About 10% of the US is diabetic, that doesn’t sound like a lot until you realize how many people there are in the US (roughly 311 million and counting). Think about it like this, every 7 seconds (roughly) a child is born. With that statistic every minute and 10 seconds leads to another person with diabetes. By the time you finish reading this, about two people in the US will be diagnosed with diabetes.[…]... Read more »
Liakat S, Bors KA, Xu L, Woods CM, Doyle J, & Gmachl CF. (2014) Noninvasive in vivo glucose sensing on human subjects using mid-infrared light. Biomedical optics express, 5(7), 2397-404. PMID: 25071973
There is no agreed terminology for how to refer to children with unexplained language problems, and diagnostic criteria are inconsistently applied. This blogpost sets the background to a Special Issue of International Journal of Language and Communication Disorders where these issues are discussed. Views are invited via live Twitter debate or internet forum.... Read more »
Bishop, D. (2010) Which Neurodevelopmental Disorders Get Researched and Why?. PLoS ONE, 5(11). DOI: 10.1371/journal.pone.0015112
Bishop, D., Clark, B., Conti-Ramsden, G., Norbury, C., & Snowling, M. (2012) RALLI: An internet campaign for raising awareness of language learning impairments. Child Language Teaching and Therapy, 28(3), 259-262. DOI: 10.1177/0265659012459467
Alternative medicine is garbage, there I said it. Thankfully there is a difference between alternative and "natural" medicine. I shudder at the term "natural" medicine, but that is typically what medicine based from things in nature (in other words practically all medicine used). Well to cut to the chase, new research shows that the onset of Alzheimer's disease can be slowed and some of its symptoms curbed by a natural compound that is found in pomegranate, unfortunately I am just a little skept........ Read more »
Alternative medicine is garbage, there I said it. Thankfully there is a difference between alternative and “natural” medicine. I shudder at the term “natural” medicine, but that is typically what medicine […]... Read more »
Top science news stories for this week include the cat genome, a real-life "Tremors" worm, a scientist ingesting tapeworms on purpose, and more!
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Tamazian, G., Simonov, S., Dobrynin, P., Makunin, A., Logachev, A., Komissarov, A., Shevchenko, A., Brukhin, V., Cherkasov, N., Svitin, A.... (2014) Annotated features of domestic cat – Felis catus genome. GigaScience, 3(1), 13. DOI: 10.1186/2047-217X-3-13
Cox, L., Yamanishi, S., Sohn, J., Alekseyenko, A., Leung, J., Cho, I., Kim, S., Li, H., Gao, Z., Mahana, D.... (2014) Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences. Cell, 158(4), 705-721. DOI: 10.1016/j.cell.2014.05.052
Russell, S., Gold, M., Reynolds, L., Willing, B., Dimitriu, P., Thorson, L., Redpath, S., Perona-Wright, G., Blanchet, M., Mohn, W.... (2014) Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases. Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2014.06.027
I cannot pretend to be an expert on microRNA (miRNA). Indeed, it was only after reading the paper by Mahesh Mundalil Vasu and colleagues  (open-access) talking about serum microRNA profiles in children diagnosed with an autism spectrum disorder (ASD), that I started my learning journey about these small non-coding RNAs. So please, go easy with me on this one...Hamlet @ Wikipedia Quite a good [short] introduction to microRNAs can be found here. If you want something a littl........ Read more »
Jonas Salk, you should know this name, but chances are you don’t. He was the inventor of the polio vaccine, a disease that was feared more than the atomic bomb. Today we don’t think about it, no one “gets” polio anymore. Scientists get a bad rap today with the whole “autism-vaccine” BS. But they don’t know Salk, instead of making a small [see: huge] fortune from the drug, he refused to patent it and gave it to the people for essentially free. You think this story would have a happy........ Read more »
Drexler JF, Grard G, Lukashev AN, Kozlovskaya LI, Böttcher S, Uslu G, Reimerink J, Gmyl AP, Taty-Taty R, Lekana-Douki SE.... (2014) Robustness against serum neutralization of a poliovirus type 1 from a lethal epidemic of poliomyelitis in the Republic of Congo in 2010. Proceedings of the National Academy of Sciences of the United States of America. PMID: 25136105
"Children with ADHD [attention-deficit hyperactivity disorder] or ASD [autism spectrum disorder] had an increased risk of allergic comorbidities, and those with both ADHD and ASD had the highest"."You built a time machine.. out of a DeLorean"That was the conclusion arrived at in the paper by Ting-Yang Lin and colleagues . For regular readers of this blog, this was yet another example of how Taiwan leads the way when it comes to the concept of 'big data' specifically employ........ Read more »
Lin, T., Lin, P., Su, T., Chen, Y., Hsu, J., Huang, K., Chang, W., Chen, T., Pan, T., Chen, M.... (2014) Autistic spectrum disorder, attention deficit hyperactivity disorder, and allergy: Is there a link? A nationwide study. Research in Autism Spectrum Disorders, 8(10), 1333-1338. DOI: 10.1016/j.rasd.2014.07.009
The ice bucket challenge has swept the nation in an effort to raise awareness for ALS. However, there seems to have been a number of concussions (or mild traumatic brain injuries) sustained from performing a seemingly altruistic act. Although some people may find the below video funny, concussions are a serious issue and can lead to serious consequences including executive dysfunction. Symptoms can include short loss of consciousness, feeling dazed and confused, loss of immediate memory, headach........ Read more »
Eierud C, Craddock RC, Fletcher S, Aulakh M, King-Casas B, Kuehl D, & LaConte SM. (2014) Neuroimaging after mild traumatic brain injury: Review and meta-analysis. NeuroImage. Clinical, 283-94. PMID: 25061565
Karr JE, Areshenkoff CN, & Garcia-Barrera MA. (2014) The neuropsychological outcomes of concussion: a systematic review of meta-analyses on the cognitive sequelae of mild traumatic brain injury. Neuropsychology, 28(3), 321-36. PMID: 24219611
Rohling, M., Larrabee, G., & Millis, S. (2012) The “Miserable Minority” Following Mild Traumatic Brain Injury: Who Are They and do Meta-Analyses Hide Them?. The Clinical Neuropsychologist, 26(2), 197-213. DOI: 10.1080/13854046.2011.647085
Stigma discredits individuals and groups, reducing social status and creating ‘spoiled identities’, says Goffman. It’s not a good thing. But hang on a minute – might it have a positive function? Could it actually help in terms of public health? Help by changing behaviour through societal pressure. If so, that would be a good thing, [...]
The post Stigma – a good thing? appeared first on Recovery Review.
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Williamson L, Thom B, Stimson GV, & Uhl A. (2014) Stigma as a public health tool: implications for health promotion and citizen involvement. The International journal on drug policy, 25(3), 333-5. PMID: 24810060
My Uncle suffered from Lupus. The disease itself should have a more sinister sounding name, given the effect it has on the body. Lupus is a form of autoimmune disease which attacks the body and causes an incredible amount of pain. It’s not pretty and complications from the disease can make life even more unbearable for people. There is no cure and sadly there are few treatments outside of managing the pain and side effects of the disease. Thankfully medical researchers have used DNA sequencing........ Read more »
Julia I Ellyard, Rebekka Jerjen, Jaime L Martin, Adrian Lee, Matthew A Field, Simon H Jiang, Jean Cappello, Svenja K Naumann, T Daniel Andrews, Hamish S Scott.... (2014) Whole exome sequencing in early-onset cerebral SLE identifies a pathogenic variant in TREX1. Arthritis . info:/10.1002/art.38824
The Charley Horse - why do we get these leg cramps and how can we prevent them? And why are they called a Charley Horse?!... Read more »
Coppin RJ, Wicke DM, & Little PS. (2005) Managing nocturnal leg cramps--calf-stretching exercises and cessation of quinine treatment: a factorial randomised controlled trial. The British journal of general practice : the journal of the Royal College of General Practitioners, 55(512), 186-91. PMID: 15808033
Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, & Hunter I. (2010) Three percent hypohydration does not affect threshold frequency of electrically induced cramps. Medicine and science in sports and exercise, 42(11), 2056-63. PMID: 20351595
A look into why we drink and what alcohol does to the brain.... Read more »
Németh Z, Kuntsche E, Urbán R, Farkas J, & Demetrovics Z. (2011) Why do festival goers drink? Assessment of drinking motives using the DMQ-R SF in a recreational setting. Drug and alcohol review, 30(1), 40-6. PMID: 21219496
Paul CA, Au R, Fredman L, Massaro JM, Seshadri S, Decarli C, & Wolf PA. (2008) Association of alcohol consumption with brain volume in the Framingham study. Archives of neurology, 65(10), 1363-7. PMID: 18852353
"Our results, combined with previous findings, suggest a 27% increase in the expected prevalence of ADHD [attention-deficit hyperactivity disorder] among young adults, comparing DSM-IV to DSM-5 criteria". So said the paper by Matte and colleagues  who as part of their study looked at "the prevalence of ADHD according to DSM-5 criteria".Europa @ Wikipedia The changes to the diagnosis of ADHD in DSM-5 can be seen here. The main difference between DSM-IV and DSM-5 diagnosis s........ Read more »
Matte, B., Anselmi, L., Salum, G., Kieling, C., Gonçalves, H., Menezes, A., Grevet, E., & Rohde, L. (2014) ADHD in DSM-5: a field trial in a large, representative sample of 18- to 19-year-old adults. Psychological Medicine, 1-13. DOI: 10.1017/S0033291714001470
Is 50% dextrose as good as 10% dextrose for treating symptomatic hypoglycemia?
If the patient is disoriented, but becomes oriented before the full dose of dextrose is given, is it appropriate to continue to treat the patient as if the patient were still disoriented? If your protocols require you to keep giving dextrose, do the same protocols require you to keep giving opioids after the pain is relieved? Is there really any difference?
50% dextrose has problems.... Read more »
Kiefer MV, Gene Hern H, Alter HJ, & Barger JB. (2014) Dextrose 10% in the treatment of out-of-hospital hypoglycemia. Prehospital and disaster medicine, 29(2), 190-4. PMID: 24735872
Levy SB, & Rosh AJ. (2006) Images in emergency medicine. Dextrose extravasation causing skin necrosis. Annals of emergency medicine, 48(3). PMID: 16934641
There is a war going on and it's not on foreign soil. This war is the fight for the status quo, a war where you are only worth your skin color, a war where you are only worth as much as your gender. This war is all around us, we see it everyday, yet we let it quietly pass us by. We do this because, in all actuality, we are losing this war. I don't blame you if you don't believe me, you shouldn't.[…]... Read more »
Weisman CS, & Chuang CH. (2014) Making the Most of the Affordable Care Act's Contraceptive Coverage Mandate for Privately-Insured Women. Women's health issues : official publication of the Jacobs Institute of Women's Health. PMID: 25128037
Short term effects of the Twin Block I am now back from my summer holidays and ready to start up the blog again. While I was away several systematic reviews have been published and there have been several comments on my blog post on self ligation. I will do my best to cover these over […]
The post Short term effects of the Twin Block appliance? appeared first on Kevin O'Brien's Orthodontic Blog.
... Read more »
Ehsani S, Nebbe B, Normando D, Lagravere MO, & Flores-Mir C. (2014) Short-term treatment effects produced by the Twin-block appliance: a systematic review and meta-analysis. European journal of orthodontics. PMID: 25052373
The paper by Woodman and colleagues  looking at trajectory and autism in adolescents and adults is the source material for today's post (another micropost). Concluding that: "Overall, autism symptoms and maladaptive behaviors were observed to improve over the study period" of about 8 years, the authors also reported that "greater improvements were associated with higher levels of maternal praise (based on maternal speech samples) and higher quality mother-child relationships". If I remember c........ Read more »
Woodman AC, Smith LE, Greenberg JS, & Mailick MR. (2014) Change in Autism Symptoms and Maladaptive Behaviors in Adolescence and Adulthood: The Role of Positive Family Processes. Journal of autism and developmental disorders. PMID: 25070471
How does the old saying go? Imitation, is the sincerest form of flattery? Well that is what we’ve been trying to do for a very long time, but mimicking the intricate networks and dynamic interactions that are inherent to living cells is difficult to achieve outside the cell. Unfortunately despite all our intelligence nature has had the upper hand on us for a long time. That has not changed… until now that is.[…]... Read more »
Karzbrun E, Tayar AM, Noireaux V, & Bar-Ziv RH. (2014) Programmable on-chip DNA compartments as artificial cells. Science (New York, N.Y.), 345(6198), 829-32. PMID: 25124443
Despite the prevalence and impact of problem gambling, few summaries or guidelines address treatment.Searching the guideline.gov website shows no recent additions to the guideline literature.A guideline was published by the Singapore Ministry of Health in 2011. This guideline is still relevant and highlights some of the key elements of a problem gambling treatment program.I will summarize some of these key elements from this source titled: "Management of gambling disorders". In their summa........ Read more »
Lee KM, Chan HN, Cheah B, Gentica GF, Guo S, Lim HK, Lim YC, Noorul F, Tan HS, Teo P.... (2011) Ministry of Health clinical practice guidelines: management of gambling disorders. Singapore medical journal, 52(6), 456. PMID: 21732000
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