As the majority of people in developed countries will be touched in some way by dementia in the 21st century, current ways of interacting in dementia care may no longer be acceptable. In particular, when people with dementia appear uncommunicative, their retained awareness and ability to interact is often dismissed or overlooked. Facing social isolation and further decline, many languish with unmet needs for human interaction. However, the intimacies of family interaction in dementia care settin........ Read more »
Walmsley, B., & McCormack, L. (2013) The dance of communication: Retaining family membership despite severe non-speech dementia. Dementia, 13(5), 626-641. DOI: 10.1177/1471301213480359
When a patient has sepsis Things can go downhill fast. A life-threatening condition in which bacteria or fungi multiply in a patient's blood -- sepsis is often too fast for antibiotics to help. But that's all about to change with the introduction of a new device -- inspired by the human spleen -- that may radically transform the way doctors treat sepsis.... Read more »
Kang JH, Super M, Yung CW, Cooper RM, Domansky K, Graveline AR, Mammoto T, Berthet JB, Tobin H, Cartwright MJ.... (2014) An extracorporeal blood-cleansing device for sepsis therapy. Nature medicine. PMID: 25216635
Maybe it was all the Who noise that made the Grinch so aggressive. Recent research out of Bulgaria suggests a link between noise pollution and displaced aggression.... Read more »
Dzhambov A, & Dimitrova D. (2014) Neighborhood noise pollution as a determinant of displaced aggression: A pilot study. Noise and Health, 16(69), 95-101. DOI: 10.4103/1463-1741.132090
Stem cells offered the promise of having a patents own organ grown to replace a failing or damaged one. Unfortunately the road to that future has been paved with seemingly insurmountable challenges. Thankfully now we are one step closer, researchers have addressed a major challenge in the quest to build replacement kidneys in the lab. Working with human-sized pig kidneys, the scientists developed the most successful method to date to keep blood vessels in the new organs open and flowing with blo........ Read more »
In Kap Ko,, Mehran Abolbashari,, Jennifer Huling,, Cheil Kim,, Sayed-Hadi Mirmalek-Sani,, Mahmoudreza Moradi,, Giuseppe Orlando,, John D. Jackson,, Tamer Aboushwareb,, Shay Soker,.... (2014) Enhanced re-endothelialization of acellular kidney scaffolds for whole organ engineering via antibody conjugation of vasculatures. Technology . info:/10.1142/S2339547814500228
Neurological disorders typically involve memory issues. Most of the problems are attributed to plaques that build up in the brain (which are typically prions), yet some causes are unknown. New research however sheds some light on at least one cause of memory problems. As it turns out brain inflammation can rapidly disrupt our ability to retrieve complex memories of similar but distinct experiences.... Read more »
Czerniawski J, & Guzowski JF. (2014) Acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(37), 12470-80. PMID: 25209285
"Overall, the present findings suggest that metabolic and hormonal disturbances such as effects on insulin and growth hormone may represent a vulnerability factor to develop mental disorders". That was the conclusion reported by van Beveren and colleagues  (open-access) looking at "disruption of insulin and growth factor signaling pathways as an increased risk factor for schizophrenia"."Years ago you served my father in the Clone Wars"Drawing on data derived from participants taking part in&n........ Read more »
van Beveren NJ, Schwarz E, Noll R, Guest PC, Meijer C, de Haan L, & Bahn S. (2014) Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the development of schizophrenia. Translational psychiatry. PMID: 25158005
Get caught up quick on the hottest science news from this week!... Read more »
Denoeud, F., Carretero-Paulet, L., Dereeper, A., Droc, G., Guyot, R., Pietrella, M., Zheng, C., Alberti, A., Anthony, F., Aprea, G.... (2014) The coffee genome provides insight into the convergent evolution of caffeine biosynthesis. Science, 345(6201), 1181-1184. DOI: 10.1126/science.1255274
Long, C., McAnally, J., Shelton, J., Mireault, A., Bassel-Duby, R., & Olson, E. (2014) Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science, 345(6201), 1184-1188. DOI: 10.1126/science.1254445
Anyone who has seen pictures or models of the human brain (like the one above) is aware that the outside layer, or cortex, of the brain is folded in an intricate pattern of “hills”, called gyri, and “valleys”, called sulci which give the brain it’s distinctive look. It turns out that the patterns of cortical folding are largely consistent across healthy humans, broadly speaking. However, disturbances in cortical folding patterns suggest deeper disturbances in brain structure and functi........ Read more »
Nanda P, Tandon N, Mathew IT, Giakoumatos CI, Abhishekh HA, Clementz BA, Pearlson GD, Sweeney J, Tamminga CA, & Keshavan MS. (2014) Local gyrification index in probands with psychotic disorders and their first-degree relatives. Biological psychiatry, 76(6), 447-55. PMID: 24369266
I had been waiting y'know. Waiting a while for the paper by Sally Rogers and colleagues  to finally appear quite a few days after the media headlines about 'reducing', 'reversing' and even 'eliminating' the signs and symptoms of autism in early infancy had appeared. Personally, I prefer the New Scientist headline: 'Early autism intervention speeds infant development' given the text of the paper. I should perhaps also add the words 'for some' to that sentence as you will hopefully see...I........ Read more »
S. J. Rogers, L. Vismara, A. L. Wagner, C. McCormick, G. Young, & S. Ozonoff. (2014) Autism Treatment in the First Year of Life: A Pilot Study of Infant Start, a Parent-Implemented Intervention for Symptomatic Infants. Journal of Autism and Developmental Disorders. info:/10.1007/s10803-014-2202-y
You may have seen headlines over the past week proclaiming that handsome men have lower-quality sperm. If this made you panic because you happen to be a great-looking guy, you can stop. (If you’re an un-handsome man who’s been gloating—sorry.) This scientific study did say a few interesting things about Spaniards, Colombians, and cheekbones. But […]The post Stop Worrying, Good-Looking Dudes: Your Sperm Is Fine appeared first on Inkfish.... Read more »
Soler C, Kekäläinen J, Núñez M, Sancho M, Alvarez JG, Núñez J, Yaber I, & Gutiérrez R. (2014) Male facial attractiveness and masculinity may provide sex- and culture-independent cues to semen quality. Journal of evolutionary biology, 27(9), 1930-8. PMID: 25056484
"These results demonstrate that n-3 PUFAs dietary supplementation, although not a panacea, has a considerable therapeutic value for FXS [Fragile X syndrome] and potentially for ASD [autism spectrum disorder], suggesting a major mediating role of neuroinflammatory mechanisms".A view @ Wikipedia That was the conclusion reached by Susanna Pietropaolo and colleagues  who "evaluated the impact of n-3 PUFA dietary supplementation in a mouse model of fragile X syndrome ........ Read more »
Pietropaolo S, Goubran MG, Joffre C, Aubert A, Lemaire-Mayo V, Crusio WE, & Layé S. (2014) Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice. Psychoneuroendocrinology, 119-129. PMID: 25080404
We like to give treatments that produce results that we can see and logically attribute to the treatments we gave.
We like to give IV (IntaVenous) furosemide (Lasix – frusemide in Commonwealth countries) for CHF (Congestive Heart Failure).
1. The patient had CHF.
2. I gave IV furosemide.
3. The patient produced urine.... Read more »
Figueras J, & Weil MH. (1978) Blood volume prior to and following treatment of acute cardiogenic pulmonary edema. Circulation, 57(2), 349-55. PMID: 618625
Francis GS, Siegel RM, Goldsmith SR, Olivari MT, Levine TB, & Cohn JN. (1985) Acute vasoconstrictor response to intravenous furosemide in patients with chronic congestive heart failure. Activation of the neurohumoral axis. Annals of internal medicine, 103(1), 1-6. PMID: 2860833
Hoffman JR, & Reynolds S. (1987) Comparison of nitroglycerin, morphine and furosemide in treatment of presumed pre-hospital pulmonary edema. Chest, 92(4), 586-93. PMID: 3115687
Multiple sclerosis (MS) is an unpredictable, often disabling disease of the central nervous system that disrupts the flow of information within the brain, and between the brain and body. The exact cause is unknown, however people with multiple sclerosis lose myelin in the gray matter of their brains and the loss is closely correlated with the severity of the disease, according to a new magnetic resonance imaging (MRI) study.... Read more »
Vasily L. Yarnykh, James D. Bowen, Alexey Samsonov, Pavle Repovic, Angeli Mayadev, Peiqing Qian, Beena Gangadharan, Bart P. Keogh, Kenneth R. Maravilla, & Lily K. Jung Henson. (2014) Fast Whole-Brain Three-dimensional Macromolecular Proton Fraction Mapping in Multiple Sclerosis. Radiological Society of North America . info:/10.1148/radiol.14140528
“Giving implies to make the other person a giver also.” So said Eric Fromm whose quote starts this research paper which travels to the heart of mutual aid. The clear message? In helping other, we help ourselves. The recovery saying “We only keep what we have by giving it away” hits the mark in this respect. What [...]
The post Altruism and AlAnon: in helping we are helped appeared first on Recovery Review.
... Read more »
Kuuluvainen, V., & Isotalus, P. (2014) Supporting others – Supporting oneself: Members’ evaluations of supportive communication in Al-Anon mutual-aid groups. Studies in Communication Sciences. DOI: 10.1016/j.scoms.2014.03.009
A strange and provocative paper by Alexander Panchin and colleagues proposes an unorthodox new idea called the “biomeme hypothesis”, which posits that the impulse behind some religious rituals could be driven by mind-altering parasites.... Read more »
Panchin AY, Tuzhikov AI, & Panchin YV. (2014) Midichlorians--the biomeme hypothesis: is there a microbial component to religious rituals?. Biology direct, 9(1), 14. PMID: 24990702
The rapid adoption of next-gen exome and genome sequencing for clinical use (i.e. with patient DNA) raises some difficult questions about the return of results to patients and their families. In contrast to traditional genetic testing, which usually checks for variants in specific genes, high-throughput sequencing has the potential to reveal a number of secondary […]... Read more »
Tabor HK, Auer PL, Jamal SM, Chong JX, Yu JH, Gordon AS, Graubert TA, O'Donnell CJ, Rich SS, Nickerson DA.... (2014) Pathogenic variants for mendelian and complex traits in exomes of 6,517 European and african americans: implications for the return of incidental results. American journal of human genetics, 95(2), 183-93. PMID: 25087612
In a post not-so-long-ago I talked about an interesting piece of research by Ahn and colleagues  suggesting that a ketogenic diet might yet hold some promise to "modify complex social behaviors and mitochondrial respiration" affected in the "prenatal valproic acid (VPA) rodent model of ASD [autism spectrum disorder]". The idea being that exposure to valproic acid (valproate) during the nine months that made us might carry some heightened risk for adverse effects on offspring development (see ........ Read more »
Wellmann KA, Varlinskaya EI, & Mooney SM. (2014) D-Cycloserine Ameliorates Social Alterations That Result From Prenatal Exposure To Valproic Acid. Brain research bulletin. PMID: 25130667
Kim JW, Seung H, Kwon KJ, Ko MJ, Lee EJ, Oh HA, Choi CS, Kim KC, Gonzales EL, You JS.... (2014) Subchronic Treatment of Donepezil Rescues Impaired Social, Hyperactive, and Stereotypic Behavior in Valproic Acid-Induced Animal Model of Autism. PloS one, 9(8). PMID: 25133713
As a male we are at higher risk for heart disease, we are also at higher risk for stroke. It’s that pesky testosterone, sure it has its benefits, don’t get me wrong I think testosterone over all is great. Estrogen has it’s own downsides too, things like certain cancers for example. Well estrogen has some other benefits and as it turns out, the same sex hormone that helps protect females from stroke may also reduce their risk of autism.... Read more »
Amanda Crider,, Roshni Thakkar,, Anthony O Ahmed, & Anilkumar Pillai. (2014) Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects. Molecular Autism . info:/10.1186/2040-2392-5-46
If your grandma got up from the sofa, did a couple toe-touches, and then ran a mile at her college track pace, she might be approaching the athletic skill of a thick-billed murre. These seabirds make incredibly deep, long dives to catch prey. As they age, their bodies slow and change like ours. But the […]The post Elderly Seabirds Dive Just as Well as Young Ones appeared first on Inkfish.... Read more »
Elliott, K., Hare, J., Le Vaillant, M., Gaston, A., Ropert-Coudert, Y., & Anderson, W. (2014) Ageing gracefully: physiology but not behaviour declines with age in a diving seabird. Functional Ecology. DOI: 10.1111/1365-2435.12316
Toxoplasma gondii (T. gondii) has been absent from discussions on this blog for a while now. I'm going to remedy that today with this post talking about the paper from Markovitz and colleagues  who concluded: "T. gondii infection may play a role in the development of GAD [generalized anxiety disorder]"."You have saved our lives. We are eternally grateful"Based on participants taking part in the Detroit Neighborhood Health Study exposure to T. gondii "defined by seropositivity a........ Read more »
Markovitz A, Simanek AM, Yolken R, Galea S, Koenen KC, Chen S, & Aiello AE. (2014) Toxoplasma gondii and anxiety disorders in a community-based sample. Brain, behavior, and immunity. PMID: 25124709
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