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  • April 12, 2016
  • 05:00 PM
  • 177 views

Dr. Kudenchuk is Misrepresenting ALPS as 'Significant'

by Rogue Medic in Rogue Medic

This study was very well done, but it was not designed to provide valid information about the effects of amiodarone or lidocaine on witnessed arrests or on EMS Witnessed arrests. Maybe the authors were overconfident.

In resuscitation research, we have abundant evidence that overconfidence is much more common than improvements in outcomes.... Read more »

Kudenchuk, P., Brown, S., Daya, M., Rea, T., Nichol, G., Morrison, L., Leroux, B., Vaillancourt, C., Wittwer, L., Callaway, C.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. New England Journal of Medicine. DOI: 10.1056/NEJMoa1514204  

Glover BM, Brown SP, Morrison L, Davis D, Kudenchuk PJ, Van Ottingham L, Vaillancourt C, Cheskes S, Atkins DL, Dorian P.... (2012) Wide variability in drug use in out-of-hospital cardiac arrest: A report from the resuscitation outcomes consortium. Resuscitation. PMID: 22858552  

  • April 12, 2016
  • 11:53 AM
  • 187 views

Bioterrorism: Lessons Learned From Anthrax

by Rita dos Santos Silva in United Academics

Anthrax attacks in 2001 were a wake-up call for the importance of preparedness.... Read more »

Riedel S. (2005) Anthrax: a continuing concern in the era of bioterrorism. Proceedings (Baylor University. Medical Center), 18(3), 234-43. PMID: 16200179  

Anderson, P. (2012) Bioterrorism: Toxins as Weapons. Journal of Pharmacy Practice, 25(2), 121-129. DOI: 10.1177/0897190012442351  

  • April 12, 2016
  • 02:51 AM
  • 207 views

Evidence of blurring on the autism spectrum edges

by Paul Whiteley in Questioning Answers

A quote to begin: "multiple types of genetic risk for ASDs [autism spectrum disorders] influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder."That was the bottom line of the findings reported by Elise Robinson and colleagues [1] looking at data from "several large ASD consortium and population-based resources" (N~38,000) including the fabulous resource that is ALSPAC. Specifically an........ Read more »

Robinson EB, St Pourcain B, Anttila V, Kosmicki JA, Bulik-Sullivan B, Grove J, Maller J, Samocha KE, Sanders SJ, Ripke S.... (2016) Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nature genetics. PMID: 26998691  

  • April 11, 2016
  • 02:19 AM
  • 196 views

Levels of paranoia are higher in autism: systematic review

by Paul Whiteley in Questioning Answers

Paranoia, defined as the unfounded or exaggerated idea that something or someone is deliberately trying to psychologically, physically or financially harm you, is not an uncommon transient sentiment among the general population at one time or another. On a more pathological level, paranoid schizophrenia perhaps represents the archetypal label where paranoia assumes an altogether more persistent and 'life-changing' effect; also potentially escalating into more extreme behaviour/s.The idea th........ Read more »

  • April 9, 2016
  • 03:59 AM
  • 233 views

Is empathising rather than systemising linked to maths achievement?

by Paul Whiteley in Questioning Answers

"Contrary to our hypothesis, we found no relationship between systemizing and math achievement after controlling for domain general abilities and no relationship between the systemizing brain type (greater discrepancy between systemizing and empathizing) and math achievement."That quote taken from the study published by Emily Escovar and colleagues [1] (open-access available here) provides some blogging fodder today. Based on some ideas proposed in autism research circles that "mathematics ........ Read more »

  • April 8, 2016
  • 09:56 AM
  • 238 views

The Antibacterial Resistance Threat: Are We Heading Toward a Post-Antibiotic Era?

by EE Giorgi in CHIMERAS

Source: PEW Charitable TrustsThe above graphic, from the Antibiotic Resistance Project by the PEW charitable trusts, summarizes how alarming the emergence of drug resistant bacterial strains has gotten over the past few decades. According to data from the Center for Disease Control (CDC), every year 2 million Americans acquire drug-resistant infections [1], in other words infections that do not respond to treatment with ordinary antibiotics. Not only do drug-resistant infections require muc........ Read more »

Hollis, A., & Ahmed, Z. (2013) Preserving Antibiotics, Rationally. New England Journal of Medicine, 369(26), 2474-2476. DOI: 10.1056/NEJMp1311479  

Cherednichenko, G., Zhang, R., Bannister, R., Timofeyev, V., Li, N., Fritsch, E., Feng, W., Barrientos, G., Schebb, N., Hammock, B.... (2012) Triclosan impairs excitation-contraction coupling and Ca2 dynamics in striated muscle. Proceedings of the National Academy of Sciences, 109(35), 14158-14163. DOI: 10.1073/pnas.1211314109  

Van Boeckel, T., Brower, C., Gilbert, M., Grenfell, B., Levin, S., Robinson, T., Teillant, A., & Laxminarayan, R. (2015) Global trends in antimicrobial use in food animals. Proceedings of the National Academy of Sciences, 112(18), 5649-5654. DOI: 10.1073/pnas.1503141112  

  • April 8, 2016
  • 03:03 AM
  • 225 views

Time to screen for vitamin D and calcium levels in autism

by Paul Whiteley in Questioning Answers

"The data highlight a gap in calcium and vitamin D supplement prescribing practices among providers caring for children with ASD [autism spectrum disorder] as well as a gap in the practice of checking 25(OH)D levels."So said research published by Shylaja Srinivasan and colleagues [1] (open-access) with findings tied into an important issue in autism research and clinical practice: potential inequalities when it comes to the provision of suitable healthcare and accessing appropriat........ Read more »

  • April 7, 2016
  • 05:19 PM
  • 246 views

Manufacturing human tissue from textiles

by Dr.Jekyll in Lunatic Laboratories

Until we can figure out our lack of regenerating our bodies, or can convince more people to donate organs, we are at mercy of either luck or technology. Bio 3-D printing offers hope that we can print personalized organs as need and rejection free. But the technology relies almost solely with tissue engineers, there job is to find processes using novel bio-materials seeded with stem cells to grow and replace missing tissues.

... Read more »

  • April 7, 2016
  • 04:18 AM
  • 257 views

On genes, environment, broccoli and autism (again)

by Paul Whiteley in Questioning Answers

Picture: Carl Warner: http://www.carlwarner.com/I'm serving up two peer-reviewed papers for your reading delight today which draw attention to the ideas that (a) the 'causes' of autism are likely complex and as heterogeneous as the label itself, (b) gene x environment interactions affecting risk of autism are starting to get some good scientific research airtime and (c) don't 'dis the broccoli [chemical] autism connection just yet...The first paper by Brandon Pearson and colleagues [1] (ope........ Read more »

  • April 6, 2016
  • 05:02 PM
  • 269 views

Uncovering the genetic elements that drive regeneration

by Dr. Jekyll in Lunatic Laboratories

Lose a hand or a leg? It will grow back… oh wait, it won’t, but why not? Trace our evolution — long before the shedding of gills or the development of opposable thumbs — and you will likely find a common ancestor with the amazing ability to regenerate lost body parts. There is theoretically no reason why we shouldn’t be able to regenerate, not quite like in the movie Deadpool, but come on, would you really complain at that point?

... Read more »

Kang, J., Hu, J., Karra, R., Dickson, A., Tornini, V., Nachtrab, G., Gemberling, M., Goldman, J., Black, B., & Poss, K. (2016) Modulation of tissue repair by regeneration enhancer elements. Nature. DOI: 10.1038/nature17644  

  • April 6, 2016
  • 12:03 PM
  • 292 views

Words We Say to Dogs (and Other Things Scientists Learned Watching People Play with Pets)

by Elizabeth Preston in Inkfish



"Who wants to generate some DATA??" are probably not words you've ever said while taking your dog's leash and tennis ball from the closet. But thanks to videos of people playing with their dogs, scientists now know what words you are likely to use. They also discovered how women's tussling and tug-of-war are different from men's—and what the professionals do better.

The scientists are Alexandra Horowitz and Julie Hecht of Barnard College's Dog Cognition Lab. They asked members of the p........ Read more »

  • April 6, 2016
  • 12:02 PM
  • 36 views

World Serology Bank: Key to a Better Understanding of Infectious Disease Dynamics?

by Pranab Chatterjee in Zoonoticus

An article published in The Lancet today has highlighted the possibility of establishing a World Serology Bank to better understand the dynamics of infectious disease dynamics, especially in an era where vaccinations against infectious diseases is becoming more and more prevalent. With rapid advance in diagnostic technologies, there has been impressive progress in what used […]... Read more »

  • April 6, 2016
  • 03:13 AM
  • 262 views

Age at autism diagnosis has not decreased in the UK over the past decade

by Paul Whiteley in Questioning Answers

"This study of over 2000 children shows that the median age of ASD [autism spectrum disorder] diagnosis in the UK has not reduced in the last decade."That was the rather important message included in the study by Denise Brett and colleagues [1] (open-access) reporting combined results from the Daslne (Database of Children with ASD Living in the North East of England) and ASD-UK (Autism Spectrum Database-UK) initiatives. Including data from over 2100 children and families, researchers s........ Read more »

  • April 5, 2016
  • 05:17 PM
  • 244 views

Suicidal thinking and US veterans

by Dr. Jekyll in Lunatic Laboratories

Something very personal about me, the thought of suicide is never too far behind. It is to the point that I need to qualify it to my counselor when I am asked if I have thoughts of suicide, I always do. A new study shows that I am far from alone Nearly 14 percent of military veterans reported suicidal thinking at one or both phases of a two-year Veterans Affairs (VA) study.... Read more »

  • April 5, 2016
  • 02:49 AM
  • 216 views

Folate receptor autoantibodies (FRAAs) and a 'type' of autism?

by Paul Whiteley in Questioning Answers

"This study suggests that FRAAs [folate receptor α (FRα) autoantibodies] are associated with specific physiological and behavioral characteristics in children with ASD [autism spectrum disorder] and provides support for the notion that these biomarkers may be useful for subgrouping children with ASD, especially with respect to targeted treatments."So said the study findings published by Richard Frye and colleagues [1] (open-access) who continued a research theme looking at ........ Read more »

Frye, R., Delhey, L., Slattery, J., Tippett, M., Wynne, R., Rose, S., Kahler, S., Bennuri, S., Melnyk, S., Sequeira, J.... (2016) Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups. Frontiers in Neuroscience. DOI: 10.3389/fnins.2016.00080  

  • April 4, 2016
  • 06:15 PM
  • 202 views

Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest

by Rogue Medic in Rogue Medic

I wrote about the start of the ALPS (Amiodarone, Lidocaine, Placebo Study) in 2012[1] and the results are now in.
... Read more »

Kudenchuk, P., Brown, S., Daya, M., Rea, T., Nichol, G., Morrison, L., Leroux, B., Vaillancourt, C., Wittwer, L., Callaway, C.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. New England Journal of Medicine. DOI: 10.1056/NEJMoa1514204  

  • April 4, 2016
  • 03:57 PM
  • 222 views

Your brain has an altered response to desirable foods

by Dr. Jekyll in Lunatic Laboratories

Hungry? Well, let’s face it, that pizza looks much better than the salad. Don’t deny it salad lovers, we all know behind closed doors you look at plenty of food porn to satiate your desires. Understanding the motivations that drive us to eat is important when we talk about weight loss and how we attempt to structure diets. Now a new study shows that for overweight individuals, the brain responses differently to desirable foods., but hold that thought, because there is hope.

... Read more »

  • April 4, 2016
  • 02:37 AM
  • 209 views

Relative age and ADHD

by Paul Whiteley in Questioning Answers

"ADHD children may just be immature, research suggests".So went the recent BBC headline with reference to the findings reported by Mu-Hong Chen and colleagues [1] (open-access) and the idea that: "Relative age, as an indicator of neurocognitive maturity, is crucial in the risk of being diagnosed with ADHD [attention-deficit hyperactivity disorder] and receiving ADHD medication among children and adolescents."Chen et al are not unfamiliar names discussed on this blog (see here........ Read more »

  • April 3, 2016
  • 03:17 PM
  • 228 views

Early detection of dementia in Parkinson’s disease might be key to treatment

by Dr. Jekyll in Lunatic Laboratories

If Parkinson’s disease wasn’t bad enough for families to have to learn to deal with, about 80% of patients also develop dementia. That’s the problem with the brain; while it has the amazing ability to adapt to just about anything, it can’t fix everything. There are no particularly good solutions to Parkinson’s or dementia, however, early detection of dementia is key to keeping it at bay and a new study may have a way to do just that.

... Read more »

Bertrand, J., McIntosh, A., Postuma, R., Kovacevic, N., Latreille, V., Panisset, M., Chouinard, S., & Gagnon, J. (2016) Brain Connectivity Alterations Are Associated with the Development of Dementia in Parkinson's Disease. Brain Connectivity, 6(3), 216-224. DOI: 10.1089/brain.2015.0390  

  • April 2, 2016
  • 04:43 PM
  • 248 views

Born to run? Love of exercise may start in the womb

by Dr. Jekyll in Lunatic Laboratories

If you see me on the street and I am running, there is a good chance you should be running as well, because something dangerous is coming. I don’t run, I hate to run, I loathe running, did I mention I don’t like to run? Maybe it’s all the running I did in the military, or if a new study is correct, it may have to do with my mother. Which is good, because now I can blame someone else for my hatred of running.

... Read more »

Eclarinal, J., Zhu, S., Baker, M., Piyarathna, D., Coarfa, C., Fiorotto, M., & Waterland, R. (2016) Maternal exercise during pregnancy promotes physical activity in adult offspring. The FASEB Journal. DOI: 10.1096/fj.201500018R  

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