An estimated three to five million cases of severe flu infection are reported each year. This isn’t the same as the “I can’t come to work today, I’ve got ‘flu’…” type of illness (often caused by the common cold), but … Continue reading →... Read more »
Lees WD, Moss DS, & Shepherd AJ. (2014) Evolution in the influenza A H3 stalk - a challenge for broad-spectrum vaccines?. The Journal of general virology, 95(Pt 2), 317-24. PMID: 24187015
I love a lot of things that are rings, especially donuts. Turns out, though, that ring chromosomes are terrible news. A recent paper shows the loss of ring chromosomes when cells are reprogrammed, suggesting possible ‘chromosome therapy’ through cell reprogramming. Ring chromosomes form when the two arms of a chromosome fuse, and are sometimes associated with large terminal deletions. These ring chromosomes lead to birth defects, mental disabilities, and growth retardation. Unfortunately........ Read more »
Bershteyn, M., Hayashi, Y., Desachy, G., Hsiao, E., Sami, S., Tsang, K., Weiss, L., Kriegstein, A., Yamanaka, S., & Wynshaw-Boris, A. (2014) Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells. Nature, 507(7490), 99-103. DOI: 10.1038/nature12923
Why do we say that spicy foods are “hot?” The painful sensation and sting of chili peppers in the mouth is likened to the burn from a heated source. This is much closer to the truth than just a verbal similarity. The capsaicin of chili peppers serve to protect the seeds from killing by Fusarium fungi; the evolutionary pressure of fungal pathogens drives higher capsaicin levels. Other studies indicate that plant growth conditions also affect capsaicin levels. Higher growth temperatur........ Read more »
González-Zamora A, Sierra-Campos E, Luna-Ortega JG, Pérez-Morales R, Rodríguez Ortiz JC, & García-Hernández JL. (2013) Characterization of different Capsicum varieties by evaluation of their capsaicinoids content by high performance liquid chromatography, determination of pungency and effect of high temperature. Molecules (Basel, Switzerland), 18(11), 13471-86. PMID: 24184818
Researchers developed a technique by which they can forecast if a person is capable of developing dementia in two to three years.This study will help to design and develop a drug that might delay or prevent the onset of disease symptoms in those individuals that are at risk.... Read more »
Mapstone, M., Cheema, A., Fiandaca, M., Zhong, X., Mhyre, T., MacArthur, L., Hall, W., Fisher, S., Peterson, D., Haley, J.... (2014) Plasma phospholipids identify antecedent memory impairment in older adults. Nature Medicine. DOI: 10.1038/nm.3466
Professor Rod DunbarCreditAuckland researchers have discovered new cells with stem cell properties in human skin, opening the door to a range of new treatments for skin diseases and unhealed wounds.The scientists, Professor Rod Dunbar, Dr Vaughan Feisst, Dr Anna Brooks and Jenni Chen, are members of the Maurice Wilkins Centre for Molecular Biodiscovery, and the research was carried out in the School of Biological Sciences at the University of Auckland.They identified mesenchymal progenitor cells........ Read more »
Feisst, V., Brooks, A., Chen, C., & Dunbar, P. (2014) Characterization of Mesenchymal Progenitor Cell Populations Directly Derived from Human Dermis. Stem Cells and Development, 23(6), 631-642. DOI: 10.1089/scd.2013.0207
Alzheimer's disease is the most widespread degenerative neurological disorder in the world. Over five million Americans live with it, and one in three senior citizens will die with the disease or a similar form of dementia. While memory loss is a common symptom of Alzheimer's, other behavioral manifestations — depression, loss of inhibition, delusions, agitation, anxiety, and aggression — can be even more challenging for victims and their families to live with.Today, Professor Daniel........ Read more »
Shruster, A., & Offen, D. (2014) Targeting neurogenesis ameliorates danger assessment in a mouse model of Alzheimer's disease. Behavioural Brain Research, 193-201. DOI: 10.1016/j.bbr.2013.12.028
The sizable amount of data generated by high throughput cell biology is increasing the demand on traditional computational tools in bioinformatics to handle large input datasets. Large sequence data sets create intractable search spaces that are beyond the scope of many conventional algorithms. One way to address this problem is to transform large sequence data sets to the constituent parts that characterize the features of interest (e.g. transcription factor binding sites, miRNA sites, etc.) of........ Read more »
Sumedha S. Gunewardena. (2014) Optimum-time, Optimum-space, Algorithms for k-mer Analysis of Whole Genome Sequences. JOURNAL OF BIOINFORMATICS AND COMPARATIVE GENOMICS, 1(1), 1-12. info:/JBCG 1: 101
Not so long ago I talked about the paper from Smith and colleagues  on autism and obstacles to medical [comorbidity] diagnosis and treatment (see here). Aside from the need for professionals to overcome the issue of "a lack of expressive speech" as an impediment to undertaking a thorough medical work-up when presented with a person with autism, an important theme of that paper was the requirement to see beyond autism as being the 'reason' for every single behaviour or issue that aff........ Read more »
Tudor ME, Walsh CE, Mulder EC, & Lerner MD. (2014) Pain as a predictor of sleep problems in youth with autism spectrum disorders. Autism : the international journal of research and practice. PMID: 24497628
College athletes who had orthopaedic surgery in high school miss more days of collegiate competition than athletes without a history of orthopaedic surgery. More specifically, athletes with a history of knee surgery were more likely to sustain another knee injury or require surgery while in college.... Read more »
Rugg, C., Wang, D., Sulzicki, P., & Hame, S. (2014) Effects of Prior Knee Surgery on Subsequent Injury, Imaging, and Surgery in NCAA Collegiate Athletes. The American Journal of Sports Medicine. DOI: 10.1177/0363546513519951
Do we do too many 12 lead ECGs on patients who do not have chest pain?
This is something that some people worry about.
Save the electrodes!
Those poor little electrodes are being abused!
Are electrodes being abused?... Read more »
Glickman SW, Shofer FS, Wu MC, Scholer MJ, Ndubuizu A, Peterson ED, Granger CB, Cairns CB, & Glickman LT. (2012) Development and validation of a prioritization rule for obtaining an immediate 12-lead electrocardiogram in the emergency department to identify ST-elevation myocardial infarction. American heart journal, 163(3), 372-82. PMID: 22424007
A new type of consumer has evolved in recent years—the love child of the Couch Potato and the Channel Surfer, raised by streaming devices and nurtured by entire seasons of shows available at the click of a remote. Neuroscience, it turns out, can partially explain the phenomenon of binge-watching TV.... Read more »
Training Characteristics Related to Running Related Injuries... Read more »
Malisoux, L., Urhausen, A., & Theisen, D. (2014) IMPACT OF TRAINING CHARACTERISTICS ON RUNNING-RELATED INJURIES IN RECREATIONAL RUNNERS. British Journal of Sports Medicine, 48(7), 631-632. DOI: 10.1136/bjsports-2014-093494.194
I discuss a recent Science review about data regarding the cold tropical Pacific and its relationship to recent global temperature data.... Read more »
Clement, A., & DiNezio, P. (2014) The Tropical Pacific Ocean--Back in the Driver's Seat?. Science, 343(6174), 976-978. DOI: 10.1126/science.1248115
Researchers at the Vienna University of Technology have succeeded for the first time in creating a diode made of tungsten diselenide. Experiments show that this material may be used to create ultrathin flexible solar cells. Even flexible displays could become possible.... Read more »
Pospischil, A., Furchi, M., & Mueller, T. (2014) Solar-energy conversion and light emission in an atomic monolayer p–n diode. Nature Nanotechnology. DOI: 10.1038/nnano.2014.14
Few areas of biomedical research have benefited more from next-gen sequencing than studies of rare inherited diseases. Rapid, inexpensive exome sequencing in individuals with rare, presumably-monogenic diseases has been hugely successful over the past few years. There’s been a lot of discussion in the NGS community about the analysis burden of the large-scale whole-genome sequencing […]... Read more »
Koboldt DC, Larson DE, Sullivan LS, Bowne SJ, Steinberg KM, Churchill JD, Buhr AC, Nutter N, Pierce EA, Blanton SH.... (2014) Exome-Based Mapping and Variant Prioritization for Inherited Mendelian Disorders. American journal of human genetics. PMID: 24560519
This month I will be focusing on sleep and the brain. The importance of sleep to normal and abnormal brain functioning is receiving increased research attention.A variety of sleep abnormalities have been described in major depression and bipolar affective disorder. Depression has been linked to delayed sleep onset, reduced time to first rapid eye movement (REM) period, reduced sleep efficiency and disruption of the circadian rhythm of sleep.Sleep physiology also varies throughout the lifesp........ Read more »
Robillard, R., Naismith, S., Smith, K., Rogers, N., White, D., Terpening, Z., Ip, T., Hermens, D., Whitwell, B., Scott, E.... (2014) Sleep-Wake Cycle in Young and Older Persons with a Lifetime History of Mood Disorders. PLoS ONE, 9(2). DOI: 10.1371/journal.pone.0087763
You might say the benefit of staying alive is an actual no-brainer: even brainless lifeforms do their best not to die. For the most part, anyway. When they’re under stress, single-celled organisms may opt to cut up their DNA and neatly implode. A new study hints that by committing suicide in this way, an organism […]The post Suicidal Algae Help Their Relatives and Harm Their Rivals appeared first on Inkfish.... Read more »
Durand, P., Choudhury, R., Rashidi, A., & Michod, R. (2014) Programmed death in a unicellular organism has species-specific fitness effects. Biology Letters, 10(2), 20131088-20131088. DOI: 10.1098/rsbl.2013.1088
Michele MarksteinUsing a new approach to systematically test chemotherapy drugs in an unusual animal model, a research team led by University of Massachusetts Amherst molecular biologist Michele Markstein, with Norbert Perrimon at Harvard Medical School, report that several have a serious side effect: Inducing hyper proliferation in stem cells that could lead to tumor recurrence.Markstein says, “We discovered that several chemotherapeutics that stop fast growing tumors have the opposite effect........ Read more »
Markstein, M., Dettorre, S., Cho, J., Neumuller, R., Craig-Muller, S., & Perrimon, N. (2014) Systematic screen of chemotherapeutics in Drosophila stem cell tumors. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1401160111
A new study by Berkeley Lab researchers at the Joint Center for Artificial Photosynthesis (JCAP) shows that nearly 90-percent of the electrons generated by a hybrid photocathode material designed to store solar energy in hydrogen are being stored in the target hydrogen molecules.... Read more »
Krawicz, A., Cedeno, D., & Moore, G. (2014) Energetics and Efficiency Analysis of a Cobaloxime-Modified Semiconductor at Simulated Air Mass 1.5 Illumination. Physical Chemistry Chemical Physics. DOI: 10.1039/c4cp00495g
What happens when you swap the order of protein synthesis in Rift Valley Fever virus?... Read more »
Brennan, B., Welch, S., & Elliott, R. (2014) The Consequences of Reconfiguring the Ambisense S Genome Segment of Rift Valley Fever Virus on Viral Replication in Mammalian and Mosquito Cells and for Genome Packaging. PLoS Pathogens, 10(2). DOI: 10.1371/journal.ppat.1003922
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