The promises of genetic modifications are endless, longer life, better health, cures for genetic based diseases that would otherwise cause an unimaginable amount of suffering all wiped out. We’ve come a long way in genetic alteration thanks, in part, to the ever faster moving pace of science. While genetic modification is the thing of horror movies, it also can change the world in ways we cannot even imagine — unfortunately getting genome-editing proteins into cells, where they need to be t........ Read more »
Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, & Liu DR. (2014) Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nature biotechnology. PMID: 25357182
In the 1980s, a few studies came out suggesting that patients with bulimia nervosa (BN) require fewer calories for weight maintenance than anorexia nervosa patients (e.g., Newman, Halmi, & Marchi, 1987) and healthy female controls (e.g., Gwirtsman et al., 1989).
Gwirtsman et al. (1989), after finding that patients with bulimia nervosa required few calories for weight maintenance than healthy volunteers, had these suggestions for clinicians:
When bulimic patient........ Read more »
de Zwaan, M., Aslam, Z., & Mitchell, J.E. (2002) Research on energy expenditure in individuals with eating disorders: a review. International Journal of Eating Disorders, 31(4), 361-9. PMID: 11948641
Gwirtsman, H.E., Kaye, W.H., Obarzanek, E., George, D.T., Jimerson, D.C., & Ebert, M.H. (1989) Decreased caloric intake in normal-weight patients with bulimia: comparison with female volunteers. American Journal of Clinical Nutrition, 49(1), 86-92. PMID: 2912015
Kotler LA, Devlin MJ, Matthews DE, & Walsh BT. (2001) Total energy expenditure as measured by doubly-labeled water in outpatients with bulimia nervosa. International Journal of Eating Disorders, 29(4), 470-6. PMID: 11285585
In the movies, spooks and phantoms are often undead humans with unfinished business. But would you be afraid of a ghostly fruit fly? In 1995, fruit fly researchers Christiane Nüsslein-Volhard and Eric Wieschaus were awarded a Nobel Prize for their research on development. They were interested in understanding how a fertilized egg develops into a complex […]... Read more »
Gilbert Lawrence I. (2008) Drosophila is an inclusive model for human diseases, growth and development. Molecular and Cellular Endocrinology, 293(1-2), 25-31. DOI: http://dx.doi.org/10.1016/j.mce.2008.02.009
Gilbert Lawrence I. (2004) Halloween genes encode P450 enzymes that mediate steroid hormone biosynthesis in Drosophila melanogaster. Molecular and Cellular Endocrinology, 215(1-2), 1-10. DOI: http://dx.doi.org/10.1016/j.mce.2003.11.003
by Shashank Gandhi in the Node
Researchers have always been interested in tissue-specific loss of function to probe the role of specific genes in embryonic development, cell physiology and disease conditions. Migration of lateral plate primordial germ cells in zebrafish, border cell migration during oogenesis in drosophila, interaction of T-cells with their target, and numerous other cases have continued to give […]... Read more »
Stolfi, A., Gandhi, S., Salek, F., & Christiaen, L. (2014) Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9. Development, 141(21), 4115-4120. DOI: 10.1242/dev.114488
Gary Marcus, Adam Marblestone, and Thomas Dean have a nice perspective piece in Science this week on the atoms of neural computation (gated): One hypothesis is that cortical neurons form a single, massively repeated “canonical” circuit, characterized as a kind of a … Continue reading →... Read more »
Qian, J., Hintze, A., & Adami, C. (2011) Colored Motifs Reveal Computational Building Blocks in the C. elegans Brain. PLoS ONE, 6(3). DOI: 10.1371/journal.pone.0017013
Borst, A. (2007) Correlation versus gradient type motion detectors: the pros and cons. Philosophical Transactions of the Royal Society B: Biological Sciences, 362(1479), 369-374. DOI: 10.1098/rstb.2006.1964
Pfeffer, C. (2014) Inhibitory Neurons: Vip Cells Hit the Brake on Inhibition. Current Biology, 24(1). DOI: 10.1016/j.cub.2013.11.001
Mysore, S., & Knudsen, E. (2012) Reciprocal Inhibition of Inhibition: A Circuit Motif for Flexible Categorization in Stimulus Selection. Neuron, 73(1), 193-205. DOI: 10.1016/j.neuron.2011.10.037
Viruses are minimalists when it comes to genomic data. This light packing of genetic information requires that every protein the virus codes for needs to be as versatile as possible. The flavivirus genus is no exception to this; its genome encodes for three structural proteins (capsid, membrane, and envelope) and seven nonstructural proteins (NS1, […]... Read more »
Muller David A. (2013) The flavivirus NS1 protein: Molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker. Antiviral Research, 98(2), 192-208. DOI: http://dx.doi.org/10.1016/j.antiviral.2013.03.008
Crook Kristen R., Clayton R. Morrison, & Frank Scholle. (2014) Modulation of innate immune signaling by the secreted form of the West Nile virus NS1 glycoprotein. Virology, 172-182. DOI: http://dx.doi.org/10.1016/j.virol.2014.04.036
Akey D. L., S. Dutta, J. Konwerski, J. Jose, T. J. Jurkiw, J. DelProposto, C. M. Ogata, G. Skiniotis, R. J. Kuhn, & J. L. Smith. (2014) Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System. Science, 343(6173), 881-885. DOI: http://dx.doi.org/10.1126/science.1247749
In this series neuroscientist Elisabeth Buhl Thubron takes a closer look at intriguing brain cases that revolutionised the field. Part I: The Man With A Whole In His Head... Read more »
Van Horn JD, Irimia A, Torgerson CM, Chambers MC, Kikinis R, & Toga AW. (2012) Mapping connectivity damage in the case of Phineas Gage. PloS one, 7(5). PMID: 22616011
Invariant Natural Killer T (iNKT) cell development is highly regulated, starting at stage 0, where DP thermocytes become committed to the iNKT cell lineage, and ending as fully mature stage 3 iNKT cells, which are capable of illiciting an immune … Continue reading →... Read more »
Wu J, Yang J, Yang K, Wang H, Gorentla B, Shin J, Qiu Y, Que LG, Foster WM, Xia Z.... (2014) iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. The Journal of clinical investigation, 124(4), 1685-98. PMID: 24614103
Wu J, Shin J, Xie D, Wang H, Gao J, & Zhong XP. (2014) Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity. Journal of immunology (Baltimore, Md. : 1950), 192(6), 2643-50. PMID: 24532578
It was a familiar story. Big media headlines such as: Caesarean sections 'may increase risk of autism' appearing all over, but when it came to finding the study behind the headlines, the publishing journal seemed to be trailing a little way behind. We've been in a similar situation before."As the flames rose to her Roman nose"Anyhow, the paper by Eileen Curran and colleagues  (open-access) has finally made it to the research table and hence is fodder for today's ramblings with the sugges........ Read more »
Curran EA, O'Neill SM, Cryan JF, Kenny LC, Dinan TG, Khashan AS, & Kearney PM. (2014) Research Review: Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. Journal of child psychology and psychiatry, and allied disciplines. PMID: 25348074
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