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  • May 24, 2017
  • 04:33 AM
  • 9 views

Irritable bowel syndrome (IBS) as a risk factor for bipolar disorder

by Paul Whiteley in Questioning Answers

"Only irritable bowel syndrome (IBS) emerged as a risk factor for BD [bipolar disorder] supported by convincing evidence."So said the results of the umbrella review of systematic reviews and meta-analyses by Beatrice Bortolato and colleagues [1] looking at the various environmental risk factors potentially linked to the diagnosis of bipolar disorder. I might add that this is a topic that has been discussed before on this blog (see here and see here for examples).If the systematic ........ Read more »

  • May 23, 2017
  • 12:38 PM
  • 24 views

Dismantle the Poverty Trap by Nurturing Community Trust

by Jalees Rehman in The Next Regeneration

Understanding the precise reasons for why people living in poverty often make decisions that seem short-sighted, such as foregoing more education or taking on high-interest short-term loans, is the first step to help them escape poverty. The obvious common-sense fix is to ensure that the basic needs of all citizens – food, shelter, clothing, health and personal safety – are met, so that they no longer have to use all new funds for survival. This is obviously easier in the developed w........ Read more »

Jachimowicz, J., Chafik, S., Munrat, S., Prabhu, J., & Weber, E. (2017) Community trust reduces myopic decisions of low-income individuals. Proceedings of the National Academy of Sciences, 201617395. DOI: 10.1073/pnas.1617395114  

  • May 23, 2017
  • 07:06 AM
  • 27 views

Multi-Loop Structure of Nonthermal Microwave Sources in a Major Long-Duration Flare by V. Grechnev et al.*

by CESRA in Solar Radio Science

Hard X-ray (HXR) and microwave observations of flares show only a few nonthermal sources. They are simple and compact, especially in impulsive flares, suggesting involvement of one to two loops. Hanaoka (1996) and Nishio et al. (1997) interpreted these observations in terms of double-loop flares. This view was later extended up to long-duration flares (Tzatzakis, Nindos, and Alissandrakis, 2008). A concept of a simple flare loop became dominant. However, observations [...]... Read more »

  • May 23, 2017
  • 02:54 AM
  • 42 views

"there is no single way for a brain to be normal" (or how 'neurotypical' is a nonsense)

by Paul Whiteley in Questioning Answers

I'm not usually so forthright with my posts on this blog, but today I'm being a little more bullish as I talk about an editorial from Simon Baron-Cohen [1] titled: "Neurodiversity – a revolutionary concept for autism and psychiatry."The crux of the SBC paper is the suggestion that use of the term 'disorder' specifically with autism in mind might have certain connotations - "Disorder should be used when there is nothing positive about the condition" - and until the "biomedical mechanistic cause........ Read more »

  • May 22, 2017
  • 03:00 PM
  • 71 views

Unraveling the Mysteries of Mischievous Microbiome

by Aurametrix team in Aurametrix Blog

Science explains why some people smell worse than others despite keeping themselves squeaky clean. The body is crawling with bacteria increasing the risk for diseases for which we have unreserved levels of sympathy. It can also lead to ​unlikable conditions such as unpredictable and embarrassing outbursts of body odor - so bad it ruins social lives and careers.  But there is no cure for metabolic body odor ... Read more »

  • May 22, 2017
  • 05:13 AM
  • 45 views

"a gluten-related subgroup of schizophrenia"?

by Paul Whiteley in Questioning Answers

A quote to begin this post: "this preliminary study demonstrates that altered AGDA [antibodies against gliadin-derived antigen] levels in the circulation are associated with schizophrenia and could serve as biomarkers for the identification of a schizophrenia subgroup that may need an alternative therapy or precision treatment."So said the findings reported by McLean and colleagues [1] (open-access) looking at an area of some interest to this blog (see here) on how dietary gluten might........ Read more »

  • May 22, 2017
  • 04:30 AM
  • 38 views

Should Athletic Trainers Add Anxiety Surveys to Preseason Baseline Testing?

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

An athlete with anxiety symptoms during preseason was more likely to get injured during a season than an athlete without symptoms.... Read more »

  • May 21, 2017
  • 10:50 AM
  • 50 views

Predictive Processing: the role of confidence and precision

by Sergio Graziosi in Writing my own user manual - Sergio Graziosi's Blog

This is the second post in a series inspired by Andy Clark’s book “Surfing Uncertainty“. In the previous post I’ve mentioned that an important concept in the Predictive Processing (PP) framework is the role of confidence. Confidence (in a prediction)…Read more ›... Read more »

Kanai R, Komura Y, Shipp S, & Friston K. (2015) Cerebral hierarchies: predictive processing, precision and the pulvinar. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 370(1668). PMID: 25823866  

  • May 21, 2017
  • 07:55 AM
  • 77 views

A Survey of Our Secret Lives

by Neuroskeptic in Neuroskeptic_Discover

What kinds of secrets does the average person keep? In a new paper, Columbia University researchers Michael L. Slepian and colleagues carried out a survey of secrets.



Slepian et al. developed a 'Common Secrets Questionnaire' (CSQ) and gave it to 600 participants recruited anonymously online. Participants were asked whether they'd ever had various secrets, at any point in their lives. The results are a monument to all our sins:

It turns out that extra-relational thoughts - meaning "thou... Read more »

Slepian, M., Chun, J., & Mason, M. (2017) The Experience of Secrecy. Journal of Personality and Social Psychology. DOI: 10.1037/pspa0000085  

  • May 20, 2017
  • 06:12 AM
  • 72 views

Gastrin-releasing peptide and autism continued

by Paul Whiteley in Questioning Answers

Yet another 'continued' or 'part 2' short post for you today, building on some previous - very preliminary research - talking about the use of gastrin-releasing peptide (GRP) and autism (see here).The authors included on the paper by Josemar Marchezan and colleagues [1] are familiar ones to this part of the autism research landscape as per the other occasions that members of this group have looked at / talked about GRP and autism in the peer-reviewed domain.GRP is all about a compound that 'does........ Read more »

Marchezan, J., Becker, M., Schwartsmann, G., Ohlweiler, L., Roesler, R., Renck, L., Gonçalves, M., Ranzan, J., & Riesgo, R. (2017) A Placebo-Controlled Crossover Trial of Gastrin-Releasing Peptide in Childhood Autism. Clinical Neuropharmacology, 1. DOI: 10.1097/WNF.0000000000000213  

  • May 19, 2017
  • 10:21 PM
  • 58 views

The warmer the dangerouser, at least if you are a caterpillar

by Piter Boll in Earthling Nature

by Piter Kehoma Boll Scientist all over the world agree that species diversity is higher at the tropics than at polar regions, i.e., the closer you get to the equator, more species you will find. But apart from making food … Continue reading →... Read more »

Roslin, T., Hardwick, B., Novotny, V., Petry, W., Andrew, N., Asmus, A., Barrio, I., Basset, Y., Boesing, A., Bonebrake, T.... (2017) Higher predation risk for insect prey at low latitudes and elevations. Science, 356(6339), 742-744. DOI: 10.1126/science.aaj1631  

  • May 19, 2017
  • 07:00 AM
  • 62 views

Friday Fellow: Common Stinkhorn

by Piter Boll in Earthling Nature

by Piter Kehoma Boll Today things are getting sort of pornographic again. Some time ago I introduced a plant whose flowers resemble a woman’s vulva, the asian pigeonwing, and now is time to look at something of the other sex. … Continue reading →... Read more »

  • May 19, 2017
  • 05:13 AM
  • 73 views

Characterization of a FLCN mutation associated with RCC

by Joana Guedes in BHD Research Blog

Mutations in the FLCN gene are the cause of Birt-Hogg-Dubé (BHD) syndrome, a rare disease characterized by renal cell carcinoma (RCC), pneumothorax and fibrofolliculomas. In their new study, Bartram et al. (2017) identify a heterozygous mutation in the FLCN gene in a patient with RCC. DNA from tumour and a metastasis was analysed and the authors demonstrated skipping of exon 11 as the consequence of this mutation leading to a shift in the reading frame and the insertion of a premature sto........ Read more »

Bartram MP, Mishra T, Reintjes N, Fabretti F, Gharbi H, Adam AC, Göbel H, Franke M, Schermer B, Haneder S.... (2017) Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer. BMC medical genetics, 18(1), 53. PMID: 28499369  

  • May 19, 2017
  • 04:26 AM
  • 66 views

Injury risk and ADHD: part 2

by Paul Whiteley in Questioning Answers

Consider this short post a sort of follow-on to a previous entry on this blog concerning the elevated risk of injury following a diagnosis of attention-deficit hyperactivity disorder (ADHD). The paper in question today is that by Wu-Chien Chien and colleagues [1] who yet again [2], brought the quite significant scientific weight of the "National Health Insurance Research Database in Taiwan" to bear on this topic.In this latest paper, Chien et al relied on data from a 'subset' of the main in........ Read more »

  • May 18, 2017
  • 04:40 AM
  • 80 views

On vaccinated and un-vaccinated homeschooled children: the disappearing-reappearing-disappearing-reappearing studies

by Paul Whiteley in Questioning Answers

I originally began writing this post in the last week of November 2016 following first sight of the study abstract by Anthony Mawson and colleagues [1] and their journey into a topic that has had its fair share of discussion/argument* (*delete as appropriate) with autism in mind down the years: are vaccines or immunisation patterns potentially linked to [some] autism?As it happened, this post was shelved for some time because (a) only an abstract appeared despite a publication date accompan........ Read more »

Anthony R Mawson, Brian D Ray, Azad R Bhuiyan, & Binu Jacob. (2017) Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year-old U.S. children. Journal of Translational Science. info:/10.15761/JTS.1000186

  • May 17, 2017
  • 03:08 PM
  • 106 views

Paper About Plagiarism Contains Plagiarism

by Neuroskeptic in Neuroskeptic_Discover

Regular readers will know that I have an interest in plagiarism. Today I discovered an amusing case of plagiarism in a paper about plagiarism.

The paper is called The confounding factors leading to plagiarism in academic writing and some suggested remedies. It recently appeared in the Journal of the Pakistan Medical Association (JPMA) and it's written by two Saudi Arabia-based authors, Salman Yousuf Guraya and Shaista Salman Guraya.



Here's an example of the plagiarism: a 2015 paper by ... Read more »

  • May 17, 2017
  • 12:00 PM
  • 89 views

Epigenetic Marks Associated to Severe Obesity

by Delphine Fradin in EpiBeat

There is growing evidence that DNA methylation might contribute to obesity. Candidate gene methylation studies in animal models and humans have demonstrated methylation changes in promoters of various genes that are implicated in obesity, appetite control and/or metabolism, insulin signaling, immunity, growth and circadian clock regulation.

Severe obesity in children is defined as greater than or equal to 99th percentile of body mass index (BMI) for age and gender or a BMI z-score ≥3.5. Po........ Read more »

Fradin, D., Boëlle, P., Belot, M., Lachaux, F., Tost, J., Besse, C., Deleuze, J., De Filippo, G., & Bougnères, P. (2017) Genome-Wide Methylation Analysis Identifies Specific Epigenetic Marks In Severely Obese Children. Scientific Reports, 46311. DOI: 10.1038/srep46311  

  • May 17, 2017
  • 11:24 AM
  • 90 views

Dad's Impact in Infant Development

by William Yates, M.D. in Brain Posts

Mother's interaction with their infants play a key role in infant development.The independent role of fathers in infant development is less well known and studied.A recent study from the United Kingdom supports a important role for father-child interactions in infant development.Here are the main elements of the design of this study:Subjects: Families of infants with typical deliveries were recruited from maternity wards in two hospitals in the United Kingdom.Design: Home assessments were comple........ Read more »

  • May 17, 2017
  • 07:02 AM
  • 80 views

Those who only kill children are neuro-psychologically different from other murderers

by Doug Keene in The Jury Room

Of course it isn’t a surprise that they are gravely disturbed, but who knew it was neuropsychological?  This is an article from researchers at Northwestern University and looks very specifically at similarities and differences in the neuropsychological test scores of those who killed only children and those who killed some adults as well as children. […]... Read more »

Azores-Gococo, N., Brook, M., Teralandur, S., & Hanlon, R. (2017) Killing A Child. Criminal Justice and Behavior., 2147483647. DOI: 10.1177/0093854817699437  

  • May 17, 2017
  • 04:30 AM
  • 85 views

Another Feather in the Cap of the FIFA 11 Injury Prevention Program

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Implementing the FIFA 11 injury prevention program decreases the risk of injury among collegiate male soccer players.... Read more »

Silvers-Granelli HJ, Bizzini M, Arundale A, Mandelbaum BR, & Snyder-Mackler L. (2017) Does the FIFA 11  Injury Prevention Program Reduce the Incidence of ACL Injury in Male Soccer Players?. Clinical orthopaedics and related research. PMID: 28389864  

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