You can lead a fish to water, but can you make it smoke?
... Read more »
Yay – another GPCR structure to look at! I just noticed that the 2.9A Dopamine D3 Receptor (in complex with Eticlopride) coordinates 3PBL have been released by the PDB earlier this week. This one will take some time to digest. My congratulations go again to the Stevens lab at TSRI. This is a great achievement, well done.... Read more »
Chien, E., Liu, W., Zhao, Q., Katritch, V., Won Han, G., Hanson, M., Shi, L., Newman, A., Javitch, J., Cherezov, V.... (2010) Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist. Science, 330(6007), 1091-1095. DOI: 10.1126/science.1197410
A well written scientific publication has high chance of getting through the peer review process. Research publication has to comply with standards concerning the document format, the use of language and the citation of prior work. Once the manuscript is written in loosely structured natural language by the researcher, the manuscript has to be validated for
1) Proper use of acronyms and their definitions.
3) GO and MeSH terms
Papermaker receives a scient........ Read more »
Rebholz-Schuhmann, D., Kavaliauskas, S., & Pezik, P. (2010) PaperMaker: validation of biomedical scientific publications. Bioinformatics, 26(7), 982-984. DOI: 10.1093/bioinformatics/btq060
A Friday Weird Science guest post on Neurotic Physiology takes a humorous look at anogenital distance and its implication for fertility in adult males.... Read more »
Eisenberg, M., Hsieh, M., Walters, R., Krasnow, R., & Lipshultz, L. (2011) The Relationship between Anogenital Distance, Fatherhood, and Fertility in Adult Men. PLoS ONE, 6(5). DOI: 10.1371/journal.pone.0018973
Recent research suggests that certain people might be more prone to infidelity than others. ... Read more »
Blow, A., & Hartnett, K. (2005) Infidelity in committed relationships: A substantive review. Journal of Marital and Family Therapy, 31(2), 217-233. DOI: 10.1111/j.1752-0606.2005.tb01556.x
Garcia JR, MacKillop J, Aller EL, Merriwether AM, Wilson DS, & Lum JK. (2010) Associations between dopamine D4 receptor gene variation with both infidelity and sexual promiscuity. PloS one, 5(11). PMID: 21152404
Fincham FD, Lambert NM, & Beach SR. (2010) Faith and unfaithfulness: can praying for your partner reduce infidelity?. Journal of personality and social psychology, 99(4), 649-59. PMID: 20718545
Lammers, J., Stoker, J. I., Jordan, J., Pollmann, M. M. H. . (2011) Power increases infidelity among men and women. Psychological Science. info:/
The paper describes how “in the past most stores were able to sell pseudoephedrine”, the US’s most popular decongestant but new laws require pharmacies, often with restricted opening hours to sell the medicine only to those carrying government issued ID. The paper argues that “it would be of great interest to have a simple synthesis of pseudoephedrine from reagents which can be more readily procured”. The study is published in the splendidly titled Journal of Apocry........ Read more »
Hai, O. Hakkenshit, I.B. (2012) A Simple and Convenient Synthesis of Pseudoephedrine From N-Methylamphetamine. Journal of Apocryphal Chemistry, 213-21. info:/1F.1BC9/b00000F00A
Examining the importance of accurate representations of science in food safety.... Read more »
O'Brien, A., Newland, J., Miller, S., Holmes, R., Smith, H., & Formal, S. (1984) Shiga-like toxin-converting phages from Escherichia coli strains that cause hemorrhagic colitis or infantile diarrhea. Science, 226(4675), 694-696. DOI: 10.1126/science.6387911
Perna, N., Plunkett, G., Burland, V., Mau, B., Glasner, J., Rose, D., Mayhew, G., Evans, P., Gregor, J., Kirkpatrick, H.... (2001) Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature, 409(6819), 529-533. DOI: 10.1038/35054089
Diez-Gonzalez F, Callaway TR, Kizoulis MG, & Russell JB. (1998) Grain feeding and the dissemination of acid-resistant Escherichia coli from cattle. Science (New York, N.Y.), 281(5383), 1666-8. PMID: 9733511
Don’t give it any more thought: according to scientists, left side of the face usually looks better, mainly because it’s more expressive than the right side. Researchers at the Wake Forest University showed a series of photographs to 37 people, some of them mirror-reversed, so the viewers wouldn’t know which side they were looking at. In most cases, they chose the left side no matter where it was in the picture.... Read more »
Blackburn, K., & Schirillo, J. (2012) Emotive hemispheric differences measured in real-life portraits using pupil diameter and subjective aesthetic preferences. Experimental Brain Research. DOI: 10.1007/s00221-012-3091-y
Gaining access to the inner workings of a neuron in the living brain offers a wealth of useful information: its patterns of electrical activity, its shape, even a profile of which genes are turned on at a given moment. However, achieving this entry is such a painstaking task that it is considered an art form; it is so difficult to learn that only a small number of labs in the world practice it.... Read more »
Kodandaramaiah, S., Franzesi, G., Chow, B., Boyden, E., & Forest, C. (2012) Automated whole-cell patch-clamp electrophysiology of neurons in vivo. Nature Methods. DOI: 10.1038/nmeth.1993
New studies in high-energy astronomy have shown that there are many more galaxies with central supermassive black holes that are actively accreting material. In a new gamma-ray survey, about 24% of the active galaxies were not previously known to have active black hole accretion, as they did not show up in lower-energy observations.... Read more »
Lisa M. Winter. (2011) Uncovering Local Absorbed Active Galactic Nuclei with Swift and Suzaku. 2011. arXiv: 1112.0545v1
The good news is that 95% of the protein aggregates in the inclusion body are your protein of interest. To get a 95% pure sample of protein you just have to lyse the cells using your preferred method (sonication works well, as does French press) in a lyses buffer containing Triton X-100. You then centrifuge your inclusion bodies containing your aggregated protein and discard the soluble supernatant. Next, you wash your inclusion body pellet in lysis buffer without Triton X-100 to remove the dete........ Read more »
A series of studies from the University of Utah found that our ancestors expanded their culinary tastes to grasses and grains, as much as 3.5 million years ago.... Read more »
Cerling TE, Manthi FK, Mbua EN, Leakey LN, Leakey MG, Leakey RE, Brown FH, Grine FE, Hart JA, Kaleme P.... (2013) Stable isotope-based diet reconstructions of Turkana Basin hominins. Proceedings of the National Academy of Sciences of the United States of America. PMID: 23733966
Wynn JG, Sponheimer M, Kimbel WH, Alemseged Z, Reed K, Bedaso ZK, & Wilson JN. (2013) Diet of Australopithecus afarensis from the Pliocene Hadar Formation, Ethiopia. Proceedings of the National Academy of Sciences of the United States of America. PMID: 23733965
In 2008, doctor Sergio Canavero, an italian neurosurgeon based in Turin, IT, have awakened a 20 years old lady from a permanent post-traumatic vegetative state, by means of a bifocal extradural cortical electro-stimulation. Today, while Science still find it hard to explain consciousness and embodied cognition – the world-class neurosurgeon made a shock announcement: “I’m ready for the first head transplant on a man.”
In the manuscript published on Surgical Neurology I........ Read more »
Canavero, S. (2013) HEAVEN: The head anastomosis venture Project outline for the first human head transplantation with spinal linkage (GEMINI). Surgical Neurology International, 4(2), 335. DOI: 10.4103/2152-7806.113444
A new study suggests hidden odours can control our food choices.... Read more »
Gaillet-Torrent, M., Sulmont-Rossé, C., Issanchou, S., Chabanet, C., & Chambaron, S. (2014) Impact of a non-attentively perceived odour on subsequent food choices. Appetite, 17-22. DOI: 10.1016/j.appet.2014.01.009
Mortality of pelagic eggs and larvae of marine fish is often assumed to be constant both in space and time due to lacking information. This may, however, be a gross oversimplification, as early life stages are likely to experience large variations in mortality both in time and space.... Read more »
Langangen, �., Stige, L., Yaragina, N., Ottersen, G., Vikebø, F., & Stenseth, N. (2014) Spatial variations in mortality in pelagic early life stages of a marine fish (Gadus morhua). Progress in Oceanography, 96-107. DOI: 10.1016/j.pocean.2014.06.003
An innovative way of rice preparation that removes more arsenic than the conventional method of cooking and a new strain of high-starch, low-methane rice are discussed.... Read more »
Carey M, Jiujin X, Gomes Farias J, & Meharg AA. (2015) Rethinking Rice Preparation for Highly Efficient Removal of Inorganic Arsenic Using Percolating Cooking Water. PloS one, 10(7). PMID: 26200355
Su J, Hu C, Yan X, Jin Y, Chen Z, Guan Q, Wang Y, Zhong D, Jansson C, Wang F.... (2015) Expression of barley SUSIBA2 transcription factor yields high-starch low-methane rice. Nature. PMID: 26200336
This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.
Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »
Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139
Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521
Social behaviours are often contagious, but why do some behaviours spread like wildfire while others remain mostly unseen? The configuration of initial adopters on a social network can systematically skew the observations people make of their friends’ behaviour. This can create the illusion that something is much more popular than it actually is, thus creating conditions for its spread.... Read more »
The germline FLCN missense mutations H255Y (Hasumi et al., 2009) and K508R (Toro et al., 2008) have been identified in patients with bilateral multifocal (BMF) kidney tumours and other clinical symptoms of Birt-Hogg-Dube (BHD) syndrome, or with BMF kidney tumours as the only manifestation. Building on their previous work identifying the H255Y mutation in human BHD kidney tumour, Hasumi et al. (2016) investigated whether these mutations have an impact on FLCN function. The authors evaluated the F........ Read more »
Hasumi H, Hasumi Y, Baba M, Nishi H, Furuya M, Vocke CD, Lang M, Irie N, Esumi C, Merino MJ.... (2016) H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation. Human molecular genetics. PMID: 28007907
Amanda Alvarez writes about how neuroscientists are studying consciousness with mathematics.... Read more »
Oizumi M, Tsuchiya N, & Amari SI. (2016) Unified framework for information integration based on information geometry. Proceedings of the National Academy of Sciences of the United States of America, 113(51), 14817-14822. PMID: 27930289
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