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  • June 2, 2015
  • 03:41 PM
  • 14 views

Neurobiology of Child Neglect/Abuse: Nemeroff Lecture Notes

by William Yates, M.D. in Brain Posts

I had the opportunity to attend the Warren Neuroscience Lecture presented by Dr. Charles Nemeroff in Tulsa, OK on June 2, 2015.Dr. Nemeroff has been an international leader in research in mood and anxiety disorders. His recent focus has been on the effects of adverse childhood environments on risk for adult mood and anxiety disorders. Here are my notes that summarize some of the key points from his lecture.Introduction:Stress is an important factor in understanding depressionEarly life stre........ Read more »

  • June 2, 2015
  • 06:48 AM
  • 33 views

The Benefits Of A Herpes Infection

by Rebekah Morrow in United Academics

Herpes boosts the immune system and helps fight off other viruses.... Read more »

Furman, D., Jojic, V., Sharma, S., Shen-Orr, S., L. Angel, C., Onengut-Gumuscu, S., Kidd, B., Maecker, H., Concannon, P., Dekker, C.... (2015) Cytomegalovirus infection enhances the immune response to influenza. Science Translational Medicine, 7(281), 281-281. DOI: 10.1126/scitranslmed.aaa2293  

  • June 2, 2015
  • 04:52 AM
  • 18 views

Yokukansan and treatment-resistant schizophrenia?

by Paul Whiteley in Questioning Answers

I'll freely admit that I'm no expert on yokukansan (YKS), the "traditional Asian herbal medicine" that comprises Atractylodis lanceae Rhizoma, Poria, Cnidii Rhizoma, Uncariae Uncis cum Ramulus, Angelicae Radix, Bupleuri Radix and Glycyrrhizae Radix. Yokukansan, in some circles also known as TJ-54, has however cropped up on my autism research radar before as per the very preliminary findings reported by Miyaoka and colleagues [1] (open-access) a few years back suggesting that the h........ Read more »

Miyaoka T, Furuya M, Horiguchi J, Wake R, Hashioka S, Thoyama M, Murotani K, Mori N, Minabe Y, Iyo M.... (2015) Efficacy and safety of yokukansan in treatment-resistant schizophrenia: a randomized, multicenter, double-blind, placebo-controlled trial. Evidence-based complementary and alternative medicine : eCAM, 201592. PMID: 25954314  

  • June 2, 2015
  • 01:46 AM
  • 34 views

Possible link between Alzheimer's disease and sleep-dependent memory consolidation?

by William Lu in The Quantum Lobe Chronicles

It has been well established that certain kinds of sleep consolidate certain kinds of memory. Mander and colleagues (2015) discovered that in older adults, beta-amyloid (the main component of amyloid plagues found in Alzheimer's disease) appears to disrupt slow wave activity in the medial frontal cortex during NREM sleep, which then impairs hippocampus-based memory consolidation. It would also be interesting to investigate possible disruptions in thalamic sleep spindle activity to see how this m........ Read more »

  • June 1, 2015
  • 03:20 PM
  • 43 views

How does human behavior lead to surgical errors? Researchers count the ways

by Dr. Jekyll in Lunatic Laboratories

Why are major surgical errors called “never events?” Because they shouldn’t happen — but do. Mayo Clinic researchers identified 69 never events among 1.5 million invasive procedures performed over five years and detailed why each occurred. Using a system created to investigate military plane crashes, they coded the human behaviors involved to identify any environmental, organizational, job and individual characteristics that led to the never events.... Read more »

Cornelius A. Thiels, DO, Tarun Mohan Lal, MS, Joseph M. Nienow, MBA, Kalyan S. Pasupathy, PhD, Renaldo C. Blocker, PhD, Johnathon M. Aho, MD, Timothy I. Morgenthaler, MD, Robert R. Cima, MD, Susan Hallbeck, PhD, & Juliane Bingener. (2015) Surgical never events and contributing human factors . Surgery . info:/http://dx.doi.org/10.1016/j.surg.2015.03.053

Cima RR, Kollengode A, Clark J, Pool S, Weisbrod C, Amstutz GJ, & Deschamps C. (2011) Using a data-matrix-coded sponge counting system across a surgical practice: impact after 18 months. Joint Commission journal on quality and patient safety / Joint Commission Resources, 37(2), 51-8. PMID: 21939132  

  • June 1, 2015
  • 04:50 AM
  • 32 views

The physical maltreatment of children with autism

by Paul Whiteley in Questioning Answers

As dramatic as the title of this post might seem, it is taken from the title of the paper by Guiqin Duan and colleagues [1] who reported that: "CPM [child physical maltreatment] is widespread in families of children with autism in Central China and more knowledge should be provided to parents of children with autism."Given the subject matter of the Duan paper I will at this point affirm that this is a blog about science (peer-reviewed science in the most part) and my discussions o........ Read more »

  • May 31, 2015
  • 03:05 PM
  • 45 views

A patient’s budding cortex — in a dish?

by Dr. Jekyll in Lunatic Laboratories

A patient tormented by suicidal thoughts gives his psychiatrist a few strands of his hair. She derives stem cells from them to grow budding brain tissue harboring the secrets of his unique illness in a petri dish. She uses the information to genetically engineer a personalized treatment to correct his brain circuit functioning. Just Sci-fi? Yes, but…... Read more »

Paşca, A., Sloan, S., Clarke, L., Tian, Y., Makinson, C., Huber, N., Kim, C., Park, J., O'Rourke, N., Nguyen, K.... (2015) Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nature Methods. DOI: 10.1038/nmeth.3415  

  • May 31, 2015
  • 02:19 PM
  • 40 views

How racial stereotypes impact the way we communicate

by Dr. Jekyll in Lunatic Laboratories

Racial stereotypes and expectations can impact the way we communicate and understand others, according to new research. The new study highlights how non-verbal “social cues” – such as photographs of Chinese Canadians – can affect how we comprehend speech.... Read more »

Babel, M., & Russell, J. (2015) Expectations and speech intelligibility. The Journal of the Acoustical Society of America, 137(5), 2823-2833. DOI: 10.1121/1.4919317  

  • May 30, 2015
  • 02:05 PM
  • 46 views

Health factors influence ex-prisoners’ chances of returning to jail

by Dr. Jekyll in Lunatic Laboratories

Ex-prisoners with a history of risky drug use, mental illness or poverty are more likely to end up back behind bars. Those who are obese, are chronically ill or have attempted suicide are more likely to remain in the community. These are some of the findings from an exploratory study into health-related factors that could be used to predict whether a person released from prison will end up in custody again.... Read more »

  • May 30, 2015
  • 01:41 PM
  • 63 views

The new normal? Addressing gun violence in America

by Dr. Jekyll in Lunatic Laboratories

Mass shootings have a significant impact on our individual and collective psyche, especially when they happen at schools. Despite the fact that children die every day from gun violence, school shootings upset us in ways that are difficult to comprehend. In our minds, schools serve as safe havens for children. When that image is shattered, the unpredictability and randomness of such heinous acts leave us wondering if anywhere is safe anymore. Thus, the shock and horror expressed following these e........ Read more »

McLeigh, J. (2015) The new normal? Addressing gun violence in America. American Journal of Orthopsychiatry, 85(3), 201-202. DOI: 10.1037/ort0000072  

  • May 30, 2015
  • 03:07 AM
  • 55 views

Autism and altered levels of essential fatty acids

by Paul Whiteley in Questioning Answers

Brigandi et al. 2015. Int. J. Mol. Sci. 16: 10061-10076.A quote to begin this post is taken from the paper by Sarah Brigandi and colleagues [1] (open-access available here): "Our study demonstrates an alteration in the PUFA [polyunsaturated fatty acids] profile and increased production of a PUFA-derived metabolite in autistic patients, supporting the hypothesis that abnormal lipid metabolism is implicated in autism."The Brigandi results were based on the analysis of blood samples for fatty ........ Read more »

Brigandi SA, Shao H, Qian SY, Shen Y, Wu BL, & Kang JX. (2015) Autistic Children Exhibit Decreased Levels of Essential Fatty Acids in Red Blood Cells. International journal of molecular sciences, 16(5), 10061-10076. PMID: 25946342  

  • May 29, 2015
  • 04:30 PM
  • 52 views

Restricting firearms access for people who misuse alcohol may prevent violence

by Dr. Jekyll in Lunatic Laboratories

Restricting access to firearms for people who misuse alcohol could prevent firearm violence, but policies that more clearly define alcohol misuse should be developed to facilitate enforcement, according to a review of existing research and public policies by the UC Davis Violence Prevention Research Program.... Read more »

  • May 29, 2015
  • 03:45 AM
  • 72 views

Reduced rumination and aggressive thoughts from a probiotic?

by Paul Whiteley in Questioning Answers

I've taken my time to come to discussing the findings from Laura Steenbergen and colleagues [1] (open-access) providing "the first evidence that the intake of probiotics may help reduce negative thoughts associated with sad mood." It's not that I didn't find such results to be really interesting and having potential for quite a few different areas of psychiatry, but rather that other blogging topics have popped up in the meantime. No mind, we're here now.Based on a growing evidence base sug........ Read more »

  • May 28, 2015
  • 03:28 AM
  • 92 views

The autisms, case reports and two 'intervention' options

by Paul Whiteley in Questioning Answers

I'm looking at two papers today which I'd like to think cover the title of this post pretty well dealing with the plurality of autism - the autisms - and the idea that intervention or management-wise, there is no 'one size fits all' when it comes to the autisms.First up are the findings reported by Ziats and colleagues [1] who presented results for a child - "A 4-year-old male with autism and two episodes of neurodevelopmental regression" - who was also found to have a "mutation in the TMLHE gen........ Read more »

  • May 27, 2015
  • 03:52 PM
  • 92 views

Expanding the code of life with new ‘letters’

by Dr. Jekyll in Lunatic Laboratories

The DNA encoding all life on Earth is made of four building blocks called nucleotides, commonly known as “letters,” that line up in pairs and twist into a double helix. Now, two groups of scientists are reporting for the first time that two new nucleotides can do the same thing — raising the possibility that entirely new proteins could be created for medical uses.... Read more »

Georgiadis, M., Singh, I., Kellett, W., Hoshika, S., Benner, S., & Richards, N. (2015) Structural Basis for a Six Nucleotide Genetic Alphabet. Journal of the American Chemical Society, 2147483647. DOI: 10.1021/jacs.5b03482  

Zhang, L., Yang, Z., Sefah, K., Bradley, K., Hoshika, S., Kim, M., Kim, H., Zhu, G., Jiménez, E., Cansiz, S.... (2015) Evolution of Functional Six-Nucleotide DNA. Journal of the American Chemical Society. DOI: 10.1021/jacs.5b02251  

  • May 27, 2015
  • 03:08 AM
  • 59 views

Predicting the onset of schizophrenia?

by Paul Whiteley in Questioning Answers

"A lower level of inflammatory response indicated by PTX3 [pentraxin-3] might be implicated in developing schizophrenia."That was the primary conclusion reported by Natalya Weber and colleagues [1] (open-access here) who "tested preonset serum specimens from 160 US military service members who were later diagnosed with schizophrenia or bipolar disorder and 160 matched controls without psychiatric disorders."PTX-3 by the way, is a compound of some note when it comes to the concept of in........ Read more »

Weber NS, Larsen RA, Yolken RH, Cowan DN, Boivin MR, & Niebuhr DW. (2015) Predictors of the Onset of Schizophrenia in US Military Personnel. The Journal of nervous and mental disease, 203(5), 319-24. PMID: 25919381  

  • May 26, 2015
  • 01:38 PM
  • 67 views

Babies can think before they can speak

by Dr. Jekyll in Lunatic Laboratories

Two pennies can be considered the same — both are pennies, just as two elephants can be considered the same, as both are elephants. Despite the vast difference between pennies and elephants, we easily notice the common relation of sameness that holds for both pairs. Analogical ability — the ability to see common relations between objects, events or ideas — is a key skill that underlies human intelligence and differentiates humans from other apes.... Read more »

  • May 26, 2015
  • 01:30 PM
  • 56 views

Researchers find essential fats for brain growth

by Dr. Jekyll in Lunatic Laboratories

New research has proved that certain special fats found in blood are essential for human brain growth and function. The two studies showed that mutations in the protein Mfsd2a causes impaired brain development in humans. Mfsd2a is the transporter in the brain for a special type of fat called lysophosphatidylcholines (LPCs) — composed of essential fatty acids like omega-3. These studies show, for the first time, the crucial role of these fats in human brain growth and function.... Read more »

  • May 26, 2015
  • 10:18 AM
  • 52 views

Conduct Disorder as a Substance Abuse Risk Factor

by William Yates, M.D. in Brain Posts

In this series of research reviews on conduct disorder several important findings are evident.Conduct disorder (CD) commonly evolves into adult antisocial personality disorderConduct disorder in children often presents along with attention deficit hyperactivity disorder and learning problemsCD in childhood and adolescence raises risk for alcohol, drug and nicotine dependence.Margaret Sibley and colleagues recently published a study of CD and ADHD and later initiation and escalation of the use of........ Read more »

  • May 26, 2015
  • 05:08 AM
  • 63 views

Health and adults on the autism spectrum

by Paul Whiteley in Questioning Answers

"Nearly all medical conditions were significantly more common in adults with autism, including immune conditions, gastrointestinal and sleep disorders, seizure, obesity, dyslipidemia, hypertension, and diabetes."So said the study results from Lisa Croen and colleagues [1] who set out to "describe the frequency of psychiatric and medical conditions among a large, diverse, insured population of adults with autism in the United States." Said participant group was derived from the interrogation of d........ Read more »

Croen LA, Zerbo O, Qian Y, Massolo ML, Rich S, Sidney S, & Kripke C. (2015) The health status of adults on the autism spectrum. Autism : the international journal of research and practice. PMID: 25911091  

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