The ice bucket challenge has swept the nation in an effort to raise awareness for ALS. However, there seems to have been a number of concussions (or mild traumatic brain injury) sustained from performing a seemingly altruistic act. Although some people may find the below video funny, concussions are a serious issue and can lead to serious consequences including executive dysfunction.Two recent meta-analyses (one examining neuropsychological performance while the other examining fMRI data) have i........ Read more »
Eierud C, Craddock RC, Fletcher S, Aulakh M, King-Casas B, Kuehl D, & LaConte SM. (2014) Neuroimaging after mild traumatic brain injury: Review and meta-analysis. NeuroImage. Clinical, 283-94. PMID: 25061565
Karr JE, Areshenkoff CN, & Garcia-Barrera MA. (2014) The neuropsychological outcomes of concussion: a systematic review of meta-analyses on the cognitive sequelae of mild traumatic brain injury. Neuropsychology, 28(3), 321-36. PMID: 24219611
Rohling, M., Larrabee, G., & Millis, S. (2012) The “Miserable Minority” Following Mild Traumatic Brain Injury: Who Are They and do Meta-Analyses Hide Them?. The Clinical Neuropsychologist, 26(2), 197-213. DOI: 10.1080/13854046.2011.647085
My Uncle suffered from Lupus. The disease itself should have a more sinister sounding name, given the effect it has on the body. Lupus is a form of autoimmune disease which attacks the body and causes an incredible amount of pain. It’s not pretty and complications from the disease can make life even more unbearable for people. There is no cure and sadly there are few treatments outside of managing the pain and side effects of the disease. Thankfully medical researchers have used DNA sequencing........ Read more »
Julia I Ellyard, Rebekka Jerjen, Jaime L Martin, Adrian Lee, Matthew A Field, Simon H Jiang, Jean Cappello, Svenja K Naumann, T Daniel Andrews, Hamish S Scott.... (2014) Whole exome sequencing in early-onset cerebral SLE identifies a pathogenic variant in TREX1. Arthritis . info:/10.1002/art.38824
The Charley Horse - why do we get these leg cramps and how can we prevent them? And why are they called a Charley Horse?!... Read more »
Coppin RJ, Wicke DM, & Little PS. (2005) Managing nocturnal leg cramps--calf-stretching exercises and cessation of quinine treatment: a factorial randomised controlled trial. The British journal of general practice : the journal of the Royal College of General Practitioners, 55(512), 186-91. PMID: 15808033
Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, & Hunter I. (2010) Three percent hypohydration does not affect threshold frequency of electrically induced cramps. Medicine and science in sports and exercise, 42(11), 2056-63. PMID: 20351595
A look into why we drink and what alcohol does to the brain.... Read more »
Németh Z, Kuntsche E, Urbán R, Farkas J, & Demetrovics Z. (2011) Why do festival goers drink? Assessment of drinking motives using the DMQ-R SF in a recreational setting. Drug and alcohol review, 30(1), 40-6. PMID: 21219496
Paul CA, Au R, Fredman L, Massaro JM, Seshadri S, Decarli C, & Wolf PA. (2008) Association of alcohol consumption with brain volume in the Framingham study. Archives of neurology, 65(10), 1363-7. PMID: 18852353
"Our results, combined with previous findings, suggest a 27% increase in the expected prevalence of ADHD [attention-deficit hyperactivity disorder] among young adults, comparing DSM-IV to DSM-5 criteria". So said the paper by Matte and colleagues  who as part of their study looked at "the prevalence of ADHD according to DSM-5 criteria".Europa @ Wikipedia The changes to the diagnosis of ADHD in DSM-5 can be seen here. The main difference between DSM-IV and DSM-5 diagnosis s........ Read more »
Matte, B., Anselmi, L., Salum, G., Kieling, C., Gonçalves, H., Menezes, A., Grevet, E., & Rohde, L. (2014) ADHD in DSM-5: a field trial in a large, representative sample of 18- to 19-year-old adults. Psychological Medicine, 1-13. DOI: 10.1017/S0033291714001470
Is 50% dextrose as good as 10% dextrose for treating symptomatic hypoglycemia?
If the patient is disoriented, but becomes oriented before the full dose of dextrose is given, is it appropriate to continue to treat the patient as if the patient were still disoriented? If your protocols require you to keep giving dextrose, do the same protocols require you to keep giving opioids after the pain is relieved? Is there really any difference?
50% dextrose has problems.... Read more »
Kiefer MV, Gene Hern H, Alter HJ, & Barger JB. (2014) Dextrose 10% in the treatment of out-of-hospital hypoglycemia. Prehospital and disaster medicine, 29(2), 190-4. PMID: 24735872
Levy SB, & Rosh AJ. (2006) Images in emergency medicine. Dextrose extravasation causing skin necrosis. Annals of emergency medicine, 48(3). PMID: 16934641
There is a war going on and it's not on foreign soil. This war is the fight for the status quo, a war where you are only worth your skin color, a war where you are only worth as much as your gender. This war is all around us, we see it everyday, yet we let it quietly pass us by. We do this because, in all actuality, we are losing this war. I don't blame you if you don't believe me, you shouldn't.[…]... Read more »
Weisman CS, & Chuang CH. (2014) Making the Most of the Affordable Care Act's Contraceptive Coverage Mandate for Privately-Insured Women. Women's health issues : official publication of the Jacobs Institute of Women's Health. PMID: 25128037
Short term effects of the Twin Block I am now back from my summer holidays and ready to start up the blog again. While I was away several systematic reviews have been published and there have been several comments on my blog post on self ligation. I will do my best to cover these over […]
The post Short term effects of the Twin Block appliance? appeared first on Kevin O'Brien's Orthodontic Blog.
... Read more »
Ehsani S, Nebbe B, Normando D, Lagravere MO, & Flores-Mir C. (2014) Short-term treatment effects produced by the Twin-block appliance: a systematic review and meta-analysis. European journal of orthodontics. PMID: 25052373
The paper by Woodman and colleagues  looking at trajectory and autism in adolescents and adults is the source material for today's post (another micropost). Concluding that: "Overall, autism symptoms and maladaptive behaviors were observed to improve over the study period" of about 8 years, the authors also reported that "greater improvements were associated with higher levels of maternal praise (based on maternal speech samples) and higher quality mother-child relationships". If I remember c........ Read more »
Woodman AC, Smith LE, Greenberg JS, & Mailick MR. (2014) Change in Autism Symptoms and Maladaptive Behaviors in Adolescence and Adulthood: The Role of Positive Family Processes. Journal of autism and developmental disorders. PMID: 25070471
How does the old saying go? Imitation, is the sincerest form of flattery? Well that is what we’ve been trying to do for a very long time, but mimicking the intricate networks and dynamic interactions that are inherent to living cells is difficult to achieve outside the cell. Unfortunately despite all our intelligence nature has had the upper hand on us for a long time. That has not changed… until now that is.[…]... Read more »
Karzbrun E, Tayar AM, Noireaux V, & Bar-Ziv RH. (2014) Programmable on-chip DNA compartments as artificial cells. Science (New York, N.Y.), 345(6198), 829-32. PMID: 25124443
Despite the prevalence and impact of problem gambling, few summaries or guidelines address treatment.Searching the guideline.gov website shows no recent additions to the guideline literature.A guideline was published by the Singapore Ministry of Health in 2011. This guideline is still relevant and highlights some of the key elements of a problem gambling treatment program.I will summarize some of these key elements from this source titled: "Management of gambling disorders". In their summa........ Read more »
Lee KM, Chan HN, Cheah B, Gentica GF, Guo S, Lim HK, Lim YC, Noorul F, Tan HS, Teo P.... (2011) Ministry of Health clinical practice guidelines: management of gambling disorders. Singapore medical journal, 52(6), 456. PMID: 21732000
"Compared with published general population prevalence, there is a fivefold increase in prevalence of ADHD in youth prison populations (30.1%) and a 10-fold increase in adult prison populations (26.2%)"."Mianly dry" apparently @ Paul WhiteleyThat was the primary conclusion reached in the meta-analysis by Young and colleagues  looking at the collected peer-reviewed literature on "the variable prevalence of attention deficit hyperactivity disorder (ADHD) in incarcerated populations".There ........ Read more »
Young S, Moss D, Sedgwick O, Fridman M, & Hodgkins P. (2014) A meta-analysis of the prevalence of attention deficit hyperactivity disorder in incarcerated populations. Psychological medicine, 1-12. PMID: 25066071
Recent research suggests AA works as well for young people as it does for older adults, although maybe in different ways. Referring to 12-step mutual aid is embodied in our National Clinical Guidelines, National Drugs Policies and by NICE. Getting people to go is a different story as a leaflet and a recommendation has a [...]
The post Young people and 12-step – what’s not to like? appeared first on Recovery Review.
... Read more »
Labbe, A., Slaymaker, V., & Kelly, J. (2014) Toward Enhancing Twelve-Step Facilitation among young people: A systematic qualitative investigation of Young Adults' 12-step Experiences. Substance Abuse. DOI: 10.1080/08897077.2014.950001
New study tests whether invertebrates produce similar DNA-based traps to neutrophil extracellular traps (NETs)to prove theory that they are an ancient immune technique... Read more »
Robb Calum T., Robert D. Gray, Adriano G. Rossi, & Valerie J. Smith. (2014) Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon. Nature Communications. DOI: http://dx.doi.org/10.1038/ncomms5627
You are now entering the Twilight Zone. You may remember the television show, with it’s odd twists and turns, but for people with schizophrenia it means something just a little […]... Read more »
Morris RW, Quail S, Griffiths KR, Green MJ, & Balleine BW. (2014) Corticostriatal Control of Goal-Directed Action Is Impaired in Schizophrenia. Biological psychiatry. PMID: 25062683
Disclaimer: The mosaic vaccine paper discussed in this article is from my own group and overlaps with some of the research I do. I'm sure you've been following the latest news about the Ebola virus outbreak in Africa."The Ebola outbreak in West Africa is the world's deadliest to date and the World Health Organization has declared an international health emergency as more than 1,000 people have died of the virus in Guinea, Liberia, Sierra Leone and Nigeria this year." [Source: BBC News]The e........ Read more »
Friedrich BM, Trefry JC, Biggins JE, Hensley LE, Honko AN, Smith DR, & Olinger GG. (2012) Potential vaccines and post-exposure treatments for filovirus infections. Viruses, 4(9), 1619-50. PMID: 23170176
Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, Funkhouser R, Kuiken C, Haynes B, Letvin NL, Walker BD.... (2007) Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nature medicine, 13(1), 100-6. PMID: 17187074
Fenimore PW, Muhammad MA, Fischer WM, Foley BT, Bakken RR, Thurmond JR, Yusim K, Yoon H, Parker M, Hart MK.... (2012) Designing and testing broadly-protective filoviral vaccines optimized for cytotoxic T-lymphocyte epitope coverage. PloS one, 7(10). PMID: 23056184
Close the blinds, lock the doors, and find a safe place to hide. Are you alone? No, no you aren’t and you may not even be in control of your […]... Read more »
Alcock J, Maley CC, & Aktipis CA. (2014) Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. BioEssays : news and reviews in molecular, cellular and developmental biology. PMID: 25103109
A very short post for readers to ponder based on the paper by Amanda Baxter and colleagues  who talked about the global epidemiology of the autism spectrum disorders (ASDs)."In 2010 there were an estimated 52 million cases of ASDs, equating to a prevalence of 7.6 per 1000 or one in 132 persons".Aside from emphasising the word 'estimated' (I highlighted that), be prepared to see the Baxter paper and that quote cited quite a bit in the peer-reviewed literature in times to come.----------[1........ Read more »
A. J. Baxter, T. S. Brugha, H. E. Erskine, R. W. Scheurer, T. Vos, & J. G. Scott. (2014) The epidemiology and global burden of autism spectrum disorders. Psychological Medicine. info:/http://dx.doi.org/10.1017/S003329171400172X
Researchers highlight a new system that is ideal for high-throughput (large numbers of animals) studies for recording sleep. A game changer for sure. ... Read more »
Mang GM, Nicod J, Emmenegger Y, Donohue KD, O'Hara BF, & Franken P. (2014) Evaluation of a piezoelectric system as an alternative to electroencephalogram/ electromyogram recordings in mouse sleep studies. Sleep, 37(8), 1383-92. PMID: 25083019
Maybe I’m dating myself here, but ever see the swamp thing movie, television show, or even the comic? Call me picky, after all we are talking about a human/plant hybrid, but he never needed to talk. I know, some of you are probably rolling your eyes at me given it’s a comic, movie or tv show [depending on your level of geek], but come on, this is science![…]... Read more »
G. Kim,, M. L. LeBlanc,, E. K. Wafula,, C. W. dePamphilis,, & J. H. Westwood. (2014) Genomic-scale exchange of mRNA between a parasitic plant and its hosts. Science. info:/10.1126/science.1253122
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