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  • October 5, 2015
  • 06:48 PM

Gut bacteria population, diversity linked to anorexia nervosa

by Dr. Jekyll in Lunatic Laboratories

Researchers at the UNC School of Medicine found that people with anorexia nervosa have very different microbial communities residing inside their guts compared to healthy individuals and that this bacterial imbalance is associated with some of the psychological symptoms related to the eating disorder.... Read more »

Kleiman, S., Watson, H., Bulik-Sullivan, E., Huh, E., Tarantino, L., Bulik, C., & Carroll, I. (2015) The Intestinal Microbiota in Acute Anorexia Nervosa and During Renourishment. Psychosomatic Medicine, 1. DOI: 10.1097/PSY.0000000000000247  

  • October 4, 2015
  • 05:36 PM

History of Cataloguing. 2. Jewett

by Anne Welsh in Library Marginalia

The second in a series on the History of Cataloguing, this post highlights OCLC's news that they will no longer be printing catalogue cards and provides an insight into Charles Coffin Jewett's suggestion that shared cataloguing be undertaken, led by the Smithsonian Institution in the mid-nineteenth century.... Read more »

Charles Coffin Jewett. (1853) On the Construction of Catalogues of Libraries, and their Publication by Means of Separate, Stereotyped Titles, with Rules and Examples. 2nd ed. Hathi Trust Digital Library. info:/

  • October 4, 2015
  • 01:39 PM

Brain networking: behind the cognitive control of thoughts

by Dr. Jekyll in Lunatic Laboratories

The human brain does not come with an operating manual. However, a group of scientists have developed a way to convert structural brain imaging techniques into “wiring diagrams” of connections between brain regions. Three researchers from UCSB’s Department of Psychological & Brain Sciences — Michael Miller, Scott Grafton and Matt Cieslak — used the structure of neural networks to reveal the fundamental rules that govern which parts of the brain are most able to exert cognitive control ........ Read more »

Gu, S., Pasqualetti, F., Cieslak, M., Telesford, Q., Yu, A., Kahn, A., Medaglia, J., Vettel, J., Miller, M., Grafton, S.... (2015) Controllability of structural brain networks. Nature Communications, 8414. DOI: 10.1038/ncomms9414  

  • October 3, 2015
  • 02:21 PM

Can exercise be replaced with a pill?

by Dr. Jekyll in Lunatic Laboratories

Everyone knows that exercise improves health, and ongoing research continues to uncover increasingly detailed information on its benefits for metabolism, circulation, and improved functioning of organs such as the heart, brain, and liver. With this knowledge in hand, scientists may be better equipped to develop “exercise pills” that could mimic at least some of the beneficial effects of physical exercise on the body. But a review of current development efforts ponders whether such pills will........ Read more »

Laher, & et al. (2015) Exercise Pills: At the Starting Line?. Trends in Pharmacological Sciences. info:/

  • October 2, 2015
  • 07:47 PM

High-fructose diet slows recovery from brain injury

by Dr. Jekyll in Lunatic Laboratories

Well bad news for those of us who have a sweet tooth, a diet high in processed fructose sabotages rat brains’ ability to heal after head trauma, UCLA neuroscientists report. While this doesn’t necessarily translate to humans quite yet, it should still raise a few eyebrows given the results from the study.... Read more »

Rahul Agrawal, Emily Noble1, Laurent Vergnes, Zhe Ying1, Karen Reue, & Fernando Gomez-Pinilla. (2015) Dietary fructose aggravates the pathobiology of traumatic brain injury by influencing energy homeostasis and plasticity. Journal of Cerebral Blood Flow . info:/10.1177/0271678X15606719

  • October 1, 2015
  • 02:41 PM

Coincidence or conspiracy? Studies investigate conspiracist thinking

by Dr. Jekyll in Lunatic Laboratories

In pop culture, conspiracy believers — like FBI agent Fox Mulder on The X Files or professor Robert Langdon in The Da Vinci Code — tend to reject the notion of coincidence or chance; even the most random-seeming events are thought to result from some sort of intention or design. And researchers have suggested that such a bias against randomness may explain real-world conspiracy beliefs. But new research from psychological scientists shows no evidence for a link between conspiracist thinking ........ Read more »

  • October 1, 2015
  • 11:44 AM

Project Making Data Count encourages sharing of research data

by SciELO in SciELO in Perspective

Sharing of research data (open data) is increasing in all areas related to scientific research, and it involves authors, journals, publishers, funding agencies, the productive sector and society. In order to encourage authors to provide and reuse datasets, it is paramount to find ways to measure their impact. The initiative ‘Making Data Count’ is efficiently doing this, find out how. … Read More →... Read more »

KRATZ, J. E.,, & STRASSER, C. (2015) Making data count. Scientific Data. DOI:  

  • September 30, 2015
  • 10:09 PM

Scientists identify key receptor as potential target for treatment of autism

by Dr. Jekyll in Lunatic Laboratories

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered a significant–and potentially treatable–relationship between a chemical that helps transmit signals in the brain and genetic mutations present in a subset of individuals with autism spectrum disorder. The new research findings focus on the role that the neurotransmitter serotonin plays in the development of social behavior.... Read more »

  • September 29, 2015
  • 02:37 PM

Scientists to bypass brain damage by re-encoding memories

by Dr. Jekyll in Lunatic Laboratories

Researchers at USC and Wake Forest Baptist Medical Center have developed a brain prosthesis that is designed to help individuals suffering from memory loss. The prosthesis, which includes a small array of electrodes implanted into the brain, has performed well in laboratory testing in animals and is currently being evaluated in human patients.... Read more »

  • September 28, 2015
  • 07:22 PM

Connecting Alzheimer’s disease and the immune system

by Dr. Jekyll in Lunatic Laboratories

The role of the immune system in Alzheimer’s disease is a hot topic, but exactly how the two are connected and what interventions could help lower risk remain a mystery. In a new study, researchers in the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital (BWH) investigate how genetic risk factors for Alzheimer’s disease may influence a key type of immune cell. Their results lay the groundwork for designing better therapeutic strategies and better prediction tools fo........ Read more »

Chan, G., White, C., Winn, P., Cimpean, M., Replogle, J., Glick, L., Cuerdon, N., Ryan, K., Johnson, K., Schneider, J.... (2015) CD33 modulates TREM2: convergence of Alzheimer loci. Nature Neuroscience. DOI: 10.1038/nn.4126  

  • September 28, 2015
  • 12:48 PM

What Animals Contageously Yawn?

by Miss Behavior in The Scorpion and the Frog

Does this sight make you want to yawn? A yawning Japanese macaque by Daisuke Tashiro at Wikimedia Commons.Do you think it would make other animals want to yawn? Many animals yawn spontaneously, but yawning in response to sensing or thinking about someone else doing it may be a completely different thing. Contagious yawning requires a sense of social connection and emotional empathy that not all species share. So far, scientists have found experimental evidence of contagious yawning in humans, ch........ Read more »

  • September 27, 2015
  • 06:24 PM

History of Cataloguing. 1. Ranganathan

by Anne Welsh in Library Marginalia

This post is the first in a series sparked by the selection of books for the History of Cataloguing section of the reading list for the core cataloguing module on the MA LIS. It highlights what Ranganathan had to say in his Five Laws (1931) regarding Cataloguing.... Read more »

S.R. Ranganathan. (1931) The Five Laws of Library Science. Hathi Trust Digital Library. info:/

  • September 27, 2015
  • 02:45 PM

Breaking the anxiety cycle

by Dr. Jekyll in Lunatic Laboratories

A woman who won’t drive long distances because she has panic attacks in the car. A man who has contamination fears so intense he cannot bring himself to use public bathrooms. A woman who can’t go to church because she fears enclosed spaces. All of these people have two things in common: they have an anxiety disorder. They’re also parents.... Read more »

  • September 26, 2015
  • 03:31 PM

Scientists discover new system for human genome editing

by Dr. Jekyll in Lunatic Laboratories

A team including the scientist who first harnessed the revolutionary CRISPR-Cas9 system for mammalian genome editing has now identified a different CRISPR system with the potential for even simpler and more precise genome engineering. In the study researchers describe the unexpected biological features of this new system and demonstrate that it can be engineered to edit the genomes of human cells.... Read more »

Zetsche, B., Gootenberg, J., Abudayyeh, O., Slaymaker, I., Makarova, K., Essletzbichler, P., Volz, S., Joung, J., van der Oost, J., Regev, A.... (2015) Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System. Cell. DOI: 10.1016/j.cell.2015.09.038  

  • September 25, 2015
  • 03:08 PM

It’s alive!! Study adds to evidence that viruses are alive

by Dr. Jekyll in Lunatic Laboratories

Classifying something as living isn’t as easy as it sounds, after all we are all atoms, so when do atoms go from nonliving to living? Despite the complexities of viruses, we have historically deemed them nonliving. However, a new analysis supports the hypothesis that viruses are living entities that share a long evolutionary history with cells. The study offers the first reliable method for tracing viral evolution back to a time when neither viruses nor cells existed in the forms recognized to........ Read more »

Arshan Nasir, & Gustavo Caetano-Anollés. (2015) A phylogenomic data-driven exploration of viral origins and evolution. Science Advances. info:/10.1126/sciadv.1500527

  • September 24, 2015
  • 02:59 PM

Mexico City’s air pollution has detrimental impact on Alzheimer’s disease gene

by Dr. Jekyll in Lunatic Laboratories

A new study by researchers heightens concerns over the detrimental impact of air pollution on hippocampal metabolites as early markers of neurodegeneration in young urbanites carrying an allele 4 of the apolipoprotein E gene (APOE). This is associated with the risk for Alzheimer disease (AD) and a susceptibility marker for poor outcome in traumatic brain injury (TBI) recovery.... Read more »

  • September 23, 2015
  • 03:27 PM

What motivates ‘Facebook stalking’ after a romantic breakup?

by Dr. Jekyll in Lunatic Laboratories

Social networking makes it easy to monitor the status and activities of a former romantic partner, an often unhealthy use of social media known as interpersonal electronic surveillance (IES) or, more commonly, “Facebook stalking.” Psychological and relationship factors and how individuals cope with the termination of a romantic relationship can help predict their use of online surveillance, according to a new study.... Read more »

  • September 23, 2015
  • 11:00 AM

The BMJ requires data sharing to publish clinical trials

by SciELO in SciELO in Perspective

Increased publication of clinical trial outcomes has been promoted by regional and global initiatives in order to increase transparency, reproducibility and reliability of the assays. The BMJ follows this movement, becoming the first journal to require availability of individual patient data, anonymously and upon request, as a prerequisite for publication. … Read More →... Read more »

  • September 23, 2015
  • 07:39 AM

What about Lignin?

by ragothamanyennamalli in Getting to know Structural Bioinformatics

Biofuel prodcution involves removing Lignin from the biomass, in fact efficient removal so that Lignin and its by-products do not inhibit the enzymatic process that follows. But, what happens to the Lignin? ... Read more »

Bourzac, K. (2015) Inner Workings: Paving with plants. Proceedings of the National Academy of Sciences, 112(38), 11743-11744. DOI: 10.1073/pnas.1509010112  

  • September 22, 2015
  • 05:02 PM

Genetic analysis supports prediction that spontaneous rare mutations cause half of autism

by Dr. Jekyll in Lunatic Laboratories

A team led by researchers at Cold Spring Harbor Laboratory (CSHL) has published a new analysis of data on the genetics of autism spectrum disorder (ASD). One commonly held theory is that autism results from the chance combinations of commonly occurring gene mutations, which are otherwise harmless. But the authors’ work provides support for a different theory.... Read more »

Ivan Iossifov, Dan Levy, Jeremy Allen, Kenny Ye, Michael Ronemus, Yoon-ha Lee, Boris Yamrom, & Michael Wigler. (2015) Low load for disruptive mutations in autism genes and their biased transmission. Proceedings of the National Academy of Sciences in the United States of America. info:/

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