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  • July 25, 2014
  • 01:47 PM
  • 21 views

Fighting the Obesity Epidemic with X-box [No, not that one]

by Gabriel in Lunatic Laboratories

Despite all the efforts, people are losing the war on obesity. There is probably a number of factors involved, genetics, underlying medical problems, most of all diet, but in any […]... Read more »

Williams KW, Liu T, Kong X, Fukuda M, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn JW.... (2014) Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis. Cell metabolism. PMID: 25017942  

  • July 25, 2014
  • 12:00 PM
  • 28 views

The Friday Five 07/25/14

by Bill Sullivan in The 'Scope

Five of the coolest news stories from the past week... Read more »

  • July 25, 2014
  • 11:02 AM
  • 20 views

Risk Factors For Sleep Disturbance After Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Sleep disturbance following traumatic brain injury (TBI) is a common clinical challenge.Hypersomnia and insomnia can both been seen in the TBI population.The risk factors related to TBI-related sleep disturbance are not well known. Identification of risk factors can provide insight into clinical assessment and management.Lijun Hou and colleagues recently examined risk factors related to subjective sleep complaints in a series of 98 TBI subjects.The study sample include adults admitted to a ........ Read more »

  • July 25, 2014
  • 03:29 AM
  • 30 views

p-cresol and autism: in need of further research

by Paul Whiteley in Questioning Answers

"These results confirm the elevation of urinary p-cresol in a sizable set of small autistic children and spur interest into biomarker roles for p-cresol and p-cresylsulfate in autism".The peasant dance @ Wikipedia That was the primary conclusion from the paper by Gabriele and colleagues [1] looking at "three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol" in samples from 33 participants diagnosed with an autism spectrum disorder (ASD)........ Read more »

Gabriele S, Sacco R, Cerullo S, Neri C, Urbani A, Tripi G, Malvy J, Barthelemy C, Bonnet-Brihault F, & Persico AM. (2014) Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 1-8. PMID: 25010144  

  • July 24, 2014
  • 07:24 PM
  • 41 views

Salmon and Spinal Cod Regeneration, er… Cord

by Gabriel in Lunatic Laboratories

Fish might not be the first thing you think about when we talk spinal cord injury but that is exactly what scientists are doing. Don’t ask where they got the […]... Read more »

  • July 24, 2014
  • 05:30 PM
  • 46 views

Grief in Children and Adolescents

by Eva Alisic in Trauma Recovery

The plane crash in Ukraine brings up many questions related to loss and grief. How will those left behind cope with the devastating event? How can we support them? With regard to how young people cope with bereavement, Dr. Mariken Spuij’s recent articles provide new insights.... Read more »

  • July 24, 2014
  • 01:34 PM
  • 57 views

Background TV and Children don’t Mix

by Gabriel in Lunatic Laboratories

Coming from a, to put it gently, very broken home, my babysitter was the television. Yep, so now that you are feeling nice and awkward let’s talk television. New research, […]... Read more »

Linebarger DL, Barr R, Lapierre MA, & Piotrowski JT. (2014) Associations Between Parenting, Media Use, Cumulative Risk, and Children's Executive Functioning. Journal of developmental and behavioral pediatrics : JDBP, 35(6), 367-77. PMID: 25007059  

Lapierre, M., Piotrowski, J., & Linebarger, D. (2012) Background Television in the Homes of US Children. PEDIATRICS, 130(5), 839-846. DOI: 10.1542/peds.2011-2581  

  • July 24, 2014
  • 04:14 AM
  • 87 views

Prenatal valproate exposure and brains

by Paul Whiteley in Questioning Answers

The paper by Amanda Wood and colleagues [1] (open-access) makes a potentially very important contribution to the growing literature looking at how prenatal exposure to sodium valproate (VPA) may affect some children. Authors reported on: "regional structural cortical brain changes in humans exposed to VPA in utero" and specifically, increased cortical thickness in the left inferior frontal gyrus.Lightning and lava @ Oliver Spalt @ Wikipedia In case you need any background on the s........ Read more »

Wood, A., Chen, J., Barton, S., Nadebaum, C., Anderson, V., Catroppa, C., Reutens, D., O'Brien, T., & Vajda, F. (2014) Altered cortical thickness following prenatal sodium valproate exposure. Annals of Clinical and Translational Neurology. DOI: 10.1002/acn3.74  

  • July 24, 2014
  • 02:55 AM
  • 34 views

Quick, Somebody Get The Name Of That Shark!

by Mark E. Lasbury in The 'Scope

There has been a rash of great white shark sightings and attacks in the news recently. But, have attacks and sightings remained constant, or are they really on the increase? Several news studies provide evidence that the Marine Mammal Protection Act of 1972, the ban on commercial whaling in 1982, and the ban on great white hunting in 1997 have increased the number of sharks on the coasts of the North America and Australia. In addition, great white sharks live much longer than previously assumed,........ Read more »

  • July 23, 2014
  • 01:13 PM
  • 115 views

Preregistration for All Medical Animal Research

by Neuroskeptic in Neuroskeptic_Discover

Writing in the European Journal of Clinical Investigation, three Dutch researchers say that All preclinical trials should be registered in advance in an online registry Citing the fact that all clinical trials are (in theory) already registered, authors Jansen of Lorkeers et al say that the system should be extended to cover preclinical medical research, […]The post Preregistration for All Medical Animal Research appeared first on Neuroskeptic.... Read more »

Jansen of Lorkeers, S., Doevendans, P., & Chamuleau, S. (2014) All preclinical trials should be registered in advance in an online registry. European Journal of Clinical Investigation. DOI: 10.1111/eci.12299  

  • July 23, 2014
  • 07:01 AM
  • 51 views

Seeing Red: A New Way To Predict Preeclampsia

by Rebekah Morrow in United Academics

New Congo red test predicts development of preeclampsia with pregnant women. A large collaboration of scientists recently reported a new method of determining which women would develop preeclampsia. Urine samples were collected from more than 600 patients and mixed with a dye called Congo red. Congo red stains large clumps of proteins, but doesn’t mark smaller separate proteins.... Read more »

Buhimschi IA, Nayeri UA, Zhao G, Shook LL, Pensalfini A, Funai EF, Bernstein IM, Glabe CG, & Buhimschi CS. (2014) Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia. Science translational medicine, 6(245). PMID: 25031267  

Whitehead, N. (2014) Proteins and a pregnancy woe. Science, 345(6194), 249-249. DOI: 10.1126/science.345.6194.249  

  • July 23, 2014
  • 03:46 AM
  • 63 views

Trauma and PTSD raise risk of autoimmune disorders?

by Paul Whiteley in Questioning Answers

I admit to some head scratching when I first read the paper by Aoife O’Donovan and colleagues [1] reporting that among war veterans of the Iraq and Afghanistan campaigns, "trauma exposure and PTSD [post-traumatic stress disorder] may increase risk of autoimmune disorders".It wasn't that I didn't believe the results, but rather that the idea that a physical event with a psychological consequence could impact on a somatic condition with an autoimmune element to it seemed to open u........ Read more »

  • July 22, 2014
  • 07:04 PM
  • 13 views

Over the counter drug addiction

by DJMac in Recovery Review

In many countries around the world, codeine is available only on prescription. It’s a weak opioid, but can still cause addiction. Low dose codeine is also available in the UK, over-the-counter (OTC) in pharmacies. It’s sold in combination with paracetamol (co-codamol, e.g. Solpadol), in combination with ibuprofen (e.g. Nurofen Plus), and in combination with dihydrocodeine (co-dydramol, e.g. [...]
The post Over the counter drug addiction appeared first on Recovery Review.
... Read more »

  • July 22, 2014
  • 06:47 PM
  • 51 views

When Crazy becomes a Crime

by Gabriel in Lunatic Laboratories

My friend has a glass eye, you would never notice and unless you knew the story you might not think anything of it. His older brother did it. Yes, you […]... Read more »

Dana Goldman,, John Fastenau,, Riad Dirani,, Eric Hellend,, Geoff Joyce,, Ryan Conrad,, & Darius Lakdawalla,. (2014) Medicaid Prior Authorization Policies and Imprisonment Among Patients With Schizophrenia. The American Journal of Managed Care, 20(7). info:/2014;20(7):577-586

  • July 22, 2014
  • 01:48 PM
  • 49 views

Fasting Improves Recovery of Bone Marrow Stem Cells after Chemotherapy

by Jalees Rehman in The Next Regeneration

Fasting is defined as either completely abstaining from or minimizing food intake for a defined period time - ranging from about 12 hours to even a few weeks. Calorie restriction, on the other hand, refers to an overall reduction in the daily calorie intake by about 20%-40% without necessarily reducing the meal intake frequency. Although calorie restriction is well-suited for weight loss and thus also reduces the risk of chronic diseases such as diabetes or heart disease, proponents of fasting c........ Read more »

  • July 22, 2014
  • 04:32 AM
  • 60 views

Common variation and the genetics of autism

by Paul Whiteley in Questioning Answers

The paper by Trent Gaugler and colleagues [1] reporting that the genetic architecture of the autism spectrum disorders (ASDs) seems in the most part to be due to "common variation" over and above "rare variants or spontaneous glitches" adds to the quite voluminous literature in this area.Everything in proportion? @ Wikipedia Based on an analysis of "a unique epidemiological sample from Sweden" researchers looked at DNA variations in some 3000 individuals with autism and asymptomatic co........ Read more »

Gaugler T, Klei L, Sanders SJ, Bodea CA, Goldberg AP, Lee AB, Mahajan M, Manaa D, Pawitan Y, Reichert J.... (2014) Most genetic risk for autism resides with common variation. Nature genetics. PMID: 25038753  

  • July 21, 2014
  • 01:27 PM
  • 89 views

Autism and Parents: Reducing stress

by Gabriel in Lunatic Laboratories

Raising an autistic child can be a gift. Unfortunately it can also be challenging and stressful. Let’s be real, it’s stressful just being a parent, throw in a disability that […]... Read more »

  • July 21, 2014
  • 08:00 AM
  • 11 views

Quick, Somebody Get The Name Of That Shark!

by Mark Lasbury in The 'Scope

Are sightings and attacks by great white sharks rare and staying rare? Or has the faster news cycle led to the need for more sensational stories and therefore more coverage? It may be a bit of both.... Read more »

  • July 21, 2014
  • 06:18 AM
  • 12 views

Obesity and Living Kidney Donation

by Cristy at Living Donor 101 in Living Donors Are People Too

First:   The link between obesity and diabetes, hypertension, and eventual kidney dysfunction is well recognized.   Glad to see the corroboration. Now the study (emphasis mine):   …BMI was evaluated in 532 donors over 11 years from 2002-2012. Measurements were made pre-operatively, at 1 year, and at the present time. Follow-up range varied from …
Continue reading »
The post Obesity and Living Kidney Donation appeared first on Living Donors Are People Too.
... Read more »

Movassaghi, M., Dru, C., Koopman, S., & Fuchs, G. (2014) Trends in Body Mass Index after Donor Nephrectomy. Journal of Endourology, 2147483647. DOI: 10.1089/end.2013-0196.ECC13  

  • July 21, 2014
  • 03:24 AM
  • 86 views

Autism and asthma yet again

by Paul Whiteley in Questioning Answers

"Asthma is approximately 35 % more common in autistic children".Pipe down @ Wikipedia That was the finding reported by Stanley Kotey and colleagues [1] based on their analysis of the 2007 National Survey of Children's Health (NSCH) dataset, a resource looking at "the physical and emotional health of children ages 0-17 years of age" resident in the United States. I don't intend to dwell too much on the Kotey findings aside from pointing out: (a) the reported prevalence of autism ca........ Read more »

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