Five different fragments of MERS-CoV S1 receptor binding domain were tested for their receptor affinity and an ability to induce the formation of neutralizing antibodies. Results suggest that the induction of high antibody titers is dependent on the absence of extended N- and C-terminal ends. ... Read more »
Ma C, Wang L, Tao X, Zhang N, Yang Y, Tseng CT, Li F, Zhou Y, Jiang S, & Du L. (2014) Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments-The importance of immunofocusing in subunit vaccine design. Vaccine. PMID: 25240756
Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J.... (2013) Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature, 500(7461), 227-31. PMID: 23831647
Mou H, Raj VS, van Kuppeveld FJ, Rottier PJ, Haagmans BL, & Bosch BJ. (2013) The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies. Journal of virology, 87(16), 9379-83. PMID: 23785207
Du L, Kou Z, Ma C, Tao X, Wang L, Zhao G, Chen Y, Yu F, Tseng CT, Zhou Y.... (2013) A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines. PloS one, 8(12). PMID: 24324708
Chen Y, Rajashankar KR, Yang Y, Agnihothram SS, Liu C, Lin YL, Baric RS, & Li F. (2013) Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus. Journal of virology, 87(19), 10777-83. PMID: 23903833
Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X.... (2013) Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell research, 23(8), 986-93. PMID: 23835475
And is dog-walking a good way to persuade people to take more exercise?Photo: Monkey Business Images / ShutterstockWe know that most people do not get the 150 minutes of exercise per week that is recommended. Could encouraging people to walk their dogs more often help, and if so, how best to go about it? A new paper by Carri Westgarth et al (2014) of the University of Liverpool reviews the state of current research.Although to some dog owners a daily walk is an essential part of the routine, the........ Read more »
Cutt, H., Giles-Corti, B., & Knuiman, M. (2008) Encouraging physical activity through dog walking: Why don't some owners walk with their dog?. Preventive Medicine, 46(2), 120-126. DOI: 10.1016/j.ypmed.2007.08.015
Westgarth, C., Christley, R., & Christian, H. (2014) How might we increase physical activity through dog walking?: A comprehensive review of dog walking correlates. International Journal of Behavioral Nutrition and Physical Activity, 11(1), 83. DOI: 10.1186/1479-5868-11-83
The plasticity of the brain is always somewhat of a shock. It's near incredible what the brain can achieve, look at people who have strokes, or any other sort of brain injury and yet still somehow manage to get up and move, or perform tasks. So I guess it should be no surprise, but still amazing that studying mice with a genetic change similar to what is found in Kabuki syndrome (an inherited disease of humans) researchers report they have used an anticancer drug to improve mental function......... Read more »
Hans T. Bjornsson, Joel S. Benjamin, Li Zhang, Jacqueline Weissman, Elizabeth E. Gerber, Yi-Chun Chen, Rebecca G. Vaurio, Michelle C. Potter, Kasper D. Hansen, & Harry C. Dietz. (2014) Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome. Science Translational Medicine. info:/10.1126/scitranslmed.3009278
This week’s tip of the week highlights the MEGA tools–MEGA is a collection of tools that perform Molecular Evolutionary Genetics Analysis. MEGA tools are not new–they’ve been developed and supported over many years. In fact, on their landing page you can see the first reference to MEGA was in 1994. How much computing were you […]... Read more »
Tamura K., G. Peterson, N. Peterson, G. Stecher, M. Nei, & S. Kumar. (2011) MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods. Molecular Biology and Evolution, 28(10), 2731-2739. DOI: http://dx.doi.org/10.1093/molbev/msr121
Tamura K., G. Stecher, D. Peterson, A. Filipski, & S. Kumar. (2013) MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0. Molecular Biology and Evolution, 30(12), 2725-2729. DOI: http://dx.doi.org/10.1093/molbev/mst197
Inspired by the recent discovery of a couple still holding hands after 700 years, this article ponders the question, "What Is Love, Anyway?"... Read more »
van Leengoed E, Kerker E, & Swanson HH. (1987) Inhibition of post-partum maternal behaviour in the rat by injecting an oxytocin antagonist into the cerebral ventricles. The Journal of endocrinology, 112(2), 275-82. PMID: 3819639
Domingue, B., Fletcher, J., Conley, D., & Boardman, J. (2014) Genetic and educational assortative mating among US adults. Proceedings of the National Academy of Sciences, 111(22), 7996-8000. DOI: 10.1073/pnas.1321426111
Recent studies have illustrated how complicated evolution by descent with adaptation can be. Convergent evolution and parallel evolution explain the fingerprints of koalas and the marsupial and placental saber-toothed cats. Dollo’s Law of Irreversibility has been shown to be plastic, as frogs have re-evolved mandibular teeth and stick insects have lost and regained wings several times. ... Read more »
Lahti, D. C., N. A. Johnson, et al. (2009) Relaxed selection in the wild. . Trends in Ecology and Evolution, , 24(9), 487-496. info:/
Wiens JJ. (2011) Re-evolution of lost mandibular teeth in frogs after more than 200 million years, and re-evaluating Dollo's law. Evolution; international journal of organic evolution, 65(5), 1283-96. PMID: 21521189
by Rita Handrich in The Jury Room
It’s been a while since we’ve done an update on neurolaw issues and we think you’ll want to read the entire article upon which this post is based. The article is published in Court Review: Journal of the American Judges Association (which is probably a journal you would benefit from perusing regularly). The article (authored […]
Confused about brain scans? Welcome to the club!
On brains, brain damage, pedophilia and other things we don’t like
Defending the Psychop........ Read more »
Rushing, SE. (2014) The admissibility of brain scans in criminal trials: The case of positron emission tomography. . Court Review, 50(2). info:/
A month feels a very long time when you’re trying to give something up. Crikey, if you’re trying to give up cigarettes then even a weekend seems an eternity. And now that October is upon us, scores of smokers are going cold turkey on the fags for a 28 day stint. It’s all part of … Continue reading →... Read more »
Lally, P., van Jaarsveld, C., Potts, H., & Wardle, J. (2010) How are habits formed: Modelling habit formation in the real world. European Journal of Social Psychology, 40(6), 998-1009. DOI: 10.1002/ejsp.674
"In conclusion, exposure to maternal C1q activity during pregnancy may be a risk factor for the development of schizophrenia and psychosis in offspring". That was the primary observation made by Emily Severance and colleagues  at Johns Hopkins, extending their scientific interest in immune system involvement being potentially linked to psychiatry ."Serve the public trust, protect the innocent, uphold the law"I've already talked about Dr Severance's previous research forays into complement ........ Read more »
Emily G. Severance, Kristin L. Gressitt, Stephen L. Buka, Tyrone D. Cannon, & Robert H. Yolken. (2014) Maternal complement C1q and increased odds for psychosis in adult offspring. Schizophrenia Research. info:/10.1016/j.schres.2014.07.053
The presence of a painful flexion arc and forward scapular posture seem to be relatively accurate in predicting who will need surgery for a SLAP tear after trying 6 weeks of rehabilitation. While this rule seems promising, more investigation is needed, and clinical decisions should be made on an individual basis.... Read more »
Moore-Reed, S., Kibler, W., Sciascia, A., & Uhl, T. (2014) Preliminary Development of a Clinical Prediction Rule for Treatment of Patients With Suspected SLAP Tears. Arthroscopy: The Journal of Arthroscopic . DOI: 10.1016/j.arthro.2014.06.015
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