Over the past few years I've covered (1,2,3) the work of Anders Eklund, a Swedish researcher who has discovered a potentially serious flaw in software commonly used to analyse fMRI data.
Eklund has shown that popular parametric statistical analysis tools for fMRI are prone to false positives - they often 'find' brain activation even where it doesn't exist. The issue affects the leading software packages such as FSL and SPM.
The main root of the problem is spatial autocorrelation - the ... Read more »
Kriegeskorte, N., Bodurka, J., & Bandettini, P. (2008) Artifactual time-course correlations in echo-planar fMRI with implications for studies of brain function. International Journal of Imaging Systems and Technology, 18(5-6), 345-349. DOI: 10.1002/ima.20166
"The results of this trial indicate that NAC [N-acetylcysteine] treatment was well tolerated, had the expected effect of boosting GSH [glutathione] production, but had no significant impact on social impairment in youth with ASD [autism spectrum disorder]."So said the results reported by Logan Wink and colleagues  (open-access) who, continuing an autism research theme, looked at whether this important L-cysteine prodrug might have more to give when it comes to a........ Read more »
Wink, L., Adams, R., Wang, Z., Klaunig, J., Plawecki, M., Posey, D., McDougle, C., & Erickson, C. (2016) A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder. Molecular Autism, 7(1). DOI: 10.1186/s13229-016-0088-6
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