Introduces some of the study results presented at the AAI annual conference - Immunology 2011 - in San Francisco.... Read more »
Querec, T. (2006) Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. Journal of Experimental Medicine, 203(2), 413-424. DOI: 10.1084/jem.20051720
Kasturi SP, Skountzou I, Albrecht RA, Koutsonanos D, Hua T, Nakaya HI, Ravindran R, Stewart S, Alam M, Kwissa M.... (2011) Programming the magnitude and persistence of antibody responses with innate immunity. Nature, 470(7335), 543-7. PMID: 21350488
Kastenmüller K, Wille-Reece U, Lindsay RW, Trager LR, Darrah PA, Flynn BJ, Becker MR, Udey MC, Clausen BE, Igyarto BZ.... (2011) Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets. The Journal of clinical investigation, 121(5), 1782-96. PMID: 21540549
McElrath MJ, & Haynes BF. (2010) Induction of immunity to human immunodeficiency virus type-1 by vaccination. Immunity, 33(4), 542-54. PMID: 21029964
Wu X, Yang ZY, Li Y, Hogerkorp CM, Schief WR, Seaman MS, Zhou T, Schmidt SD, Wu L, Xu L.... (2010) Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science (New York, N.Y.), 329(5993), 856-61. PMID: 20616233
Laura M. Fahey, Elizabeth B. Wilson, Heidi Elsaesser1, Chris D. Fistonich, Dorian B. McGavern, and David G. Brooks. (2011) Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. Journal of Experimental Medicine, 208(5), 987-99. info:/21536743
Suthar MS, Ma DY, Thomas S, Lund JM, Zhang N, Daffis S, Rudensky AY, Bevan MJ, Clark EA, Kaja MK.... (2010) IPS-1 is essential for the control of West Nile virus infection and immunity. PLoS pathogens, 6(2). PMID: 20140199
Terenzi, F., Saikia, P., & Sen, G. (2008) Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. The EMBO Journal, 27(24), 3311-3321. DOI: 10.1038/emboj.2008.241
Varki NM, Strobert E, Dick EJ Jr, Benirschke K, & Varki A. (2011) Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology. Annual review of pathology, 365-93. PMID: 21073341
Junt, T., Moseman, E., Iannacone, M., Massberg, S., Lang, P., Boes, M., Fink, K., Henrickson, S., Shayakhmetov, D., Di Paolo, N.... (2007) Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature, 450(7166), 110-114. DOI: 10.1038/nature06287
Iannacone, M., Moseman, E., Tonti, E., Bosurgi, L., Junt, T., Henrickson, S., Whelan, S., Guidotti, L., & von Andrian, U. (2010) Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature, 465(7301), 1079-1083. DOI: 10.1038/nature09118
Nguyen KB, Cousens LP, Doughty LA, Pien GC, Durbin JE, & Biron CA. (2000) Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox. Nature immunology, 1(1), 70-6. PMID: 10881178
Nguyen KB, Salazar-Mather TP, Dalod MY, Van Deusen JB, Wei XQ, Liew FY, Caligiuri MA, Durbin JE, & Biron CA. (2002) Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection. Journal of immunology (Baltimore, Md. : 1950), 169(8), 4279-87. PMID: 12370359
Nguyen, K. (2002) Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-gamma Response to Viral Infection. Science, 297(5589), 2063-2066. DOI: 10.1126/science.1074900
Miyagi, T., Gil, M., Wang, X., Louten, J., Chu, W., & Biron, C. (2007) High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. Journal of Experimental Medicine, 204(10), 2383-2396. DOI: 10.1084/jem.20070401
Lee, S., Kim, K., Fodil-Cornu, N., Vidal, S., & Biron, C. (2009) Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection. Journal of Experimental Medicine, 206(10), 2235-2251. DOI: 10.1084/jem.20082387
Forthal DN, Gilbert PB, Landucci G, & Phan T. (2007) Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate. Journal of immunology (Baltimore, Md. : 1950), 178(10), 6596-603. PMID: 17475891
A Science Fiction story about the Age of the Superbug
There was something about her... a pale, reddish complexion, so rare these days... all the other desks in the dull classroom where occupied by students who faded together in their blue and gray hues... who snuck furtive glances at the ruddy newcomer, in her bright blue overalls and frizzy, untamed hair.
... Read more »
We hope publishing the argument in this high-visibility venue will inspire hallway conversations amongst scientists and influence how they view long-term data archive funding. Particularly those scientists who also wear hats in funding agencies!... Read more »
Some assumptions about aging adults are debunked in a recent review on social relationships across the adulthood. Here are just some of the many things to look forward to in older adulthood.... Read more »
Luong, G., Charles, S., & Fingerman, K. (2010) Better with age: Social relationships across adulthood. Journal of Social and Personal Relationships, 28(1), 9-23. DOI: 10.1177/0265407510391362
Research shows that there are things you can do to enhance closeness with someone new. It’s as easy as knowing which questions to ask and what conversations to have. Find out what to say on your next date.... Read more »
Aron, A., Melinat, E., Aron, E., Vallone, R., & Bator, R. (1997) The Experimental Generation of Interpersonal Closeness: A Procedure and Some Preliminary Findings. Personality and Social Psychology Bulletin, 23(4), 363-377. DOI: 10.1177/0146167297234003
Slatcher, R. (2010) When Harry and Sally met Dick and Jane: Creating closeness between couples. Personal Relationships, 17(2), 279-297. DOI: 10.1111/j.1475-6811.2010.01276.x
Environmental science is about as politically charged a discipline you might find, stem cells GMOs, vaccines, and nuclear energy notwithstanding. In some circles, particularly certain sectors of academia and the media, environmental discussions are synonymous with controversial debates. So, asks environmental scientist, Chyrisse Tabone of Argosy University in Pittsburgh, USA, how can educators teach students [...]Why is teaching environmental science so controversial? is a post from: Sciencebase........ Read more »
Chyrisse P. Tabone. (2011) Environmental education under assault: can instructors teach environmental science without fear?. Interdisciplinary Environmental Review, 12(2), 146-153. info:/
A long history of research has shown the power of forgiving. It benefits the transgressor and the victim. One of the things that research has been showing recently is that forgiveness isn’t the same across all relationships and can have big impacts on the entire family.... Read more »
Maio, G.R., Thomas, G., Fincham, F.D., & Carnelley, K.B. (2008) Unraveling the role of forgiveness in family relationships. Journal of personality and social psychology, 94(2), 307-19. PMID: 18211179
At the time, I didn't write much about the Martin Nowab et al. paper which appeared in Nature about a year back, but it generated a bunch a hubbub mostly because everyone thought they were completely wrong.
I thought they were completely wrong, initially. Kin Selection is a wonderfully simple and elegant concept, that is honestly hard to imagine as possibly being wrong. Its too simple and fundamental. I also didn't want it to be wrong because it underlies many of my own core beliefs and persona........ Read more »
Rousset F, & Lion S. (2011) Much ado about nothing: Nowak et al.'s charge against inclusive fitness theory. Journal of evolutionary biology. PMID: 21457170
A comparison between modern UFO abductions and supernatural abductions in folklore... Read more »
Just how bad is pollution? A little head scratching could yield an answer. Ad hoc and non-systematic collection of air and water samples provide some useful information and underpin a wide range of environmental pollution studies. However, scientists have been scratching their heads for years hoping to come up with a better way of monitoring [...]Just how bad is pollution? is a post from: Sciencebase Science Blog
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Zaichick, S., & Zaichick, V. (2011) The scalp hair as a monitor for trace elements in biomonitoring of atmospheric pollution. International Journal of Environment and Health, 5(1/2), 106. DOI: 10.1504/IJENVH.2011.039860
Does science make you queasy? Thinking about physics tends to make me feel rather seasick. If you’ve ever tried to imagine how big infinity is then you’ll probably know what I mean. News agencies have been buzzing with reports that the discovery of the fabled ‘God particle’ is close at hand. But who really knows … Continue reading »... Read more »
David E Rowe. (2006) Einstein's Allies and Enemies: Debating Relativity in Germany, 1916–1920. Boston Studies in the Philosophy of Science, 231-280. DOI: 10.1007/978-1-4020-5195-1_8
Discusses the different types of human monocytes, and their involvement in the antiviral immune response.... Read more »
Auffray, C., Sieweke, M., & Geissmann, F. (2009) Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells. Annual Review of Immunology, 27(1), 669-692. DOI: 10.1146/annurev.immunol.021908.132557
Cros J, Cagnard N, Woollard K, Patey N, Zhang SY, Senechal B, Puel A, Biswas SK, Moshous D, Picard C.... (2010) Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity, 33(3), 375-86. PMID: 20832340
Who is more likely to say “I love you” first – men or women? A when is the appropriate time to say it? Learn more about this recent research, and find out how your gender, relationship goals, and sexual activity influence your reactions to declarations of love. ... Read more »
Ackerman, J., Griskevicius, V., & Li, N. (2011) Let's get serious: Communicating commitment in romantic relationships. Journal of Personality and Social Psychology. DOI: 10.1037/a0022412
“Understanding how the term junk science is used will enhance debates surrounding the science of sustainability. For by better understanding what science is, we will be better positioned to use it optimally and accurately as we seek to plot a sustainable path forward.” That’s the conclusion of US social scientist Michael Carolan of Colorado State [...]10 definitions of junk science is a post from: Sciencebase Science Blog
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Carolan, M. (2011) When does science become 'junk'? An examination of junk science claims in mainstream print media. International Journal of Sustainable Society, 3(2), 116. DOI: 10.1504/IJSSOC.2011.039917
The interest of Sir Richard Branson , chairman of Virgin Group , seems to have...... Read more »
Allesina S., & Levine J. M. (2011) A competitive network theory of species diversity. Proceedings of the National Academy of Sciences USA, 108(14), 5638-42. PMID: 21415368
One of the questions during this ‘social media’ election is, can Facebook, a social networking site that was developed as a venue for friends and family to stay in touch and strengthen personal connections, also be used as an effective platform to engage in political discussion? Most of the political parties and candidates running for [...]... Read more »
Lewis, K., Kaufman, J., Gonzalez, M., Wimmer, A., & Christakis, N. (2008) Tastes, ties, and time: A new social network dataset using Facebook.com. Social Networks, 30(4), 330-342. DOI: 10.1016/j.socnet.2008.07.002
Summarizes the Barbalat Nature Immunology paper "Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands".... Read more »
Barbalat, R., Lau, L., Locksley, R., & Barton, G. (2009) Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nature Immunology, 10(11), 1200-1207. DOI: 10.1038/ni.1792
I already reviewed some articles of Denis Towill primarily because he does some interesting research on simulation and supply chains, but also because I like his clear style in his articles.
In one of his early papers (1992) he teamed up with Naim and Wikner and described state of the art strategies to fight the bullwhip effect or as it is called in the paper by its older name: Industrial Dynamics.
I already described the causes of the bullwhip effect and how to measure........ Read more »
Towill, D., Naim, M., & Wikner, J. (1992) Industrial Dynamics Simulation Models in the Design of Supply Chains. International Journal of Physical Distribution , 22(5), 3-13. DOI: 10.1108/09600039210016995
Social networking sites, forums, blogs and wikis are increasingly open, readily available and user friendly and as such have become platforms for human interaction that can foster and promote the development of networks and learning communities. The great potential for unplanned interaction and serendipitous discovery through such tools also seems to have a synergistic effect [...]Post from: David Bradley's Sciencetext Tech TalkSocial learning ... Read more »
Margarida Lucas, & António Moreira. (2011) Using social web tools for knowledge construction. Int. J. Technology Enhanced Learning, 3(2), 151-161. info:/
In the race to spread their political messages and win over voters during this year’s election, all of the leaders and their parties are making a mad dash to see who can gain the most number of followers, “Likes”, retweets, and comments, etc. on social media. For many in the mainstream media, these absolute numbers [...]... Read more »
Chu, Z., Gianvecchio, S., Wang, H. and Jajodia, S. (2010) Who is tweeting on Twitter: human, bot, or cyborg?. Proceedings of the 26th Annual Computer Security Applications Conference (ACSAC ’10). ACM, New York, NY, USA, 21-30. info:/10.1145/1920261.1920265
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