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  • May 24, 2016
  • 01:14 PM
  • 21 views

Raising The Standards Of Open Access Journals

by Nesru Koroso in United Academics

The Directory of Open Access Journals bans dubious journals from its index.... Read more »

  • May 24, 2016
  • 12:32 PM
  • 20 views

The James Earl Jones (or Barry White) Effect now applies to women too! 

by Doug Keene in The Jury Room

Almost five years ago, we wrote about research saying men with deep voices were more persuasive. Science has moved forward though and now, women can also be more persuasive when using a deeper voice. Some call it a “sultry voice”. New work tells us your voice doesn’t have be a deep and resonant baritone to […]

Related posts:
Who has the deepest voice amongst the Republican  candidates for President?
Feel the power of that deep and resonant voice!
Here’s why that movie wasn’t ........ Read more »

  • May 24, 2016
  • 11:59 AM
  • 21 views

A critical comment on “Contextual sensitivity in scientific reproducibility”

by Richard Kunert in Brain's Idea

Psychological science is surprisingly difficult to replicate (Open Science Collaboration, 2015). Researchers are desperate to find out why. A new study in the prestigious journal PNAS (Van Bavel et al., 2016) claims unknown contextual factors of psychological phenomena (“hidden moderators”) are to blame. The more an effect is sensitive to unknown contextual factors, the less […]... Read more »

Dreber, A., Pfeiffer, T., Almenberg, J., Isaksson, S., Wilson, B., Chen, Y., Nosek, B., & Johannesson, M. (2015) Using prediction markets to estimate the reproducibility of scientific research. Proceedings of the National Academy of Sciences, 112(50), 15343-15347. DOI: 10.1073/pnas.1516179112  

Van Bavel, J.J., Mende-Siedlecki, P., Brady, W.J., & Reinero, D.A. (2016) Contextual sensitivity in scientific reproducibility. PNAS. info:/

  • May 24, 2016
  • 11:27 AM
  • 22 views

ZIKV infection in mice: cell cycle defects as a cause for microcephaly?

by thelonevirologist in Virology Tidbits

Zika Virus (ZIKV) was first isolated in 1947 from a sentinel monkey in Uganda and despite sporadic local outbreaks only caused mild disease in humans. The emergence of ZIKV combined with severe pathogenicity in South America as early as 2014 however raised questions about the molecular evolution of ZIKV since ZIKV was previously only associated with arthralgia and a mild febrile illness but not neuropathological disorders including abnormal foetal brain development and Guillan-Barre Syndrome (GB........ Read more »

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870  

Rodriguez-Morales AJ, Bandeira AC, & Franco-Paredes C. (2016) The expanding spectrum of modes of transmission of Zika virus: a global concern. Annals of clinical microbiology and antimicrobials, 13. PMID: 26939897  

Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK.... (2016) Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell, 165(5), 1081-91. PMID: 27180225  

Cugola, F., Fernandes, I., Russo, F., Freitas, B., Dias, J., Guimarães, K., Benazzato, C., Almeida, N., Pignatari, G., Romero, S.... (2016) The Brazilian Zika virus strain causes birth defects in experimental models. Nature. DOI: 10.1038/nature18296  

Deng YQ, Zhao H, Li XF, Zhang NN, Liu ZY, Jiang T, Gu DY, Shi L, He JA, Wang HJ.... (2016) Isolation, identification and genomic characterization of the Asian lineage Zika virus imported to China. Science China. Life sciences, 59(4), 428-30. PMID: 26993654  

Grant, A., Ponia, S., Tripathi, S., Balasubramaniam, V., Miorin, L., Sourisseau, M., Schwarz, M., Sánchez-Seco, M., Evans, M., Best, S.... (2016) Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling. Cell Host . DOI: 10.1016/j.chom.2016.05.009  

Ashour J, Laurent-Rolle M, Shi PY, & García-Sastre A. (2009) NS5 of dengue virus mediates STAT2 binding and degradation. Journal of virology, 83(11), 5408-18. PMID: 19279106  

Gelman A, Rawet-Slobodkin M, & Elazar Z. (2015) Huntingtin facilitates selective autophagy. Nature cell biology, 17(3), 214-5. PMID: 25720962  

Amaral N, Vendrell A, Funaya C, Idrissi FZ, Maier M, Kumar A, Neurohr G, Colomina N, Torres-Rosell J, Geli MI.... (2016) The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress. Nature cell biology, 18(5), 516-26. PMID: 27111841  

Schröder-Heurich B, Wieland B, Lavin MF, Schindler D, & Dörk T. (2014) Protective role of RAD50 on chromatin bridges during abnormal cytokinesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(3), 1331-41. PMID: 24344331  

Uchil, P., Kumar, A., & Satchidanandam, V. (2006) Nuclear Localization of Flavivirus RNA Synthesis in Infected Cells. Journal of Virology, 80(11), 5451-5464. DOI: 10.1128/JVI.01982-05  

  • May 24, 2016
  • 10:44 AM
  • 14 views

Does Flu Vaccination Reduce Dementia Risk?

by William Yates, M.D. in Brain Posts

In my daily review of neuroscience news I ran across an article flu vaccination and dementia risk in heart failure.This study was reported at the 3rd World Congress on Acute Heart Failure by Dr. Ju-Chi Liu from Taipei Medical University.So how might influenza vaccination be related to dementia risk?  We do know acute influenza infection reaches the brain causing headache and increasing brain inflammation, at least temporarily. We also know brain inflammation may be involved in the mechanism........ Read more »

  • May 24, 2016
  • 10:02 AM
  • 13 views

Should Biologists be Guided by Beauty?

by Jalees Rehman in The Next Regeneration

One key characteristic of a beautiful scientific theory is the simplicity of the underlying concepts. According to Weinberg, Einstein's theory of gravitation is described in fourteen equations whereas Newton's theory can be expressed in three. Despite the appearance of greater complexity in Einstein's theory, Weinberg finds it more beautiful than Newton's theory because the Einsteinian approach rests on one elegant central principle – the equivalence of gravitation and ........ Read more »

Dietrich, M., Ankeny, R., & Chen, P. (2014) Publication Trends in Model Organism Research. Genetics, 198(3), 787-794. DOI: 10.1534/genetics.114.169714  

Weinberg, Steven. (1992) Dreams of a Final Theory . Vintage Books. info:/

  • May 24, 2016
  • 03:07 AM
  • 31 views

Around 1 in 5 with autism will experience seizure or seizure disorder

by Paul Whiteley in Questioning Answers

The paper by Jennifer Jaskiewicz and colleagues [1] recently offered a further important insight into the relationship between autism and seizure or seizure disorder (i.e. epilepsy).Based on the examination of records of nearly 50,000 children and young adults diagnosed with an autism spectrum disorder (ASD) compared with approximately quarter of a million 'not-autism' participants, authors reported some interesting trends. Concluding that some 19% of participants with autism experienced "s........ Read more »

Jennifer Jaskiewicz, Apryl Susi, Elizabeth Hisle-Gorman, David Dennison, Gregory Gorman, Cade Nylund, & Christine Erdie-Lalena. (2016) Quantification of Risks of Seizure in Autism. Neurology. info:/

  • May 23, 2016
  • 04:13 PM
  • 56 views

Extreme beliefs often mistaken for insanity, new study finds

by Dr. Jekyll in Lunatic Laboratories

In the aftermath of violent acts such as mass shootings, many people assume mental illness is the cause. After studying the 2011 case of Norwegian mass murderer Anders Breivik, researchers are suggesting a new forensic term to classify non-psychotic behavior that leads to criminal acts of violence.

... Read more »

Rahman T, Resnick PJ, & Harry B. (2016) Anders Breivik: Extreme Beliefs Mistaken for Psychosis. The journal of the American Academy of Psychiatry and the Law, 44(1), 28-35. PMID: 26944741  

  • May 23, 2016
  • 10:39 AM
  • 44 views

Emotional Processing: A Key to Depression Treatment?

by William Yates, M.D. in Brain Posts

In my last post I reported on the use of machine learning to aid in predicting response to depression treatment.Another interesting depression prediction tool is being investigated in a trial in England funded by the Oxford Health NHS Foundation Trust.This trial uses a visual facial recognition tool. The hypothesis is that early antidepressant action can be identified by changes in facial emotional recognition.This trial stems from work by Catherine Harmer Ph.D. from the University of Oxford. He........ Read more »

  • May 23, 2016
  • 07:55 AM
  • 45 views

Positive Stereotypes Are Pervasive and Powerful

by Jeremiah Stanghini in Jeremiah Stanghini

Pop quiz: hands up — how many of you think positive stereotypes are OK? I suspect that for many of you, your first reaction may have been, “well, yeah, they’re positive, right?” I can totally empathize with that shortcut, but … Continue reading →... Read more »

Czopp, A., Kay, A., & Cheryan, S. (2015) Positive Stereotypes Are Pervasive and Powerful. Perspectives on Psychological Science, 10(4), 451-463. DOI: 10.1177/1745691615588091  

  • May 23, 2016
  • 04:30 AM
  • 51 views

Females at Increased Risk of Protracted Concussion Symptoms

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Clinical factors that related with persistent postconcussion symptoms were sex, greater worsening symptoms from day of concussion to first concussion evaluation, continued activity participation, loss of consciousness, anterograde amnesia, and premorbid headaches, emotional symptoms on the day of concussion, and greater symptoms the day of the clinical examination. ... Read more »

  • May 23, 2016
  • 02:48 AM
  • 45 views

Sex-specific immune response to Candida albicans in schizophrenia and beyond

by Paul Whiteley in Questioning Answers

I have quite a bit of time for the various members of the Stanley Division of Developmental Neurovirology at Johns Hopkins on this blog. Not least because of the interesting work of one researcher in particular - Emily Severance - as a name behind some potentially very important research on how food, infection and immune function might come together in complicated conditions such as [some] schizophrenia and [some] bipolar disorder (see here and see here).Continuing their 'gut-brain' theme (........ Read more »

Severance, E., Gressitt, K., Stallings, C., Katsafanas, E., Schweinfurth, L., Savage, C., Adamos, M., Sweeney, K., Origoni, A., Khushalani, S.... (2016) Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder. npj Schizophrenia, 16018. DOI: 10.1038/npjschz.2016.18  

  • May 22, 2016
  • 08:17 PM
  • 46 views

Piggybacking Instead of Killing: New Insights Into Virus Community Dynamics

by Geoffrey Hannigan in Prophage

The human microbiome is an important component of human health and disease. It is an ecosystem of microbes that exists in and on humans, and can affect disease states through disturbances in composition, diversity, metabolism, etc. Understanding the human microbiome will not only allow us to better understand human health, but it will also allow us to treat medical conditions in new and effective ways (e.g. Fecal Microbiota Transplants).... Read more »

Knowles B, Silveira CB, Bailey BA, Barott K, Cantu VA, Cobián-Güemes AG, Coutinho FH, Dinsdale EA, Felts B, Furby KA.... (2016) Lytic to temperate switching of viral communities. Nature, 531(7595), 466-70. PMID: 26982729  

  • May 22, 2016
  • 04:04 PM
  • 67 views

How depression and antidepressant drugs work

by Dr. Jekyll in Lunatic Laboratories

Treating depression is kind of a guessing game. Trying to find a medication that works without causing side effects can take months, or more likely, years. However, new research demonstrates the effectiveness of ketamine to treat depression in a mouse model of the disease and brings together two hypotheses for the cause of depression.

... Read more »

  • May 22, 2016
  • 11:07 AM
  • 61 views

Robert Epstein’s empty essay

by Sergio Graziosi in Writing my own user manual - Sergio Graziosi's Blog

Sometimes reading a flawed argument triggers my rage, I really do get angry, a phenomenon that invariably surprises and amuses me. What follows is my attempt to use my anger in a constructive way, it may include elements of a…Read more ›... Read more »

  • May 22, 2016
  • 05:51 AM
  • 71 views

Pinpointing the Origins of Migraine in the Brain

by Neuroskeptic in Neuroskeptic_Discover

Migraines are a very unpleasant variety of headaches, often associated with other symptoms such as nausea, vomiting, photophobia (aversion to light) and visual disturbances. Hundreds of millions of people around the world suffer regular migraines, but their brain basis remains largely unclear.



Now a new paper reports that the origin of migraines may have been pinpointed - in the brain of one sufferer, at least. German neuroscientists Laura H. Schulte and Arne May used fMRI to record brain... Read more »

  • May 21, 2016
  • 03:44 PM
  • 91 views

Bacteria in branches naturally fertilize trees

by Dr. Jekyll in Lunatic Laboratories

The bacteria in and on our bodies have been shown to be vital for human health, influencing nutrition, obesity and protection from diseases. But science has only recently delved into the importance of the microbiome of plants. Since plants can't move, they are especially reliant on partnerships with microbes to help them get nutrients.

... Read more »

Doty, S., Sher, A., Fleck, N., Khorasani, M., Bumgarner, R., Khan, Z., Ko, A., Kim, S., & DeLuca, T. (2016) Variable Nitrogen Fixation in Wild Populus. PLOS ONE, 11(5). DOI: 10.1371/journal.pone.0155979  

  • May 21, 2016
  • 10:21 AM
  • 66 views

Quick Aspirin Use Reduces Stroke Risk in TIA

by William Yates, M.D. in Brain Posts

A free full-text commentary in the Lancet summarizes recent evidence of the benefit of aspirin in stroke prevention.This commentary focused on what is called secondary prevention. Secondary prevention is defined as prevention following events related to the disease in question.So secondary prevention in stroke would be reduction in stroke risk in those who have had a stroke or pre-stroke syndromes such as transient ischemic attacks (TIA).The key take-home message from the commentary by Graeme Ha........ Read more »

  • May 21, 2016
  • 08:19 AM
  • 77 views

The persistence of wealth and modern-day samurai

by gdw in FictionalFieldwork

The rich stay rich If you had rich ancestors, you might just be in luck. Two Italian economists used tax data to identify the wealthiest families in the city-state Florence in 1427. In contrast with the idea that you’re largely responsible for your own fortune, they found that the wealth of the 1427 families was […]... Read more »

Barone, G and Mocetti, S. (2016) Intergenerational mobility in the very long run: Florence 1427-2011. Bank of Italy working papers. info:/

  • May 21, 2016
  • 02:57 AM
  • 111 views

Add-on nutraceuticals for depression?

by Paul Whiteley in Questioning Answers

It came as no surprise to me that the systematic review and meta-analysis article by Jerome Sarris and colleagues [1] found what it did in relation to the use of [certain] adjunctive (add-on) nutraceuticals alongside antidepressants to reduce depressive symptoms: some of them might actually be clinically useful.With no medical or clinical advice given or intended, the authors report that "adjunctive use of SAMe, methylfolate, omega-3, and vitamin D with antidepressants" might be something to con........ Read more »

Sarris J, Murphy J, Mischoulon D, Papakostas GI, Fava M, Berk M, & Ng CH. (2016) Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. The American journal of psychiatry. PMID: 27113121  

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