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  • September 10, 2016
  • 05:27 AM
  • 591 views

Prevalence of self-injurious behaviors among children with autism

by Paul Whiteley in Questioning Answers

Just over a quarter of children diagnosed with an autism spectrum disorder (ASD) present with self-injurious behaviour (SIB).That was the headline finding reported by Gnakub Soke and colleagues [1] who surveyed the 8000+ children "in the Autism and Developmental Disabilities Monitoring (ADDM) Network during the 2000, 2006, and 2008 surveillance years." THE ADDM network, as some people might know, is one and the same network that comes up with the [estimated] prevalence of autism in the Unit........ Read more »

Soke GN, Rosenberg SA, Hamman RF, Fingerlin T, Robinson C, Carpenter L, Giarelli E, Lee LC, Wiggins LD, Durkin MS.... (2016) Brief Report: Prevalence of Self-injurious Behaviors among Children with Autism Spectrum Disorder-A Population-Based Study. Journal of autism and developmental disorders. PMID: 27565654  

  • September 9, 2016
  • 03:16 PM
  • 542 views

Study could herald new treatment for muscular dystrophy

by Dr. Jekyll in Lunatic Laboratories

New research has shown that the corticosteroid deflazacort is a safe and effective treatment for Duchenne muscular dystrophy. The findings could pave the way for first U.S.-approved treatment for the disease.

... Read more »

Griggs, R., Miller, J., Greenberg, C., Fehlings, D., Pestronk, A., Mendell, J., Moxley, R., King, W., Kissel, J., Cwik, V.... (2016) Efficacy and safety of deflazacort vs prednisone and placebo for Duchenne muscular dystrophy. Neurology, 10. DOI: 10.1212/WNL.0000000000003217  

  • September 9, 2016
  • 01:10 PM
  • 895 views

Statin Therapy: Rethinking Benefits and Risks

by William Yates, M.D. in Brain Posts

A recent 30-page manuscript provides an exhaustive review of the evidence for the efficacy and safety of statin therapy.The authors of this excellent review provide some context for the relative value of statins.The note that putting 10000 individuals with a history of a vascular event on a statin drug for 5 years would prevent 1,000 subsequent events. This is an example of secondary prevention--preventing another adverse outcome in those already experiencing an adverse event.But the statin drug........ Read more »

Collins, Rory, Reith, Christina, & Emberson, Jonathan. (2016) Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet. info:/http://dx.doi.org/10.1016/S0140-6736(16)31357-5

  • September 9, 2016
  • 03:40 AM
  • 594 views

Post-exertional malaise (PEM) in CFS might mean more than one thing

by Paul Whiteley in Questioning Answers

"The results suggest that post-exertional malaise [PEM] is composed of two empirically different experiences, one for generalized fatigue and one for muscle-specific fatigue."So said the findings reported by Stephanie McManimen and colleagues [1] looking at one of the most common and debilitating aspects of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and how rough-and-ready generalised descriptions often do little to reveal the complexities of this particular sympt........ Read more »

  • September 8, 2016
  • 10:16 AM
  • 882 views

CRISPR on my plate, and some GMO’s on the side

by gdw in FictionalFieldwork

A CRISPR recipe Less than a month ago, the world’s first official CRISPR/Cas9 meal was served. CRISPR/Cas9 is a fairly new technology to edit genomes, and cut and paste genes at will. Well, it’s not exactly that new. It’s actually been around for a long time. CRISPR, or *humhum* Clustered regularly interspaced short palindromic repeats […]... Read more »

Snell C, Bernheim A, Bergé JB, Kuntz M, Pascal G, Paris A, & Ricroch AE. (2012) Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4), 1134-48. PMID: 22155268  

  • September 8, 2016
  • 05:34 AM
  • 575 views

Metformin to tackle medication induced weight gain in autism?

by Paul Whiteley in Questioning Answers

"Metformin may be effective in decreasing weight gain associated with atypical antipsychotic use and is well tolerated by children and adolescents with ASD [autism spectrum disorder]."So said the paper by Evdokia Anagnostou and colleagues [1] (open-access) tackling an increasingly important health issue related to the pharmacological 'management' of some aspects of some autism.Metformin is the treatment of choice when it comes to the management of type 2 diabetes (the one where "t........ Read more »

  • September 7, 2016
  • 03:15 PM
  • 808 views

Antimicrobial chemicals found with antibiotic-resistance genes in indoor dust

by Dr. Jekyll in Lunatic Laboratories

Researchers have found links between the levels of antimicrobial chemicals and antibiotic-resistance genes in the dust of an aging building used for athletics and academics. One of the antimicrobials seen in the study is triclosan, a commonly used antibacterial ingredient in many personal care products.

... Read more »

Hartmann, E., Hickey, R., Hsu, T., Betancourt Román, C., Chen, J., Schwager, R., Kline, J., Brown, G., Halden, R., Huttenhower, C.... (2016) Antimicrobial Chemicals Are Associated with Elevated Antibiotic Resistance Genes in the Indoor Dust Microbiome. Environmental Science . DOI: 10.1021/acs.est.6b00262  

  • September 7, 2016
  • 01:05 PM
  • 629 views

Nuturing the Gifted: II

by William Yates, M.D. in Brain Posts

Earlier this summer I posted a review and commentary on a Duke University study of the outcome of children identified as gifted.You can access this post by clicking HERE.Today in Nature News, Tom Clynes publishes a nice review of the history of this topic.He notes there have several large scale studies to examine prospectively children with high academic potential. The cohorts include:Study of Mathematically Precocious Youth-SMPY (Johns Hopkins)Duke University Talent Identification ProgramMunich........ Read more »

  • September 7, 2016
  • 03:40 AM
  • 555 views

On (banned) organochlorine compounds and autism risk

by Paul Whiteley in Questioning Answers

'Chemicals banned decades ago linked to increased autism risk today' went the press release attached to the findings reported by Kristen Lyall and colleagues [1] (open-access).Observing that "higher levels of some organochlorine compounds during pregnancy are associated with ASD [autism spectrum disorder] and ID [intellectual disability]" the Lyall results once again push environmental factors back into the research spotlight. Indeed, environmental factors that were bann........ Read more »

  • September 6, 2016
  • 12:17 PM
  • 637 views

Keeping the Weight Off

by William Yates, M.D. in Brain Posts

Weight loss and maintenance of weight loss is difficult if not nearly impossible for most people.A registry of individuals who have lost 30 pounds or more and maintained their weight loss over a year exists in the U.S. This research effort is known as the National Weight Control Registry. It currently has over 10,000.I was looking at some of the published research results from this study. A paper published in 2012 used cluster analysis to identify sub-types of individuals with successful long-te........ Read more »

  • September 6, 2016
  • 09:55 AM
  • 554 views

A Literal "Beer Gut"

by Bill Sullivan in The 'Scope

Free beer, made right inside your stomach! This rare condition converts your gut into a brewery, and it is more of a nightmare than a dream come true.
... Read more »

  • September 6, 2016
  • 03:51 AM
  • 568 views

"The maternal body as environment in autism science"

by Paul Whiteley in Questioning Answers

Although I'm not really one for deep philosophical discussions or anything related (unless linked to a specific galaxy far, far away...), I was recently interested to read the paper by Martine Lappé [1] talking about how "complex narratives of autism’s causes and social anxieties surrounding child development have helped situate autism risk in women’s bodies before and during pregnancy."I'm as guilty as anyone for discussing the pretty constant stream of peer-reviewed research evidence........ Read more »

  • September 5, 2016
  • 03:34 PM
  • 840 views

Drugs in the water? Don't blame the students

by Dr. Jekyll in Lunatic Laboratories

With nearly sixty percent of American adults now taking prescription medications--from antidepressants to cholesterol treatments--there is growing concern about how many drugs are flowing through wastewater treatment facilities and into rivers and lakes. Research confirms that pharmaceutical pollution can cause damage to fish and other ecological problems--and may pose risks to human health too.

... Read more »

  • September 5, 2016
  • 04:08 AM
  • 569 views

Fatty acids and reading ability replicated

by Paul Whiteley in Questioning Answers

I'm a fan of scientific replication on this blog. Y'know, when one group comes out with some new marvellous research findings and another [independent] group says 'yep, we found that too'.It is with that sentiment in mind that I'm talking about the results published by Mats Johnson and colleagues [1] who suggested that "3 months of Omega 3/6 treatment improved reading ability" following a "3-month parallel, randomized, double-blind, placebo-controlled trial" with schoolchildren aged 9-10 years o........ Read more »

  • September 3, 2016
  • 06:06 AM
  • 610 views

Bipolar disorder in irritable bowel syndrome (IBS): real gut-brain axis stuff

by Paul Whiteley in Questioning Answers

"Our results support a significantly higher prevalence rate of BD [bipolar disorder] in IBS [irritable bowel syndrome] patients than in controls."So said the results of the meta-analysis and systematic review published by Ping-Tao Tseng and colleagues [1] (open-access available here) based on the suggestion that "both IBS and BD may, at least partially, share a similar mechanism of pathophysiology" specifically with immune function in mind.Building on previous research sugges........ Read more »

  • September 2, 2016
  • 03:21 PM
  • 649 views

Babies chew on subtle social, cultural cues at mealtime

by Dr. Jekyll in Lunatic Laboratories

At the dinner table, babies do a lot more than play with their sippy cups, new research suggests. Babies pay close attention to what food is being eaten around them - and especially who is eating it. The study adds evidence to a growing body of research suggesting even very young children think in sophisticated ways about subtle social cues.

... Read more »

Liberman, Z., Woodward, A., Sullivan, K., & Kinzler, K. (2016) Early emerging system for reasoning about the social nature of food. Proceedings of the National Academy of Sciences, 113(34), 9480-9485. DOI: 10.1073/pnas.1605456113  

  • September 2, 2016
  • 12:53 PM
  • 673 views

Obesity Surgery: VA Outcome Study

by William Yates, M.D. in Brain Posts

Weight loss (bariatric) surgery is likely to become increasingly important to address the obesity epidemic in the U.S. and other nations.There are several types of surgical techniques used for bariatric surgery.One of the most invasive is the Rous-en-Y gastric bypass (RYG) operation. This operation involves bisection of the small intestine and reattachment of the upper section to a position lower down the small intestine. This provides for a shorter distance for food to be absorbed.Less invasive........ Read more »

Maciejewski ML, Arterburn DE, Van Scoyoc L, Smith VA, Yancy WS Jr, Weidenbacher HJ, Livingston EH, & Olsen MK. (2016) Bariatric Surgery and Long-term Durability of Weight Loss. JAMA surgery. PMID: 27579793  

  • September 2, 2016
  • 11:41 AM
  • 735 views

This Month in Blastocystis Research - AUG

by Christen Rune Stensvold in Blastocystis Parasite Blog

About the factors potentially limiting susceptibility to Blastocystis colonisation/infection.... Read more »

Blessmann, J., Ali, I., Ton Nu, P., Dinh, B., Ngo Viet, T., Le Van, A., Clark, C., & Tannich, E. (2003) Longitudinal Study of Intestinal Entamoeba histolytica Infections in Asymptomatic Adult Carriers. Journal of Clinical Microbiology, 41(10), 4745-4750. DOI: 10.1128/JCM.41.10.4745-4750.2003  

Scanlan PD, Stensvold CR, Rajilić-Stojanović M, Heilig HG, De Vos WM, O'Toole PW, & Cotter PD. (2014) The microbial eukaryote Blastocystis is a prevalent and diverse member of the healthy human gut microbiota. FEMS microbiology ecology, 90(1), 326-30. PMID: 25077936  

  • September 2, 2016
  • 04:52 AM
  • 592 views

Parental concerns about offspring autism: listen up!

by Paul Whiteley in Questioning Answers

"The developmental concerns expressed by parents of undiagnosed toddlers were highly consistent with the diagnosis the child later received."So said the findings reported by Megan Richards and colleagues [1] who continue a research theme suggesting that when it comes to 'developmental concerns' about offspring behaviour, parents are generally pretty good at spotting potential red flags and professionals should perhaps take further note.Based on data derived from "a toddler screening study" some ........ Read more »

  • September 1, 2016
  • 02:36 PM
  • 582 views

Trauma's epigenetic fingerprint observed in children of Holocaust survivors

by Dr. Jekyll in Lunatic Laboratories

The children of traumatized people have long been known to be at increased risk for posttraumatic stress disorder (PTSD), and mood and anxiety disorders. However, there are very few opportunities to examine biologic alterations in the context of a watershed trauma in exposed people and their adult children born after the event.

... Read more »

Yehuda, R., Daskalakis, N., Bierer, L., Bader, H., Klengel, T., Holsboer, F., & Binder, E. (2016) Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. Biological Psychiatry, 80(5), 372-380. DOI: 10.1016/j.biopsych.2015.08.005  

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