Most of the detergents that are in use today were available 5 or 10 years ago. Maybe the purity has increased over time, but the list of detergents extracted from successfully crystallized membrane proteins really hasn't seen any substantial additions in the past few years. In the previous blog "Applying the 80/20 rule to membrane protein crystallization pre-screening" I showed a list of detergents and referenced statistics that show that with just 8 detergents (dodecyl maltoside, decyl maltosid........ Read more »
Chae, P., Rasmussen, S., Rana, R., Gotfryd, K., Chandra, R., Goren, M., Kruse, A., Nurva, S., Loland, C., Pierre, Y.... (2010) Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nature Methods, 7(12), 1003-1008. DOI: 10.1038/nmeth.1526
Information technology has a carbon footprint, that’s beyond doubt. Now, writing in a special issue of the Journal of Industrial Ecology, Christopher Weber, Jonathan Koomey and Scott Matthews in the US in work supported by grants from Microsoft Corporation and Intel Corporation have calculated that purchasing music digitally reduces the energy and carbon dioxide emissions [...]Climate change and digital music is a post from: Sciencebase Science Blog
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Weber, C., Koomey, J., & Matthews, H. (2010) The Energy and Climate Change Implications of Different Music Delivery Methods. Journal of Industrial Ecology, 14(5), 754-769. DOI: 10.1111/j.1530-9290.2010.00269.x
After the last more general entries on managers perception of risk and measuring SC performance I wanted to make a detour back to the basics.
Simulation is one of the tools, which can be used for analyzing supply chain dynamics, optimization and to support corporate decision making.
One major question when starting a supply chain model has always been what level of detail should you choose? Someone could start with a single worker in an agent based simulation model and continue with the mac........ Read more »
Persson, J. F. (2002) The impact of different levels of detail in manufacturing systems simulation models. Robotics and Computer-Integrated Manufacturing, 18(3-4), 319-325. DOI: 10.1016/S0736-5845(02)00024-8
Today being Thanksgiving, it's pretty reasonable to assume (if you live in the U.S.) that you will likely be sitting down to a large meal involving lots of turkey, stuffing, and cranberry sauce. It is also pretty likely, that somewhere in the house, football games will be on the television. Which brings us to one of the quintessential questions in football: It's 4th down, your team is on the opposing team's 30 yard line and they have only one yard to go to get a first down. Sho........ Read more »
Romer, D. (2006) Do Firms Maximize? Evidence from Professional Football. Journal of Political Economy, 114(2), 340-365. DOI: 10.1086/501171
The pharmaceutical industry is facing tough times. The patents for many of the billion-dollar blockbuster drugs have expired, generics have taken market share. Health insurance companies and national health services are under increasing pressure to cut costs. Manufacturers and governments in the developing world are either ignoring intellectual property rights totally and producing generics for [...]Pharma industry could thrive in open is a post from: Sciencebase Science Blog
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Ram Subramanian, Jeffrey H. Toney, & C. Jayachandran. (2011) The evolution of research and development in the pharmaceutical industry: toward the open innovation model – can pharma reinvent itself?. Int. J. Business Innovation and Research, 5(1), 63-74. info:/
This is the forth contribution to my series on doctoral dissertations on Supply Chain Risk Management. An immense effort and dedication is spent on these works only to find the results hidden in the libraries. So the goal is raise interest in the research of my peers.
Author / Topic
This dissertation was written by Brian Tomlin in 1999 as his doctoral thesis at the Massachusetts Institute of Technology, Cambridge, USA. It can be downloaded here at his homepage at his current employer (Tuck........ Read more »
Brian T. Tomlin. (2000) Supply Chain Design: Capacity, Flexibility and Wholesale Price Strategies. Massachusetts Institute of Technology, Dissertation. info:/
On October 28th 2010, YouTube subscribers base reached 1 billion, helping to make it the third most popular website in the world. YouTube is a video-sharing website that allows user to upload, share and view videos online. On the main YouTube site, one can find videos on a wide variety of subjects matters from music [...]... Read more »
Colman, D. (2009) Introducing YouTube EDU. Blog post. info:/
Twitter describes itself as “a service for friends, family, and co-workers to communicate and stay connected through the exchange of quick, frequent answers to one simple question: What are you doing?” . The “answers” are equally simple, because the tweet (that what is being “said”) must fit in 140 characters. The tweet does not only [...]... Read more »
Dr. Kevin Mitchell, a neuroscientist at Smurfit Institute of Genetics, University of Dublin, posted at his excellent blog Wiring the Brain about a weird, interesting study* that points to a possible genetic explanation of synaesthesia** (e.g., hearing a word and experience the color red). The authors were studying pain mechanisms in fruit flies (turns out the mechanisms are similar to us mammals, whuddathunk?). Once they identified a particular gene they dubbed straightjacket*** which is "involv........ Read more »
Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB.... (2010) A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene. Cell, 143(4), 628-38. PMID: 21074052
Andersson, J (2010). Peer-to-peer-based file-sharing beyond the dichotomy of ‘downloading is theft’ vs. ‘information wants to be free’: How Swedish file-sharers motivate their action Unpublished as yet Discussion of paper: <em>Peer-to-peer-based file-sharing beyond the dichotomy of ‘downloading is theft’ vs. ‘information wants to be free’: How Swedish file-sharers motivate their action</em> by Jonas Andersson of [...]... Read more »
Andersson, J. (2010) Peer-to-peer-based file-sharing beyond the dichotomy of ‘downloading is theft’ vs. ‘information wants to be free’: How Swedish file-sharers motivate their action. Unpublished as yet. info:/
Last week I conducted another Interview for the empirical part of my research. And we also discussed how to measure performance within the SC. As it turns out, multiple measures, namely service, cost, working capital are used. Sadly in literature many authors still focus on a single measure only and I wanted to know more about it. So I read an article by B. Beamon (Measuring Supply Chain Performance) to get an overview over performance measures used and how to select the right one(s).
Hist........ Read more »
We've all heard about autistic "savants" with amazing mathematical, memory or artistic abilities. But could autism give you the power to kill 1,000 men armed only with a donkey bone?Samson was the original Chuck Norris. Granted mighty strength by God so long as he didn't cut his hair or shave, Samson's first act of heroism was ripping a lion to shreds with his bear hands. Then he moved onto people. According to the Book of Judges:"And Samson said, With the jawbone of an ass, heaps upon heaps, wi........ Read more »
Mathew SK, & Pandian JD. (2010) Newer insights to the neurological diseases among biblical characters of old testament. Annals of Indian Academy of Neurology, 13(3), 164-166. PMID: 21085524
Lucas & Griffiths present a hierarchical Bayesian model of causal structure learning, and show that it predicts the performance of adults and children better than the Power PC model and the delta P model... Read more »
Lucas, C. G., & Griffiths, T. (2010) Learning the Form of Causal Relationships Using Hierarchical Bayesian Models. Cognitive Science, 34(1). info:/
The Naming Game looks at how communication systems evolve in populations of agents. In this post I’ll show that the algorithms used have implicit mutual exclusivity biases, which favour monolingual viewpoints. I’ll also show that this bias is not necessary and obscures some interesting insights into evolutionary dynamics of langauge.... Read more »
Andrea Baronchelli. (2010) Do you agree? Role of feedback and broadcasting in the Naming Game. ArXiv e-prints. arXiv: 1009.4798v1
There are only a few ways to watch the brain in action and one is to follow its electromagnetic waves. Doesburg and his group have looked at the waves that accompany conscious awareness. They use binocular rivalry to mark when the content of consciousness changes (If different images are sent to the two eyes, we [...]... Read more »
Doesburg, S., Green, J., McDonald, J., & Ward, L. (2009) Rhythms of Consciousness: Binocular Rivalry Reveals Large-Scale Oscillatory Network Dynamics Mediating Visual Perception. PLoS ONE, 4(7). DOI: 10.1371/journal.pone.0006142
GPCRs could be a conversation starter over a Thanksgiving Dinner conversation.... Read more »
Let's have a look and see if we can decide. Read the rest of this post... | Read the comments on this post...... Read more »
Steen, R. (2010) Retractions in the scientific literature: do authors deliberately commit research fraud?. Journal of Medical Ethics. DOI: 10.1136/jme.2010.038125
At the moment I am looking for gaps in my reading up to now and I found that I have not read much about information risks. It also seems that those risks are not (yet?) in focus, neither in research nor business. So I was happy to find "Information risks management in supply chains: an assessment and mitigation framework" by Faisal, Banwet and Shankar.
Topic / Methodology
The purpose of the paper is to provide a framework for the management of information risks, and to device a way to meas........ Read more »
Faisal, M., Banwet, D., & Shankar, R. (2007) Information risks management in supply chains: an assessment and mitigation framework. Journal of Enterprise Information Management, 20(6), 677-699. DOI: 10.1108/17410390710830727
This post reviews research into how the built environment may affect activity rates and health outcomes, and discusses the implications this may have on planning and design... Read more »
Bassett DR Jr, Pucher J, Buehler R, Thompson DL, & Crouter SE. (2008) Walking, cycling, and obesity rates in Europe, North America, and Australia. Journal of physical activity , 5(6), 795-814. PMID: 19164816
Pucher, J., & Buehler, R. (2008) Making Cycling Irresistible: Lessons from The Netherlands, Denmark and Germany. Transport Reviews, 28(4), 495-528. DOI: 10.1080/01441640701806612
These two articles sit rather nicely together; one discusses leaf-cutter ants, which use leaves as food for underground fungus farms and the second article discusses how bees find new homes after a beehive reaches capacity. In both examples we see...... Read more »
Farooq Khan. (2010) Scouting Bees and Fungus-Farming Ants. Nature Network . info:/
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