"Comorbid anxiety symptoms are ubiquitous among psychiatric patients with mood or schizophrenia spectrum disorders, and in almost half of them, reportedly severe."So said the findings reported by Karpov and colleagues  who sought to put some further research flesh on to the bones of the idea that clinically relevant anxiety symptoms might not be unstrange bedfellows with a variety of other psychiatric labels.Based on the analysis of various patient groups included in the "Helsinki University ........ Read more »
Karpov, B., Joffe, G., Aaltonen, K., Suvisaari, J., Baryshnikov, I., Näätänen, P., Koivisto, M., Melartin, T., Oksanen, J., Suominen, K.... (2016) Anxiety symptoms in a major mood and schizophrenia spectrum disorders. European Psychiatry, 1-7. DOI: 10.1016/j.eurpsy.2016.04.007
In an effort to reduce pain or fix other health problems, some people will submit to having suction temporarily applied to various regions of their skin, usually the neck, shoulders, and back, via a collection of plastic or glass cups. This is known as cupping, and is a great way to embrace your inner Polkaroo.... Read more »
Pesticides beekeepers are using to improve honeybee health may actually be harming the bees by damaging the bacteria communities in their guts. The discovery is a concern because alterations can affect the gut's ability to metabolize sugars and peptides, processes that are vital for honeybee health.
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Madhavi Kakumanu, Alison M. Reeves, Troy Anderson, Richard R. Rodrigues, & Mark A. Williams. (2016) Honey bee gut microbiome is altered by in-hive pesticide exposures. Frontiers in Microbiology. info:/10.3389/fmicb.2016.01255
I tread carefully in discussing the findings reported by Karola Dillenburger and colleagues  (open-access) on the question of "knowledge and training with regards to autism" received by "health, social care, and education staff who work within the statutory autism services sector in the UK." The observation that "an acute lack of autism-specific training that has detrimental impacts" was apparent is a worrying sign indeed.Although not intimately involved in the autism services sector, I ........ Read more »
Feeling stiff first thing in the morning? It's not your imagination, new research has found a protein created by the body's "biological clock" that actively represses inflammatory pathways within the affected limbs during the night. This protein, called CRYPTOCHROME, has proven anti-inflammatory effects in cultured cells and presents new opportunities for the development of drugs that may be used to treat inflammatory diseases and conditions, such as arthritis.
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Hand, L., Hopwood, T., Dickson, S., Walker, A., Loudon, A., Ray, D., Bechtold, D., & Gibbs, J. (2016) The circadian clock regulates inflammatory arthritis. The FASEB Journal. DOI: 10.1096/fj.201600353R
The idea that use of the diagnostic label called attention-deficit hyperactivity disorder (ADHD) is on the increase, and pretty significantly so, is quite common-place these days (see here). Appreciating that not everyone is convinced that the increase is necessarily genuine (see here) I would like to discuss some interesting data coming out of the 'big data' country that is Taiwan in the form of the findings reported by Wang and colleagues .As regular readers might already know, Taiwan is th........ Read more »
Wang, L., Lee, S., Yuan, S., Yang, C., Yang, K., Huang, T., Chou, W., Chou, M., Lee, M., Lee, T.... (2016) Prevalence rates of youths diagnosed with and medicated for ADHD in a nationwide survey in Taiwan from 2000 to 2011. Epidemiology and Psychiatric Sciences, 1-11. DOI: 10.1017/S2045796016000500
Long before Zika virus made it a household word, the birth defect called microcephaly puzzled scientists and doctors -- even as it changed the lives of the babies born with it during the pre-Zika era. But new discoveries reported by an international team of scientists may help explain what happens in the developing brains of babies still in the womb, causing them to be born with small brains and heads.
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Li, H., Bielas, S., Zaki, M., Ismail, S., Farfara, D., Um, K., Rosti, R., Scott, E., Tu, S., Chi, N.... (2016) Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly. The American Journal of Human Genetics, 99(2), 501-510. DOI: 10.1016/j.ajhg.2016.07.004
Many lower organisms retain the miraculous ability to regenerate form and function of almost any tissue after injury. Humans share many of our genes with these organisms, but our capacity for regeneration is limited. So scientists are studying the genetics of these organisms to find out how regenerative mechanisms might be activated in humans.
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King, B., & Yin, V. (2016) A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration. PLOS ONE, 11(6). DOI: 10.1371/journal.pone.0157106
by Piter Kehoma Boll What if the cure for cancer has been living in your garden all this time and you have been trying to get rid of it because it is an annoying weed? I cannot assure you that … Continue reading →... Read more »
Brandão, M., Krettli, A., Soares, L., Nery, C., & Marinuzzi, H. (1997) Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds. Journal of Ethnopharmacology, 57(2), 131-138. DOI: 10.1016/S0378-8741(97)00060-3
Chang, J., Chiang, L., Chen, C., Liu, L., Wang, K., & Lin, C. (2001) Antileukemic Activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb. The American Journal of Chinese Medicine, 29(02), 303-312. DOI: 10.1142/S0192415X01000320
Chiang, L., Chang, J., Chen, C., Ng, L., & Lin, C. (2003) Anti-Herpes Simplex Virus Activity of Bidens pilosa and Houttuynia cordata. The American Journal of Chinese Medicine, 31(03), 355-362. DOI: 10.1142/S0192415X03001090
Deba, F., Xuan, T., Yasuda, M., & Tawata, S. (2008) Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. var. Radiata. Food Control, 19(4), 346-352. DOI: 10.1016/j.foodcont.2007.04.011
Kviecinski, M., Felipe, K., Schoenfelder, T., de Lemos Wiese, L., Rossi, M., Gonçalez, E., Felicio, J., Filho, D., & Pedrosa, R. (2008) Study of the antitumor potential of Bidens pilosa (Asteraceae) used in Brazilian folk medicine. Journal of Ethnopharmacology, 117(1), 69-75. DOI: 10.1016/j.jep.2008.01.017
Oliveira, F., Andrade-Neto, V., Krettli, A., & Brandão, M. (2004) New evidences of antimalarial activity of Bidens pilosa roots extract correlated with polyacetylene and flavonoids. Journal of Ethnopharmacology, 93(1), 39-42. DOI: 10.1016/j.jep.2004.03.026
Pereira, R., Ibrahim, T., Lucchetti, L., da Silva, A., & de Moraes, V. (1999) Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L. Immunopharmacology, 43(1), 31-37. DOI: 10.1016/S0162-3109(99)00039-9
Sun, Y., Zhou, Q., Wang, L., & Liu, W. (2009) Cadmium tolerance and accumulation characteristics of Bidens pilosa L. as a potential Cd-hyperaccumulator. Journal of Hazardous Materials, 161(2-3), 808-814. DOI: 10.1016/j.jhazmat.2008.04.030
"Individuals hospitalized with acute mania have a markedly increased rate of bacterial infections, as evidenced by the recent prescription of antimicrobial agents. The prevention and effective treatment of bacterial infections may be important interventions for the management of individuals with mania."That was the research bottom-line reported by Robert Yolken and colleagues  (yes, that Robert Yolken) who continued a theme of how immune function/response might be something pretty important w........ Read more »
Yolken R, Adamos M, Katsafanas E, Khushalani S, Origoni A, Savage C, Schweinfurth L, Stallings C, Sweeney K, & Dickerson F. (2016) Individuals hospitalized with acute mania have increased exposure to antimicrobial medications. Bipolar disorders. PMID: 27425597
A new case study shows that biomimicry, a relatively new field that seeks to emulate nature to find solutions to human problems, can potentially expand intellectual property, increase energy savings and accelerate product innovation.
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Emily Barbara Kennedy, & Thomas Andrew Marting. (2016) Biomimicry: Streamlining the Front End of Innovation for Environmentally Sustainable Products. Research-Technology Management. info:/10.1080/08956308.2016.1185342
"Vitamin D supplements 'advised for everyone'" was just one media headline following the publication of a report (see here) - "a government commissioned report" - by the advisory board of the Scientific Advisory Committee on Nutrition (SACN) here in Blighty recently.After oodles and oodles of peer-reviewed research (quite a bit of it covered in that SACN report) potentially linking issues with vitamin D availability to everything from depression (see here) to schizophrenia (see here) a........ Read more »
Muscogiuri G, Altieri B, Annweiler C, Balercia G, Pal HB, Boucher BJ, Cannell JJ, Foresta C, Grübler MR, Kotsa K.... (2016) Vitamin D and chronic diseases: the current state of the art. Archives of toxicology. PMID: 27425218
Fellow exercise enthusiasts, you can breath a sigh of relief and so can your brain. Research has found that exercise causes more new neurons to be formed in a critical brain region, and contrary to an earlier study, these new neurons do not cause the individual to forget old memories, according to new research.
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Kodali, M., Megahed, T., Mishra, V., Shuai, B., Hattiangady, B., & Shetty, A. (2016) Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory. Journal of Neuroscience, 36(31), 8112-8122. DOI: 10.1523/JNEUROSCI.0766-16.2016
There is only her and the track. The people standing on her left and right do not matter now. She has only one adversary: time. In her head she plays how the future might…will unfold. Forty seven strides. That’s all she needs. All things on the periphery disappear. Her world, her universe becomes a single […]... Read more »
Savulescu J, Foddy B, & Clayton M. (2004) Why we should allow performance enhancing drugs in sport. British journal of sports medicine, 38(6), 666-70. PMID: 15562155
Gaviglio CM, Osborne M, Kelly VG, Kilduff LP, & Cook CJ. (2015) Salivary testosterone and cortisol responses to four different rugby training exercise protocols. European journal of sport science, 15(6), 497-504. PMID: 25743223
Park HY, Hwang H, Park J, Lee S, & Lim K. (2016) The effects of altitude/hypoxic training on oxygen delivery capacity of the blood and aerobic exercise capacity in elite athletes - a meta-analysis. Journal of exercise nutrition , 20(1), 15-22. PMID: 27298808
I read with great interest the paper by Ruairi Robertson and colleagues  (open-access available here) recently, talking about how "neurobehavioural changes induced by altering n-3 PUFA [omega-3 polyunsaturated fatty acids] status are closely associated with comprehensive alterations in gut microbiota composition, HPA-axis activity and inflammation" in mice.Coming out of the 'bacterial research powerhouse' that is University College Cork, such research potentially unites some im........ Read more »
Robertson RC, Oriach CS, Murphy K, Moloney GM, Cryan JF, Dinan TG, Paul Ross R, & Stanton C. (2016) Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood. Brain, behavior, and immunity. PMID: 27423492
The high levels of caffeine in energy drinks may lead to cardiac complications. A new case report adds to previous reports of adverse cardiovascular events related to consuming energy drinks, including abnormal heart rhythms (arrhythmias).
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Sattari M, Sattari A, & Kazory A. (2016) Energy Drink Consumption and Cardiac Complications: A Case for Caution. Journal of addiction medicine, 10(4), 280-2. PMID: 27471919
I appreciate that the title of this post is probably going to result in an immediate 'click away' for some folk but for those who've endured it I'd like to talk briefly about the findings reported by Eman Khaled and colleagues . Namely the observation that: "ASD [autism spectrum disorder] children in the present study had increased blood Hg [mercury] and Pb [lead] levels compared with healthy control children indicating that disordered porphyrin metabolism might ........ Read more »
Khaled EM, Meguid NA, Bjørklund G, Gouda A, Bahary MH, Hashish A, Sallam NM, Chirumbolo S, & El-Bana MA. (2016) Altered urinary porphyrins and mercury exposure as biomarkers for autism severity in Egyptian children with autism spectrum disorder. Metabolic brain disease. PMID: 27406246
What are your thoughts on Blastocystis carriage and age? Please comment!... Read more »
Forsell J, Granlund M, Samuelsson L, Koskiniemi S, Edebro H, & Evengård B. (2016) High occurrence of Blastocystis sp. subtypes 1-3 and Giardia intestinalis assemblage B among patients in Zanzibar, Tanzania. Parasites , 9(1), 370. PMID: 27356981
Poulsen CS, Efunshile AM, Nelson JA, & Stensvold CR. (2016) Epidemiological Aspects of Blastocystis Colonization in Children in Ilero, Nigeria. The American journal of tropical medicine and hygiene, 95(1), 175-9. PMID: 27139454
A new mechanism that affects how our immune cells perform - and hence their ability to prevent disease - has been discovered by an international team of researchers. To date, researchers have identified hundreds of genetic variants that increase or decrease the risk of developing diseases from cancer and diabetes to tuberculosis and mental health disorders.
... Read more »
M Zaeem Cader, Katharina Boroviak, Qifeng Zhang, Ghazaleh Assadi, Sarah L Kempster, Gavin W Sewell, Svetlana Saveljeva, Jonathan W Ashcroft, Simon Clare, Subhankar Mukhopadhyay, Karen P Brown, Markus Tschurtschenthaler, Tim Raine, Brendan Doe, Edwin R Chilvers, Jules L Griffin, Nicole C Kaneider, R Andres Floto, Mauro D'Amato, Allan Bradley, Michael J O Wakelam.... (2016) C13orf31 (FAMIN) is a central regulator of immunometabolic function. Nature Immunology. info:/10.1038/ni.3532
'Physical activity boosts kids' brain power and academic prowess' went the press release accompanying the consensus statement published by Jens Bangsbo and colleagues  (open-access).The consensus statement brought together researchers from around the world "and from a variety of academic disciplines" to emphasise how undertaking all-manner of different kinds of exercise "are still a good investment in academic achievement" when it comes to children aged between 6-18 years of age.The stat........ Read more »
Bangsbo J, Krustrup P, Duda J, Hillman C, Andersen LB, Weiss M, Williams CA, Lintunen T, Green K, Hansen PR.... (2016) The Copenhagen Consensus Conference 2016: children, youth, and physical activity in schools and during leisure time. British journal of sports medicine. PMID: 27354718
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