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  • July 24, 2014
  • 07:24 PM
  • 9 views

Salmon and Spinal Cod Regeneration, er… Cord

by Gabriel in Lunatic Laboratories

Fish might not be the first thing you think about when we talk spinal cord injury but that is exactly what scientists are doing. Don’t ask where they got the […]... Read more »

  • July 24, 2014
  • 01:34 PM
  • 22 views

Background TV and Children don’t Mix

by Gabriel in Lunatic Laboratories

Coming from a, to put it gently, very broken home, my babysitter was the television. Yep, so now that you are feeling nice and awkward let’s talk television. New research, […]... Read more »

Linebarger DL, Barr R, Lapierre MA, & Piotrowski JT. (2014) Associations Between Parenting, Media Use, Cumulative Risk, and Children's Executive Functioning. Journal of developmental and behavioral pediatrics : JDBP, 35(6), 367-77. PMID: 25007059  

Lapierre, M., Piotrowski, J., & Linebarger, D. (2012) Background Television in the Homes of US Children. PEDIATRICS, 130(5), 839-846. DOI: 10.1542/peds.2011-2581  

  • July 23, 2014
  • 05:05 PM
  • 92 views

Japanese Encephalitis Virus (JEV), ER stress, and Apoptosis

by thelonevirologist in Virology Tidbits

Japanese Encephalitis Virus (JEV) is a causative agent of acute encephalitis in humans, and being an arthropod borne virus transmitted predominately by mosquitoes ( that primarily target domestic animals and humans, with an estimated mortality of up to 70000 deaths reported per annum. Upon infection the viral proteins localise to the ER where they induce the ER stress which eventually induces Caspase dependent apoptosis.
... Read more »

Unni SK, Růžek D, Chhatbar C, Mishra R, Johri MK, & Singh SK. (2011) Japanese encephalitis virus: from genome to infectome. Microbes and infection / Institut Pasteur, 13(4), 312-21. PMID: 21238600  

Cui J, Counor D, Shen D, Sun G, He H, Deubel V, & Zhang S. (2008) Detection of Japanese encephalitis virus antibodies in bats in Southern China. The American journal of tropical medicine and hygiene, 78(6), 1007-11. PMID: 18541785  

Mori Y, Okabayashi T, Yamashita T, Zhao Z, Wakita T, Yasui K, Hasebe F, Tadano M, Konishi E, Moriishi K.... (2005) Nuclear localization of Japanese encephalitis virus core protein enhances viral replication. Journal of virology, 79(6), 3448-58. PMID: 15731239  

Uchil PD, Kumar AV, & Satchidanandam V. (2006) Nuclear localization of flavivirus RNA synthesis in infected cells. Journal of virology, 80(11), 5451-64. PMID: 16699025  

Ghosh Roy S, Sadigh B, Datan E, Lockshin RA, & Zakeri Z. (2014) Regulation of cell survival and death during Flavivirus infections. World journal of biological chemistry, 5(2), 93-105. PMID: 24921001  

Lu, M., Lawrence, D., Marsters, S., Acosta-Alvear, D., Kimmig, P., Mendez, A., Paton, A., Paton, J., Walter, P., & Ashkenazi, A. (2014) Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science, 345(6192), 98-101. DOI: 10.1126/science.1254312  

Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M.... (2013) ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature cell biology, 15(5), 481-90. PMID: 23624402  

  • July 23, 2014
  • 01:21 PM
  • 92 views

Voyager has hit interstellar space…. maybe?

by Gabriel in Lunatic Laboratories

Poor Voyager, he just can’t catch a break. We’ve said it’s hit interstellar space more times than we want to admit and in 2012, the Voyager mission team announced that […]... Read more »

G. Gloeckler, & L. A. Fisk. (2014) A test for whether or not Voyager 1 has crossed the heliopause. Geophysical Research Letters. info:/10.1002/2014GL060781

  • July 23, 2014
  • 01:13 PM
  • 106 views

Preregistration for All Medical Animal Research

by Neuroskeptic in Neuroskeptic_Discover

Writing in the European Journal of Clinical Investigation, three Dutch researchers say that All preclinical trials should be registered in advance in an online registry Citing the fact that all clinical trials are (in theory) already registered, authors Jansen of Lorkeers et al say that the system should be extended to cover preclinical medical research, […]The post Preregistration for All Medical Animal Research appeared first on Neuroskeptic.... Read more »

Jansen of Lorkeers, S., Doevendans, P., & Chamuleau, S. (2014) All preclinical trials should be registered in advance in an online registry. European Journal of Clinical Investigation. DOI: 10.1111/eci.12299  

  • July 22, 2014
  • 06:47 PM
  • 50 views

When Crazy becomes a Crime

by Gabriel in Lunatic Laboratories

My friend has a glass eye, you would never notice and unless you knew the story you might not think anything of it. His older brother did it. Yes, you […]... Read more »

Dana Goldman,, John Fastenau,, Riad Dirani,, Eric Hellend,, Geoff Joyce,, Ryan Conrad,, & Darius Lakdawalla,. (2014) Medicaid Prior Authorization Policies and Imprisonment Among Patients With Schizophrenia. The American Journal of Managed Care, 20(7). info:/2014;20(7):577-586

  • July 22, 2014
  • 01:19 PM
  • 44 views

Optical Cables, from Thin Air!

by Gabriel in Lunatic Laboratories

It’s a project that would make Tesla proud. Just imagine being able to instantaneously run an optical cable or fiber to any point on earth, or even into space. That’s what researchers are trying to do. Did I mention it was instantaneous and involved no connection other than the air around us? Well if you are as excited as I am, then you should read on! If not, two words, laser weapons!!... Read more »

Rosenthal, E., Jhajj, N., Wahlstrand, J., & Milchberg, H. (2014) Collection of remote optical signals by air waveguides. Optica, 1(1), 5. DOI: 10.1364/OPTICA.1.000005  

Jhajj, N., Rosenthal, E., Birnbaum, R., Wahlstrand, J., & Milchberg, H. (2014) Demonstration of Long-Lived High-Power Optical Waveguides in Air. Physical Review X, 4(1). DOI: 10.1103/PhysRevX.4.011027  

  • July 21, 2014
  • 01:27 PM
  • 87 views

Autism and Parents: Reducing stress

by Gabriel in Lunatic Laboratories

Raising an autistic child can be a gift. Unfortunately it can also be challenging and stressful. Let’s be real, it’s stressful just being a parent, throw in a disability that […]... Read more »

  • July 20, 2014
  • 09:13 PM
  • 76 views

Parasite Cures Cancer

by Viputheshwar Sitaraman in Draw Science

A parasite commonly found in the intestines of cats turns out to be an immune system boost against cancer!... Read more »

  • July 20, 2014
  • 11:33 AM
  • 50 views

Antiretrovirals and Pregnancy Risk

by Gabriel in Lunatic Laboratories

Don’t drink when you are pregnant, we all know that you aren’t supposed to do that. We also know you shouldn’t smoke, use drugs, and should talk to your Doctor […]... Read more »

Mugo NR, Hong T, Celum C, Donnell D, Bukusi EA, John-Stewart G, Wangisi J, Were E, Heffron R, Matthews LT.... (2014) Pregnancy Incidence and Outcomes Among Women Receiving Preexposure Prophylaxis for HIV Prevention: A Randomized Clinical Trial. JAMA : the journal of the American Medical Association, 312(4), 362-371. PMID: 25038355  

  • July 20, 2014
  • 11:21 AM
  • 39 views

Slowing Heart Disease

by Viputheshwar Sitaraman in Draw Science

Stopping just one minor enzyme leads to an entire cascade of pathways that can slow heart disease.... Read more »

Blazevic T, Schwaiberger AV, Schreiner CE, Schachner D, Schaible AM, Grojer CS, Atanasov AG, Werz O, Dirsch VM, & Heiss EH. (2013) 12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3. The Journal of biological chemistry, 288(49), 35592-603. PMID: 24165129  

  • July 19, 2014
  • 02:39 PM
  • 79 views

HIV and Hepatitis C: A New Treatment Coming Soon!!

by Gabriel in Lunatic Laboratories

The old saying it could always be worse might not sound like it would apply to HIV patients. Then again if you had HIV and hepatitis C, that would probably […]... Read more »

Sulkowski, M., Naggie, S., Lalezari, J., Fessel, W., Mounzer, K., Shuhart, M., Luetkemeyer, A., Asmuth, D., Gaggar, A., Ni, L.... (2014) Sofosbuvir and Ribavirin for Hepatitis C in Patients With HIV Coinfection. JAMA, 312(4), 353. DOI: 10.1001/jama.2014.7734  

  • July 18, 2014
  • 08:05 PM
  • 73 views

Unraveling the Connections of the Brain

by Gabriel in Lunatic Laboratories

The brain is complex, heck if it wasn’t then we wouldn’t be smart enough to figure out how it works. I guess it’s one of those stupid catch-22 type things. […]... Read more »

  • July 18, 2014
  • 12:56 PM
  • 83 views

The Brain, Down Syndrome, and Antibiotics

by Gabriel in Lunatic Laboratories

At first glance the title might sound a little weird. But if that is the case then you probably want to read this. Researchers  have identified a group of cells in […]... Read more »

Chen, C., Jiang, P., Xue, H., Peterson, S., Tran, H., McCann, A., Parast, M., Li, S., Pleasure, D., Laurent, L.... (2014) Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells. Nature Communications. DOI: 10.1038/ncomms5430  

  • July 17, 2014
  • 01:04 PM
  • 71 views

A New way to Fight HIV, Using your Genome!

by Gabriel in Lunatic Laboratories

Outsmarting something as “simple” as a virus doesn’t seem like much of a challenge. If only you could set it down to take the SAT’s or something. Unfortunately in the body fighting HIV is more like guerrilla warfare, you take the big losses for a small win. This is no way to wage a war, but HIV is smart. It mutates and sidesteps anything we’ve been able to throw at it. We don’t have a cure, or a vaccine, but we do have scientists trying. New research has made a crucial jump to throwi........ Read more »

  • July 16, 2014
  • 08:58 PM
  • 78 views

Linear is beautiful! A simple relationship provides guidance for optimal battery design

by Jonathan Trinastic in Goodnight Earth

Computational physicists to the rescue! Researchers have found a linear relationship between key quantities in battery electrodes to aid the guidance of choosing optimal materials for performance.... Read more »

  • July 16, 2014
  • 08:17 PM
  • 109 views

The Mediterranean Diet and Cognitive Decline

by Gabriel in Lunatic Laboratories

The Mediterranean diet, it may have broad health benefits [let's face it we can't seem to escape the push for it here in the US], but a new study suggests that […]... Read more »

Koyama, A., Houston, D., Simonsick, E., Lee, J., Ayonayon, H., Shahar, D., Rosano, C., Satterfield, S., & Yaffe, K. (2014) Association Between the Mediterranean Diet and Cognitive Decline in a Biracial Population. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. DOI: 10.1093/gerona/glu097  

  • July 16, 2014
  • 03:33 PM
  • 48 views

Coronavirus nsp, ER stress, UPR, and ERAD

by thelonevirologist in Virology Tidbits

The essential step in the intracellular life cycle of many positive strand ssRNA viruses is the generation of double membrane vesicles (DMVs) that in most cases (but not all) contain the viral replication and transcription complexes (RTC) and hence serve as the replication platform. In the case of both the Nidovirales and the Flaviviridae these are formed by subverting the membrane of the ER in the absence of conventional ER and secretory pathway markers. Additionally, non-structural proteins (........ Read more »

Noack J, Bernasconi R, & Molinari M. (2014) How viruses hijack the ERAD tuning machinery. Journal of virology. PMID: 24990995  

Hagemeijer MC, Ulasli M, Vonk AM, Reggiori F, Rottier PJ, & de Haan CA. (2011) Mobility and interactions of coronavirus nonstructural protein 4. Journal of virology, 85(9), 4572-7. PMID: 21345958  

Bernasconi R, Galli C, Noack J, Bianchi S, de Haan CA, Reggiori F, & Molinari M. (2012) Role of the SEL1L:LC3-I complex as an ERAD tuning receptor in the mammalian ER. Molecular cell, 46(6), 809-19. PMID: 22633958  

Sun S, Shi G, Han X, Francisco AB, Ji Y, Mendonça N, Liu X, Locasale JW, Simpson KW, Duhamel GE.... (2014) Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proceedings of the National Academy of Sciences of the United States of America, 111(5). PMID: 24453213  

  • July 16, 2014
  • 01:01 PM
  • 80 views

More Horror from Deepwater Horizon Oil Spill

by Gabriel in Lunatic Laboratories

Deepwater Horizon, it was a technological feat to get oil that deep in the water. Then the spill occurred, when it happened I honestly think more people were in shock […]... Read more »

White, H., Lyons, S., Harrison, S., Findley, D., Liu, Y., & Kujawinski, E. (2014) Long-Term Persistence of Dispersants following the Deepwater Horizon Oil Spill. Environmental Science , 1(7), 295-299. DOI: 10.1021/ez500168r  

  • July 15, 2014
  • 01:30 PM
  • 73 views

Schizophrenia and Autism: A New Connection

by Gabriel in Lunatic Laboratories

Autism and Schizophrenia, at first glance there probably isn’t a whole lot in common other than they are disorders that fall in that lovely book the DCM-5. The brain is […]... Read more »

Chie Shimamoto1,, Tetsuo Ohnishi, Motoko Maekawa, Akiko Watanabe, Hisako Ohba, Ryoichi Arai, Yoshimi Iwayama, Yasuko Hisano, Tomoko Toyota, Manabu Toyoshima.... (2014) Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. Human Molecular Genetics. info:/10.1093/hmg/ddu369

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