Researchers have found that the adults, who have less education and income, are more prone to be frail, i.e. physically weak, in the older ages whether they are from lower income countries or from higher income countries.
Researchers, in the present study, utilized the two multi-country studies: the Study on Health, Ageing and Retirement in Europe (SHARE) and the World Health Organization's (WHO) Study on global AGEing and adu........ Read more »
Harttgen K, Kowal P, Strulik H, Chatterji S, Vollmer S. (2013) Patterns of Frailty in Older Adults: Comparing Results from Higher and Lower Income Countries Using the Survey of Health, Ageing and Retirement in Europe (SHARE) and the Study on Global AGEing and Adult Health (SAGE). PLoS ONE. DOI: 10.1371/journal.pone.0075847
Researchers in Denmark recently reviewed the current research on exercise programs for injury prevention, and crunched some numbers to see what does or doesn’t work. What did they find?
Strength training reduces sports injuries by about 68%, proprioception training reduces injuries by about 45%, and stretching programs do not reduce injuries reliably. Interestingly, combined programs only reduced injuries by about 35% (all of which included strength training)...... Read more »
Lauersen JB, Bertelsen DM, & Andersen LB. (2013) The effectiveness of exercise interventions to prevent sports injuries: a systematic review and meta-analysis of randomised controlled trials. British journal of sports medicine. PMID: 24100287
A lot of public attention is given over to cancer, genetic disease and lolcats, but have you ever thought of what will happen if we ever run out of antibiotics? Think about it…playing football would no longer be a fun weekend activity; it could become a battle of life and death as you grapple with that infection you got from a scraped knee, an infection that modern medicine would be helpless to cure. Bacterial antibiotic-resistance is becoming a major problem. There’s no denying it......... Read more »
Gerdes K. (2000) Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress. Journal of bacteriology, 182(3), 561-72. PMID: 10633087
Pedersen K, Christensen SK, & Gerdes K. (2002) Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins. Molecular microbiology, 45(2), 501-10. PMID: 12123459
Masters athletes complain about aches and pain just as much as anyone else. Maybe more. They may complain more because they tend to hurt themselves fairly often. Masters athletesThe post Masters Athletes: life-long physical activity helps keep your brain from falling apart appeared first on WODMasters.... Read more »
Tseng BY, Gundapuneedi T, Khan MA, Diaz-Arrastia R, Levine BD, Lu H, Huang H, & Zhang R. (2013) White matter integrity in physically fit older adults. NeuroImage, 510-6. PMID: 23769914
Debette S, & Markus HS. (2010) The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ (Clinical research ed.). PMID: 20660506
I spent last night rewatching the Steven Soderbergh classic “Contagion“. Halfway through I realized that a story of an unidentified, mind-bending infectious brain disease would make the perfect neuroscience halloween tale. This is not “based” on a true story. It IS a true story. The year is 1917. Dr. Constantin Economo sat deep in thought, staring […]... Read more »
Vilensky JA, Foley P, & Gilman S. (2007) Children and encephalitis lethargica: a historical review. Pediatric neurology, 37(2), 79-84. PMID: 17675021
Dourmashkin RR, Dunn G, Castano V, & McCall SA. (2012) Evidence for an enterovirus as the cause of encephalitis lethargica. BMC infectious diseases, 136. PMID: 22715890
Dale RC, Church AJ, Surtees RA, Lees AJ, Adcock JE, Harding B, Neville BG, & Giovannoni G. (2004) Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity. Brain : a journal of neurology, 127(Pt 1), 21-33. PMID: 14570817
I ran across an interesting genetic study examining the potential genetic contributions to educational attainment. There have been quite a few genome-wide association studies (GWAS) of intelligence quotient (IQ).... Read more »
Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, Westra HJ, Shakhbazov K, Abdellaoui A, Agrawal A.... (2013) GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (New York, N.Y.), 340(6139), 1467-71. PMID: 23722424
FVIII light chain expressed in Pichia. Antibody AND phospholipid both bind this light chain. Literature says either but not both can bind. ... Read more »
Sudheer Reddy AR, Padikara Kutty Satheeshkumar, & Mookambeswaran A. Vijayalakshmi. (2013) Expression, purification, and partial in vitro characterization of biologically active human coagulation Factor VIII chain (A3-C1-C2) in Pichia pastoris. Applied Biochemistry and Biotechnology. DOI: 10.1007/s12010-013-0338-4
In today’s economic environment, globalization of pharmaceutical products has turned into the key to success for drug manufacturers. Investors in new drug development are therefore required to do more at less cost and faster rate now. However, sponsors are facing a new challenge due to ethnic factors, as the pharmacodynamic or clinical data in the original population could vary with the population in the new region. ... Read more »
by Andrea in Science of Eating Disorders
Recently, I was browsing the Twittersphere and came across (yet another) tweet about so-called “drunkorexia,” or the phenomenon of drinking to excess coupled with restrictive behaviours around food. After firing off a mildly miffed tweet bemoaning our societal tendency to add the suffix “orexia” to all “new” potentially problematic behaviours around food, I took to Scholar’s Portal to see if academics, too, were using this term. I wondered if “drunkorexia” was piquing sch........ Read more »
Barry AE, & Piazza-Gardner AK. (2012) Drunkorexia: understanding the co-occurrence of alcohol consumption and eating/exercise weight management behaviors. Journal of American College Health, 60(3), 236-43. PMID: 22420701
The effects of IBS on quality of life may be more substantial than those of many other chronic diseases. It affects school, work and life, putting the sufferers at risk for social isolation. Numerous books, columns and blogs about this condition usually affirm that social problems arise because the sufferers are trying to hide the fact they have IBS from others. Keeping secrets is stressful, while being upfront and coming out of the closet is the best strategy. Is it really?........ Read more »
I’m guessing you’ve all heard of oral or genital thrush. It’s very common- one-third of women will have an incidence of vaginal thrush once in their lifetime. You may think thrush is a nasty infection, however the fungus that causes it (Candida albicans) can also enter the bloodstream and spread throughout the body to cause invasive candidiasis, which is much worse.
Symptoms for invasive candidiasis are non-specific, generally they include fever and chills and other symptom........ Read more »
Shapiro RS, Uppuluri P, Zaas AK, Collins C, Senn H, Perfect JR, Heitman J, & Cowen LE. (2009) Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. Current biology : CB, 19(8), 621-9. PMID: 19327993
The recent PBS Frontline series on concussion sequelae in the NFL is an important advance in the discussion on this important topic. Significant research is needed to better understand the risk of football-related brain injury.An additional important issue on this topic related to the interaction between sport-related brain trauma and developmental stage. Football training and full-contact games begin during elementary school in many parts of the U.S. So this is not just an NFL........ Read more »
Savica R, Parisi JE, Wold LE, Josephs KA, & Ahlskog JE. (2012) High school football and risk of neurodegeneration: a community-based study. Mayo Clinic proceedings. Mayo Clinic, 87(4), 335-40. PMID: 22469346
Ginger a sailor's best friend? An apple a day keeps the docter away? All kinds of health benefits of seawater, seaweed and silver? I decided to find out if actual peer-review concurs in any way to these claims. Turns out there is some agreement.... Read more »
Slapak I, Skoupá J, Strnad P, & Horník P. (2008) Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children. Archives of otolaryngology--head , 134(1), 67-74. PMID: 18209140
Nezamoddin Berjis, Seyyed Mehdi Sonbolastan, Seyyed Hanif Okhovat, Ali Asghar Narimani, & Jaleh Razmjui. (2011) Normal Saline Versus Hypertonic 3% Saline: It’s Efficacy in Non-Acute Rhinosinusitis . Iranian Journal of Otorhinolaryngology. info:/
Zava TT, & Zava DT. (2011) Assessment of Japanese iodine intake based on seaweed consumption in Japan: A literature-based analysis. Thyroid research, 14. PMID: 21975053
Jun Sung Kim, DVM, PhD,a Eunye Kuk, MS,b Kyeong Nam Yu, MS,a Jong-Ho Kim, MS,g, Sung Jin Park, BS,a Hu Jang Lee, DVM, PhD,c So Hyun Kim, DVM, PhD,d, Young Kyung Park, DVM, MS,d Yong Ho Park, DVM, PhD,d, Cheol-Yong Hwang, DVM, PhD,e Yong-Kwon Kim, PhD,f Yoon-Sik Lee, PhD,g, Dae Hong Jeong, PhD,b,, & Myung-Haing Cho, DVM, PhD. (2007) Antimicrobial effects of silver nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine. DOI: 10.1016/j.nano.2006.12.001
Nanthakomon T, & Pongrojpaw D. (2006) The efficacy of ginger in prevention of postoperative nausea and vomiting after major gynecologic surgery. Journal of the Medical Association of Thailand . PMID: 17725149
Regular readers are probably quite tired of hearing me go on about autoimmunity and autism. It's a research topic which seems to come up pretty regularly these days for all manner of reasons and in all manner of places (see here). Indeed, now even being linked to the new kid on the block that is MAR autism (see here).As I've mentioned before, I don't think we can quite say that all autism (all of the autisms sorry) 'are autoimmunity' because immune function is a pretty varied thing when it ........ Read more »
Milo Careaga,Robin L. Hansen,Irva Hertz-Piccotto,Judy Van de Water,Paul Ashwood. (2013) Increased Anti-Phospholipid Antibodies in Autism Spectrum Disorders. Mediators of Inflammation. DOI: 10.1155/2013/935608
Photo: Steven PamThere is an industry in Australia that relies on an integral piece of equipment, but the system behind product development process is flawed, and lives are at stake. From farm dogs to military explosive detection dogs, guide dogs to greyhounds, Australia’s working and sporting dog industry claims a 50-70% fail rate as normal. The welfare of these dogs is intimately linked to their working performance. It can be an emotive topic, so let’s take the emotion out of it and o........ Read more »
Kruger Justin, & Dunning David. (1999) Unskilled and unaware of it: How difficulties in recognizing one's own incompetence lead to inflated self-assessments. Journal of Personality and Social Psychology, 77(6), 1121-1134. DOI: 10.1037//0022-3522.214.171.1241
Dunning David, Johnson Kerri, Ehrlinger Joyce, & Kruger Justin. (2003) Why people fail to recognize their own incompetence. Current Directions in Psychological Science, 12(3), 83-87. DOI: 10.1111/1467-8721.01235
Ehrlinger Joyce, Johnson Kerri, Banner Matthew, Dunning David, & Kruger Justin. (2008) Why the unskilled are unaware: Further explorations of (absent) self-insight among the incompetent. Organizational Behavior and Human Decision Processes, 105(1), 98-121. DOI: 10.1016/j.obhdp.2007.05.002
Dunning David. (2011) The Dunning-Kruger effect: On being ignorant of one's own ignorance. Advances in Experimental Social Psychology, 247-296. DOI: 10.1016/B978-0-12-385522-0.00005-6
There are lots of exciting new ideas for fighting cancer. One idea is to genetically engineer T cells against cancer – but how exactly do we go about programming this ‘search and destroy’ activity? ... Read more »
Does your workweek schedule dig you into an ever-deepening hole of sleep deprivation? Do you sleep in on the weekends to try to boost yourself back out? You're in good company. But even if you feel recovered by the following week, your brainpower might be suffering.
In a survey by the National Sleep Foundation, 40 percent of respondents said they try to "catch up" on sleep during the weekend. Pennsylvania State University professor and physician Alexandros Vgontzas, along with a group of col........ Read more »
Pejovic S, Basta M, Vgontzas AN, Kritikou I, Shaffer ML, Tsaoussoglou M, Stiffler D, Stefanakis Z, Bixler EO, & Chrousos GP. (2013) Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance. American journal of physiology. Endocrinology and metabolism, 305(7). PMID: 23941878
The term MAR autism - maternal autoantibody-related autism - whilst still a relatively new addition to the autism research vocabulary, has nevertheless already courted some controversy. This follows a decision to try and commercialise the growing research base in this area (see here) which raised a few eyebrows in various quarters.Speculating on a dead cat bounce? @ Wikipedia As I indicated on my previous post about said commercialisation, there are a few questions which perhaps ........ Read more »
Brimberg L, Sadiq A, Gregersen PK, & Diamond B. (2013) Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder. Molecular psychiatry. PMID: 23958959
Everyone knows that too much sugar is bad for you, but how much is too much? According to a study …Continue reading »... Read more »
Ruff JS, Suchy AK, Hugentobler SA, Sosa MM, Schwartz BL, Morrison LC, Gieng SH, Shigenaga MK, & Potts WK. (2013) Human-relevant levels of added sugar consumption increase female mortality and lower male fitness in mice. Nature communications, 2245. PMID: 23941916
So just last night my twitter feed was abuzz with bacterial infection drama. The Frontline PBS show was doing a whole episode called “Hunting the Nightmare Bacteria” and based on the chatter I’d say they struck a nerve. Our antibiotic arsenal is failing us, and it’s crucial to figure out new ways to battle these […]... Read more »
Gillespie J. J., Wattam A. R., Cammer S. A., Gabbard J. L., Shukla M. P., Dalay O., Driscoll T., Hix D., Mane S. P., & Mao C. (2011) PATRIC: the Comprehensive Bacterial Bioinformatics Resource with a Focus on Human Pathogenic Species. Infection and Immunity, 79(11), 4286-4298. DOI: 10.1128/IAI.00207-11
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