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  • November 29, 2010
  • 05:25 PM

New Detergent Class for Membrane Proteins

by Peter Nollert in Protein Crystallization Blog

Most of the detergents that are in use today were available 5 or 10 years ago. Maybe the purity has increased over time, but the list of detergents extracted from successfully crystallized membrane proteins really hasn't seen any substantial additions in the past few years. In the previous blog "Applying the 80/20 rule to membrane protein crystallization pre-screening" I showed a list of detergents and referenced statistics that show that with just 8 detergents (dodecyl maltoside, decyl maltosid........ Read more »

Chae, P., Rasmussen, S., Rana, R., Gotfryd, K., Chandra, R., Goren, M., Kruse, A., Nurva, S., Loland, C., Pierre, Y.... (2010) Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nature Methods, 7(12), 1003-1008. DOI: 10.1038/nmeth.1526  

  • November 29, 2010
  • 12:00 PM

Climate change and digital music

by sciencebase in Sciencebase Science Blog

Information technology has a carbon footprint, that’s beyond doubt. Now, writing in a special issue of the Journal of Industrial Ecology, Christopher Weber, Jonathan Koomey and Scott Matthews in the US in work supported by grants from Microsoft Corporation and Intel Corporation have calculated that purchasing music digitally reduces the energy and carbon dioxide emissions [...]Climate change and digital music is a post from: Sciencebase Science Blog
... Read more »

  • November 29, 2010
  • 09:48 AM

Level of Detail in a Simulation Model

by Daniel Dumke in SCRM Blog - Supply Chain Risk Management

After the last more general entries on managers perception of risk and measuring SC performance I wanted to make a detour back to the basics.
Simulation is one of the tools, which can be used for analyzing supply chain dynamics, optimization and to support corporate decision making.
One major question when starting a supply chain model has always been what level of detail should you choose? Someone could start with a single worker in an agent based simulation model and continue with the mac........ Read more »

  • November 25, 2010
  • 01:49 PM

Thanksgiving and Football: Why you should always go for it on 4th and short

by Brad Walters in Cortical Hemming and Hawing

Today being Thanksgiving, it's pretty reasonable to assume (if you live in the U.S.) that you will likely be sitting down to a large meal involving lots of turkey, stuffing, and cranberry sauce.  It is also pretty likely, that somewhere in the house, football games will be on the television.  Which brings us to one of the quintessential questions in football: It's 4th down, your team is on the opposing team's 30 yard line and they have only one yard to go to get a first down.  Sho........ Read more »

  • November 24, 2010
  • 12:00 PM

Pharma industry could thrive in open

by sciencebase in Sciencebase Science Blog

The pharmaceutical industry is facing tough times. The patents for many of the billion-dollar blockbuster drugs have expired, generics have taken market share. Health insurance companies and national health services are under increasing pressure to cut costs. Manufacturers and governments in the developing world are either ignoring intellectual property rights totally and producing generics for [...]Pharma industry could thrive in open is a post from: Sciencebase Science Blog
... Read more »

Ram Subramanian, Jeffrey H. Toney, & C. Jayachandran. (2011) The evolution of research and development in the pharmaceutical industry: toward the open innovation model – can pharma reinvent itself?. Int. J. Business Innovation and Research, 5(1), 63-74. info:/

  • November 24, 2010
  • 11:49 AM

Supply Chain Risk Management Dissertations (Supply Chain Design: Capacity, Flexibility and Wholesale Price Strategies)

by Daniel Dumke in SCRM Blog - Supply Chain Risk Management

This is the forth contribution to my series on doctoral dissertations on Supply Chain Risk Management. An immense effort and dedication is spent on these works only to find the results hidden in the libraries. So the goal is raise interest in the research of my peers.

Author / Topic
This dissertation was written by Brian Tomlin in 1999 as his doctoral thesis at the Massachusetts Institute of Technology, Cambridge, USA. It can be downloaded here at his homepage at his current employer (Tuck........ Read more »

Brian T. Tomlin. (2000) Supply Chain Design: Capacity, Flexibility and Wholesale Price Strategies. Massachusetts Institute of Technology, Dissertation. info:/

  • November 24, 2010
  • 08:00 AM

YouTube EDU: There is more to YouTube than Justin Bieber’s Video

by Anatoliy Gruzd in Social Media Lab

On October 28th 2010, YouTube subscribers base reached 1 billion, helping to make it the third most popular website in the world. YouTube is a video-sharing website that allows user to upload, share and view videos online. On the main YouTube site, one can find videos on a wide variety of subjects matters from music [...]... Read more »

Colman, D. (2009) Introducing YouTube EDU. Blog post. info:/

  • November 23, 2010
  • 04:15 PM

Implementing Twitter in a Health Sciences Library

by Laika in Laika's Medliblog

Twitter describes itself as “a service for friends, family, and co-workers to communicate and stay connected through the exchange of quick, frequent answers to one simple question: What are you doing?” [2]. The “answers” are equally simple, because the tweet (that what is being “said”) must fit in 140 characters. The tweet does not only [...]... Read more »

Cuddy, C., Graham, J., & Morton-Owens, E. (2010) Implementing Twitter in a Health Sciences Library. Medical Reference Services Quarterly, 29(4), 320-330. DOI: 10.1080/02763869.2010.518915  

  • November 23, 2010
  • 07:33 AM

purple pain and a gene called 'straightjacket'

by Chris in The Lousy Linguist

Dr. Kevin Mitchell, a neuroscientist at Smurfit Institute of Genetics, University of Dublin, posted at his excellent blog Wiring the Brain about a weird, interesting study* that points to a possible genetic explanation of synaesthesia** (e.g., hearing a word and experience the color red). The authors were studying pain mechanisms in fruit flies (turns out the mechanisms are similar to us mammals, whuddathunk?). Once they identified a particular gene they dubbed straightjacket*** which is "involv........ Read more »

  • November 23, 2010
  • 03:42 AM

Discussions beyond the dichotomy of ‘downloading is theft’

by Tomas Rawlings in A Great Becoming

Andersson, J (2010). Peer-to-peer-based file-sharing beyond the dichotomy of ‘downloading is theft’ vs. ‘information wants to be free’: How Swedish file-sharers motivate their action Unpublished as yet Discussion of paper: <em>Peer-to-peer-based file-sharing beyond the dichotomy of ‘downloading is theft’ vs. ‘information wants to be free’: How Swedish file-sharers motivate their action</em> by Jonas Andersson of [...]... Read more »

Andersson, J. (2010) Peer-to-peer-based file-sharing beyond the dichotomy of ‘downloading is theft’ vs. ‘information wants to be free’: How Swedish file-sharers motivate their action. Unpublished as yet. info:/

  • November 22, 2010
  • 07:47 AM

Measuring Supply Chain Performance

by Daniel Dumke in SCRM Blog - Supply Chain Risk Management

Last week I conducted another Interview for the empirical part of my research. And we also discussed how to measure performance within the SC. As it turns out, multiple measures, namely service, cost, working capital are used. Sadly in literature many authors still focus on a single measure only and I wanted to know more about it. So I read an article by B. Beamon (Measuring Supply Chain Performance) to get an overview over performance measures used and how to select the right one(s).

Hist........ Read more »

Beamon, B. (1999) Measuring supply chain performance. International Journal of Operations , 19(3), 275-292. DOI: 10.1108/01443579910249714  

  • November 21, 2010
  • 06:41 AM

Autism Gives You Biblical Superpowers

by Neuroskeptic in Neuroskeptic

We've all heard about autistic "savants" with amazing mathematical, memory or artistic abilities. But could autism give you the power to kill 1,000 men armed only with a donkey bone?Samson was the original Chuck Norris. Granted mighty strength by God so long as he didn't cut his hair or shave, Samson's first act of heroism was ripping a lion to shreds with his bear hands. Then he moved onto people. According to the Book of Judges:"And Samson said, With the jawbone of an ass, heaps upon heaps, wi........ Read more »

  • November 19, 2010
  • 01:04 PM

Learning the Form of Causal Relationships Using Hierarchical Bayesian Models

by Sean Roberts in The Adventures of Auck

Lucas & Griffiths present a hierarchical Bayesian model of causal structure learning, and show that it predicts the performance of adults and children better than the Power PC model and the delta P model... Read more »

Lucas, C. G., & Griffiths, T. (2010) Learning the Form of Causal Relationships Using Hierarchical Bayesian Models. Cognitive Science, 34(1). info:/

  • November 19, 2010
  • 06:04 AM

Mutual Exclusivity in the Naming Game

by Sean Roberts in A Replicated Typo 2.0

The Naming Game looks at how communication systems evolve in populations of agents. In this post I’ll show that the algorithms used have implicit mutual exclusivity biases, which favour monolingual viewpoints. I’ll also show that this bias is not necessary and obscures some interesting insights into evolutionary dynamics of langauge.... Read more »

Andrea Baronchelli. (2010) Do you agree? Role of feedback and broadcasting in the Naming Game. ArXiv e-prints. arXiv: 1009.4798v1

Vittorio Loreto, Andrea Baronchelli, & Andrea Puglisi. (2009) Mathematical Modeling of Language Games . Evolution of Communication and Language in Embodied Agents. DOI: 10.1007/978-3-642-01250-1_15  

  • November 18, 2010
  • 12:47 AM

A step towards correlates of consciousness

by Janet Kwasniak in Thoughts on thoughts

There are only a few ways to watch the brain in action and one is to follow its electromagnetic waves. Doesburg and his group have looked at the waves that accompany conscious awareness. They use binocular rivalry to mark when the content of consciousness changes (If different images are sent to the two eyes, we [...]... Read more »

  • November 17, 2010
  • 07:33 PM

How to tell your parents about those GPCRs

by Peter Nollert in Emerald BioStructures Blog

GPCRs could be a conversation starter over a Thanksgiving Dinner conversation.... Read more »

Bucci M, Goodman C, & Sheppard TL. (2010) A decade of chemical biology. Nature chemical biology, 6(12), 847-854. PMID: 21079586  

  • November 17, 2010
  • 02:20 PM

An excellent example of either crappy science reporting or crappy science ...

by Greg Laden in Greg Laden's Blog

Let's have a look and see if we can decide. Read the rest of this post... | Read the comments on this post...... Read more »

  • November 17, 2010
  • 07:32 AM

Managing Information Risks

by Daniel Dumke in SCRM Blog - Supply Chain Risk Management

At the moment I am looking for gaps in my reading up to now and I found that I have not read much about information risks. It also seems that those risks are not (yet?) in focus, neither in research nor business. So I was happy to find "Information risks management in supply chains: an assessment and mitigation framework" by Faisal, Banwet and Shankar.

Topic / Methodology
The purpose of the paper is to provide a framework for the management of information risks, and to device a way to meas........ Read more »

  • November 15, 2010
  • 03:00 PM

Design Solutions to Reduce Obesity

by Kim Gordon in LS3P Knowledge Center

This post reviews research into how the built environment may affect activity rates and health outcomes, and discusses the implications this may have on planning and design... Read more »

  • November 15, 2010
  • 12:49 PM

Scouting Bees and Fungus-Farming Ants

by Farooq Khan in Complex systems + science

These two articles sit rather nicely together; one discusses leaf-cutter ants, which use leaves as food for underground fungus farms and the second article discusses how bees find new homes after a beehive reaches capacity. In both examples we see...... Read more »

Farooq Khan. (2010) Scouting Bees and Fungus-Farming Ants. Nature Network . info:/

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