5 posts · 3,832 views
I'm Canadian Grad Student researching miRNAs in plants down under. G'day eh?
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- May 3, 2011
- 12:00 PM
- 946 views
An After Thought to Evolution: Exceptional ways of Controlling Gene “Expression”
Unusual control of miR166/65 expression by AGO10 is required for meristem development in Arabidopsis... Read more »
Zhu H, Hu F, Wang R, Zhou X, Sze SH, Liou LW, Barefoot A, Dickman M, & Zhang X. (2011) Arabidopsis Argonaute10 Specifically Sequesters miR166/165 to Regulate Shoot Apical Meristem Development. Cell, 145(2), 242-56. PMID: 21496644
- April 12, 2011
- 12:00 PM
- 286 views
miRNA Elevation
by Linda in Oz Blog 159
How over-expression of certain miRNA can lead to profound changes in plant development.... Read more »
Jones-Rhoades, M., Bartel, D., & Bartel, B. (2006) MicroRNAs AND THEIR REGULATORY ROLES IN PLANTS. Annual Review of Plant Biology, 57(1), 19-53. DOI: 10.1146/annurev.arplant.57.032905.105218
Millar, A. (2005) The Arabidopsis GAMYB-Like Genes, MYB33 and MYB65, Are MicroRNA-Regulated Genes That Redundantly Facilitate Anther Development. THE PLANT CELL ONLINE, 17(3), 705-721. DOI: 10.1105/tpc.104.027920
Achard, P. (2004) Modulation of floral development by a gibberellin-regulated microRNA. Development, 131(14), 3357-3365. DOI: 10.1242/dev.01206
- February 17, 2011
- 08:04 PM
- 972 views
A Lab Murder Mystery
“A researcher is found dead hunched over her lab bench, and seven suspects are in custody. Now it’s up to 30 high school students to determine who killed her.” To quote from the UBC Science newsletter. Don’t be alarmed, this isn’t tabloid fodder. It’s actually part of a high school out-reach program, organized by UBC’s grad student [...]... Read more »
Caylib Durand and Santiago Ramón-García. (2010) The Use of Popular Fiction to Present a Professional Scientific Career to High School Students. JOURNAL OF MICROBIOLOGY , 166-167. info:/10.1128/jmbe.v11i2.19
- January 18, 2011
- 01:09 PM
- 682 views
RNAi in the Nucleus ~ It’s no longer limited to the cytoplasm
Hot off the press from the holidays is an article from PNAS that’s worth a gander if you’re into RNAi. We know RNAi associated with epigenetics is possible in the nucleus (Somehow, siRNAs could trigger the methylation and silencing of genes in the nucleus.) However, one soy bean group was able to provide evidence for [...]... Read more »
Hoffer, P., Ivashuta, S., Pontes, O., Vitins, A., Pikaard, C., Mroczka, A., Wagner, N., & Voelker, T. (2010) Posttranscriptional gene silencing in nuclei. Proceedings of the National Academy of Sciences, 108(1), 409-414. DOI: 10.1073/pnas.1009805108
Guang, S., Bochner, A., Pavelec, D., Burkhart, K., Harding, S., Lachowiec, J., & Kennedy, S. (2008) An Argonaute Transports siRNAs from the Cytoplasm to the Nucleus. Science, 321(5888), 537-541. DOI: 10.1126/science.1157647
Heinrichs, A. (2008) Gene expression: Argonaute on the move. Nature Reviews Molecular Cell Biology, 9(9), 666-666. DOI: 10.1038/nrm2473
Hwang, H., Wentzel, E., & Mendell, J. (2007) A Hexanucleotide Element Directs MicroRNA Nuclear Import. Science, 315(5808), 97-100. DOI: 10.1126/science.1136235
- January 11, 2011
- 09:26 AM
- 946 views
Arrested Development in miRNA Mutants
Animals and Plants have hundreds of miRNAs with diverse roles in gene regulation. In humans, each miRNA family can control up to several hundred genes (or 500 to be exact, in humans). A loss of function in one, can lead to array of developmental defects. Similarly in plants, an miRNA mutant can have a variety of phenotypes. However, interestingly, many miRNAs only have one target, which is frequently a transcription factor that in turn, controls many genes itself. It's really like a house of cards.... Read more »
Garzon, R., Marcucci, G., & Croce, C. (2010) Targeting microRNAs in cancer: rationale, strategies and challenges. Nature Reviews Drug Discovery, 9(10), 775-789. DOI: 10.1038/nrd3179
Allen, R., Li, J., Stahle, M., Dubroue, A., Gubler, F., & Millar, A. (2007) From the Cover: Genetic analysis reveals functional redundancy and the major target genes of the Arabidopsis miR159 family. Proceedings of the National Academy of Sciences, 104(41), 16371-16376. DOI: 10.1073/pnas.0707653104
Schwab, R., & Voinnet, O. (2009) miRNA processing turned upside down. The EMBO Journal, 28(23), 3633-3634. DOI: 10.1038/emboj.2009.334
SCHAUER, S., JACOBSEN, S., MEINKE, D., & RAY, A. (2002) : blind men and elephants in development. Trends in Plant Science, 7(11), 487-491. DOI: 10.1016/S1360-1385(02)02355-5
Laufs, P. (2004) MicroRNA regulation of the CUC genes is required for boundary size control in Arabidopsis meristems. Development, 131(17), 4311-4322. DOI: 10.1242/dev.01320
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