37 posts · 27,932 views
Medical Biologist by education and Medical Librarian by profession. Working at a library of an Academic hospital and for the Cochrane Collaboration. Specialized in EBM, searching for systematic reviews and guidelines.
Laika's Medliblog
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- May 17, 2012
- 08:35 PM
- 57 views
The Scatter of Medical Research and What to do About it.
by Laika Spoetnik in Laika's Medliblog
Paul Glasziou, GP and professor in Evidence Based Medicine, co-authored a new article in the BMJ [1]. Similar to another paper [2] I discussed before [3] this paper deals with the difficulty for clinicians of staying up-to-date with the literature. But where the previous paper [2,3] highlighted the mere increase in number of research articles over time, the current paper looks at the scatter of randomized clinical trials (RCTs) and systematic reviews (SR’s) accross different journals cited in one year (2009) in PubMed.... Read more »
Hoffmann, Tammy, Erueti, Chrissy, Thorning,Sarah, & Glasziou, Paul. (2012) The scatter of research: cross sectional comparison of randomised trials and systematic reviews across specialties. BMJ. info:/10.1136/bmj.e3223
Bastian, H., Glasziou, P., & Chalmers, I. (2010) Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up?. PLoS Medicine, 7(9). DOI: 10.1371/journal.pmed.1000326
- May 12, 2012
- 08:56 AM
- 96 views
Can Guidelines Harm Patients?
by Laika Spoetnik in Laika's Medliblog
Recently I saw an intriguing “personal view” in the BMJ written by Grant Hutchison entitled: “Can Guidelines Harm Patients Too?” Hutchison is a consultant anesthetist with -as he calls it- chronic guideline fatigue syndrome. Hutchison underwent an acute exacerbation of his “condition” with the arrival of another set of guidelines in his email inbox. Hutchison:
On reviewing the level of evidence provided for the various recommendations being offered, I was struck by the fact that no relevant clinical trials had been carried out in the population of interest. Eleven out of 25 of the recommendations made were supported only by the lowest levels of published evidence ... Read more »
Hutchison, G. (2012) Guidelines can harm patients too. BMJ, 344(apr18 1). DOI: 10.1136/bmj.e2685
Tricoci P, Allen JM, Kramer JM, Califf RM, & Smith SC Jr. (2009) Scientific evidence underlying the ACC/AHA clinical practice guidelines. JAMA : the journal of the American Medical Association, 301(8), 831-41. PMID: 19244190
Lee, D., & Vielemeyer, O. (2011) Analysis of Overall Level of Evidence Behind Infectious Diseases Society of America Practice Guidelines. Archives of Internal Medicine, 171(1), 18-22. DOI: 10.1001/archinternmed.2010.482
Menéndez R, Reyes S, Martínez R, de la Cuadra P, Manuel Vallés J, & Vallterra J. (2007) Economic evaluation of adherence to treatment guidelines in nonintensive care pneumonia. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, 29(4), 751-6. PMID: 17005580
Sackett, D., Rosenberg, W., Gray, J., Haynes, R., & Richardson, W. (1996) Evidence based medicine: what it is and what it isn't. BMJ, 312(7023), 71-72. DOI: 10.1136/bmj.312.7023.71
Aylett, V. (2010) Do geriatricians need guidelines?. BMJ, 341(sep29 3). DOI: 10.1136/bmj.c5340
- May 11, 2012
- 12:50 AM
- 107 views
What Did Deep DNA Sequencing of Traditional Chinese Medicines (TCMs) Really Reveal?
by Laika Spoetnik in Laika's Medliblog
A recent study published in PLOS genetics[1] on a genetic audit of Traditional Chinese Medicines (TCMs) was widely covered in the news. The headlines are a bit confusing as they said different things. Some headlines say “Dangers of Chinese Medicine Brought to Light by DNA Studies“, others that Bear and Antelope DNA are Found in Traditional Chinese Medicine, and still others more neutrally: Breaking down traditional Chinese medicine.
What have Bunce and his group really done and what is the newsworthiness of this article?... Read more »
Coghlan ML, Haile J, Houston J, Murray DC, White NE, Moolhuijzen P, Bellgard MI, & Bunce M. (2012) Deep Sequencing of Plant and Animal DNA Contained within Traditional Chinese Medicines Reveals Legality Issues and Health Safety Concerns. PLoS genetics, 8(4). PMID: 22511890
- October 18, 2011
- 10:45 AM
- 385 views
Evidence Based Point of Care Summaries [2] More Uptodate with Dynamed.
by Laika in Laika's Medliblog
This post is part of a short series about Evidence Based Point of Care Summaries or POCs. In this series I will review 3 recent papers that objectively compare a selection of POCs. In the previous post I reviewed a paper from Rita Banzi and colleagues from the Italian Cochrane Centre [1]. They analyzed 18 POCs with respect to their [...]... Read more »
Banzi, R., Liberati, A., Moschetti, I., Tagliabue, L., & Moja, L. (2010) A Review of Online Evidence-based Practice Point-of-Care Information Summary Providers. Journal of Medical Internet Research, 12(3). DOI: 10.2196/jmir.1288
Banzi, R., Cinquini, M., Liberati, A., Moschetti, I., Pecoraro, V., Tagliabue, L., & Moja, L. (2011) Speed of updating online evidence based point of care summaries: prospective cohort analysis. BMJ, 343(sep22 2). DOI: 10.1136/bmj.d5856
Shurtz, S., & Foster, M. (2011) Developing and using a rubric for evaluating evidence-based medicine point-of-care tools. Journal of the Medical Library Association : JMLA, 99(3), 247-254. DOI: 10.3163/1536-5050.99.3.012
Ketchum, A., Saleh, A., & Jeong, K. (2011) Type of Evidence Behind Point-of-Care Clinical Information Products: A Bibliometric Analysis. Journal of Medical Internet Research, 13(1). DOI: 10.2196/jmir.1539
- October 13, 2011
- 12:19 PM
- 280 views
Evidence Based Point of Care Summaries [1] No “Best” Among the Bests?
by Laika in Laika's Medliblog
For many of today’s busy practicing clinicians, keeping up with the enormous and ever growing amount of medical information, poses substantial challenges [6]. Its impractical to do a PubMed search to answer each clinical question and then synthesize and appraise the evidence. Simply, because busy health care providers have limited time and many questions per day. As [...]... Read more »
Banzi, R., Liberati, A., Moschetti, I., Tagliabue, L., & Moja, L. (2010) A Review of Online Evidence-based Practice Point-of-Care Information Summary Providers. Journal of Medical Internet Research, 12(3). DOI: 10.2196/jmir.1288
Alper, B. (2010) Review of Online Evidence-based Practice Point-of-Care Information Summary Providers: Response by the Publisher of DynaMed. Journal of Medical Internet Research, 12(3). DOI: 10.2196/jmir.1622
Goodyear-Smith F, Kerse N, Warren J, & Arroll B. (2008) Evaluation of e-textbooks. DynaMed, MD Consult and UpToDate. Australian family physician, 37(10), 878-82. PMID: 19002313
Ketchum, A., Saleh, A., & Jeong, K. (2011) Type of Evidence Behind Point-of-Care Clinical Information Products: A Bibliometric Analysis. Journal of Medical Internet Research, 13(1). DOI: 10.2196/jmir.1539
McKibbon, K., & Fridsma, D. (2006) Effectiveness of Clinician-selected Electronic Information Resources for Answering Primary Care Physicians' Information Needs. Journal of the American Medical Informatics Association, 13(6), 653-659. DOI: 10.1197/jamia.M2087
- September 8, 2011
- 10:28 AM
- 262 views
FUTON Bias. Or Why Limiting to Free Full Text Might not Always be a Good Idea.
by Laika in Laika's Medliblog
A few weeks ago I was discussing possible relevant papers for the Twitter Journal Club (Hashtag #TwitJC), a succesful initiative on Twitter, that I have discussed previously here and here [7,8]. I proposed an article, that appeared behind a paywall. Annemarie Cunningham (@amcunningham) immediately ran the idea down, stressing that open-access (OA) is a pre-requisite for the TwitJC [...]... Read more »
Björk, B., Welling, P., Laakso, M., Majlender, P., Hedlund, T., & Guðnason, G. (2010) Open Access to the Scientific Journal Literature: Situation 2009. PLoS ONE, 5(6). DOI: 10.1371/journal.pone.0011273
Matsubayashi, M., Kurata, K., Sakai, Y., Morioka, T., Kato, S., Mine, S., & Ueda, S. (2009) Status of open access in the biomedical field in 2005. Journal of the Medical Library Association : JMLA, 97(1), 4-11. DOI: 10.3163/1536-5050.97.1.002
WENTZ, R. (2002) Visibility of research: FUTON bias. The Lancet, 360(9341), 1256-1256. DOI: 10.1016/S0140-6736(02)11264-5
Murali NS, Murali HR, Auethavekiat P, Erwin PJ, Mandrekar JN, Manek NJ, & Ghosh AK. (2004) Impact of FUTON and NAA bias on visibility of research. Mayo Clinic proceedings. Mayo Clinic, 79(8), 1001-6. PMID: 15301326
Carney PA, Poor DA, Schifferdecker KE, Gephart DS, Brooks WB, & Nierenberg DW. (2004) Computer use among community-based primary care physician preceptors. Academic medicine : journal of the Association of American Medical Colleges, 79(6), 580-90. PMID: 15165980
Krieger, M., Richter, R., & Austin, T. (2008) An exploratory analysis of PubMed's free full-text limit on citation retrieval for clinical questions. Journal of the Medical Library Association : JMLA, 96(4), 351-355. DOI: 10.3163/1536-5050.96.4.010
- August 21, 2011
- 03:21 PM
- 678 views
PubMed’s Higher Sensitivity than OVID MEDLINE… & other Published Clichés.
by Laika in Laika's Medliblog
Is it just me, or are biomedical papers about searching for a systematic review often of low quality or just too damn obvious? I’m seldom excited about papers dealing with optimal search strategies or peculiarities of PubMed, even though it is my specialty. It is my impression, that many of the lower quality and/or less relevant papers are [...]... Read more »
Winchester DE, & Bavry AA. (2010) Limitations of the MEDLINE database in constructing meta-analyses. Annals of internal medicine, 153(5), 347-8. PMID: 20820050
Leclercq E, Kramer B, & Schats W. (2011) Limitations of the MEDLINE database in constructing meta-analyses. Annals of internal medicine, 154(5), 371. PMID: 21357916
- June 19, 2011
- 07:37 PM
- 671 views
HOT TOPIC: Does Soy Relieve Hot Flashes?
by Laika in Laika's Medliblog
The theme of the Upcoming Grand Rounds held at June 21th (1st day of the Summer) at Shrink Rap is “hot”. A bit far-fetched, but aah you know….shrinks“. Of course they hope assume that we will express Weiner-like exhibitionism at our blogs. Or go into spicy details of hot sexpectations or other Penis Friday NCBI-ROFL posts. But no, not me, [...]... Read more »
Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, & Brown J. (2007) Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database of Systematic Reviews. info:/10.1002/14651858.CD001395.pub3.
Bolaños R, Del Castillo A, & Francia J. (2010) Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and meta-analysis. Menopause (New York, N.Y.), 17(3), 660-6. PMID: 20464785
- March 13, 2011
- 07:48 PM
- 802 views
A New Safe Blood Test to Diagnose Down Syndrome
by Laika in Laika's Medliblog
The established method to prenatally diagnose chromosomal gross abnormalities is to obtain fetal cells from the womb with a fine needle, either by Amniocentesis (a sample of the fluid surrounding the foetus in the womb) or by Chorionic villus sampling (CVS, a sample of the placenta taken via the vaginal route). The procedures are not to be sneezed [...]... Read more »
LO, Y., CORBETTA, N., CHAMBERLAIN, P., RAI, V., SARGENT, I., REDMAN, C., & WAINSCOAT, J. (1997) Presence of fetal DNA in maternal plasma and serum. The Lancet, 350(9076), 485-487. DOI: 10.1016/S0140-6736(97)02174-0
Chiu, R., Akolekar, R., Zheng, Y., Leung, T., Sun, H., Chan, K., Lun, F., Go, A., Lau, E., To, W.... (2011) Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ, 342(jan11 1). DOI: 10.1136/bmj.c7401
Papageorgiou, E., Karagrigoriou, A., Tsaliki, E., Velissariou, V., Carter, N., & Patsalis, P. (2011) Fetal-specific DNA methylation ratio permits noninvasive prenatal diagnosis of trisomy 21. Nature Medicine. DOI: 10.1038/nm.2312
- February 8, 2011
- 10:16 PM
- 672 views
Much Ado About ADHD-Research: Is there a Misrepresentation of ADHD in Scientific Journals?
by Laika in Laika's Medliblog
The reliability of science is increasingly under fire. We all know that media often gives a distorted picture of scientific findings (i.e. Hot news: Curry, Curcumin, Cancer & cure). But there is also an ever growing number of scientific misreports or even fraud (see bmj editorial announcing retraction of the Wakefield paper about causal relation beteen MMR vaccination [...]... Read more »
Gonon, F., Bezard, E., & Boraud, T. (2011) Misrepresentation of Neuroscience Data Might Give Rise to Misleading Conclusions in the Media: The Case of Attention Deficit Hyperactivity Disorder. PLoS ONE, 6(1). DOI: 10.1371/journal.pone.0014618
Ioannidis, J. (2005) Why Most Published Research Findings Are False. PLoS Medicine, 2(8). DOI: 10.1371/journal.pmed.0020124
Barbaresi, W., Katusic, S., Colligan, R., Weaver, A., & Jacobsen, S. (2007) Modifiers of Long-Term School Outcomes for Children with Attention-Deficit/Hyperactivity Disorder: Does Treatment with Stimulant Medication Make a Difference? Results from a Population-Based Study. Journal of Developmental , 28(4), 274-287. DOI: 10.1097/DBP.0b013e3180cabc28
GONON, F. (2009) The dopaminergic hypothesis of attention-deficit/hyperactivity disorder needs re-examining. Trends in Neurosciences, 32(1), 2-8. DOI: 10.1016/j.tins.2008.09.010
- November 23, 2010
- 04:15 PM
- 637 views
Implementing Twitter in a Health Sciences Library
by Laika in Laika's Medliblog
Twitter describes itself as “a service for friends, family, and co-workers to communicate and stay connected through the exchange of quick, frequent answers to one simple question: What are you doing?” [2]. The “answers” are equally simple, because the tweet (that what is being “said”) must fit in 140 characters. The tweet does not only [...]... Read more »
Cuddy, C., Graham, J., & Morton-Owens, E. (2010) Implementing Twitter in a Health Sciences Library. Medical Reference Services Quarterly, 29(4), 320-330. DOI: 10.1080/02763869.2010.518915
- October 6, 2010
- 03:45 PM
- 669 views
How will we ever keep up with 75 Trials and 11 Systematic Reviews a Day?
by Laika in Laika's Medliblog
An interesting paper was published in PLOS Medicine [1]. As an information specialist and working part time for the Cochrane Collaboration* (see below), this topic is close to my heart. The paper, published in PLOS Medicine is written by Hilda Bastian and two of my favorite EBM devotees ànd critics, Paul Glasziou and Iain Chalmers. Their article gives [...]... Read more »
Bastian, H., Glasziou, P., & Chalmers, I. (2010) Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up?. PLoS Medicine, 7(9). DOI: 10.1371/journal.pmed.1000326
- September 28, 2010
- 06:38 PM
- 578 views
A Filter for Finding “All Studies on Animal Experimentation in PubMed”
by Laika in Laika's Medliblog
For an introduction to search filters you can first read this post. Most people searching PubMed try to get rid of publications about animals. But basic scientists and lab animal technicians just want to find those animal studies. PubMed has built-in filters for that: the limits. There is a limit for “humans” and a limit for “animals”. [...]... Read more »
Hooijmans CR, Tillema A, Leenaars M, & Ritskes-Hoitinga M. (2010) Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed. Laboratory animals, 44(3), 170-5. PMID: 20551243
- August 29, 2010
- 11:32 PM
- 853 views
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
by Laika in Laika's Medliblog
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week [1]. The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors [2], because it contradicted [...]... Read more »
Lo SC, Pripuzova N, Li B, Komaroff AL, Hung GC, Wang R, & Alter HJ. (2010) Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors. Proceedings of the National Academy of Sciences of the United States of America. PMID: 20798047
Erlwein, O., Kaye, S., McClure, M., Weber, J., Wills, G., Collier, D., Wessely, S., & Cleare, A. (2010) Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008519
Groom, H., Boucherit, V., Makinson, K., Randal, E., Baptista, S., Hagan, S., Gow, J., Mattes, F., Breuer, J., Kerr, J.... (2010) Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome. Retrovirology, 7(1), 10. DOI: 10.1186/1742-4690-7-10
van Kuppeveld, F., Jong, A., Lanke, K., Verhaegh, G., Melchers, W., Swanink, C., Bleijenberg, G., Netea, M., Galama, J., & van der Meer, J. (2010) Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort. BMJ, 340(feb25 1). DOI: 10.1136/bmj.c1018
McClure, M., & Wessely, S. (2010) Chronic fatigue syndrome and human retrovirus XMRV. BMJ, 340(feb25 1). DOI: 10.1136/bmj.c1099
Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B.... (2009) Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science (New York, N.Y.), 326(5952), 585-9. PMID: 19815723
Enserink M. (2010) Chronic fatigue syndrome. New XMRV paper looks good, skeptics admit--yet doubts linger. Science (New York, N.Y.), 329(5995), 1000. PMID: 20798285
- August 8, 2010
- 12:52 PM
- 641 views
Collaborating and Delivering Literature Search Results to Clinical Teams Using Web 2.0 Tools
by Laika in Laika's Medliblog
There seem to be two camps in the library, the medical and many other worlds: those who embrace Web 2.0, because they consider it useful for their practice and those who are unaware of Web 2.0 or think it is just a fad. There are only a few ways the Web 2.0-critical people can be convinced: by [...]... Read more »
Damani S, & Fulton S. (2010) Collaborating and delivering literature search results to clinical teams using web 2.0 tools. Medical reference services quarterly, 29(3), 207-17. PMID: 20677061
- June 22, 2010
- 06:07 PM
- 724 views
Will Nano-Publications & Triplets Replace The Classic Journal Articles?
by Laika in Laika's Medliblog
“Libraries and journals articles as we know them will cease to exists” said Barend Mons at the symposium in honor of our Library 25th Anniversary (June 3rd). “Possibly we will have another kind of party in another 25 years”…. he continued, grinning. What he had to say the next half hour intrigued me. And although [...]... Read more »
van Haagen HH, 't Hoen PA, Botelho Bovo A, de Morrée A, van Mulligen EM, Chichester C, Kors JA, den Dunnen JT, van Ommen GJ, van der Maarel SM.... (2009) Novel protein-protein interactions inferred from literature context. PloS one, 4(11). PMID: 19924298
- June 8, 2010
- 11:45 AM
- 866 views
PubMed versus Google Scholar for Retrieving Evidence
by Laika in Laika's Medliblog
A while ago a resident in dermatology told me she got many hits out of PubMed, but zero results out of TRIP. It appeared she had used the same search for both databases: alopecea areata and diphenciprone (a drug with a lot of synonyms). Searching TRIP for alopecea (in the title) only, we found a Cochrane [...]... Read more »
Anders ME, & Evans DP. (2010) Comparison of PubMed and Google Scholar Literature Searches. Respiratory care, 55(5), 578-83. PMID: 20420728
- May 11, 2010
- 01:18 PM
- 734 views
What One Short Night’s Sleep does to your Glucose Metabolism
by Laika in Laika's Medliblog
As a blogger I regularly sleep 3-5 hours just to finish a post. I know that this has its effects on how I feel the next day. I also know short nights don’t promote my clear-headedness and I also recognize short-term effects on memory, cognitive functions, reaction time and mood (irritability), as depicted in the [...]... Read more »
Donga E, van Dijk M, van Dijk JG, Biermasz NR, Lammers GJ, van Kralingen KW, Corssmit EP, & Romijn JA. (2010) A Single Night of Partial Sleep Deprivation Induces Insulin Resistance in Multiple Metabolic Pathways in Healthy Subjects. The Journal of clinical endocrinology and metabolism. PMID: 20371664
Donga E, van Dijk M, van Dijk JG, Biermasz NR, Lammers GJ, van Kralingen K, Hoogma RP, Corssmit EP, & Romijn JA. (2010) Partial sleep restriction decreases insulin sensitivity in type 1 diabetes. Diabetes care. PMID: 20357381
Nielsen LS, Danielsen KV, & Sørensen TI. (2010) Short sleep duration as a possible cause of obesity: critical analysis of the epidemiological evidence. Obesity reviews : an official journal of the International Association for the Study of Obesity. PMID: 20345429
Monasta L, Batty GD, Cattaneo A, Lutje V, Ronfani L, van Lenthe FJ, & Brug J. (2010) Early-life determinants of overweight and obesity: a review of systematic reviews. Obesity reviews : an official journal of the International Association for the Study of Obesity. PMID: 20331509
Cappuccio FP, D'Elia L, Strazzullo P, & Miller MA. (2010) Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes care, 33(2), 414-20. PMID: 19910503
- April 27, 2010
- 12:45 PM
- 599 views
Three Studies Now Refute the Presence of XMRV in Chronic Fatigue Syndrome (CFS)
by Laika in Laika's Medliblog
.“Removing the doubt is part of the cure” (RedLabs) Two months ago I wrote about two contradictory studies on the presence of the novel XMRV retrovirus in blood of patients with Chronic Fatigue Syndrome (CFS). The first study, published in autumn last year by investigators of the Whittemore Peterson Institute (WPI) in the USA [1], [...]... Read more »
Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B.... (2009) Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science (New York, N.Y.), 326(5952), 585-9. PMID: 19815723
Erlwein, O., Kaye, S., McClure, M., Weber, J., Wills, G., Collier, D., Wessely, S., & Cleare, A. (2010) Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008519
van Kuppeveld, F., Jong, A., Lanke, K., Verhaegh, G., Melchers, W., Swanink, C., Bleijenberg, G., Netea, M., Galama, J., & van der Meer, J. (2010) Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort. BMJ, 340(feb25 1). DOI: 10.1136/bmj.c1018
McClure, M., & Wessely, S. (2010) Chronic fatigue syndrome and human retrovirus XMRV. BMJ, 340(feb25 1). DOI: 10.1136/bmj.c1099
- April 10, 2010
- 10:03 AM
- 711 views
Irreversible Effects of Previous Cortisol Excess on Cognitive Functions in Cushing’s Disease
by Laika in Laika's Medliblog
April 8th is Cushing’s Awareness Day. This day has been chosen as a day of awareness as it is the birthday of Dr. Harvey Cushing, a neurosurgeon, who discovered this illness.
Cushing’s disease is a rare hormone disease caused by prolonged exposure to high levels of the stress hormone cortisol in the blood, whereas Addison’s disease [...]... Read more »
Tiemensma J, Kokshoorn NE, Biermasz NR, Keijser BJ, Wassenaar MJ, Middelkoop HA, Pereira AM, & Romijn JA. (2010) Subtle Cognitive Impairments in Patients with Long-Term Cure of Cushing's Disease. The Journal of clinical endocrinology and metabolism. PMID: 20371667
Patil CG, Lad SP, Katznelson L, & Laws ER Jr. (2007) Brain atrophy and cognitive deficits in Cushing's disease. Neurosurgical focus, 23(3). PMID: 17961025
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