by Maria Noemi Llanos Roman in genome ecology evolution etc
In the times in which publishing a paper is not always totally related with the new knowledge´s contribution but leaded by how the researchers sell this new knowledge, it is quite refreshing to find a paper that outstands because deals … Continue reading →... Read more »
Freedman, A., Gronau, I., Schweizer, R., Ortega-Del Vecchyo, D., Han, E., Silva, P., Galaverni, M., Fan, Z., Marx, P., Lorente-Galdos, B.... (2014) Genome Sequencing Highlights the Dynamic Early History of Dogs. PLoS Genetics, 10(1). DOI: 10.1371/journal.pgen.1004016
Although the native Maasai and Kambala tribes live in reasonable harmony with elephants, there have been episodes where Maasai men have speared elephants. Elephants, in order to protect themselves, have learnt to recognize the voices of Maasai men as a warning sign of danger.... Read more »
McComb, K., Shannon, G., Sayialel, K., & Moss, C. (2014) Elephants can determine ethnicity, gender, and age from acoustic cues in human voices. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1321543111
New research from Karolinska Institutet and Umeå University demonstrates for the first time that there is a close relationship between body perception and the ability to remember. For us to be able to store new memories from our lives, we need to feel that we are in our own body. According to researchers, the results could be of major importance in understanding the memory problems that psychiatric patients often exhibit.
Press release March 12, 2014 Editor: Karin Wikman Umeå Uni........ Read more »
Cancer is one of the major causes of deaths seen in the humans. This is one of the major problems which have to be addressed with priority. There are many naturally available drugs for cancer. Juglone is a naturally available plant component which has a host of biological roles. This also has proven to be an anticancer drug. In the present article Juglone and Juglone compounds were docked with 1 KMS to evaluate their binding affinities.... Read more »
Shailima RD Vardhini*. (2014) Evaluating the Binding Affinity of Juglone on 1kms- An In Silico Approach. JOURNAL OF BIOINFORMATICS AND COMPARATIVE GENOMICS, 1(1), 1-2. info:/JBCG 1: 102
As Philip Gerlee pointed out, mathematical oncologists has contributed two main focuses to cancer research. In following Nowell (1976), they’ve stressed the importance of viewing cancer progression as an evolutionary process, and — of less clear-cut origin — recognizing the heterogeneity of tumours. Hence, it would seem appropriate that mathematical oncologists might enjoy Feyerabend’s philosophy: […]... Read more »
“Two canine scientists, Julie Hecht and Mia Cobb, met briefly at a conference in Barcelona in late July 2012. They share a passion for canine science, good communication, social media and fun.” So reads the 'About' page at Do You Believe in Dog?. After a brief hello at the 3rd Canine Science Forum in Barcelona, we decided to embark on an adventure as digital pen pals, taking turns blogging on topics related to our own research, that of other research groups and general dog science themes.&n........ Read more »
Cobb Mia, Branson Nick, & McGreevy Paul. (2013) Advancing the welfare of Australia’s iconic working dogs. Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.054
Hecht J., & Horowitz A. (2013) Physical prompts to anthropomorphism of the domestic dog (Canis familiaris). Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.013
Racca A., Range F., Virányi Z., & Huber L. (2013) Discrimination of familiar human faces in domestic dogs. Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.071
Dreschel N.A., & Entendencia K. (2013) Stress during certification testing in prison drug detection dogs and their handlers. Journal of Veterinary Behavior: Clinical Applications and Research, 8(4). DOI: 10.1016/j.jveb.2013.04.005
At a quarry on Alaska’s North Slope, scientists have found the fossil skull of an unusual new type of Arctic tyrannosaur.
... Read more »
Fiorillo, A., & Tykoski, R. (2014) A Diminutive New Tyrannosaur from the Top of the World. PLoS ONE, 9(3). DOI: 10.1371/journal.pone.0091287
Unable to display content. Adobe Flash is required. When I was doing my Ph.D. in the ancient days of the Sanger Method sequencing and reading in the results with one hand on the keyboard and reading the GATCs on the read (and going to the lab in the snow uphill both ways), my purpose for […]... Read more »
Conow, C., Fielder, D., Ovadia, Y., & Libeskind-Hadas, R. (2010) Jane: a new tool for the cophylogeny reconstruction problem. Algorithms for Molecular Biology, 5(1), 16. DOI: 10.1186/1748-7188-5-16
An estimated three to five million cases of severe flu infection are reported each year. This isn’t the same as the “I can’t come to work today, I’ve got ‘flu’…” type of illness (often caused by the common cold), but … Continue reading →... Read more »
Lees WD, Moss DS, & Shepherd AJ. (2014) Evolution in the influenza A H3 stalk - a challenge for broad-spectrum vaccines?. The Journal of general virology, 95(Pt 2), 317-24. PMID: 24187015
I love a lot of things that are rings, especially donuts. Turns out, though, that ring chromosomes are terrible news. A recent paper shows the loss of ring chromosomes when cells are reprogrammed, suggesting possible ‘chromosome therapy’ through cell reprogramming. Ring chromosomes form when the two arms of a chromosome fuse, and are sometimes associated with large terminal deletions. These ring chromosomes lead to birth defects, mental disabilities, and growth retardation. Unfortunately........ Read more »
Bershteyn, M., Hayashi, Y., Desachy, G., Hsiao, E., Sami, S., Tsang, K., Weiss, L., Kriegstein, A., Yamanaka, S., & Wynshaw-Boris, A. (2014) Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells. Nature, 507(7490), 99-103. DOI: 10.1038/nature12923
Why do we say that spicy foods are “hot?” The painful sensation and sting of chili peppers in the mouth is likened to the burn from a heated source. This is much closer to the truth than just a verbal similarity. The capsaicin of chili peppers serve to protect the seeds from killing by Fusarium fungi; the evolutionary pressure of fungal pathogens drives higher capsaicin levels. Other studies indicate that plant growth conditions also affect capsaicin levels. Higher growth temperatur........ Read more »
González-Zamora A, Sierra-Campos E, Luna-Ortega JG, Pérez-Morales R, Rodríguez Ortiz JC, & García-Hernández JL. (2013) Characterization of different Capsicum varieties by evaluation of their capsaicinoids content by high performance liquid chromatography, determination of pungency and effect of high temperature. Molecules (Basel, Switzerland), 18(11), 13471-86. PMID: 24184818
The sizable amount of data generated by high throughput cell biology is increasing the demand on traditional computational tools in bioinformatics to handle large input datasets. Large sequence data sets create intractable search spaces that are beyond the scope of many conventional algorithms. One way to address this problem is to transform large sequence data sets to the constituent parts that characterize the features of interest (e.g. transcription factor binding sites, miRNA sites, etc.) of........ Read more »
Sumedha S. Gunewardena. (2014) Optimum-time, Optimum-space, Algorithms for k-mer Analysis of Whole Genome Sequences. JOURNAL OF BIOINFORMATICS AND COMPARATIVE GENOMICS, 1(1), 1-12. info:/JBCG 1: 101
Not so long ago I talked about the paper from Smith and colleagues  on autism and obstacles to medical [comorbidity] diagnosis and treatment (see here). Aside from the need for professionals to overcome the issue of "a lack of expressive speech" as an impediment to undertaking a thorough medical work-up when presented with a person with autism, an important theme of that paper was the requirement to see beyond autism as being the 'reason' for every single behaviour or issue that aff........ Read more »
Tudor ME, Walsh CE, Mulder EC, & Lerner MD. (2014) Pain as a predictor of sleep problems in youth with autism spectrum disorders. Autism : the international journal of research and practice. PMID: 24497628
Few areas of biomedical research have benefited more from next-gen sequencing than studies of rare inherited diseases. Rapid, inexpensive exome sequencing in individuals with rare, presumably-monogenic diseases has been hugely successful over the past few years. There’s been a lot of discussion in the NGS community about the analysis burden of the large-scale whole-genome sequencing […]... Read more »
Koboldt DC, Larson DE, Sullivan LS, Bowne SJ, Steinberg KM, Churchill JD, Buhr AC, Nutter N, Pierce EA, Blanton SH.... (2014) Exome-Based Mapping and Variant Prioritization for Inherited Mendelian Disorders. American journal of human genetics. PMID: 24560519
You might say the benefit of staying alive is an actual no-brainer: even brainless lifeforms do their best not to die. For the most part, anyway. When they’re under stress, single-celled organisms may opt to cut up their DNA and neatly implode. A new study hints that by committing suicide in this way, an organism […]The post Suicidal Algae Help Their Relatives and Harm Their Rivals appeared first on Inkfish.... Read more »
Durand, P., Choudhury, R., Rashidi, A., & Michod, R. (2014) Programmed death in a unicellular organism has species-specific fitness effects. Biology Letters, 10(2), 20131088-20131088. DOI: 10.1098/rsbl.2013.1088
What happens when you swap the order of protein synthesis in Rift Valley Fever virus?... Read more »
Brennan, B., Welch, S., & Elliott, R. (2014) The Consequences of Reconfiguring the Ambisense S Genome Segment of Rift Valley Fever Virus on Viral Replication in Mammalian and Mosquito Cells and for Genome Packaging. PLoS Pathogens, 10(2). DOI: 10.1371/journal.ppat.1003922
The bite of an infected Ixodes hard tick transmits the Lyme disease spirochete, Borrelia burgdorferi, to humans. Ticks acquire B. burgdorferi by feeding on reservoir hosts colonized with the spirochete. Reservoir hosts include small mammals such as the white-footed mouse, the main reservoir of B. burgdorferi in the northeastern United States.A study that just came out in The Yale Journal of Biology and Medicine is accompanied by videos of Borrelia burgdorferi being transmitted betwee........ Read more »
Bockenstedt LK, Gonzalez D, Mao J, Li M, Belperron AA, & Haberman A. (2014) What ticks do under your skin: two-photon intravital imaging of Ixodes scapularis feeding in the presence of the Lyme disease spirochete. The Yale Journal of Biology and Medicine, 87(1), 3-13. PMID: 24600332
Nakayama Y, & Spielman A. (1989) Ingestion of Lyme disease spirochetes by ticks feeding on infected hosts. The Journal of infectious diseases, 160(1), 166-7. PMID: 2732513
Most folks who read this blog will be aware that a new human genome assembly has been completed, released, and is available for anyone to obtain. One of my favorite overviews of that new version can be found in this readable piece at Bio-IT World: Deanna Church on the Reference Genome Past, Present and Future. […]... Read more »
Today I'm highlighting the paper by Krystle Graham and colleagues  which talked about a possible association between the presence of urinary tract infections (UTIs) in various types of psychosis. With my interest in all things biology-behaviour, remembering such posts as impulsivity and uric acid (see here), once again we have an example of how the two areas just might fit together.The bullfighter (deceased) @Manet @Wikipedia So, take several groups of adult........ Read more »
Prehistoric giant virus buried in the Siberian ice recovered from a scientific expedition. No, it is not the plot of “The Thing”, but the utter truth: a thirty- thousand- year old virus, whose dimensions are 50 times bigger than the ones of average virus from today, was found by Abergel and Claverie’s team in the Russian permafrost.... Read more »
Legendre M, Bartoli J, Shmakova L, Jeudy S, Labadie K, Adrait A, Lescot M, Poirot O, Bertaux L, Bruley C.... (2014) Thirty-thousand-year-old distant relative of giant icosahedral DNA viruses with a pandoravirus morphology. Proceedings of the National Academy of Sciences of the United States of America. PMID: 24591590
Philippe N, Legendre M, Doutre G, Couté Y, Poirot O, Lescot M, Arslan D, Seltzer V, Bertaux L, Bruley C.... (2013) Pandoraviruses: amoeba viruses with genomes up to 2.5 Mb reaching that of parasitic eukaryotes. Science (New York, N.Y.), 341(6143), 281-6. PMID: 23869018
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