Parkinson’s disease affects neurons in a particular brain region, when it develops brain cells have their mitochondrial activity cease and then the cells die. But now researchers have shown that supplying D-lactate […]... Read more »
Toyoda Y, Erkut C, Pan-Montojo F, Boland S, Stewart MP, Müller DJ, Wurst W, Hyman AA, & Kurzchalia TV. (2014) Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival. Biology open. PMID: 25063200
Five of the coolest science news stories of the week! Friends & DNA, Alzheimer’s, a satanic gecko, fist bumps, and political brains... Read more »
Hibbing, J., Smith, K., & Alford, J. (2014) Differences in negativity bias underlie variations in political ideology. Behavioral and Brain Sciences, 37(03), 297-307. DOI: 10.1017/S0140525X13001192
Tumours are incredibly heterogeneic- that is that they have different properties including morphology (how they look), metabolism (the processes they use to generate energy), proliferation (how fast they grow, divide and replicate themselves) and potential to metastasise (where a tumour moves to another part of the body). But why is this so?
Many people are under the assumption that a cancer will arise from a single mutation in the DNA, but this is not actually the case. For a cancer to dev........ Read more »
Lo, Y., Corbetta, N., Chamberlain, P., Rai, V., Sargent, I., Redman, C., & Wainscoat, J. (1997) Presence of fetal DNA in maternal plasma and serum. The Lancet, 350(9076), 485-487. DOI: 10.1016/S0140-6736(97)02174-0
Vasioukhin V, Anker P, Maurice P, Lyautey J, Lederrey C, & Stroun M. (1994) Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia. British journal of haematology, 86(4), 774-9. PMID: 7918071
De Mattos-Arruda L, Weigelt B, Cortes J, Won HH, Ng CK, Nuciforo P, Bidard FC, Aura C, Saura C, Peg V.... (2014) Capturing Intra-Tumor Genetic Heterogeneity by De Novo Mutation Profiling of Circulating Cell-Free Tumor DNA: A Proof-of-Principle. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. PMID: 25009010
Pantel K, & Alix-Panabières C. (2013) Real-time liquid biopsy in cancer patients: fact or fiction?. Cancer research, 73(21), 6384-8. PMID: 24145355
Rutgers researchers have developed a new catalyst for commercially viable hydrogen production. It is based on carbon nanotubes and performs almost as well as cost-prohibitive platinum-based catalysts.... Read more »
Zou, X., Huang, X., Goswami, A., Silva, R., Sathe, B., Mikmeková, E., & Asefa, T. (2014) Cobalt-Embedded Nitrogen-Rich Carbon Nanotubes Efficiently Catalyze Hydrogen Evolution Reaction at All pH Values. Angewandte Chemie, 126(17), 4461-4465. DOI: 10.1002/ange.201311111
In the UK, a significant amount of medical research funding – an estimated £2.9 billion in 2012/13 – comes from the public purse through taxes and charitable donations, or from the Wellcome Trust, so it is important to see whether … Continue reading →... Read more »
Glover M, Buxton M, Guthrie S, Hanney S, Pollitt A, & Grant J. (2014) Estimating the returns to UK publicly funded cancer-related research in terms of the net value of improved health outcomes. BMC medicine, 99. PMID: 24930803
Short term, lack of sleep scrambles our mental functioning. Long term, the health consequences can be dire. What's stopping us from getting enough?For many, adequate sleep is elusive because of sleep disorders, including varieties of insomnia. For others there are practical challenges - baby care or night shifts, for example. A new study focuses on another major, yet strangely overlooked, reason - bedtime procrastination. You want to go to bed early. You know you need to get to bed. And yet you ........ Read more »
Kroese, F., Evers, C., Adriaanse, M., & de Ridder, D. (2014) Bedtime procrastination: A self-regulation perspective on sleep insufficiency in the general population. Journal of Health Psychology. DOI: 10.1177/1359105314540014
Today I'm bringing to your attention the paper by Eva Troyb and colleagues  and the quite dramatic assertion: "Reports of current behavior indicated that RRB's [restricted and repetitive behaviors] had almost totally disappeared in the OO [optimal outcomes] group". RRBs just in case you might not know include quite an array of behaviours, some of which might not be considered 'disabling' such as the presence of certain circumscribed interests. Others, such as an insistence........ Read more »
Troyb E, Orinstein A, Tyson K, Eigsti IM, Naigles L, & Fein D. (2014) Restricted and Repetitive Behaviors in Individuals with a History of ASDs Who Have Achieved Optimal Outcomes. Journal of autism and developmental disorders. PMID: 25030967
Fried Egg JellyfishCotylorhiza tuberculataThe common name says it all. This weird-looking jellyfish literally looks like a fried egg! Scientifically known as Cotylorhiza tuberculata, it is one of the two jellyfish species that resemble a fried egg. The other one is Phacellophora camtschatica. Not surprisingly, it also goes by the same name.They may look tasty, but you probably don't want to have one for breakfast! However, you can have a lot of fun with C. tuberculata. This jellyfish has a ........ Read more »
Reum, J., Hunsicker, M., & Paulsen, C. (2010) Species Composition and Relative Abundance of Large Medusae in Puget Sound, Washington. Northwest Science, 84(2), 131-140. DOI: 10.3955/046.084.0202
Widmer, C. (2006) Life cycle of Phacellophora camtschatica (Cnidaria: Scyphozoa). Invertebrate Biology, 125(2), 83-90. DOI: 10.1111/j.1744-7410.2006.00043.x
Towanda, T., & Thuesen, E. (2006) Ectosymbiotic behavior of Cancer gracilis and its trophic relationships with its host Phacellophora camtschatica and the parasitoid Hyperia medusarum. Marine Ecology Progress Series, 221-236. DOI: 10.3354/meps315221
So far in this series of posts on “tracing the connections” between ancient Pueblo sites like Chaco Canyon and modern Pueblos, I’ve discussed evidence from linguistics and folklore, but of course if the issue is determining which modern groups are physically descended from which ancient ones it’s hard to beat evidence from actual physical remains. […]... Read more »
Schillaci, M., & Stojanowski, C. (2002) A Reassessment of Matrilocality in Chacoan Culture. American Antiquity, 67(2), 343. DOI: 10.2307/2694571
This happens many times every day. A patient falls and may have hit her head, but there is no change from her normal mental status. To complicate matter, she takes an anticoagulant.
There are no clear signs of serious trauma. so should we automatically go to the trauma center?
What can help us decide?... Read more »
Hamden K, Agresti D, Jeanmonod R, Woods D, Reiter M, & Jeanmonod D. (2014) Characteristics of elderly fall patients with baseline mental status: high-risk features for intracranial injury. The American journal of emergency medicine. PMID: 24929771
Although the words “anorexia nervosa” typically conjure up images of emaciated bodies, eating disorders characterized by dietary restriction or weight loss can — and do — occur at any weight. However, precisely because anorexia nervosa is associated with underweight, doctors are less likely to identify eating disorders among individuals who are in the so-called “normal” or above normal weight range, even if they have........ Read more »
Lebow, J., Sim, L., & Kransdorf, L. (2014) Prevalence of a History of Overweight and Obesity in Adolescents With Restrictive Eating Disorders. Journal of Adolescent Health. DOI: 10.1016/j.jadohealth.2014.06.005
The creation of the category “Twitter Psychosis" tells us more about the culture of contemporary psychiatry than it does about the purported dangers of social media overuse. Can Twitter really “cause” psychotic symptoms in predisposed individuals? Or is Twitter merely the latest technical innovation that influences “the form, origin and content of delusional beliefs” (Bell et al., 2005)? Twitter as the new telephone tower, radio waves, microchip implant or personal TV show, if you wil........ Read more »
Kalbitzer J, Mell T, Bermpohl F, Rapp MA, & Heinz A. (2014) Twitter Psychosis: A Rare Variation or a Distinct Syndrome?. The Journal of nervous and mental disease, 202(8), 623. PMID: 25075647
As a “World Cup tie in post” this one’s a bit late, but here’s a story that’s been getting a lot of attention: According to scientists, Neymar uses instinct and not his brain when playing football Yes, if you believe the headlines, research has shown that legendary Brazilian forward Neymar da Silva Santos is so […]The post Functional Neuroimaging’s Neymar Problem appeared first on Neuroskeptic.... Read more »
Eiichi Naito, & Satoshi Hirose. (2014) Efficient foot motor control by Neymar’s brain. Front. Hum. Neurosci. info:/
I’m sure you can all relate, you go to fix the sink and in the process you build a new kitchen on accident. Anyone… no? Well that is sort of […]... Read more »
Lisanti, S., Tavecchio, M., Chae, Y., Liu, Q., Brice, A., Thakur, M., Languino, L., & Altieri, D. (2014) Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks. Cell Reports. DOI: 10.1016/j.celrep.2014.06.061
Biostars is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the community and find it very useful. Often questions and answers arise at Biostars that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here […]... Read more »
Voegele C., N. Robinot, J. McKay, P. Damiecki, & L. Alteyrac. (2013) A universal open-source Electronic Laboratory Notebook. Bioinformatics, 29(13), 1710-1712. DOI: http://dx.doi.org/10.1093/bioinformatics/btt253
Scientists at at Rice University predict functional advantages of a three-dimensional porous nanostructure that could benefit gas storage, nanoelectronics, and composite materials that perform multiple functions.... Read more »
Sakhavand, N., & Shahsavari, R. (2014) Synergistic Behavior of Tubes, Junctions and Sheets Imparts Mechano-Mutable Functionality in 3D Porous Boron Nitride Nanostructures. The Journal of Physical Chemistry C, 2147483647. DOI: 10.1021/jp5044706
The new Planet of the Apes movie has talking apes! In the old Charleton Heston versions, the apes had thousands of years to evolve speech capabilities, but Dawn of the Planet of the Apes takes place only 10 years after their escape from the lab. Anatomical differences between human and ape hyoid position, rib musculature and tongue show us why speech is not possible for Cesar and his friends. In addition, new research points out the importance of the foxp2 protein for speech and auditory functio........ Read more »
Ackermann H, Hage SR, & Ziegler W. (2014) Brain mechanisms of acoustic communication in humans and nonhuman primates: An evolutionary perspective. The Behavioral and brain sciences, 1-84. PMID: 24827156
Do you ever feel nostalgic for a specific paper? Maybe this paper inspired your own research, or maybe it was a paper you immediately knew would be game-changing. Maybe, like today’s TBT paper, it was a great paper about solidly executed research with a memorable giggle-inducing technique. Thanks to a nostalgic HighMag reader and friend, Omar Quintero, we are being re-introduced to gonad sandwiches. In mammals, sex determination refers to the changes during early development that lead ........ Read more »
Martineau, J., Nordqvist, K., Tilmann, C., Lovell-Badge, R., & Capel, B. (1997) Male-specific cell migration into the developing gonad. Current Biology, 7(12), 958-968. DOI: 10.1016/S0960-9822(06)00415-5
When a patient with schizophrenia hears voices in their head, is the experience shaped by the culture they live in? Tanya Luhrmann and her colleagues investigated by interviewing twenty people diagnosed with schizophrenia living in San Mateo, California; twenty in Accra, Ghana; and twenty others in Chennai India. There were similarities across cultures, including descriptions of good and bad voices, but also striking differences.In San Mateo the interviewees talked about their condition as a bra........ Read more »
Luhrmann, T., Padmavati, R., Tharoor, H., & Osei, A. (2014) Differences in voice-hearing experiences of people with psychosis in the USA, India and Ghana: interview-based study. The British Journal of Psychiatry. DOI: 10.1192/bjp.bp.113.139048
Serum levels of dipeptidyl peptidase (DPP) IV were found to be lower in children with autism compared to asymptomatic controls according to the study by Shahid Bashira & Laila AL-Ayadhi . Based on analysis by ELISA, researchers concluded that "alterations in the plasma level of DPP IV play a role in the pathophysiology of autism".A sailor went to sea, sea, sea... @ Wikipedia Anyone who has followed the autism research scene for any length of time might have already heard ab........ Read more »
Bashir, S., & AL-Ayadhi, L. (2014) Alterations in plasma dipeptidyl peptidase IV in autism: A pilot study. Neurology, Psychiatry and Brain Research, 20(2), 41-44. DOI: 10.1016/j.npbr.2014.03.001
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