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  • August 21, 2014
  • 01:02 PM
  • 19 views

Jonas Salk and the Polio Comeback

by Gabriel in Lunatic Laboratories

Jonas Salk, you should know this name, but chances are you don’t. He was the inventor of the polio vaccine, a disease that was feared more than the atomic bomb. Today we don’t think about it, no one “gets” polio anymore. Scientists get a bad rap today with the whole “autism-vaccine” BS. But they don’t know Salk, instead of making a small [see: huge] fortune from the drug, he refused to patent it and gave it to the people for essentially free. You think this story would have a happy........ Read more »

Drexler JF, Grard G, Lukashev AN, Kozlovskaya LI, Böttcher S, Uslu G, Reimerink J, Gmyl AP, Taty-Taty R, Lekana-Douki SE.... (2014) Robustness against serum neutralization of a poliovirus type 1 from a lethal epidemic of poliomyelitis in the Republic of Congo in 2010. Proceedings of the National Academy of Sciences of the United States of America. PMID: 25136105  

  • August 21, 2014
  • 03:56 AM
  • 23 views

Autism, ADHD and allergy: Taiwan and big data (again)

by Paul Whiteley in Questioning Answers

"Children with ADHD [attention-deficit hyperactivity disorder] or ASD [autism spectrum disorder] had an increased risk of allergic comorbidities, and those with both ADHD and ASD had the highest"."You built a time machine.. out of a DeLorean"That was the conclusion arrived at in the paper by Ting-Yang Lin and colleagues [1]. For regular readers of this blog, this was yet another example of how Taiwan leads the way when it comes to the concept of 'big data' specifically employ........ Read more »

Lin, T., Lin, P., Su, T., Chen, Y., Hsu, J., Huang, K., Chang, W., Chen, T., Pan, T., Chen, M.... (2014) Autistic spectrum disorder, attention deficit hyperactivity disorder, and allergy: Is there a link? A nationwide study. Research in Autism Spectrum Disorders, 8(10), 1333-1338. DOI: 10.1016/j.rasd.2014.07.009  

  • August 21, 2014
  • 01:30 AM
  • 30 views

How to prevent a possible concussion from the ALS ice bucket challenge

by William Lu in The Quantum Lobe Chronicles

The ice bucket challenge has swept the nation in an effort to raise awareness for ALS. However, there seems to have been a number of concussions (or mild traumatic brain injuries) sustained from performing a seemingly altruistic act. Although some people may find the below video funny, concussions are a serious issue and can lead to serious consequences including executive dysfunction. Symptoms can include short loss of consciousness, feeling dazed and confused, loss of immediate memory, headach........ Read more »

  • August 20, 2014
  • 12:30 PM
  • 41 views

The DNA Signature of Lupus

by Gabriel in Lunatic Laboratories

My Uncle suffered from Lupus. The disease itself should have a more sinister sounding name, given the effect it has on the body. Lupus is a form of autoimmune disease which attacks the body and causes an incredible amount of pain. It’s not pretty and complications from the disease can make life even more unbearable for people. There is no cure and sadly there are few treatments outside of managing the pain and side effects of the disease. Thankfully medical researchers have used DNA sequencing........ Read more »

Julia I Ellyard, Rebekka Jerjen, Jaime L Martin, Adrian Lee, Matthew A Field, Simon H Jiang, Jean Cappello, Svenja K Naumann, T Daniel Andrews, Hamish S Scott.... (2014) Whole exome sequencing in early-onset cerebral SLE identifies a pathogenic variant in TREX1. Arthritis . info:/10.1002/art.38824

  • August 20, 2014
  • 09:35 AM
  • 50 views

I hate you Charley, and the horse you rode in on

by Bill Sullivan in The 'Scope

The Charley Horse - why do we get these leg cramps and how can we prevent them? And why are they called a Charley Horse?!... Read more »

Garrison SR, Allan GM, Sekhon RK, Musini VM, & Khan KM. (2012) Magnesium for skeletal muscle cramps. The Cochrane database of systematic reviews. PMID: 22972143  

El-Tawil S, Al Musa T, Valli H, Lunn MP, El-Tawil T, & Weber M. (2010) Quinine for muscle cramps. The Cochrane database of systematic reviews. PMID: 21154358  

Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, & Hunter I. (2010) Three percent hypohydration does not affect threshold frequency of electrically induced cramps. Medicine and science in sports and exercise, 42(11), 2056-63. PMID: 20351595  

  • August 20, 2014
  • 09:30 AM
  • 53 views

State Fairs and Stiff Beers: Why We Can't Stop Drinking

by Aarti Chawla in The 'Scope

A look into why we drink and what alcohol does to the brain.... Read more »

Diamond I, & Messing RO. (1994) Neurologic effects of alcoholism. The Western journal of medicine, 161(3), 279-87. PMID: 7975567  

Paul CA, Au R, Fredman L, Massaro JM, Seshadri S, Decarli C, & Wolf PA. (2008) Association of alcohol consumption with brain volume in the Framingham study. Archives of neurology, 65(10), 1363-7. PMID: 18852353  

  • August 20, 2014
  • 08:00 AM
  • 43 views

Because He Is The One

by Mark Lasbury in As Many Exceptions As Rules

Swatting a fly is hard. They always seem to know you’re coming, and even if you do surprise them, they often avoid your assassination attempts. New research is showing how they do it. A 2014 paper indicates that animals with faster metabolic rates actually process information and react quicker than larger animals. This, along with recent data showing how flies can jump away from a visual stimulus before taking flight and how they can coordinate a 0.03 second banking turn with incoming visu........ Read more »

Muijres FT, Elzinga MJ, Melis JM, & Dickinson MH. (2014) Flies evade looming targets by executing rapid visually directed banked turns. Science (New York, N.Y.), 344(6180), 172-7. PMID: 24723606  

Jumpertz R, Hanson RL, Sievers ML, Bennett PH, Nelson RG, & Krakoff J. (2011) Higher energy expenditure in humans predicts natural mortality. The Journal of clinical endocrinology and metabolism, 96(6). PMID: 21450984  

  • August 20, 2014
  • 06:06 AM
  • 48 views

How Stress Promotes Atherosclerosis

by Agnese Mariotti in United Academics

There is evidence that chronic stress increases the risk of atherosclerosis, but no mechanism linking the two phenomena has been demonstrated so far. Since stressful emotional states can affect the function of the immune system, Heidt and colleagues of the Massachusetts General Hospital hypothesized that stress increases the activity of inflammatory cells in the plaques facilitating their rupture, as you can read in their recently published article.... Read more »

Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J.... (2014) Chronic variable stress activates hematopoietic stem cells. Nature medicine, 20(7), 754-8. PMID: 24952646  

  • August 20, 2014
  • 04:35 AM
  • 55 views

ADHD in DSM-5: what did you think would happen?

by Paul Whiteley in Questioning Answers

"Our results, combined with previous findings, suggest a 27% increase in the expected prevalence of ADHD [attention-deficit hyperactivity disorder] among young adults, comparing DSM-IV to DSM-5 criteria". So said the paper by Matte and colleagues [1] who as part of their study looked at "the prevalence of ADHD according to DSM-5 criteria".Europa @ Wikipedia The changes to the diagnosis of ADHD in DSM-5 can be seen here. The main difference between DSM-IV and DSM-5 diagnosis s........ Read more »

Matte, B., Anselmi, L., Salum, G., Kieling, C., Gonçalves, H., Menezes, A., Grevet, E., & Rohde, L. (2014) ADHD in DSM-5: a field trial in a large, representative sample of 18- to 19-year-old adults. Psychological Medicine, 1-13. DOI: 10.1017/S0033291714001470  

  • August 19, 2014
  • 10:15 PM
  • 48 views

Dextrose 10% in the Treatment of Out-of-Hospital Hypoglycemia

by Rogue Medic in Rogue Medic

Is 50% dextrose as good as 10% dextrose for treating symptomatic hypoglycemia?

If the patient is disoriented, but becomes oriented before the full dose of dextrose is given, is it appropriate to continue to treat the patient as if the patient were still disoriented? If your protocols require you to keep giving dextrose, do the same protocols require you to keep giving opioids after the pain is relieved? Is there really any difference?

50% dextrose has problems.... Read more »

Kiefer MV, Gene Hern H, Alter HJ, & Barger JB. (2014) Dextrose 10% in the treatment of out-of-hospital hypoglycemia. Prehospital and disaster medicine, 29(2), 190-4. PMID: 24735872  

  • August 19, 2014
  • 02:17 PM
  • 60 views

Hobby Lobby and the War on Race and Women

by Gabriel in Lunatic Laboratories

There is a war going on and it's not on foreign soil. This war is the fight for the status quo, a war where you are only worth your skin color, a war where you are only worth as much as your gender. This war is all around us, we see it everyday, yet we let it quietly pass us by. We do this because, in all actuality, we are losing this war. I don't blame you if you don't believe me, you shouldn't.[…]... Read more »

  • August 19, 2014
  • 04:23 AM
  • 51 views

Family processes and trajectory in autism

by Paul Whiteley in Questioning Answers

The paper by Woodman and colleagues [1] looking at trajectory and autism in adolescents and adults is the source material for today's post (another micropost). Concluding that: "Overall, autism symptoms and maladaptive behaviors were observed to improve over the study period" of about 8 years, the authors also reported that "greater improvements were associated with higher levels of maternal praise (based on maternal speech samples) and higher quality mother-child relationships". If I remember c........ Read more »

  • August 18, 2014
  • 01:21 PM
  • 56 views

We can Build it Better: The First Artificial Cell Network

by Gabriel in Lunatic Laboratories

How does the old saying go? Imitation, is the sincerest form of flattery? Well that is what we’ve been trying to do for a very long time, but mimicking the intricate networks and dynamic interactions that are inherent to living cells is difficult to achieve outside the cell. Unfortunately despite all our intelligence nature has had the upper hand on us for a long time. That has not changed… until now that is.[…]... Read more »

Karzbrun E, Tayar AM, Noireaux V, & Bar-Ziv RH. (2014) Programmable on-chip DNA compartments as artificial cells. Science (New York, N.Y.), 345(6198), 829-32. PMID: 25124443  

  • August 18, 2014
  • 01:00 PM
  • 40 views

Five Facts You Did Not Know About Eggshells

by Shefali Sabharanjak in United Academics

Don't just throw away your Sunday morning egg shell. The humble eggshell and the shell membrane – the thin paperish sheet on the inner part of the eggshell- has a large number of surprising uses. Here’s a short list of five:... Read more »

  • August 18, 2014
  • 10:16 AM
  • 52 views

Guidelines for Treatment of Problem Gambling

by William Yates, M.D. in Brain Posts

Despite the prevalence and impact of problem gambling, few summaries or guidelines address treatment.Searching the guideline.gov website shows no recent additions to the guideline literature.A guideline was published by the Singapore Ministry of Health in 2011. This guideline is still relevant and highlights some of the key elements of a problem gambling treatment program.I will summarize some of these key elements from this source titled: "Management of gambling disorders".  In their summa........ Read more »

Lee KM, Chan HN, Cheah B, Gentica GF, Guo S, Lim HK, Lim YC, Noorul F, Tan HS, Teo P.... (2011) Ministry of Health clinical practice guidelines: management of gambling disorders. Singapore medical journal, 52(6), 456. PMID: 21732000  

  • August 18, 2014
  • 04:10 AM
  • 52 views

ADHD in the prison population: a micropost

by Paul Whiteley in Questioning Answers

"Compared with published general population prevalence, there is a fivefold increase in prevalence of ADHD in youth prison populations (30.1%) and a 10-fold increase in adult prison populations (26.2%)"."Mianly dry" apparently @ Paul WhiteleyThat was the primary conclusion reached in the meta-analysis by Young and colleagues [1] looking at the collected peer-reviewed literature on "the variable prevalence of attention deficit hyperactivity disorder (ADHD) in incarcerated populations".There ........ Read more »

  • August 17, 2014
  • 02:36 PM
  • 79 views

Schizophrenia and the Twilight Zone

by Gabriel in Lunatic Laboratories

You are now entering the Twilight Zone. You may remember the television show, with it’s odd twists and turns, but for people with schizophrenia it means something just a little […]... Read more »

  • August 17, 2014
  • 11:26 AM
  • 61 views

A mosaic vaccine that could potentially protect from different ebola strains

by EE Giorgi in CHIMERAS

Disclaimer: The mosaic vaccine paper discussed in this article is from my own group and overlaps with some of the research I do. I'm sure you've been following the latest news about the Ebola virus outbreak in Africa."The Ebola outbreak in West Africa is the world's deadliest to date and the World Health Organization has declared an international health emergency as more than 1,000 people have died of the virus in Guinea, Liberia, Sierra Leone and Nigeria this year." [Source: BBC News]The e........ Read more »

Friedrich BM, Trefry JC, Biggins JE, Hensley LE, Honko AN, Smith DR, & Olinger GG. (2012) Potential vaccines and post-exposure treatments for filovirus infections. Viruses, 4(9), 1619-50. PMID: 23170176  

Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, Funkhouser R, Kuiken C, Haynes B, Letvin NL, Walker BD.... (2007) Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nature medicine, 13(1), 100-6. PMID: 17187074  

  • August 16, 2014
  • 01:00 PM
  • 92 views

Is your Stomach… Controlling your Mind?

by Gabriel in Lunatic Laboratories

Close the blinds, lock the doors, and find a safe place to hide. Are you alone? No, no you aren’t and you may not even be in control of your […]... Read more »

  • August 16, 2014
  • 03:21 AM
  • 88 views

The epidemiology of autism spectrum disorders

by Paul Whiteley in Questioning Answers

A very short post for readers to ponder based on the paper by Amanda Baxter and colleagues [1] who talked about the global epidemiology of the autism spectrum disorders (ASDs)."In 2010 there were an estimated 52 million cases of ASDs, equating to a prevalence of 7.6 per 1000 or one in 132 persons".Aside from emphasising the word 'estimated' (I highlighted that), be prepared to see the Baxter paper and that quote cited quite a bit in the peer-reviewed literature in times to come.----------[1........ Read more »

A. J. Baxter, T. S. Brugha, H. E. Erskine, R. W. Scheurer, T. Vos, & J. G. Scott. (2014) The epidemiology and global burden of autism spectrum disorders. Psychological Medicine. info:/http://dx.doi.org/10.1017/S003329171400172X

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