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  • November 25, 2015
  • 10:15 AM
  • 828 views

The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR

by Rogue Medic in Rogue Medic

This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.

Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »

Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139  

Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521  

  • November 24, 2015
  • 02:52 PM
  • 575 views

Insights into protein structure could change the future of biomedicine

by Dr. Jekyll in Lunatic Laboratories

Researchers at the University of Waterloo have discovered a new way to create designer proteins that have the potential to transform biotechnology and personalized medicines.

In a range of experiments Professor Elizabeth Meiering, in collaboration with colleagues from India and the United States, created a protein that can withstand a range of physiological and environmental conditions – a problem that has challenged chemists looking to create super stable, highly functional proteins.... Read more »

Broom, A., Ma, S., Xia, K., Rafalia, H., Trainor, K., Colon, W., Gosavi, S., & Meiering, E. (2015) Designed protein reveals structural determinants of extreme kinetic stability. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1510748112  

  • November 23, 2015
  • 07:00 PM
  • 598 views

Dopamine measurements reveal insights into how we learn

by Dr. Jekyll in Lunatic Laboratories

Virginia Tech Carilion Research Institute scientists have reported measurements of dopamine release with unprecedented temporal precision in the brains of people with Parkinson’s disease. The measurements, collected during brain surgery as the conscious patients played an investment game, demonstrate how rapid dopamine release encodes information crucial for human choice.... Read more »

Kenneth T. Kishida, Ignacio Saez, Terry Lohrenz, Mark R. Witcher, Adrian W. Laxton, Stephen B. Tatter, Jason P. White, Thomas L. Ellis, Paul E. M. Phillips, & P. Read Montague. (2015) Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward. Proceedings of the natural sciences academy of the United States of America. info:/10.1073/pnas.1513619112

  • November 22, 2015
  • 03:01 PM
  • 664 views

Neuroscience and the search for happiness

by Dr. Jekyll in Lunatic Laboratories

Exercising, meditating, scouring self-help books… we go out of our way to be happy, but do we really know what happiness is? Wataru Sato and his team at Kyoto University have found an answer from a neurological perspective.... Read more »

Sato, W., Kochiyama, T., Uono, S., Kubota, Y., Sawada, R., Yoshimura, S., & Toichi, M. (2015) The structural neural substrate of subjective happiness. Scientific Reports, 16891. DOI: 10.1038/srep16891  

  • November 22, 2015
  • 09:14 AM
  • 836 views

Are pre-registrations the solution to the replication crisis in Psychology? Not really.

by Richard Kunert in Brain's Idea

Most psychology findings are not replicable. What can be done? In his Psychological Science editorial, Stephen Lindsay advertises pre-registration as the solution, writing that “Personally, I aim never again to submit for publication a report of a study that was not preregistered”. I took a look at whether pre-registrations are effective and feasible [TL;DR: no […]... Read more »

  • November 21, 2015
  • 05:09 PM
  • 578 views

The mysterious fungus that has major health consequences

by Dr. Jekyll in Lunatic Laboratories

Researchers at the University of Toronto examined fungi in the mucus of patients with cystic fibrosis and discovered how one particularly cunning fungal species has evolved to defend itself against neighbouring bacteria. A regular resident of our microbiome – and especially ubiquitous in the lungs of cystic fibrosis patients -the Candida albicans fungus is an “opportunistic pathogen.”
... Read more »

  • November 20, 2015
  • 02:43 PM
  • 669 views

Inflammation linked to weakened reward circuits in depression

by Dr. Jekyll in Lunatic Laboratories

About one third of people with depression have high levels of inflammation markers in their blood. New research indicates that persistent inflammation affects the brain in ways that are connected with stubborn symptoms of depression, such as anhedonia, the inability to experience pleasure.... Read more »

  • November 19, 2015
  • 07:55 PM
  • 572 views

Yin and yang of serotonin neurons in mood regulation

by Dr. Jekyll in Lunatic Laboratories

Low levels of serotonin in the brain are known to play a role in depression and anxiety, and it is customary to treat these disorders with medications that increase the amount of this neurotransmitter. However, a new study carried out by researchers suggests that this approach may be too simple. It appears that neighboring serotonin-producing brainstem regions exert different and sometimes opposing effects on behavior.... Read more »

Anne Teissier, Alexei Chemiakine, Benjamin Inbar, Susan M. Dymecki, Holly Moore, & Mark S. Ansorge. (2015) Activity of Raphe´ Serotonergic Neurons Controls Emotional Behaviors. Cell Reports. info:/http://dx.doi.org/10.1016/j.celrep.2015.10.061

  • November 18, 2015
  • 07:37 PM
  • 634 views

Master switch for brain development

by Dr. Jekyll in Lunatic Laboratories

Scientists at the Institute of Molecular Biology (IMB) in Mainz have unraveled a complex regulatory mechanism that explains how a single gene can drive the formation of brain cells. The research is an important step towards a better understanding of how the brain develops. It also harbors potential for regenerative medicine.... Read more »

  • November 18, 2015
  • 03:15 PM
  • 868 views

Making climate change local: how to motivate city-wide adaptation strategies

by Jonathan Trinastic in Goodnight Earth

More than 80% of the US population lives in cities, making their adaptation strategies one of the most important political decisions in the coming decades. Here we discuss a new study that identifies reasons why some cities have already prepared response programs while others haven't yet started.... Read more »

  • November 17, 2015
  • 04:48 PM
  • 729 views

What’s in a name? More than you think…

by Dr. Jekyll in Lunatic Laboratories

What’s in a name? In the case of the usernames of video gamers, a remarkable amount of information about their real world personalities, according to research. Analysis of anonymised data from one of the world’s most popular computer games by scientists in the Department of Psychology at York also revealed information about their ages.... Read more »

  • November 16, 2015
  • 08:37 PM
  • 529 views

Strongest evidence yet of a link between breakfast and educational outcomes

by Dr. Jekyll in Lunatic Laboratories

A direct and positive link between pupils’ breakfast quality and consumption, and their educational attainment, has for the first time been demonstrated in a ground-breaking new study carried out by public health experts at Cardiff University. The study of 5000 9-11 year-olds from more than 100 primary schools sought to examine the link between breakfast consumption and quality and subsequent attainment in Key Stage 2 Teacher Assessments* 6-18 months later.... Read more »

  • November 15, 2015
  • 04:00 PM
  • 749 views

Some Notes on Reductionism

by Joshua Fisher in Text Savvy

We can and should (and do) avoid the idea that stringing together "nothing but" pieces of content is sufficient to make 'holistic' understanding bubble up as an emergent property of student learning. But equally dubious, and equally unsubscribed, is the idea that learning can be transformed from fragmented to holistic by subtracting something from the experience.... Read more »

  • November 15, 2015
  • 03:19 PM
  • 717 views

The rise of do-it-yourself biology

by Dr. Jekyll in Lunatic Laboratories

The Wilson Center’s Synthetic Biology Project has released a short documentary on the growth of the do-it-yourself biology (DIYbio) movement as seen through a community DIYbio lab in Baltimore, Maryland. ... Read more »

The Wilson Center. (2015) The rise of do-it-yourself biology: A look at the Baltimore Underground Science Space. Synthetic Biology Project. info:other/Link

  • November 14, 2015
  • 04:18 PM
  • 520 views

3-D printing aids in understanding food enjoyment

by Dr. Jekyll in Lunatic Laboratories

Tasting food relies on food volatiles moving from the back of the mouth to the nasal cavity, but researchers have wondered why airflow doesn’t carry them in the other direction, into the lungs. Now a team of engineers, using a 3D printed model of the human airway from nostril to trachea, has determined that the shape of the airway preferentially transfers volatiles to the nasal cavity and allows humans to enjoy the smell of good food.... Read more »

Ni, R., Michalski, M., Brown, E., Doan, N., Zinter, J., Ouellette, N., & Shepherd, G. (2015) Optimal directional volatile transport in retronasal olfaction. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1511495112  

  • November 13, 2015
  • 08:32 PM
  • 589 views

Not so happy old age?

by Dr. Jekyll in Lunatic Laboratories

The notion that older people are happier than younger people is being challenged following a recent study led by a University of Bradford lecturer. In fact it suggests that people get more depressed from age 65 onwards. The study, led by psychology lecturer Dr Helena Chui, builds on a 15-year project observing over 2,000 older Australians living in the Adelaide area.... Read more »

  • November 13, 2015
  • 08:43 AM
  • 793 views

Predatory journals: the dark side of Open Access

by SciELO in SciELO in Perspective

Low quality non peer reviewed open access journals called ‘predatory’ compromise the credibility of open access publishing and cause damage to this business model’s reputation. A detailed study analyzes these journals and their publishers, including geographic location and authors’ profile. … Read More →... Read more »

  • November 12, 2015
  • 02:13 PM
  • 534 views

It’s music to my eyes

by Dr. Jekyll in Lunatic Laboratories

When people are listening to music, their emotional reactions to the music are reflected in changes in their pupil size. Researchers from the University of Vienna and the University of Innsbruck, Austria, are the first to show that both the emotional content of the music and the listeners’ personal involvement with music influence pupil dilation. This study demonstrates that pupil size measurement can be effectively used to probe listeners’ reactions to music.... Read more »

  • November 11, 2015
  • 04:53 PM
  • 503 views

A protein-RNA structure hints at how viruses commandeer human proteins

by Dr. Jekyll in Lunatic Laboratories

Researchers at Case Western Reserve University and the University of Michigan have produced the first image of an important human protein as it binds with ribonucleic acid (RNA), a discovery that could offer clues to how some viruses, including HIV, control expression of their genetic material. That information could lead to new strategies to block viruses from replicating, thereby limiting or halting infection.... Read more »

  • November 11, 2015
  • 11:10 AM
  • 796 views

Short-term stability and long-term collapse: exploring the complex behavior of the Antarctic ice sheet

by Jonathan Trinastic in Goodnight Earth

A recent study indicates that Antarctic sea ice is growing, but what about its long-term evolution? Read on to see what scientists have discovered about the Antarctic's future.... Read more »

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