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  • April 25, 2015
  • 01:59 PM
  • 34 views

Mental disorders do not predict violence, so please stop

by Dr. Jekyll in Lunatic Laboratories

When Sandy Hook happened, it was so shocking that to this day, some don’t actually believe it happened. Shortly after, something frustrating happened, the shooter was labeled with aspergers. This helped drive the mental health and violence connection to the point that Time came out with an article dispelling that myth. Even now according to new longitudinal study of delinquent youth, most psychiatric disorders – including depression — do not predict future violent behavior. The only except........ Read more »

Elkington, K., Teplin, L., Abram, K., Jakubowski, J., Dulcan, M., & Welty, L. (2015) Psychiatric Disorders and Violence: A Study of Delinquent Youth After Detention. Journal of the American Academy of Child , 54(4), 302-31200000. DOI: 10.1016/j.jaac.2015.01.002  

  • April 25, 2015
  • 03:27 AM
  • 34 views

Kids with autism: a highly [psychotropic] medicated group?

by Paul Whiteley in Questioning Answers

"In keeping with international studies this sample of children with ASD [autism spectrum disorder] was a highly medicated group."So said the results of the study reported by Kerry-Ann Louw and colleagues [1] back in 2013 who noted that approximately one quarter of their cohort were currently in receipt of "psychotropic medications". I don't want to linger too much on this topic given that such findings tally with other peer-reviewed reports including those with much larger partici........ Read more »

  • April 24, 2015
  • 04:19 PM
  • 53 views

Diabetes drug found in freshwater potential cause of intersex fish

by Dr. Jekyll in Lunatic Laboratories

A medication commonly taken for Type II diabetes, which is being found in freshwater systems worldwide, has been shown to cause intersex in fish –or male fish that produce eggs. The study determined exposure to the diabetes medicine metformin causes physical changes in male fish exposed to doses similar to the amount in wastewater effluent.... Read more »

  • April 24, 2015
  • 07:12 AM
  • 52 views

Momnesia: Does Pregnancy Really Change The Brain?

by Rebekah Morrow in United Academics

Pregnancy does cause brain alterations, but scientists still disagree about other factors.... Read more »

Standtlander, L. (2013) Memory and Perceptual Changes during Pregnancy. International Journal of Childbirth, 28(2). info:/

  • April 24, 2015
  • 07:12 AM
  • 54 views

Momnesia: Does Pregnancy Really Change The Brain?

by Rebekah Morrow in United Academics

Pregnancy does cause brain alterations, but scientists still disagree about other factors.... Read more »

Standtlander, L. (2013) Memory and Perceptual Changes during Pregnancy. International Journal of Childbirth, 28(2). info:/

  • April 24, 2015
  • 04:44 AM
  • 54 views

DSM-5 impacting on autism numbers

by Paul Whiteley in Questioning Answers

"Consistent with previous reviews, the majority of included studies indicated between 50 and 75 % of individuals will maintain diagnoses."That was one of the conclusions reached by Isaac Smith and colleagues [1] following their systematic review of studies comparing DSM-IV and DSM-5 criteria for autism spectrum disorder (ASD) and what the changes mean for eligibility for the label.Authors further reported that: "the greatest decreases [were] among high-functioning populations with IQs over ........ Read more »

  • April 23, 2015
  • 06:25 PM
  • 62 views

Scientists create worlds first genetically modified human embryos

by Dr. Jekyll in Lunatic Laboratories

A funny thing happened on the way to the publisher. In a world first, China has successfully created genetically modified human embryos. It was certainly an amazing piece of science, but the paper was rejected by both Nature and Science. Not because the study was flawed, or because the data was falsified, the paper was rejected for ethical reasons.... Read more »

Liang, P., Xu, Y., Zhang, X., Ding, C., Huang, R., Zhang, Z., Lv, J., Xie, X., Chen, Y., Li, Y.... (2015) CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein . DOI: 10.1007/s13238-015-0153-5  

  • April 23, 2015
  • 02:53 PM
  • 59 views

Whooping cough: A small drop in vaccine protection can lead to a case upsurge

by Dr. Jekyll in Lunatic Laboratories

In 2012 the USA saw the highest number of pertussis (whooping cough) cases since 1955. New research finds that a likely explanation for this rise in disease is a drop in the degree of vaccine protection for each vaccinated individual. The team worked with 60 years of pertussis disease data to determine what best explained the recent increase in the disease.... Read more »

Gambhir M, Clark TA, Cauchemez S, Tartof SY, Swerdlow DL, & Ferguson NM. (2015) A Change in Vaccine Efficacy and Duration of Protection Explains Recent Rises in Pertussis Incidence in the United States. PLOS Computational Biology. info:/10.1371/journal.pcbi.1004138

  • April 23, 2015
  • 08:40 AM
  • 68 views

And I Keep Hitting Re-peat-peat-peat-peat-peat-peat

by Sarah Deffit in The 'Scope

Why do we do the things we do? Knowing the science behind bad habits may help you to break them. ... Read more »

Graybiel AM. (2008) Habits, rituals, and the evaluative brain. Annual review of neuroscience, 359-87. PMID: 18558860  

Quinn JM, Pascoe A, Wood W, & Neal DT. (2010) Can't control yourself? Monitor those bad habits. Personality , 36(4), 499-511. PMID: 20363904  

Yin HH, & Knowlton BJ. (2006) The role of the basal ganglia in habit formation. Nature reviews. Neuroscience, 7(6), 464-76. PMID: 16715055  

  • April 23, 2015
  • 01:46 AM
  • 58 views

Does maternal asthma 'prime' for offspring neurodevelopmental disorder?

by Paul Whiteley in Questioning Answers

The paper from Jared Schwartzer and colleagues [1] (open-access) including a couple of familiar names on the authorship list (Charity Onore and Paul Ashwood) caught my attention recently. Based on mouse studies and the artificial induction of maternal allergy/asthma in pregnant mice, researchers reported that: "Activation of the maternal immune system with an allergy/asthma insult significantly perturbed developmental growth and species-typical behaviors in offspring." Further that the........ Read more »

  • April 22, 2015
  • 04:27 PM
  • 49 views

Researchers find genetic link between overactive and underactive immune systems

by Dr. Jekyll in Lunatic Laboratories

In the largest genetic study to date of a challenging immunodeficiency disorder, scientists have identified a gene that may be a “missing link” between overactive and underactive immune activity. The gene candidate also plays a key role in autoimmune diseases such as type 1 diabetes, rheumatoid arthritis and even allergies.... Read more »

Li J, Jørgensen SF, Maggadottir SM, Bakay M, Warnatz K, Glessner J, Pandey R, Salzer U, Schmidt RE, Perez E.... (2015) Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. Nature communications, 6804. PMID: 25891430  

  • April 22, 2015
  • 12:13 PM
  • 58 views

Brain EEG and the Genetics of ADHD

by William Yates, M.D. in Brain Posts

Twin studies in ADHD demonstrate a significant genetic contribution to the disorder.Linking this genetic influence to specific biomarkers may provide a better understanding of the pathophysiology of ADHD.Grainne McLoughlin and colleagues at the University of California San Diego and King's College London recently published a twin study of brain EEG and the genetics of ADHD.In their study 67 twin pairs (34 monozygotic and 33 dizygotic) between the ages of 12 and 15 years completed tasks measuring........ Read more »

  • April 22, 2015
  • 07:01 AM
  • 94 views

Hair Plucking Could Treat Baldness

by Geetanjali Yadav in United Academics

Plucking sends out a signal by quorum sensing which leads to a surge of hair re-growth. ... Read more »

Chen CC, Wang L, Plikus MV, Jiang TX, Murray PJ, Ramos R, Guerrero-Juarez CF, Hughes MW, Lee OK, Shi S.... (2015) Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell, 161(2), 277-90. PMID: 25860610  

  • April 22, 2015
  • 04:39 AM
  • 47 views

MMR vaccine was not associated with increased risk of autism

by Paul Whiteley in Questioning Answers

"In this large sample of privately insured children with older siblings, receipt of the MMR [measles-mumps-rubella] vaccine was not associated with increased risk of ASD [autism spectrum disorder], regardless of whether older siblings had ASD. These findings indicate no harmful association between MMR vaccine receipt and ASD even among children already at higher risk for ASD."That was the conclusion reached in the study by Anjali Jain and colleagues [1] (open-access) based on........ Read more »

  • April 21, 2015
  • 02:01 PM
  • 41 views

Type 1 diabetes: On the way to an insulin vaccine

by Dr. Jekyll in Lunatic Laboratories

Pseudoscience claims about vaccines are seemingly hitting a fever pitch. Despite that, a new vaccine may be on the horizon for children at risk for diabetes, and that is a good thing. Researchers have found that children at risk for type 1 diabetes, who were given daily doses of oral insulin, developed a protective immune response to the disease that could lay the groundwork for a vaccine against the chronic illness.... Read more »

Ezio Bonifacio, PhD, Anette G. Ziegler, MD, Georgeanna Klingensmith, MD, Edith Schober, MD, Polly J. Bingley, MD, Marietta Rottenkolber, Anke Theil, PhD, Anne Eugster, PhD, Ramona Puff, PhD, Claudia Peplow.... (2015) Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes The Pre-POINT Randomized Clinical Trial. Journal of American Medical Association . info:/10.1001/jama.2015.2928

Jay S. Skyler, MD. (2015) Toward Primary Prevention of Type 1 Diabetes. Journal of American Medical Association . info:/10.1001/jama.2015.2054.

  • April 21, 2015
  • 08:23 AM
  • 48 views

Gout in Living Kidney Donors

by Cristy at Living Donor 101 in Living Donors Are People Too

A recent study indicates that living kidney donors are at a higher risk of gout than non-donors. ” Gout developed in significantly more donors than non-donors (3.4% vs. 2.0%), a difference that translated into a 60% increased risk of gout among living donors” This appears to be due to living kidney donors’ higher serum uric …
Continue reading »
The post Gout in Living Kidney Donors appeared first on Living Donors Are People Too.
... Read more »

Lam N.N., Garg A.X., Segev D.L., Schnitzler M.A., Xiao H., Axelrod D., Brennan D.C., Kasiske B.L., Tuttle-Newhall J.E., & Lentine K.L. (2015) Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications. American Journal of Nephrology, 14(3), 231-240. info:/

  • April 21, 2015
  • 04:31 AM
  • 60 views

Jessica Biesiekierski on non-coeliac gluten sensitivity (NCGS)

by Paul Whiteley in Questioning Answers

It's not often that I dedicate a blog post to a specific individual and their views and opinions on a particular topic. Today however, I'm doing just that to provide you with a link to the paper from Jessica Biesiekierski on the topic of non-coeliac gluten sensitivity (NCGS) [1] (open-access).The reason? Well, aside from being one of the primary protagonists in the research topic of gluten-related ills outside of the autoimmune condition known as coeliac (celiac) disease (itself the to........ Read more »

Biesiekierski, J., & Iven, J. (2015) Non-coeliac gluten sensitivity: piecing the puzzle together. United European Gastroenterology Journal, 3(2), 160-165. DOI: 10.1177/2050640615578388  

  • April 20, 2015
  • 02:23 PM
  • 61 views

Miracle fat-burning hormone doesn't exist after all

by Isabel Torres in Science in the clouds

Scientists are humans, and as such, they can sometimes get carried away when they make a breakthrough discovery. Because of this premature excitement, they may lose attention to detail, over-interpret results, or cut corners to speed up that much-desired Nature publication. The discovery of irisin, or ‘exercise hormone’, is one such example. Once thought to be a promising exercise-free solution for obesity and diabetes, irisin has now been shown to be no more than a random blood protein dete........ Read more »

Albrecht Elke, Bernd Thiede, Torgeir Holen, Tomoo Ohashi, Lisa Schering, Sindre Lee, Julia Brenmoehl, Selina Thomas, Christian A. Drevon, & Harold P. Erickson. (2015) Irisin – a myth rather than an exercise-inducible myokine. Scientific Reports, 8889. DOI: http://dx.doi.org/10.1038/srep08889  

  • April 20, 2015
  • 11:39 AM
  • 66 views

The Human Epigenome Roadmap

by Daniel Koboldt in Massgenomics

Aside from the occasional somatic mutation, the genome of every cell in an individual’s body is largely preserved. Yet different types of cells (and tissues, and organs) are incredibly diverse. The majority of that specialization is governed by epigenetic changes — histone modifications, DNA accessibility, and methylation — that influence when and how genes are expressed. […]... Read more »

Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J.... (2015) Integrative analysis of 111 reference human epigenomes. Nature, 518(7539), 317-30. PMID: 25693563  

  • April 20, 2015
  • 11:32 AM
  • 69 views

ADHD and Autism Overlap: Adult Twin Study

by William Yates, M.D. in Brain Posts

Clinical studies show high rates of ADHD in adults with autism or autism spectrum disorder (ASD). These studies have estimated the prevalence of ADHD in adults with ASD at between 28 and 44% of individuals. The prevalence of ADHD in the adult general population without ASD is estimated at 2.5%.Given the overlap between these two developmental disorders, it makes sense to examine genetic factors that might contribute to co-occurrence.TJC Polderman along with colleagues from the Netherlands, ........ Read more »

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