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  • August 25, 2016
  • 02:50 PM
  • 24 views

The relationship between low physical activity and psychotic symptoms

by Dr. Jekyll in Lunatic Laboratories

Physical activity can help reduce cardiovascular disease and premature mortality in people with psychological problems. However, there is limited data on exercise in people with serious mental disorders, especially from low- and middle-income countries. This study explored whether complying with the World Health Organization recommendations of 150 minutes of moderate-vigorous exercise per week is related to psychotic symptoms or the diagnosis of a psychosis.

... Read more »

Brendon Stubbs, Ai Koyanagi, Felipe Schuch, Joseph Firth, Simon Rosenbaum, Fiona Gaughran, James Mugisha, & Davy Vancampfort. (2016) Physical Activity Levels and Psychosis: A Mediation Analysis of Factors Influencing Physical Activity Target Achievement Among 204 186 People Across 46 Low- and Middle-Income Countries. Schizophrenia bulletin . info:/10.1093/schbul/sbw111

  • August 25, 2016
  • 09:40 AM
  • 44 views

How to rebuild a brain

by gdw in FictionalFieldwork

After the stroke The human brain is complicated. Very complicated. And like any piece of complex machinery that relies on the smooth functioning of many components, it’s not immune to malfunction. When a part of the brain doesn’t get proper nutrition through a nice and smooth blood flow, things go awry and a stroke occurs. […]... Read more »

  • August 25, 2016
  • 03:45 AM
  • 29 views

Hospitalisation for infection and risk of death by suicide

by Paul Whiteley in Questioning Answers

"An increased risk of death by suicide was found among individuals hospitalized with infection in prospective and dose-response relationships. These findings indicate that infections may have a relevant role in the pathophysiological mechanisms of suicidal behavior."Some intriguing data has been recently reported by Helene Lund-Sørensen and colleagues [1] (open-access) examining the possibility that certain types of infection (or perhaps the biological response to infection) might inc........ Read more »

  • August 24, 2016
  • 02:51 PM
  • 54 views

How long do you want to live? Your expectations for old age matter

by Dr. Jekyll in Lunatic Laboratories

Why do some people want to live a very long time, while others would prefer to die relatively young? In a latest study, a team of researchers investigated how long young and middle-aged adults in the United States say they want to live in relation to a number of personal characteristics. The results showed that more than one out of six people would prefer to die younger than age 80, before reaching average life expectancy.

... Read more »

  • August 24, 2016
  • 04:30 AM
  • 54 views

Has There Been Any Change in ACL Injury Rates?

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Anterior cruciate ligament (ACL) injury affect a small number of athletes. While overall ACL injury rates are decreasing, ACL injuries still affect a disproportionally higher number of women than ... Read more »

  • August 24, 2016
  • 04:13 AM
  • 57 views

ALSPAC says maybe to link between prenatal paracetamol exposure and childhood behavioural difficulties

by Paul Whiteley in Questioning Answers

ALSPAC - the Avon Longitudinal Study of Parents and Children - continues to give in research terms as today I approach the findings reported by Evie Stergiakouli and colleagues [1]. They observed that: "Children exposed to acetaminophen [paracetamol] prenatally are at increased risk of multiple behavioral difficulties, and the associations do not appear to be explained by unmeasured behavioral or social factors linked to acetaminophen use insofar as they are not observed........ Read more »

  • August 24, 2016
  • 03:05 AM
  • 48 views

Keeping Your “Ion” The Ball – Salts and Life

by Mark Lasbury in As Many Exceptions As Rules

Lost at sea is no way to go to your everlasting reward. Sit in the sunshine too long and you lose your salts and all your functions go bonkers. Drink seawater and you end up with too much sodium and potassium and go nuts. Either way your dead, and it all has to do with your body’s tipping point and the kidney’s function in maintaining an osmotic potential. What is weirder - licorice can cause just about the same problem. ... Read more »

Räikkönen, K., Seckl, J., Heinonen, K., Pyhälä, R., Feldt, K., Jones, A., Pesonen, A., Phillips, D., Lahti, J., Järvenpää, A.... (2010) Maternal prenatal licorice consumption alters hypothalamic–pituitary–adrenocortical axis function in children. Psychoneuroendocrinology, 35(10), 1587-1593. DOI: 10.1016/j.psyneuen.2010.04.010  

  • August 23, 2016
  • 02:31 PM
  • 73 views

Too much activity in certain areas of the brain is bad for memory and attention

by Dr. Jekyll in Lunatic Laboratories

Neurons in the brain interact by sending each other chemical messages, so-called neurotransmitters. Gamma-aminobutyric acid (GABA) is the most common inhibitory neurotransmitter, which is important to restrain neural activity, preventing neurons from getting too trigger-happy and from firing too much or responding to irrelevant stimuli.

... Read more »

  • August 23, 2016
  • 11:30 AM
  • 66 views

Otulipenia – A New Inflammatory Disease

by Rita dos Santos Silva in United Academics

Researchers from the U.S. National Institutes of Health, working in collaboration with Turkish and British teams, discovered a new inflammatory disease.... Read more »

Zhou, Q., Wang, H., Schwartz, D., Stoffels, M., Park, Y., Zhang, Y., Yang, D., Demirkaya, E., Takeuchi, M., Tsai, W.... (2015) Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nature Genetics, 48(1), 67-73. DOI: 10.1038/ng.3459  

Elliott, P., Nielsen, S., Marco-Casanova, P., Fiil, B., Keusekotten, K., Mailand, N., Freund, S., Gyrd-Hansen, M., & Komander, D. (2014) Molecular Basis and Regulation of OTULIN-LUBAC Interaction. Molecular Cell, 54(3), 335-348. DOI: 10.1016/j.molcel.2014.03.018  

  • August 23, 2016
  • 11:29 AM
  • 58 views

Otulipenia – A New Inflammatory Disease

by Rita dos Santos Silva in United Academics

Researchers from the U.S. National Institutes of Health, working in collaboration with Turkish and British teams, discovered a new inflammatory disease.... Read more »

Zhou, Q., Wang, H., Schwartz, D., Stoffels, M., Park, Y., Zhang, Y., Yang, D., Demirkaya, E., Takeuchi, M., Tsai, W.... (2015) Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nature Genetics, 48(1), 67-73. DOI: 10.1038/ng.3459  

Elliott, P., Nielsen, S., Marco-Casanova, P., Fiil, B., Keusekotten, K., Mailand, N., Freund, S., Gyrd-Hansen, M., & Komander, D. (2014) Molecular Basis and Regulation of OTULIN-LUBAC Interaction. Molecular Cell, 54(3), 335-348. DOI: 10.1016/j.molcel.2014.03.018  

  • August 23, 2016
  • 10:36 AM
  • 72 views

The Brain: Red Meat and Mediterranean Diet

by William Yates, M.D. in Brain Posts

Entorhinal Cortex Highlighted in BluePrevious posts in this blog have highlighted some the research related to links between brain health and elements of the Mediterranean diet.I want to inform readers of a new important research study from the Mayo Clinic.In this study, researchers completed brain cortical thickness analyses on 672 cognitively normal adults. It is generally accepted that greater cortical thickness relates to improved cognitive performance.The participants completed an extensive........ Read more »

Staubo SC, Aakre JA, Vemuri P, Syrjanen JA, Mielke MM, Geda YE, Kremers WK, Machulda MM, Knopman DS, Petersen RC.... (2016) Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness. Alzheimer's . PMID: 27461490  

  • August 23, 2016
  • 03:47 AM
  • 77 views

Autism and/or ADHD in Down's syndrome

by Paul Whiteley in Questioning Answers

"High rates of ASD [autism spectrum disorder] and ADHD [attention-deficit hyperactivity disorder] were found: 17 (42%) and 14 (34%) of the 41 children met DSM criteria for ASD and ADHD respectively."That was the conclusion reached in the study by Ulrika Oxelgren and colleagues [1] looking at the "prevalence of autism spectrum disorder (ASD) and attention-deficit-hyperactivity disorder (ADHD) in a population-based group of children and adolescents with Down syndrome." The populatio........ Read more »

Oxelgren UW, Myrelid Å, Annerén G, Ekstam B, Göransson C, Holmbom A, Isaksson A, Åberg M, Gustafsson J, & Fernell E. (2016) Prevalence of autism and attention-deficit-hyperactivity disorder in Down syndrome: a population-based study. Developmental medicine and child neurology. PMID: 27503703  

  • August 22, 2016
  • 03:00 PM
  • 65 views

Stroke-like brain damage is reduced in mice injected with omega-3s

by Dr. Jekyll in Lunatic Laboratories

A stroke can happen at any age, and as with anything that involves the brain, a few seconds can be life altering. Usually the rule is time lost is brain lost, but there might be some good news regarding that, researchers found that omega-3 fatty acids reduced brain damage in a neonatal mouse model of stroke.

... Read more »

  • August 22, 2016
  • 05:17 AM
  • 88 views

"Theory of mind is not theory of emotion"

by Paul Whiteley in Questioning Answers

A rather interesting paper by Beth Oakley and colleagues [1] (open-access might be available here) appeared recently providing a "cautionary note on the Reading the Mind in the Eyes Test" [2], one of the premier assessments thought to offer a performance-based measure "involving mental state attribution and complex facial emotion recognition from photographs where only the eye region of the face is available."Most people with some knowledge about autism research history will have heard about the........ Read more »

  • August 21, 2016
  • 02:53 PM
  • 99 views

In cells, some oxidants are needed

by Dr. Jekyll in Lunatic Laboratories

Within our bodies, high levels of reactive forms of oxygen can damage proteins and contribute to diabetic complications and many other diseases. But some studies are showing that these reactive oxygen species (ROS) molecules sometimes can aid in maintaining health--findings now boosted by a surprising discovery by researchers.

... Read more »

Hourihan, J., Moronetti Mazzeo, L., Fernández-Cárdenas, L., & Blackwell, T. (2016) Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response. Molecular Cell, 63(4), 553-566. DOI: 10.1016/j.molcel.2016.07.019  

  • August 21, 2016
  • 03:00 AM
  • 114 views

Brawn, Brain and Beauty

by Aurametrix team in Aurametrix Blog

In the future all humans will be tall and beautiful look-alikes, as in GATTACA. Or they will split into frail beauties and sturdy beasts, as described in H. G. Wells' The Time Machine. British evolutionary psychologist Oliver Curry and paleoanthropologist Matthew Skinner believe in the possibility of similar scenarios, based on either the rich and poor divide ("gracile" vs "robust" species) or climate change-related evolution (pale hairy giants vs aquatic and space humans). The change may b........ Read more »

Crabtree, G. (2013) Our fragile intellect. Part II. Trends in Genetics, 29(1), 3-5. DOI: 10.1016/j.tig.2012.10.003  

Dickenson, E., O'Connor, P., Robinson, P., Campbell, R., Ahmed, I., Fernandez, M., Hawkes, R., Charles, H., & Griffin, D. (2016) Hip morphology in elite golfers: asymmetry between lead and trail hips. British Journal of Sports Medicine, 50(17), 1081-1086. DOI: 10.1136/bjsports-2016-096007  

  • August 20, 2016
  • 04:47 AM
  • 109 views

Polycystic ovary syndrome (PCOS) and risk of psychiatric disorder

by Paul Whiteley in Questioning Answers

"Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 5-15% of reproductive-aged women and characterized by high levels of circulating androgens."OK, go on."Women with PCOS had higher risks for a range of psychiatric disorders not shown before. Elevated risk in their siblings suggests shared familial factors between PCOS and psychiatric disorders."So said the findings reported by Carolyn Cesta and colleagues [1] who using Swedish national register data concluded that there ma........ Read more »

  • August 19, 2016
  • 03:34 PM
  • 105 views

Cloth masks offer poor protection against air pollution

by Dr. Jekyll in Lunatic Laboratories

Results of a new study by environmental health scientists suggest that inexpensive cloth masks worn by people who hope to reduce their exposure to air pollution vary widely in effectiveness and could be giving users a false sense of security, especially in highly polluted areas.

... Read more »

Shakya, K., Noyes, A., Kallin, R., & Peltier, R. (2016) Evaluating the efficacy of cloth facemasks in reducing particulate matter exposure. Journal of Exposure Science and Environmental Epidemiology. DOI: 10.1038/jes.2016.42  

  • August 19, 2016
  • 07:00 AM
  • 102 views

Friday Fellow: Asian Pigeonwing

by Piter Boll in Earthling Nature

by Piter Kehoma Boll Today’s Friday Fellow is a creeping (but not creepy) plant with nice deep blue flowers shaped like a human female genitalia. Yeah, you read that right. Its scientific name is Clitoria ternatea, the genus name being a … Continue reading →... Read more »

  • August 19, 2016
  • 04:35 AM
  • 104 views

Childhood inflammation and hypomanic symptoms in young adulthood?

by Paul Whiteley in Questioning Answers

"Higher levels of systemic inflammatory marker IL-6 in childhood were associated with hypomanic symptoms in young adulthood, suggesting that inflammation may play a role in the pathophysiology of mania."That was the conclusion reached by Joseph Hayes and colleagues [1] (open-access available here) who drew on data derived from the excellent resource that is ALSPAC ("Charting the health of 14,500 families in the Bristol area to improve the health of future generations"). I'll be talking abou........ Read more »

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