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  • July 31, 2014
  • 01:33 PM
  • 8 views

Mitochondria and Anti Aging

by Gabriel in Lunatic Laboratories

I’m sure you can all relate, you go to fix the sink and in the process you build a new kitchen on accident. Anyone… no? Well that is sort of […]... Read more »

  • July 31, 2014
  • 09:22 AM
  • 9 views

What’s the Answer? (electronic lab notebooks)

by Mary in OpenHelix

Biostars is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the community and find it very useful. Often questions and answers arise at Biostars that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here […]... Read more »

Voegele C., N. Robinot, J. McKay, P. Damiecki, & L. Alteyrac. (2013) A universal open-source Electronic Laboratory Notebook. Bioinformatics, 29(13), 1710-1712. DOI: http://dx.doi.org/10.1093/bioinformatics/btt253  

  • July 31, 2014
  • 08:10 AM
  • 14 views

Tough Talking Apes

by Mark E. Lasbury in The 'Scope

The new Planet of the Apes movie has talking apes! In the old Charleton Heston versions, the apes had thousands of years to evolve speech capabilities, but Dawn of the Planet of the Apes takes place only 10 years after their escape from the lab. Anatomical differences between human and ape hyoid position, rib musculature and tongue show us why speech is not possible for Cesar and his friends. In addition, new research points out the importance of the foxp2 protein for speech and auditory functio........ Read more »

  • July 31, 2014
  • 08:01 AM
  • 9 views

July 31, 2014

by Erin Campbell in HighMag Blog

Do you ever feel nostalgic for a specific paper? Maybe this paper inspired your own research, or maybe it was a paper you immediately knew would be game-changing. Maybe, like today’s TBT paper, it was a great paper about solidly executed research with a memorable giggle-inducing technique. Thanks to a nostalgic HighMag reader and friend, Omar Quintero, we are being re-introduced to gonad sandwiches. In mammals, sex determination refers to the changes during early development that lead ........ Read more »

Martineau, J., Nordqvist, K., Tilmann, C., Lovell-Badge, R., & Capel, B. (1997) Male-specific cell migration into the developing gonad. Current Biology, 7(12), 958-968. DOI: 10.1016/S0960-9822(06)00415-5  

  • July 31, 2014
  • 04:18 AM
  • 12 views

Dipeptidyl peptidase (DPP) IV and autism: supporting opioid-excess?

by Paul Whiteley in Questioning Answers

Serum levels of dipeptidyl peptidase (DPP) IV were found to be lower in children with autism compared to asymptomatic controls according to the study by Shahid Bashira & Laila AL-Ayadhi [1]. Based on analysis by ELISA, researchers concluded that "alterations in the plasma level of DPP IV play a role in the pathophysiology of autism".A sailor went to sea, sea, sea... @ Wikipedia Anyone who has followed the autism research scene for any length of time might have already heard ab........ Read more »

  • July 30, 2014
  • 04:00 PM
  • 8 views

SCIENCE IN THE NEWS: THE 2014 EBOLA OUTBREAK

by Emily Lawson in Antisense Science

If you’ve been watching the news recently, you’ll probably have seen reports on the Ebola outbreak in West Africa. Around 673 people in Guinea and Liberia have died so far (including one case of a Liberian government employee who died shortly after arriving at Lagos airport in Nigeria), making this the most deadly outbreak to date. So what exactly is Ebola, and why is it so deadly?

Ebola virus disease (EVD) has an incredibly high mortality rate – while the current outbreak h........ Read more »

Dixon MG, Schafer IJ, & EIS officer, CDC. (2014) Ebola viral disease outbreak - west Africa, 2014. MMWR. Morbidity and mortality weekly report, 63(25), 548-51. PMID: 24964881  

Gatherer, D. (2014) The 2014 Ebola virus disease outbreak in West Africa. Journal of General Virology, 95(Pt_8), 1619-1624. DOI: 10.1099/vir.0.067199-0  

  • July 30, 2014
  • 01:31 PM
  • 33 views

Suicide, it might be in the blood

by Gabriel in Lunatic Laboratories

I tried to kill myself, more than once in fact. It was a troubling time for me and as a former active duty Marine that might not be too surprising […]... Read more »

  • July 30, 2014
  • 10:46 AM
  • 38 views

Influenza: How the Great War helped create the greatest pandemic the world has ever known | @GrrlScientist

by GrrlScientist in GrrlScientist

The Great War helped create the influenza pandemic of 1918, which eventually brought an early end to the Great War. Continue reading...... Read more »

  • July 30, 2014
  • 09:41 AM
  • 27 views

Video Tip of the Week: PhenDisco, “phenotype discoverer” for dbGap data

by Mary in OpenHelix

The dbGaP, database of Genotypes and Phenotypes, repository at NCBI collects information from research projects that link genotype and phenotype information and human variation, across many different types of studies, providing leads on variation that may be important to understand clinical issues. Some of the data is publicly available de-identified patient information, and some of the […]... Read more »

Doan Son, Lin Ko-Wei, Conway Mike, Ohno-Machado Lucila, Hsieh Alex, Feupe Stephanie Feudjio, Garland Asher, Ross Mindy K, Jiang Xiaoqian, & Farzaneh Seena. (2013) PhenDisco: phenotype discovery system for the database of genotypes and phenotypes. Journal of the American Medical Informatics Association : JAMIA. PMID: 23989082  

Tryka K. A., A. Sturcke, Y. Jin, Z. Y. Wang, L. Ziyabari, M. Lee, N. Popova, N. Sharopova, M. Kimura, & M. Feolo. (2013) NCBI's Database of Genotypes and Phenotypes: dbGaP. Nucleic Acids Research, 42(D1). DOI: http://dx.doi.org/10.1093/nar/gkt1211  

  • July 30, 2014
  • 08:10 AM
  • 93 views

Does Life Come In XXXS?

by Mark Lasbury in As Many Exceptions As Rules

Is there a minimum size for life? How would you measure it, cell volume or genome size? People do both. The current minimum example of life is Mycoplasma genitalium, at just 200 nm by 600 nm in well-fed cultures. M. genitalium also has the smallest known genome for a free-living organism (520 genes, we have about 27,000). Some organisms have fewer genes (137 or so) but are endosymbionts, so they can get away with trashing some of their DNA. New research shows that M. genitalium is a pathogenic o........ Read more »

Manhart LE. (2013) Mycoplasma genitalium: An emergent sexually transmitted disease?. Infectious disease clinics of North America, 27(4), 779-92. PMID: 24275270  

Gibson DG, Glass JI, Lartigue C, Noskov VN, Chuang RY, Algire MA, Benders GA, Montague MG, Ma L, Moodie MM.... (2010) Creation of a bacterial cell controlled by a chemically synthesized genome. Science (New York, N.Y.), 329(5987), 52-6. PMID: 20488990  

  • July 30, 2014
  • 05:27 AM
  • 27 views

Subduing the Hive Mind: An enemy’s enemy could become an unlikely friend

by socgenmicro in Microbe Post

Leafcutter ants form some of the biggest, most remarkable animal societies on Earth, living in sprawling colonies of up to 8 million individuals. These ants harvest more greenery in South American rainforests than any other animal, consuming almost 20% of … Continue reading →... Read more »

  • July 30, 2014
  • 04:52 AM
  • 27 views

Immunological effects from risperidone treatment in autism

by Paul Whiteley in Questioning Answers

The findings from Jai Eun Choi and colleagues [1] suggesting that use of the antipsychotic risperidone may impact on levels of certain cytokines - messenger cells of the immune system - in some cases of autism spectrum disorder (ASD) grabbed my attention recently. I've always been pretty interested in the complexity of the immune system when it comes to something like autism (see here) as well as the various examples of how many of the medications used to 'manage' aspects of autis........ Read more »

Choi JE, Widjaja F, Careaga M, Bent S, Ashwood P, & Hendren RL. (2014) Change in Plasma Cytokine Levels During Risperidone Treatment in Children with Autism. Journal of child and adolescent psychopharmacology. PMID: 24828014  

  • July 29, 2014
  • 01:15 PM
  • 47 views

Can’t Handle the Stress? Blame your Brain

by Gabriel in Lunatic Laboratories

Do you rise to the occasion, or do you fold under the pressure? No matter which side of the fence you’re, you can thank [or blame] your brain. Some people […]... Read more »

  • July 29, 2014
  • 12:02 PM
  • 40 views

When Mom and Dad Have Different Migratory Routes, Kids Fly Right Down the Middle

by Elizabeth Preston in Inkfish

It sounds like the setup to a bad joke told by zoologists: What do you get when you cross a bird that always flies to the west with one that always flies east? But the punch line is weirder than you’d guess. Birds’ migratory routes are partly coded into their DNA. A baby that inherits […]The post When Mom and Dad Have Different Migratory Routes, Kids Fly Right Down the Middle appeared first on Inkfish.... Read more »

  • July 29, 2014
  • 11:55 AM
  • 39 views

Japanese Encephalitis Virus, Coronavirus, Autophagy, and the ER stress response

by thelonevirologist in Virology Tidbits

The accumulation of misfolded proteins in the ER lumen induces a stress response commonly known as the Unfolded Protein Response (UPR) or ER stress response, an adaptive signalling pathway increasing the expression of ER chaperones, inhibiting mRNA translation, and stimulating ER associated degradation (ERAD) of accumulated proteins. The degradation via the ERAD pathway in particular requires the formation of double membrane vesicles -more commonly referred to as autophagosomes - which subsequen........ Read more »

Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I, & Harris AL. (2010) Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene, 29(31), 4424-35. PMID: 20514020  

Li JK, Liang JJ, Liao CL, & Lin YL. (2012) Autophagy is involved in the early step of Japanese encephalitis virus infection. Microbes and infection / Institut Pasteur, 14(2), 159-68. PMID: 21946213  

Cottam EM, Whelband MC, & Wileman T. (2014) Coronavirus NSP6 restricts autophagosome expansion. Autophagy, 10(8). PMID: 24991833  

  • July 29, 2014
  • 10:37 AM
  • 25 views

STING-associated autoinflammatory disease

by Aurelie in The Immuno Blog

A study published in the New England Journal of Medicine describes an autoinflammatory syndrome associated with mutations in the gene encoding STING. Dubbed SAVI, for STING-associated vasculopathy with onset in infancy, the disease is characterized by systemic inflammation, severe cutaneous … Continue reading →... Read more »

Liu, Y., Jesus, A., Marrero, B., Yang, D., Ramsey, S., Sanchez, G., Tenbrock, K., Wittkowski, H., Jones, O., Kuehn, H.... (2014) Activated STING in a Vascular and Pulmonary Syndrome. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1312625  

  • July 29, 2014
  • 07:30 AM
  • 36 views

Is homosexuality "natural"?

by Bill Sullivan in The 'Scope

In the beginning, there was no sex. That’s because in the beginning, there was no Barry White. A playful look at examples of homosexuality in nature.... Read more »

Van Houdenhove E, Gijs L, T'sjoen G, & Enzlin P. (2014) Asexuality: A Multidimensional Approach. Journal of sex research, 1-10. PMID: 24750031  

  • July 29, 2014
  • 04:04 AM
  • 39 views

Ketogenic diet and the valproate mouse model of autism

by Paul Whiteley in Questioning Answers

A brief entry today and yet another blog post that starts with a quote (sorry)... "The offspring exposed to VPA [valproic acid] prenatally demonstrated a significant decrease in the number of play initiations/attacks and this was reversed with the KD [ketogenic diet]".Gloucester Old Spot @ Wikipedia That finding reported in the paper by Ahn and colleagues [1] continues my interest in all-things related to prenatal VPA exposure and the reported effects on some offspring (........ Read more »

  • July 28, 2014
  • 03:10 PM
  • 123 views

This Month In Blastocystis Research (JUL 2014)

by Christen Rune Stensvold in Blastocystis Parasite Blog

A new study from Colombia sees Blastocystis as a quasi-ubiquitous organism.... Read more »

  • July 28, 2014
  • 01:13 PM
  • 48 views

A New Hepatitis C Treatment offers Hope

by Gabriel in Lunatic Laboratories

Well this might seem weird, but today is world hepatitis day. I guess I should qualify weird with the fact that it’s only weird because no one really knows. What […]... Read more »

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