Not so long ago, there was a hope in the research community that common genetic variation, i.e. variants present at minor allele frequencies >5% in human populations, might explain most or all of the heritability of common complex disease. That would have been convenient, because such variants can be genotyped with precise, inexpensive, high-density SNP […]... Read more »
Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL, Burdon KP, Hebbring SJ, Wen C, Gorski M.... (2016) A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nature genetics, 48(2), 134-43. PMID: 26691988
The title of this quite brief post refers to an important finding detailed by Derek Nord and colleagues  who, when analysing data from the "2008–09 National Core Indicators Adult Consumer Survey", concluded that there were some important inequalities when it came to employment rates for those diagnosed on the autism spectrum.Employment rates and work opportunities for people diagnosed with an autism spectrum disorder (ASD) is a hot topic at the moment. The Nord findings build upon report af........ Read more »
Nord, D., Stancliffe, R., Nye-Lengerman, K., & Hewitt, A. (2016) Employment in the community for people with and without autism: A comparative analysis. Research in Autism Spectrum Disorders, 11-16. DOI: 10.1016/j.rasd.2015.12.013
There may be a genetic connection between some mental health disorders and type 2 diabetes. In a new report, scientists show that a gene called “DISC1,” which is believed to play a role in mental health disorders, such as schizophrenia, bipolar disorder and some forms of depression, influences the function of pancreatic beta cells which produce insulin to maintain normal blood glucose levels.
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Jurczyk A, Nowosielska A, Przewozniak N, Aryee KE, DiIorio P, Blodgett D, Yang C, Campbell-Thompson M, Atkinson M, Shultz L.... (2016) Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(2), 983-93. PMID: 26546129
Plasticity of the brain, what does that even mean? Well the good news is that it isn’t just a marketing ploy, the brain needs to be “plastic” because we need to be able to adapt. Frankly speaking, the brain still has a lot to learn about itself. Scientists at the Virginia Tech Carilion Research Institute have made a key finding of the striking differences in how the brain’s cells can change through experience.
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Saez, I., & Friedlander, M. (2016) Role of GABAA-Mediated Inhibition and Functional Assortment of Synapses onto Individual Layer 4 Neurons in Regulating Plasticity Expression in Visual Cortex. PLOS ONE, 11(2). DOI: 10.1371/journal.pone.0147642
"The primary finding from the study was evidence of an improvement in several objective sleep parameters in participants in whom the increased colonization of lactic acid producing organisms was resolved after antibiotic treatment."Those were the words written by Melinda Jackson and colleagues  (open-access) who, during an open-label trial, looked at whether administration of an antibiotic (erythromycin 400 mg) over the course of 6 days might have some important effects on elements of sleep i........ Read more »
Jackson ML, Butt H, Ball M, Lewis DP, & Bruck D. (2015) Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study. Sleep Science (Sao Paulo, Brazil), 8(3), 124-33. PMID: 26779319
Underwater sound linked to human activity could alter the behaviour of seabed creatures that play a vital role in marine ecosystems, according to new research from the University of Southampton. The study found that exposure to sounds that resemble shipping traffic and offshore construction activities results in behavioural responses in certain invertebrate species that live in the marine sediment.
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Solan, M., Hauton, C., Godbold, J., Wood, C., Leighton, T., & White, P. (2016) Anthropogenic sources of underwater sound can modify how sediment-dwelling invertebrates mediate ecosystem properties. Scientific Reports, 20540. DOI: 10.1038/srep20540
"Vitamin D deficiency might contribute to the aetiology of ASD [autism spectrum disorder]. Supplementation of vitamin D3, which is a safe and cost-effective form of treatment, may significantly improve the outcome of some children with ASD, especially younger children."More big words have appeared from a research group who seem to be particularly interested in how vitamin D (the sunshine vitamin/hormone) might have some important links to at least some cases of autism. The findings thi........ Read more »
Feng J, Shan L, Du L, Wang B, Li H, Wang W, Wang T, Dong H, Yue X, Xu Z.... (2016) Clinical improvement following vitamin D3 supplementation in Autism Spectrum Disorder. Nutritional neuroscience. PMID: 26783092
Genes could help in determining whether a person likes to rise early in the morning or not.
Researchers, in affiliation with 23andMe, Inc. recently worked on the DNA of 89,283 individuals, and found that genes could show some specific variations more frequently in the people, who self-identify themselves as early risers or morning people. They found 15 different spots in the genetic makeup that can vary between morning........ Read more »
Hu, Y., Shmygelska, A., Tran, D., Eriksson, N., Tung, J., & Hinds, D. (2016) GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person. Nature Communications, 10448. DOI: 10.1038/ncomms10448
More than two million citizens have been Tased by police as Taser stun guns have become one of the preferred less-lethal weapons by police departments across the United States during the past decade. But what does that 50,000-volt shock do to a person's brain?
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Kane, R., & White, M. (2015) TASER Exposure and Cognitive Impairment: Implications for Valid Miranda Waivers and the Timing of Police Custodial Interrogations . Criminology . DOI: 10.1111/1745-9133.12173
The findings reported by Ciro Marangoni and colleagues  made for some interesting reading recently and their systematic review of longitudinal studies looking at the various environmental exposures put forward as possible risk factors pertinent to the development of bipolar disorder (BD).Trawling through the peer-reviewed material on this topic, the authors were able to 'clump' the various proposed risk factors into one of three categories: "neurodevelopment (maternal influenza during pr........ Read more »
Marangoni C, Hernandez M, & Faedda GL. (2016) The role of environmental exposures as risk factors for bipolar disorder: A systematic review of longitudinal studies. Journal of affective disorders, 165-174. PMID: 26773919
Men who use mobile phone more frequently and place their phone close to their groin have higher chances of getting abnormal sperm concentration.
Reproductive BioMedicine Online
Researchers have reported that male infertility constitutes about 30% to 40% of all infertility cases. They also reported that studies are showing continuous decline in semen quality since the start of the last century. One of the potential contributing factors in th........ Read more »
Zilberlicht, A., Wiener-Megnazi, Z., Sheinfeld, Y., Grach, B., Lahav-Baratz, S., & Dirnfeld, M. (2015) Habits of cell phone usage and sperm quality – does it warrant attention?. Reproductive BioMedicine Online, 31(3), 421-426. DOI: 10.1016/j.rbmo.2015.06.006
Depression is a serious issue for expecting mothers. Left untreated, depression could have implications for a fetus’s health. But treating the disease during pregnancy may carry health risks for the developing fetus, which makes an expecting mother’s decision whether to take medication a very difficult one. To better understand how antidepressants affect fetuses during pregnancy, scientists studied exposure in mice.
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Velasquez, J., Goeden, N., Herod, S., & Bonnin, A. (2016) Maternal Pharmacokinetics and Fetal Disposition of (±)-Citalopram during Mouse Pregnancy. ACS Chemical Neuroscience. DOI: 10.1021/acschemneuro.5b00287
In the U.S., people face 25 times more chances of being killed by guns as compared to many other developed nations.
The American Journal of Medicine
In a study on “violent death rates”, researchers have reported that the rate of gun-related murder in the U.S. is about 25 times higher as compared to 22 other high-income countries. Moreover, gun-related suicide rate in the U.S. is about 8 times more than other high-income nations;........ Read more »
Grinshteyn, E., & Hemenway, D. (2015) Violent Death Rates: The US Compared with Other High-income OECD Countries, 2010. The American Journal of Medicine. DOI: 10.1016/j.amjmed.2015.10.025
I decided to look for something I wrote that I have been wrong about. I thought about Masimo and their RAD-57. I had been very critical of Dr. Michael O’Reilly (then Executive Vice President of Masimo Corporation) for being an advocate of bad science, but he has been hired away by Apple. He should be less dangerous with a telephone than he was with the RAD-57. At the time, he wrote –... Read more »
Weaver, L., Churchill, S., Deru, K., & Cooney, D. (2012) False Positive Rate of Carbon Monoxide Saturation by Pulse Oximetry of Emergency Department Patients. Respiratory Care. DOI: 10.4187/respcare.01744
Hampson NB, & Holm JR. (2015) Suicidal carbon monoxide poisoning has decreased with controls on automobile emissions. Undersea , 42(2), 159-64. PMID: 26094291
Roderique, J., Josef, C., Feldman, M., & Spiess, B. (2015) A modern literature review of carbon monoxide poisoning theories, therapies, and potential targets for therapy advancement. Toxicology, 45-58. DOI: 10.1016/j.tox.2015.05.004
Touger, M., Birnbaum, A., Wang, J., Chou, K., Pearson, D., & Bijur, P. (2010) Performance of the RAD-57 Pulse Co-Oximeter Compared With Standard Laboratory Carboxyhemoglobin Measurement. Annals of Emergency Medicine, 56(4), 382-388. DOI: 10.1016/j.annemergmed.2010.03.041
O'Reilly, M. (2010) Performance of the Rad-57 Pulse Co-Oximeter Compared With Standard Laboratory Carboxyhemoglobin Measurement. Annals of Emergency Medicine, 56(4), 442-444. DOI: 10.1016/j.annemergmed.2010.08.016
Zika. Ebola. MERS. HIV. Where Do “New” Viruses Come From?... Read more »
Forterre P. (2006) The origin of viruses and their possible roles in major evolutionary transitions. Virus research, 117(1), 5-16. PMID: 16476498
"The average prevalence of ASD [autism spectrum disorder] was 35/10 000 children and was about 4-fold higher in males."I don't have too much to add to the findings reported by Karolina Skonieczna-Żydecka and colleagues  who estimated the prevalence of ASD in two regions of Poland: "West Pomeranian and Pomeranian regions." Based on the analysis of data from "Provincial Disability Services Commissions", researchers concluded that approximately 3 children in 1000 in those regions........ Read more »
Skonieczna-Żydecka K, Gorzkowska I, Pierzak-Sominka J, & Adler G. (2016) The Prevalence of Autism Spectrum Disorders in West Pomeranian and Pomeranian Regions of Poland. Journal of applied research in intellectual disabilities : JARID. PMID: 26771078
Between 1993 and 2015, cattle killed 13 people who were out for walks in the United Kingdom. Dozens more walkers received broken bones or other injuries from the animals.
Murderous cattle are an understudied phenomenon, say veterinarian Angharad Fraser-Williams and other researchers at the University of Liverpool in the United Kingdom. So they scoured news articles and scientific literature to learn about cattle attacks over two decades. They turned up some advice for people wishing to av........ Read more »
Inflammation is a good thing, it helps the body fight disease, and without it we wouldn't survive. Unfortunately, when inflammation isn't kept under control it can wreak havoc on the body. From potentially causing alzheimer's to arthritis it seems that unchecked inflammation can cause all sorts of issues. In fact, a new study adds to the list of issues out of control inflammation causes in the body.
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Dowell, N., Cooper, E., Tibble, J., Voon, V., Critchley, H., Cercignani, M., & Harrison, N. (2016) Acute Changes in Striatal Microstructure Predict the Development of Interferon-Alpha Induced Fatigue. Biological Psychiatry, 79(4), 320-328. DOI: 10.1016/j.biopsych.2015.05.015
A quote to begin: "Taken together, there are no published evidence to suggest that there is a high overall concordance between ASD [autism spectrum disorders] and cancer or between ASD and specific cancers."Those words reported by Svend Erik Mouridsen and colleagues  (who knows a thing or two about autism research) should offer some relief to both people on the autism spectrum and their loved ones.Based on the analysis of over 100 adults "diagnosed with infantile autism (IA) in........ Read more »
Mouridsen, S., Rich, B., & Isager, T. (2016) Risk of cancer in adult people diagnosed with infantile autism in childhood: A longitudinal case control study based on hospital discharge diagnoses. Research in Autism Spectrum Disorders, 203-209. DOI: 10.1016/j.rasd.2015.12.010
An estimated 1 in 68 children in the United States has autism. The neurodevelopmental disorder, which impairs communication and social interaction skills, can be treated with medications and behavioral therapies, though there is no cure. Now, University of Missouri researchers have found that a medication commonly used to treat high blood pressure and irregular heartbeats may have the potential to improve some social functions of individuals with autism.
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Zamzow, R., Ferguson, B., Stichter, J., Porges, E., Ragsdale, A., Lewis, M., & Beversdorf, D. (2016) Effects of propranolol on conversational reciprocity in autism spectrum disorder: a pilot, double-blind, single-dose psychopharmacological challenge study. Psychopharmacology. DOI: 10.1007/s00213-015-4199-0
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