 11:42 AM
  • 143 views

Genetics "Experts" Surveyed on Returning Incidental Findings

by Daniel Koboldt in Massgenomics

In my last post, I wrote about the return of results from next-gen sequencing, specifically a recent paper in AJHG about secondary findings in ~6500 ESP exomes. Today we’ll delve into another paper in the same issue on the attitudes of genetics professionals on return of incidental findings from whole genome sequencing (WGS) and exome sequencing […]... Read more »

  • September 24, 2014
  • 09:10 AM
  • 159 views

6 Things You Need To Know About Your Microbiome

by Bill Sullivan in The 'Scope

Surprising new facts about the bacteria living on and in you.... Read more »

Lax S, Smith DP, Hampton-Marcell J, Owens SM, Handley KM, Scott NM, Gibbons SM, Larsen P, Shogan BD, Weiss S.... (2014) Longitudinal analysis of microbial interaction between humans and the indoor environment. Science (New York, N.Y.), 345(6200), 1048-52. PMID: 25170151  

Bisgaard, H., Li, N., Bonnelykke, K., Chawes, B., Skov, T., Paludan-Müller, G., Stokholm, J., Smith, B., & Krogfelt, K. (2011) Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. Journal of Allergy and Clinical Immunology, 128(3), 646-65200000. DOI: 10.1016/j.jaci.2011.04.060  

Stefka, A., Feehley, T., Tripathi, P., Qiu, J., McCoy, K., Mazmanian, S., Tjota, M., Seo, G., Cao, S., Theriault, B.... (2014) Commensal bacteria protect against food allergen sensitization. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1412008111  

Williams NT. (2010) Probiotics. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 67(6), 449-58. PMID: 20208051  

  • September 24, 2014
  • 07:20 AM
  • 60 views

Orthodontics: What would the Martian say?

by Kevin OBrien in Kevin OBrien's Orthodontic Blog

Orthodontics: What would the Martian say? This blog has a strange title and I will start by explaining this. When I was a much younger researcher, I had several in depth conversations with a now retired USA based Professor of Orthodontics, he always attempted to open my mind. A favourite of his was to ask this […]
The post Orthodontics: What would the Martian say? appeared first on Kevin O'Brien's Orthodontic Blog.
... Read more »

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