Most parents don’t want to think about their children as depressed, but that can be a deadly mistake. Short of clinical diagnosis through cost prohibitive therapy, there is no real way to tell if a child is at risk for depression. However, according to new research from Binghamton University , how much a child’s pupil dilates in response to seeing an emotional image can predict his or her risk of depression over the next two years.... Read more »
Burkhouse, K., Siegle, G., Woody, M., Kudinova, A., & Gibb, B. (2015) Pupillary Reactivity to Sad Stimuli as a Biomarker of Depression Risk: Evidence From a Prospective Study of Children. Journal of Abnormal Psychology. DOI: 10.1037/abn0000072
One the early things I was taught in my neuroscience training was that new-onset visual hallucinations need to be assessed for medical or "organic causes".Auditory hallucinations were felt to be more characteristic of schizophrenia.One medical disorder linked to visual hallucinations is dementia with Lewy bodies (DLB). DLB is second to Alzheimer's disease in producing neurodegenerative dementia. Visual hallucinations is a hallmark of DLB and is found in up to 70% of clinical samples with th........ Read more »
Heitz C, Noblet V, Cretin B, Philippi N, Kremer L, Stackfleth M, Hubele F, Armspach JP, Namer I, & Blanc F. (2015) Neural correlates of visual hallucinations in dementia with Lewy bodies. Alzheimer's research , 7(1), 6. PMID: 25717349
To assess the value of spirituality, this article aims to give a clear, imaginable and humble impression of spirituality research. It describes research of spiritual practices, which are practiced by people of multiple religious affiliations and even by irreligious people.... Read more »
Vickhoff, B., Malmgren, H., Åström, R., Nyberg, G., Ekström, S., Engwall, M., Snygg, J., Nilsson, M., & Jörnsten, R. (2013) Music structure determines heart rate variability of singers. Frontiers in Psychology. DOI: 10.3389/fpsyg.2013.00334
de Ridder D, Kroese F, Adriaanse M, & Evers C. (2014) Always gamble on an empty stomach: hunger is associated with advantageous decision making. PloS one, 9(10). PMID: 25340399
Friese M, Schweizer L, Arnoux A, Sutter F, & Wänke M. (2014) Personal prayer counteracts self-control depletion. Consciousness and cognition, 90-5. PMID: 25277947
Bhasin MK, Dusek JA, Chang BH, Joseph MG, Denninger JW, Fricchione GL, Benson H, & Libermann TA. (2013) Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PloS one, 8(5). PMID: 23650531
Ybarra O, Burnstein E, Winkielman P, Keller MC, Manis M, Chan E, & Rodriguez J. (2008) Mental exercising through simple socializing: social interaction promotes general cognitive functioning. Personality , 34(2), 248-59. PMID: 18212333
"Parents of children with ASD [autism spectrum disorder] living in Stockholm, Sweden in 2006 were more likely to be on sick leave, not in the labor force, or earning low income when compared to parents who did not have a child with ASD and these results remained after adjusting for familial socioeconomic factors and parental psychiatric care."That was the rather grim conclusion reached by Miranda McEvilly and colleagues  (open-access) following their analysis of families taking........ Read more »
McEvilly M, Wicks S, & Dalman C. (2015) Sick Leave and Work Participation Among Parents of Children with Autism Spectrum Disorder in the Stockholm Youth Cohort: A Register Linkage Study in Stockholm, Sweden. Journal of autism and developmental disorders. PMID: 25697737
Mohamed Boutjdir, PhD, professor of medicine, cell biology, and physiology and pharmacology at SUNY Downstate Medical Center, has led a study with international collaborators identifying the mechanism by which patients with various autoimmune and connective tissue disorders may be at risk for life-threatening cardiac events if they take certain anti-histamine or anti-depressant medications. Dr. Boutjdir is also director of the Cardiac Research Program at VA New York Harbor Healthcare System.... Read more »
Yue, Y., Castrichini, M., Srivastava, U., Fabris, F., Shah, K., Li, Z., Qu, Y., El-Sherif, N., Zhou, Z., January, C.... (2015) Pathogenesis of the Novel Autoimmune-Associated Long QT Syndrome. Circulation. DOI: 10.1161/CIRCULATIONAHA.115.009800
Providers of mental-health services still rely on intervention techniques such as physical restraint and confinement to control some psychiatric hospital patients, a practice which can cause harm to both patients and care facilities, according to a new study from the University of Waterloo. The study found that almost one in four psychiatric patients in Ontario hospitals are restrained using control interventions, such as chairs that prevent rising, wrist restraints, seclusion rooms or acute con........ Read more »
Mah, T., Hirdes, J., Heckman, G., & Stolee, P. (2015) Use of control interventions in adult in-patient mental health services. Healthcare Management Forum, 28(4), 139-145. DOI: 10.1177/0840470415581230
In answer to the question posed in the title of this post on whether coeliac disease (CD) might show some connection to intellectual (learning) disability, 'probably not' is the finding reported by Taner Sezer and colleagues .Researchers initially looked at "serum levels of tissue transglutaminase antibody and total IgA" in over 230 children diagnosed with nonsyndromic intellectual disability compared with about the same number of asymptomatic controls. Nonsyndromic intellectual dis........ Read more »
Sezer T, Balcı O, Özçay F, Bayraktar N, & Alehan F. (2015) Is Celiac Disease an Etiological Factor in Children with Nonsyndromic Intellectual Disability?. Journal of child neurology. PMID: 26078418
Prior concussion that resulted in loss of consciousness is a risk factor for decreased hippocampal regions and mild cognitive impairment later in life.... Read more »
Strain JF, Womack KB, Didehbani N, Spence JS, Conover H, Hart J Jr, Kraut MA, & Cullum CM. (2015) Imaging Correlates of Memory and Concussion History in Retired National Football League Athletes. JAMA Neurology. PMID: 25985094
Flu vaccines can be something of a shot in the dark. Not only must they be given yearly, there’s no guarantee the strains against which they protect will be the ones circulating once the season arrives. New research by Rockefeller University scientists suggests it may be possible to harness a previously unknown mechanism within the immune system to create more effective and efficient vaccines against this ever-mutating virus.... Read more »
Wang, T., Maamary, J., Tan, G., Bournazos, S., Davis, C., Krammer, F., Schlesinger, S., Palese, P., Ahmed, R., & Ravetch, J. (2015) Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy. Cell, 162(1), 160-169. DOI: 10.1016/j.cell.2015.06.026
MedicalResearch.com Interview with: Igho Onakpoya MD MSc Clarendon Scholar University of Oxford Centre for Evidence-Based Medicine Nuffield Department of Primary Care Health Sciences Oxford UK MedicalResearch: What is the background for this study? What are the main findings? Dr. Onakpoya: Several … Continue reading →
The post Evidence of Value of Orphan Drugs Inconsistent appeared first on MedicalResearch.com Medical Research Interviews and News.
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Igho Onakpoya MD MSc, & Clarendon Scholar. (2015) Evidence of Value of Orphan Drugs Inconsistent. medicalresearch.com. info:/
Research from Columbia University Medical Center (CUMC) has uncovered further evidence of a system in the brain that persistently maintains memories for long periods of time. And paradoxically, it works in the same way as mechanisms that cause mad cow disease, kuru, and other degenerative brain diseases.... Read more »
Fioriti, L., Myers, C., Huang, Y., Li, X., Stephan, J., Trifilieff, P., Colnaghi, L., Kosmidis, S., Drisaldi, B., Pavlopoulos, E.... (2015) The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3. Neuron, 86(6), 1433-1448. DOI: 10.1016/j.neuron.2015.05.021
Drisaldi, B., Colnaghi, L., Fioriti, L., Rao, N., Myers, C., Snyder, A., Metzger, D., Tarasoff, J., Konstantinov, E., Fraser, P.... (2015) SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3. Cell Reports, 11(11), 1694-1702. DOI: 10.1016/j.celrep.2015.04.061
Stephan, J., Fioriti, L., Lamba, N., Colnaghi, L., Karl, K., Derkatch, I., & Kandel, E. (2015) The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton. Cell Reports, 11(11), 1772-1785. DOI: 10.1016/j.celrep.2015.04.060
Fiumara, F., Rajasethupathy, P., Antonov, I., Kosmidis, S., Sossin, W., & Kandel, E. (2015) MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream Targets. Cell Reports, 11(12), 1866-1875. DOI: 10.1016/j.celrep.2015.05.034
I must thank Leah Hardy (@LeahFHardy) for bringing to my attention the paper by Qinglong Shang and colleagues  (open-access available here) reporting that: "Ad36 [Human adenovirus 36] infection is associated with an increased risk of obesity development."Based on a meta-analysis of the available research literature examining whether Ad-36 - "a nonenveloped icosahedral virus comprised of double-stranded DNA and is one of 56 serotypes in 7 subgroups of human adenoviruses" - might........ Read more »
Shang Q, Wang H, Song Y, Wei L, Lavebratt C, Zhang F, & Gu H. (2014) Serological data analyses show that adenovirus 36 infection is associated with obesity: a meta-analysis involving 5739 subjects. Obesity (Silver Spring, Md.), 22(3), 895-900. PMID: 23804409
Rapid eye movement or REM sleep actively converts waking experiences into lasting memories and abilities in young brains reports a new study. The finding broadens the understanding of children’s sleep needs and calls into question the increasing use of REM-disrupting medications such as stimulants and antidepressants.
... Read more »
Michelle C. Dumoulin Bridi, Sara J. Aton, Julie Seibt, Leslie Renouard, Tammi Coleman1, & Marcos G. Frank. (2015) Rapid eye movement sleep promotes cortical plasticity in the developing brain. Science Advances. info:/10.1126/sciadv.1500105
The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed. A group of researchers discovered a new mechanism of DNA repair, which opens up new perspectives for the treatment and prevention of neurodegenerative diseases.... Read more »
Nikolay A. Pestov, Nadezhda S. Gerasimova, Olga I. Kulaeva, & Vasily M. Studitsky. (2015) Structure of transcribed chromatin is a sensor of DNA damage. Science Advances. info:/10.1126/sciadv.1500021
MedicalResearch.com Interview with: Prof. Patrick L Kinney Ph.D. Professor of Environmental Health Sciences and Director, Columbia Climate and Health Program Mailman School of Public Health Columbia University, New York, NY Medical Research: What is the background for this study? Dr. Kinney: … Continue reading →
The post Warming Climate May Not Reduce Winter Mortality appeared first on MedicalResearch.com Medical Research Interviews and News.
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Prof. Patrick L Kinney Ph.D., & Professor of Environmental Health Sciences. (2015) Warming Climate May Not Reduce Winter Mortality. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Dr. F. Xavier Pi–Sunyer MD Division of Endocrinology and Obesity Research Center Columbia University, New York Medical Research: What is the background for this study? What are the main findings? Dr. Pi-Sunye: In a large randomized trial, … Continue reading →
The post Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Dr. F. Xavier Pi-Sunyer MD, & Division of Endocrinology and Obesity Research Center. (2015) Diabetes Medication Reduced Weight and Improved Metabolic Parameters in Obese Patients. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Michael S. Irwig MD Division of Endocrinology Medical Faculty Associates George Washington University Medical Research: What is the background for this study? What are the main findings? Response: Many factors are associated with lower testosterone levels and … Continue reading →
The post Low Testosterone Linked To Obesity and Depression In Men appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »
Michael S. Irwig MD Division of Endocrinology Medical Faculty Associates. (2015) Low Testosterone Linked To Obesity and Depression In Men. MedicalResearch.com. info:/
Animal models can be useful for understanding disease pathology and as preclinical models for drug testing. As BHD patients develop renal cell carcinomas (RCCs) of varied histologies, associated with a loss of FLCN, BHD animal models could be used to study of a wide range of renal cancer subtypes. Current BHD mouse models include kidney-specific Flcn-knockouts (Chen et al., 2008, Baba et al., 2008) and ubiquitous knockouts (Hasumi et al., 2009, Hartman et al., 2009, Hudon et al., 2010). The form........ Read more »
Chen J, Huang D, Rubera I, Futami K, Wang P, Zickert P, Khoo SK, Dykema K, Zhao P, Petillo D.... (2015) Disruption of tubular Flcn expression as a mouse model for renal tumor induction. Kidney international. PMID: 26083655
Adding some ‘worry time’ to your day could work better than pills.... Read more »
Koffel EA, Koffel JB, & Gehrman PR. (2015) A meta-analysis of group cognitive behavioral therapy for insomnia. Sleep medicine reviews, 6-16. PMID: 24931811
Sivertsen B, Omvik S, Pallesen S, Bjorvatn B, Havik OE, Kvale G, Nielsen GH, & Nordhus IH. (2006) Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. JAMA, 295(24), 2851-8. PMID: 16804151
I was really rather happy to see the "preliminary evidence" reported by Rebecca Schmidt and colleagues  when it came to examining whether selected vitamin D metabolic gene variants might show linkage to autism spectrum disorder (ASD) based on data derived from the CHARGE initiative.For quite a while now I've discussed the various peer-reviewed science on the topic of vitamin D deficiency / insufficiency with autism in mind on this blog (see here and see here for example). Specifically, h........ Read more »
Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Sconberg JL, Schmidt LC, Volk HE, & Tassone F. (2015) Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early human development, 91(8), 483-489. PMID: 26073892
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