116 posts · 93,865 views
BodyInMind looks at the relationship between the body, the brain and the mind and how they interact particularly in chronic and complex pain disorders. Lorimer Moseley and collaborators explore how the mind influences physiological regulation of the body and how we can teach people about it all in a way that is both interesting and accurate.
BodyInMind
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- July 7, 2011
- 04:30 PM
- 715 views
Bizarro World at the World Congress of Physical Therapy
by Lorimer Moseley in BodyInMind
The World Congress of Physical Therapy was a bit like Bizarro world for me. Steven Kamper, provided a great post summarizing the conference, but I wanted to build on it a little. ... Read more »
Stanton TR, Fritz JM, Hancock MJ, Latimer J, Maher CG, Wand BM, & Parent EC. (2011) Evaluation of a treatment-based classification algorithm for low back pain: a cross-sectional study. Physical therapy, 91(4), 496-509. PMID: 21330450
- July 5, 2011
- 01:32 AM
- 768 views
rTMS and chronic pain: Our two penny’s worth
by Lorimer Moseley in BodyInMind
Some of you might have heard of repetitive transcranial magnetic stimulation (rTMS) and its use in chronic pain - what is the efficacy?... Read more »
O'Connell N, Wand B, Marston L, Spencer S, & Desouza L. (2011) Non-invasive brain stimulation techniques for chronic pain. A report of a Cochrane systematic review and meta-analysis. European journal of physical and rehabilitation medicine, 47(2), 309-26. PMID: 21494222
O'Connell NE, & Wand BM. (2011) Repetitive transcranial magnetic stimulation for chronic pain: Time to evolve from exploration to confirmation?. Pain. PMID: 21703764
- June 29, 2011
- 12:20 AM
- 850 views
Promising results from a graded retraining programme in chronic back pain
by Lorimer Moseley in BodyInMind
TweetReduction in pain and disability with a graded sensorimotor retraining program in chronic back pain Our team recently returned home from Darwin, where we all attended the Australian Pain Society’s Annual Scientific Meeting. We all presented some of our work up there and had a lot of fun while we were at it. I presented [...]... Read more »
van Tulder MW, Koes B, & Malmivaara A. (2006) Outcome of non-invasive treatment modalities on back pain: an evidence-based review. European spine journal. PMID: 16320031
- June 23, 2011
- 04:58 AM
- 901 views
Clinical features and PATHOPHYSIOLOGY OF CRPS – a long-awaited review
by Lorimer Moseley in BodyInMind
At the world congress on pain in Glasgow, 2008, a small group of CRPS researchers got around a table and asked each other something like ‘isn’t it high time we got together and wrote a current concepts in CRPS pathophysiology paper?’ ... Read more »
Marinus J, Moseley GL, Birklein F, Baron R, Maihöfner C, Kingery WS, & van Hilten JJ. (2011) Clinical features and pathophysiology of complex regional pain syndrome. Lancet neurology, 10(7), 637-48. PMID: 21683929
- June 6, 2011
- 04:30 PM
- 628 views
Back Pains, Rubbery Brains, Doubts Remain
by Lorimer Moseley in BodyInMind
A while back Ben Wand blogged here about grey matter density changes in the brain and chronic pain. A new study, published in the Journal of Neuroscience by David Seminowicz et al tells what appears to be a similar story.... Read more »
Seminowicz DA, Wideman TH, Naso L, Hatami-Khoroushahi Z, Fallatah S, Ware MA, Jarzem P, Bushnell MC, Shir Y, Ouellet JA.... (2011) Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function. The Journal of neuroscience, 31(20), 7540-50. PMID: 21593339
Apkarian, A. (2004) Chronic Back Pain Is Associated with Decreased Prefrontal and Thalamic Gray Matter Density. Journal of Neuroscience, 24(46), 10410-10415. DOI: 10.1523/JNEUROSCI.2541-04.2004
Wood PB. (2010) Variations in brain gray matter associated with chronic pain. Current rheumatology reports, 12(6), 462-9. PMID: 20857244
Ioannidis JP. (2011) Excess Significance Bias in the Literature on Brain Volume Abnormalities. Archives of general psychiatry. PMID: 21464342
- June 2, 2011
- 09:30 AM
- 683 views
Giving him the (fake) finger. Introducing the plastic finger illusion.
by Lorimer Moseley in BodyInMind
Does proprioceptive input, from muscle spindles and joint receptors for example, contribute to our sense of body ownership?... Read more »
[1] Botvinick M, & Cohen J. (1998) Rubber hands 'feel' touch that eyes see. Nature, 391(6669), 756. PMID: 9486643
[2] Walsh LD, Moseley GL, Taylor JL, & Gandevia SC. (2011) Proprioceptive signals contribute to the sense of body ownership. The Journal of physiology. PMID: 21521765
- May 31, 2011
- 02:30 AM
- 613 views
The cortical body matrix. Reloaded.
by Lorimer Moseley in BodyInMind
People with chronic pain have some pretty odd perceptual disturbances. In an attempt to integrate this smorgasboard of body-related dysfunction, we recently proposed the idea of a cortical body matrix.... Read more »
[1] Moseley, G. (2005) Distorted body image in complex regional pain syndrome. Neurology, 65(5), 773-773. DOI: 10.1212/01.wnl.0000174515.07205.11
[2] Moseley GL. (2008) I can't find it! Distorted body image and tactile dysfunction in patients with chronic back pain. Pain, 140(1), 239-43. PMID: 18786763
[3] Lotze M, & Moseley GL. (2007) Role of distorted body image in pain. Current rheumatology reports, 9(6), 488-96. PMID: 18177603
[4] Moseley GL, Gallace A, & Spence C. (2011) Bodily illusions in health and disease: Physiological and clinical perspectives and the concept of a cortical 'body matrix'. Neuroscience and biobehavioral reviews. PMID: 21477616
[5] Moseley, G., Parsons, T., & Spence, C. (2008) Visual distortion of a limb modulates the pain and swelling evoked by movement. Current Biology, 18(22). DOI: 10.1016/j.cub.2008.09.031
- May 26, 2011
- 02:10 AM
- 317 views
Don’t just rub it better, cross it over – the analgesic effect of crossing your arms.
by Lorimer Moseley in BodyInMind
There is a new paper just out in Pain that raises the possibility of a quick and easy analgesic strategy – crossing your arms. My mum reckons that her mum was onto that decades ago ... Read more »
[1]Gallace A, Torta DM, Moseley GL, & Iannetti GD. (2011) The analgesic effect of crossing the arms. Pain, 152(6), 1418-23. PMID: 21440992
- May 23, 2011
- 04:41 PM
- 653 views
Subgroups in low back pain – were the assumptions correct?
by Lorimer Moseley in BodyInMind
Our study aimed to evaluate a treatment-based classification algorithm for low back pain. This algorithm was created to provide a clinical decision-making paradigm to help guide treatment selection for back pain. Were the assumptions correct?... Read more »
[1] Stanton TR, Fritz JM, Hancock MJ, Latimer J, Maher CG, Wand BM, & Parent EC. (2011) Evaluation of a treatment-based classification algorithm for low back pain: a cross-sectional study. Physical therapy, 91(4), 496-509. PMID: 21330450
[2] Flynn T, Fritz J, Whitman J, Wainner R, Magel J, Rendeiro D, Butler B, Garber M, & Allison S. (2002) A clinical prediction rule for classifying patients with low back pain who demonstrate short-term improvement with spinal manipulation. Spine, 27(24), 2835-43. PMID: 12486357
[3] Hicks GE, Fritz JM, Delitto A, & McGill SM. (2005) Preliminary development of a clinical prediction rule for determining which patients with low back pain will respond to a stabilization exercise program. Archives of physical medicine and rehabilitation, 86(9), 1753-62. PMID: 16181938
[4] Browder DA, Childs JD, Cleland JA, & Fritz JM. (2007) Effectiveness of an extension-oriented treatment approach in a subgroup of subjects with low back pain: a randomized clinical trial. Physical therapy, 87(12), 1608. PMID: 17895350
[5] Long A, Donelson R, & Fung T. (2004) Does it matter which exercise? A randomized control trial of exercise for low back pain. Spine, 29(23), 2593-602. PMID: 15564907
[6] Fritz, J., Lindsay, W., Matheson, J., Brennan, G., Hunter, S., Moffit, S., Swalberg, A., & Rodriquez, B. (2007) Is There a Subgroup of Patients With Low Back Pain Likely to Benefit From Mechanical Traction?. Spine, 32(26). DOI: 10.1097/BRS.0b013e31815d001a
[7] Brennan GP, Fritz JM, Hunter SJ, Thackeray A, Delitto A, & Erhard RE. (2006) Identifying subgroups of patients with acute/subacute "nonspecific" low back pain: results of a randomized clinical trial. Spine, 31(6), 623-31. PMID: 16540864
- May 19, 2011
- 09:37 AM
- 381 views
Subgroups in low back pain – a treatment-based classification algorithm
by Lorimer Moseley in BodyInMind
This study aimed to evaluate a treatment-based classification algorithm for low back pain. This algorithm was created to provide a clinical decision-making paradigm to help guide treatment selection for back pain. ... Read more »
[1] Stanton TR, Fritz JM, Hancock MJ, Latimer J, Maher CG, Wand BM, & Parent EC. (2011) Evaluation of a treatment-based classification algorithm for low back pain: a cross-sectional study. Physical therapy, 91(4), 496-509. PMID: 21330450
[2] Flynn T, Fritz J, Whitman J, Wainner R, Magel J, Rendeiro D, Butler B, Garber M, & Allison S. (2002) A clinical prediction rule for classifying patients with low back pain who demonstrate short-term improvement with spinal manipulation. Spine, 27(24), 2835-43. PMID: 12486357
[3] Hicks GE, Fritz JM, Delitto A, & McGill SM. (2005) Preliminary development of a clinical prediction rule for determining which patients with low back pain will respond to a stabilization exercise program. Archives of physical medicine and rehabilitation, 86(9), 1753-62. PMID: 16181938
[4] Browder DA, Childs JD, Cleland JA, & Fritz JM. (2007) Effectiveness of an extension-oriented treatment approach in a subgroup of subjects with low back pain: a randomized clinical trial. Physical therapy, 87(12), 1608. PMID: 17895350
[5] Long A, Donelson R, & Fung T. (2004) Does it matter which exercise? A randomized control trial of exercise for low back pain. Spine, 29(23), 2593-602. PMID: 15564907
[6] Fritz, J., Lindsay, W., Matheson, J., Brennan, G., Hunter, S., Moffit, S., Swalberg, A., & Rodriquez, B. (2007) Is There a Subgroup of Patients With Low Back Pain Likely to Benefit From Mechanical Traction?. Spine, 32(26). DOI: 10.1097/BRS.0b013e31815d001a
[7] Brennan GP, Fritz JM, Hunter SJ, Thackeray A, Delitto A, & Erhard RE. (2006) Identifying subgroups of patients with acute/subacute "nonspecific" low back pain: results of a randomized clinical trial. Spine, 31(6), 623-31. PMID: 16540864
- May 17, 2011
- 02:00 AM
- 577 views
It’s semantical my dear Watson
by Lorimer Moseley in BodyInMind
I recently read an interesting article from Vraceany et al titled “Less specific arm illnesses". The authors make some very good points about what are frequently futile clinical approaches. However, the foundations they erect to support these arguments made me think about how we approach the whole idea of what is and isn’t biopsychosocial treatment.... Read more »
Vranceanu AM, Barsky A, & Ring D. (2011) Less specific arm illnesses. Journal of hand therapy : official journal of the American Society of Hand Therapists, 24(2), 118-23. PMID: 21392938
- April 18, 2011
- 10:42 PM
- 986 views
Neuroimmunology for dummies. Part 1: Immune system in learning and memory – T cells.
by Lorimer Moseley in BodyInMind
A common way to investigate what role particular biological markers play is to breed (in the loosest sense of the word - ie genetically engineer) an animal that doesn’t have those biomarkers. Mice are the usual suckers. Mice can be ‘bred’ to have no T cells (T cells are otherwise known as T lymphocytes, white blood cells that are produced primarily in the thymus - hence the ‘T’...... Read more »
[1] Kipnis, J. (2004) T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. Proceedings of the National Academy of Sciences, 101(21), 8180-8185. DOI: 10.1073/pnas.0402268101
[2] Brynskikh, A., Warren, T., Zhu, J., & Kipnis, J. (2008) Adaptive immunity affects learning behavior in mice. Brain, Behavior, and Immunity, 22(6), 861-869. DOI: 10.1016/j.bbi.2007.12.008
[3] Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N, Cohen H, Kipnis J, & Schwartz M. (2006) Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nature neuroscience, 9(2), 268-75. PMID: 16415867
[4] Derecki, N., Cardani, A., Yang, C., Quinnies, K., Crihfield, A., Lynch, K., & Kipnis, J. (2010) Regulation of learning and memory by meningeal immunity: a key role for IL-4. Journal of Experimental Medicine, 207(5), 1067-1080. DOI: 10.1084/jem.20091419
[5] Kipnis J, Derecki NC, Yang C, & Scrable H. (2008) Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?. Trends in immunology, 29(10), 455-63. PMID: 18789764
[6] Yirmiya R, & Goshen I. (2011) Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain, behavior, and immunity, 25(2), 181-213. PMID: 20970492
[7] Marchand, F., Perretti, M., & McMahon, S. (2005) Role of the Immune system in chronic pain. Nature Reviews Neuroscience, 6(7), 521-532. DOI: 10.1038/nrn1700
[8] Uçeyler N, Valenza R, Stock M, Schedel R, Sprotte G, & Sommer C. (2006) Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain. Arthritis and rheumatism, 54(8), 2656-64. PMID: 16871547
[9] Dick BD, & Rashiq S. (2007) Disruption of attention and working memory traces in individuals with chronic pain. Anesthesia and analgesia, 104(5), 1223. PMID: 17456678
- April 13, 2011
- 07:17 PM
- 927 views
Mutterings of a neurocentric. Or, neuroimmunology for dummies
by Lorimer Moseley in BodyInMind
TweetI was going to call this post ‘Immune effects on thinking, memory, neuroplasticity and neurogenesis’ but I thought it sounded a bit high-brow. In fact, for the first time in my brief bloglife I have found myself stuck on an opening, but I think I might know why. It is 5.20am, I rode my bike [...]... Read more »
[1] Yirmiya R, & Goshen I. (2011) Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain, behavior, and immunity, 25(2), 181-213. PMID: 20970492
[2] Teitelbaum SL. (2000) Bone resorption by osteoclasts. Science (New York), 289(5484), 1504-8. PMID: 10968780
[3] Besedovsky, H., & Rey, A. (2007) Physiology of psychoneuroimmunology: A personal view. Brain, Behavior, and Immunity, 21(1), 34-44. DOI: 10.1016/j.bbi.2006.09.008
- March 31, 2011
- 08:30 AM
- 908 views
What’s in a name? Nociception by any other name will hurt, or not hurt, just as much
by Lorimer Moseley in BodyInMind
A while back I wrote a piece about Consciousness and Pain, in which I argued that consciousness might be the key ingredient for pain. I even tried my hand at a bit of maths, with this little equation (not to be taken too exactly): pain = nociception + consciousness.... Read more »
[1] Merksey, H. (1986) Pain terms: a current list with definitions and notes on usage. Pain Suppl. 3 S215-S221. info:/
- March 28, 2011
- 03:30 PM
- 762 views
Of shiny pictures and poorer outcomes: Spinal MRI and back pain
by Lorimer Moseley in BodyInMind
Diagnosing low back pain is a nightmare. It established that apart from the 15% of back pain cases which can be attributed to a specific spinal pathology, the majority of cases fall under the unsatisfactory umbrella label of “non-specific low back pain”... Read more »
van Ravesteijn H, van Dijk I, Darmon D, van de Laar F, Lucassen P, Hartman TO, van Weel C, & Speckens A. (2011) The reassuring value of diagnostic tests: A systematic review. Patient education and counseling. PMID: 21382687
Carragee EJ, Alamin TF, Miller JL, & Carragee JM. (2005) Discographic, MRI and psychosocial determinants of low back pain disability and remission: a prospective study in subjects with benign persistent back pain. The spine journal : official journal of the North American Spine Society, 5(1), 24-35. PMID: 15653082
Kalichman L, Kim DH, Li L, Guermazi A, & Hunter DJ. (2010) Computed tomography-evaluated features of spinal degeneration: prevalence, intercorrelation, and association with self-reported low back pain. The spine journal : official journal of the North American Spine Society, 10(3), 200-8. PMID: 20006557
Kalichman L, Li L, Kim DH, Guermazi A, Berkin V, O'Donnell CJ, Hoffmann U, Cole R, & Hunter DJ. (2008) Facet joint osteoarthritis and low back pain in the community-based population. Spine, 33(23), 2560-5. PMID: 18923337
Jarvik JJ, Hollingworth W, Heagerty P, Haynor DR, & Deyo RA. (2001) The Longitudinal Assessment of Imaging and Disability of the Back (LAIDBack) Study: baseline data. Spine, 26(10), 1158-66. PMID: 11413431
Kalichman L, Hodges P, Li L, Guermazi A, & Hunter DJ. (2010) Changes in paraspinal muscles and their association with low back pain and spinal degeneration: CT study. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 19(7), 1136-44. PMID: 20033739
Kalichman L, Kim DH, Li L, Guermazi A, Berkin V, & Hunter DJ. (2009) Spondylolysis and spondylolisthesis: prevalence and association with low back pain in the adult community-based population. Spine, 34(2), 199-205. PMID: 19139672
Webster BS, & Cifuentes M. (2010) Relationship of early magnetic resonance imaging for work-related acute low back pain with disability and medical utilization outcomes. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine, 52(9), 900-7. PMID: 20798647
- March 22, 2011
- 03:28 PM
- 972 views
Can photoshop make my bottom smaller?
by Lorimer Moseley in BodyInMind
I had my annual viewing of Susan Boyle on Britain’s got talent this morning. Then I came across this amazing demonstration of what photoshop can do. Is it possible that if you think you look a particular way, your body changes the way it works to match that?... Read more »
Wansink, B. (2005) Shape of glass and amount of alcohol poured: comparative study of effect of practice and concentration. BMJ, 331(7531), 1512-1514. DOI: 10.1136/bmj.331.7531.1512
Brian Wansink and Koert van Ittersum. (2006) The Visual Illusions of Food: Why Plates, Bowls, and Spoons Can Bias Consumption Volum. The FASEB Journal. info:/
Moseley GL, Olthof N, Venema A, Don S, Wijers M, Gallace A, & Spence C. (2008) Psychologically induced cooling of a specific body part caused by the illusory ownership of an artificial counterpart. Proceedings of the National Academy of Sciences of the United States of America, 105(35), 13169-73. PMID: 18725630
Moseley GL, Parsons TJ, & Spence C. (2008) Visual distortion of a limb modulates the pain and swelling evoked by movement. Current biology : CB, 18(22). PMID: 19036329
- March 21, 2011
- 01:13 AM
- 655 views
Your somatic markers know when to hold ‘em
by Lorimer Moseley in BodyInMind
There is a very large body of data that show that the body affects the mind. That is, bodily processes and responses to stimuli affect our thoughts about those stimuli and our behavioural responses to them. Some of the most intriguing research in this area has been done by Antonio Damasio..... Read more »
Bechara, A. (1997) Deciding Advantageously Before Knowing the Advantageous Strategy. Science, 275(5304), 1293-1295. DOI: 10.1126/science.275.5304.1293
Damasio AR. (1996) The somatic marker hypothesis and the possible functions of the prefrontal cortex. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 351(1346), 1413-20. PMID: 8941953
Moseley, G., Olthof, N., Venema, A., Don, S., Wijers, M., Gallace, A., & Spence, C. (2008) Psychologically induced cooling of a specific body part caused by the illusory ownership of an artificial counterpart. Proceedings of the National Academy of Sciences, 105(35), 13169-13173. DOI: 10.1073/pnas.0803768105
Moseley, G., Parsons, T., & Spence, C. (2008) Visual distortion of a limb modulates the pain and swelling evoked by movement. Current Biology, 18(22). DOI: 10.1016/j.cub.2008.09.031
- March 10, 2011
- 07:30 AM
- 753 views
Maintenance spinal manipulation: The cherry-pickers quandary
by Lorimer Moseley in BodyInMind
A closer look at a new study that purportedly demonstrates a real benefit to spinal manipulation in chronic back pain and seems to validate that controversial practice of regularly seeing patients between flare-ups for a “quick click” to keep the spine tip-top.... Read more »
Senna MK, & Machaly SA. (2011) Does maintained Spinal manipulation therapy for chronic non-specific low back pain result in better long term outcome?. Spine. PMID: 21245790
Rubinstein SM, van Middelkoop M, Assendelft WJ, de Boer MR, & van Tulder MW. (2011) Spinal manipulative therapy for chronic low-back pain. Cochrane database of systematic reviews (Online). PMID: 21328304
Martel J, Dugas C, Dubois JD, & Descarreaux M. (2011) A randomised controlled trial of preventive spinal manipulation with and without a home exercise program for patients with chronic neck pain. BMC musculoskeletal disorders, 41. PMID: 21303529
- March 7, 2011
- 02:30 PM
- 1,250 views
Sadness, soreness and staying alert—all in the same place
by Lorimer Moseley in BodyInMind
Sadness, soreness and staying alert - are they all in the same place of the brain?... Read more »
Shackman AJ, Salomons TV, Slagter HA, Fox AS, Winter JJ, & Davidson RJ. (2011) The integration of negative affect, pain and cognitive control in the cingulate cortex. Nature reviews. Neuroscience, 12(3), 154-67. PMID: 21331082
Dum RP, Levinthal DJ, & Strick PL. (2009) The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(45), 14223-35. PMID: 19906970
Kanske P, Heissler J, Schönfelder S, Bongers A, & Wessa M. (2010) How to Regulate Emotion? Neural Networks for Reappraisal and Distraction. Cerebral cortex (New York, N.Y. : 1991). PMID: 21041200
- February 24, 2011
- 07:43 AM
- 1,302 views
Does smoking hurt as well as harm? (or, as if you needed another reason)
by Lorimer Moseley in BodyInMind
TweetI have a couple of mates who are veritable smoke-stacks. They love smoking but sort of hate being a smoker. I must confess that, at least within my community, smoking is now officially uncool and my mates are sick of people telling them good reasons to give up. Well, as if they needed another reason, [...]... Read more »
Pisinger C, Aadahl M, Toft U, Birke H, Zytphen-Adeler J, & Jørgensen T. (2011) The association between active and passive smoking and frequent pain in a general population. European journal of pain (London, England), 15(1), 77-83. PMID: 20627783
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