34 posts · 23,652 views

The Focus of the blog is on Medical Librarianship, Library Science, Medicine, EBM, Epidemiology and Science. I've a PhD in Medical Biology and work as an information specialist in a Medical Library (3 days) and for The Cochrane Collaboration (1 day).

Laika
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October 18, 2011
10:45 AM
255 views

Evidence Based Point of Care Summaries [2] More Uptodate with Dynamed.

by Laika in Laika's Medliblog

This post is part of a short series about Evidence Based Point of Care Summaries or POCs. In this series I will review 3 recent papers that objectively compare a selection of POCs. In the previous post I reviewed a paper from Rita Banzi and colleagues from the Italian Cochrane Centre [1]. They analyzed 18 POCs with respect to their [...]... Read more »

Banzi, R., Liberati, A., Moschetti, I., Tagliabue, L., & Moja, L. (2010) A Review of Online Evidence-based Practice Point-of-Care Information Summary Providers. Journal of Medical Internet Research, 12(3). DOI: 10.2196/jmir.1288

Banzi, R., Cinquini, M., Liberati, A., Moschetti, I., Pecoraro, V., Tagliabue, L., & Moja, L. (2011) Speed of updating online evidence based point of care summaries: prospective cohort analysis. BMJ, 343(sep22 2). DOI: 10.1136/bmj.d5856

Shurtz, S., & Foster, M. (2011) Developing and using a rubric for evaluating evidence-based medicine point-of-care tools. Journal of the Medical Library Association : JMLA, 99(3), 247-254. DOI: 10.3163/1536-5050.99.3.012

Ketchum, A., Saleh, A., & Jeong, K. (2011) Type of Evidence Behind Point-of-Care Clinical Information Products: A Bibliometric Analysis. Journal of Medical Internet Research, 13(1). DOI: 10.2196/jmir.1539

October 13, 2011
12:19 PM
158 views

Evidence Based Point of Care Summaries [1] No “Best” Among the Bests?

by Laika in Laika's Medliblog

For many of today’s busy practicing clinicians, keeping up with the enormous and ever growing amount of medical information, poses substantial challenges [6]. Its impractical to do a PubMed search to answer each clinical question and then synthesize and appraise the evidence. Simply, because busy health care providers have limited time and many questions per day. As [...]... Read more »

Banzi, R., Liberati, A., Moschetti, I., Tagliabue, L., & Moja, L. (2010) A Review of Online Evidence-based Practice Point-of-Care Information Summary Providers. Journal of Medical Internet Research, 12(3). DOI: 10.2196/jmir.1288

Alper, B. (2010) Review of Online Evidence-based Practice Point-of-Care Information Summary Providers: Response by the Publisher of DynaMed. Journal of Medical Internet Research, 12(3). DOI: 10.2196/jmir.1622

Goodyear-Smith F, Kerse N, Warren J, & Arroll B. (2008) Evaluation of e-textbooks. DynaMed, MD Consult and UpToDate. Australian family physician, 37(10), 878-82. PMID: 19002313

Ketchum, A., Saleh, A., & Jeong, K. (2011) Type of Evidence Behind Point-of-Care Clinical Information Products: A Bibliometric Analysis. Journal of Medical Internet Research, 13(1). DOI: 10.2196/jmir.1539

McKibbon, K., & Fridsma, D. (2006) Effectiveness of Clinician-selected Electronic Information Resources for Answering Primary Care Physicians' Information Needs. Journal of the American Medical Informatics Association, 13(6), 653-659. DOI: 10.1197/jamia.M2087

September 8, 2011
10:28 AM
159 views

FUTON Bias. Or Why Limiting to Free Full Text Might not Always be a Good Idea.

by Laika in Laika's Medliblog

A few weeks ago I was discussing possible relevant papers for the Twitter Journal Club (Hashtag #TwitJC), a succesful initiative on Twitter, that I have discussed previously here and here [7,8]. I proposed an article, that appeared behind a paywall. Annemarie Cunningham (@amcunningham) immediately ran the idea down, stressing that open-access (OA) is a pre-requisite for the TwitJC [...]... Read more »

Björk, B., Welling, P., Laakso, M., Majlender, P., Hedlund, T., & Guðnason, G. (2010) Open Access to the Scientific Journal Literature: Situation 2009. PLoS ONE, 5(6). DOI: 10.1371/journal.pone.0011273

Matsubayashi, M., Kurata, K., Sakai, Y., Morioka, T., Kato, S., Mine, S., & Ueda, S. (2009) Status of open access in the biomedical field in 2005. Journal of the Medical Library Association : JMLA, 97(1), 4-11. DOI: 10.3163/1536-5050.97.1.002

WENTZ, R. (2002) Visibility of research: FUTON bias. The Lancet, 360(9341), 1256-1256. DOI: 10.1016/S0140-6736(02)11264-5

Murali NS, Murali HR, Auethavekiat P, Erwin PJ, Mandrekar JN, Manek NJ, & Ghosh AK. (2004) Impact of FUTON and NAA bias on visibility of research. Mayo Clinic proceedings. Mayo Clinic, 79(8), 1001-6. PMID: 15301326

Carney PA, Poor DA, Schifferdecker KE, Gephart DS, Brooks WB, & Nierenberg DW. (2004) Computer use among community-based primary care physician preceptors. Academic medicine : journal of the Association of American Medical Colleges, 79(6), 580-90. PMID: 15165980

Krieger, M., Richter, R., & Austin, T. (2008) An exploratory analysis of PubMed's free full-text limit on citation retrieval for clinical questions. Journal of the Medical Library Association : JMLA, 96(4), 351-355. DOI: 10.3163/1536-5050.96.4.010

August 21, 2011
03:21 PM
450 views

PubMed’s Higher Sensitivity than OVID MEDLINE… & other Published Clichés.

by Laika in Laika's Medliblog

Is it just me, or are biomedical papers about searching for a systematic review often of low quality or just too damn obvious? I’m seldom excited about papers dealing with optimal search strategies or peculiarities of PubMed, even though it is my specialty. It is my impression, that many of the lower quality and/or less relevant papers are [...]... Read more »

Winchester DE, & Bavry AA. (2010) Limitations of the MEDLINE database in constructing meta-analyses. Annals of internal medicine, 153(5), 347-8. PMID: 20820050

Leclercq E, Kramer B, & Schats W. (2011) Limitations of the MEDLINE database in constructing meta-analyses. Annals of internal medicine, 154(5), 371. PMID: 21357916

June 19, 2011
07:37 PM
484 views

HOT TOPIC: Does Soy Relieve Hot Flashes?

by Laika in Laika's Medliblog

The theme of the Upcoming Grand Rounds held at June 21th (1st day of the Summer) at Shrink Rap is “hot”. A bit far-fetched, but aah you know….shrinks“. Of course they hope assume that we will express Weiner-like exhibitionism at our blogs. Or go into spicy details of hot sexpectations or other Penis Friday NCBI-ROFL posts. But no, not me, [...]... Read more »

Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, & Brown J. (2007) Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database of Systematic Reviews. info:/10.1002/14651858.CD001395.pub3.

Bolaños R, Del Castillo A, & Francia J. (2010) Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and meta-analysis. Menopause (New York, N.Y.), 17(3), 660-6. PMID: 20464785

March 13, 2011
07:48 PM
616 views

A New Safe Blood Test to Diagnose Down Syndrome

by Laika in Laika's Medliblog

The established method to prenatally diagnose chromosomal gross abnormalities is to obtain fetal cells from the womb with a fine needle, either by Amniocentesis (a sample of the fluid surrounding the foetus in the womb) or by Chorionic villus sampling (CVS, a sample of the placenta taken via the vaginal route). The procedures are not to be sneezed [...]... Read more »

LO, Y., CORBETTA, N., CHAMBERLAIN, P., RAI, V., SARGENT, I., REDMAN, C., & WAINSCOAT, J. (1997) Presence of fetal DNA in maternal plasma and serum. The Lancet, 350(9076), 485-487. DOI: 10.1016/S0140-6736(97)02174-0

Chiu, R., Akolekar, R., Zheng, Y., Leung, T., Sun, H., Chan, K., Lun, F., Go, A., Lau, E., To, W.... (2011) Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ, 342(jan11 1). DOI: 10.1136/bmj.c7401

Papageorgiou, E., Karagrigoriou, A., Tsaliki, E., Velissariou, V., Carter, N., & Patsalis, P. (2011) Fetal-specific DNA methylation ratio permits noninvasive prenatal diagnosis of trisomy 21. Nature Medicine. DOI: 10.1038/nm.2312

February 8, 2011
10:16 PM
550 views

Much Ado About ADHD-Research: Is there a Misrepresentation of ADHD in Scientific Journals?

by Laika in Laika's Medliblog

The reliability of science is increasingly under fire. We all know that media often gives a distorted picture of scientific findings (i.e. Hot news: Curry, Curcumin, Cancer & cure). But there is also an ever growing number of scientific misreports or even fraud (see bmj editorial announcing retraction of the Wakefield paper about causal relation beteen MMR vaccination [...]... Read more »

Gonon, F., Bezard, E., & Boraud, T. (2011) Misrepresentation of Neuroscience Data Might Give Rise to Misleading Conclusions in the Media: The Case of Attention Deficit Hyperactivity Disorder. PLoS ONE, 6(1). DOI: 10.1371/journal.pone.0014618

Ioannidis, J. (2005) Why Most Published Research Findings Are False. PLoS Medicine, 2(8). DOI: 10.1371/journal.pmed.0020124

Barbaresi, W., Katusic, S., Colligan, R., Weaver, A., & Jacobsen, S. (2007) Modifiers of Long-Term School Outcomes for Children with Attention-Deficit/Hyperactivity Disorder: Does Treatment with Stimulant Medication Make a Difference? Results from a Population-Based Study. Journal of Developmental , 28(4), 274-287. DOI: 10.1097/DBP.0b013e3180cabc28

GONON, F. (2009) The dopaminergic hypothesis of attention-deficit/hyperactivity disorder needs re-examining. Trends in Neurosciences, 32(1), 2-8. DOI: 10.1016/j.tins.2008.09.010

November 23, 2010
04:15 PM
495 views

Implementing Twitter in a Health Sciences Library

by Laika in Laika's Medliblog

Twitter describes itself as “a service for friends, family, and co-workers to communicate and stay connected through the exchange of quick, frequent answers to one simple question: What are you doing?” [2]. The “answers” are equally simple, because the tweet (that what is being “said”) must fit in 140 characters. The tweet does not only [...]... Read more »

Cuddy, C., Graham, J., & Morton-Owens, E. (2010) Implementing Twitter in a Health Sciences Library. Medical Reference Services Quarterly, 29(4), 320-330. DOI: 10.1080/02763869.2010.518915

October 6, 2010
03:45 PM
546 views

How will we ever keep up with 75 Trials and 11 Systematic Reviews a Day?

by Laika in Laika's Medliblog

An interesting paper was published in PLOS Medicine [1]. As an information specialist and working part time for the Cochrane Collaboration* (see below), this topic is close to my heart. The paper, published in PLOS Medicine is written by Hilda Bastian and two of my favorite EBM devotees ànd critics, Paul Glasziou and Iain Chalmers. Their article gives [...]... Read more »

Bastian, H., Glasziou, P., & Chalmers, I. (2010) Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up?. PLoS Medicine, 7(9). DOI: 10.1371/journal.pmed.1000326

September 28, 2010
06:38 PM
467 views

A Filter for Finding “All Studies on Animal Experimentation in PubMed”

by Laika in Laika's Medliblog

For an introduction to search filters you can first read this post. Most people searching PubMed try to get rid of publications about animals. But basic scientists and lab animal technicians just want to find those animal studies. PubMed has built-in filters for that: the limits. There is a limit for “humans” and a limit for “animals”. [...]... Read more »

Hooijmans CR, Tillema A, Leenaars M, & Ritskes-Hoitinga M. (2010) Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed. Laboratory animals, 44(3), 170-5. PMID: 20551243

August 29, 2010
11:32 PM
538 views

Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.

by Laika in Laika's Medliblog

The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week [1]. The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors [2], because it contradicted [...]... Read more »

Lo SC, Pripuzova N, Li B, Komaroff AL, Hung GC, Wang R, & Alter HJ. (2010) Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors. Proceedings of the National Academy of Sciences of the United States of America. PMID: 20798047

Erlwein, O., Kaye, S., McClure, M., Weber, J., Wills, G., Collier, D., Wessely, S., & Cleare, A. (2010) Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008519

Groom, H., Boucherit, V., Makinson, K., Randal, E., Baptista, S., Hagan, S., Gow, J., Mattes, F., Breuer, J., Kerr, J.... (2010) Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome. Retrovirology, 7(1), 10. DOI: 10.1186/1742-4690-7-10

van Kuppeveld, F., Jong, A., Lanke, K., Verhaegh, G., Melchers, W., Swanink, C., Bleijenberg, G., Netea, M., Galama, J., & van der Meer, J. (2010) Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort. BMJ, 340(feb25 1). DOI: 10.1136/bmj.c1018

McClure, M., & Wessely, S. (2010) Chronic fatigue syndrome and human retrovirus XMRV. BMJ, 340(feb25 1). DOI: 10.1136/bmj.c1099

Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B.... (2009) Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science (New York, N.Y.), 326(5952), 585-9. PMID: 19815723

Enserink M. (2010) Chronic fatigue syndrome. New XMRV paper looks good, skeptics admit--yet doubts linger. Science (New York, N.Y.), 329(5995), 1000. PMID: 20798285

August 8, 2010
12:52 PM
529 views

Collaborating and Delivering Literature Search Results to Clinical Teams Using Web 2.0 Tools

by Laika in Laika's Medliblog

There seem to be two camps in the library, the medical and many other worlds: those who embrace Web 2.0, because they consider it useful for their practice and those who are unaware of Web 2.0 or think it is just a fad. There are only a few ways the Web 2.0-critical people can be convinced: by [...]... Read more »

Damani S, & Fulton S. (2010) Collaborating and delivering literature search results to clinical teams using web 2.0 tools. Medical reference services quarterly, 29(3), 207-17. PMID: 20677061

June 22, 2010
06:07 PM
611 views

Will Nano-Publications & Triplets Replace The Classic Journal Articles?

by Laika in Laika's Medliblog

“Libraries and journals articles as we know them will cease to exists” said Barend Mons at the symposium in honor of our Library 25th Anniversary (June 3rd). “Possibly we will have another kind of party in another 25 years”…. he continued, grinning. What he had to say the next half hour intrigued me. And although [...]... Read more »

van Haagen HH, 't Hoen PA, Botelho Bovo A, de Morrée A, van Mulligen EM, Chichester C, Kors JA, den Dunnen JT, van Ommen GJ, van der Maarel SM.... (2009) Novel protein-protein interactions inferred from literature context. PloS one, 4(11). PMID: 19924298

June 8, 2010
11:45 AM
732 views

PubMed versus Google Scholar for Retrieving Evidence

by Laika in Laika's Medliblog

A while ago a resident in dermatology told me she got many hits out of PubMed, but zero results out of TRIP. It appeared she had used the same search for both databases: alopecea areata and diphenciprone (a drug with a lot of synonyms). Searching TRIP for alopecea (in the title) only, we found a Cochrane [...]... Read more »

Anders ME, & Evans DP. (2010) Comparison of PubMed and Google Scholar Literature Searches. Respiratory care, 55(5), 578-83. PMID: 20420728

May 11, 2010
01:18 PM
623 views

What One Short Night’s Sleep does to your Glucose Metabolism

by Laika in Laika's Medliblog

As a blogger I regularly sleep 3-5 hours just to finish a post. I know that this has its effects on how I feel the next day. I also know short nights don’t promote my clear-headedness and I also recognize short-term effects on memory, cognitive functions, reaction time and mood (irritability), as depicted in the [...]... Read more »

Donga E, van Dijk M, van Dijk JG, Biermasz NR, Lammers GJ, van Kralingen KW, Corssmit EP, & Romijn JA. (2010) A Single Night of Partial Sleep Deprivation Induces Insulin Resistance in Multiple Metabolic Pathways in Healthy Subjects. The Journal of clinical endocrinology and metabolism. PMID: 20371664

Donga E, van Dijk M, van Dijk JG, Biermasz NR, Lammers GJ, van Kralingen K, Hoogma RP, Corssmit EP, & Romijn JA. (2010) Partial sleep restriction decreases insulin sensitivity in type 1 diabetes. Diabetes care. PMID: 20357381

Nielsen LS, Danielsen KV, & Sørensen TI. (2010) Short sleep duration as a possible cause of obesity: critical analysis of the epidemiological evidence. Obesity reviews : an official journal of the International Association for the Study of Obesity. PMID: 20345429

Monasta L, Batty GD, Cattaneo A, Lutje V, Ronfani L, van Lenthe FJ, & Brug J. (2010) Early-life determinants of overweight and obesity: a review of systematic reviews. Obesity reviews : an official journal of the International Association for the Study of Obesity. PMID: 20331509

Cappuccio FP, D'Elia L, Strazzullo P, & Miller MA. (2010) Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes care, 33(2), 414-20. PMID: 19910503

April 27, 2010
12:45 PM
508 views

Three Studies Now Refute the Presence of XMRV in Chronic Fatigue Syndrome (CFS)

by Laika in Laika's Medliblog

.“Removing the doubt is part of the cure” (RedLabs) Two months ago I wrote about two contradictory studies on the presence of the novel XMRV retrovirus in blood of patients with Chronic Fatigue Syndrome (CFS). The first study, published in autumn last year by investigators of the Whittemore Peterson Institute (WPI) in the USA [1], [...]... Read more »

Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B.... (2009) Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science (New York, N.Y.), 326(5952), 585-9. PMID: 19815723

Erlwein, O., Kaye, S., McClure, M., Weber, J., Wills, G., Collier, D., Wessely, S., & Cleare, A. (2010) Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008519

van Kuppeveld, F., Jong, A., Lanke, K., Verhaegh, G., Melchers, W., Swanink, C., Bleijenberg, G., Netea, M., Galama, J., & van der Meer, J. (2010) Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort. BMJ, 340(feb25 1). DOI: 10.1136/bmj.c1018

McClure, M., & Wessely, S. (2010) Chronic fatigue syndrome and human retrovirus XMRV. BMJ, 340(feb25 1). DOI: 10.1136/bmj.c1099

April 10, 2010
10:03 AM
615 views

Irreversible Effects of Previous Cortisol Excess on Cognitive Functions in Cushing’s Disease

by Laika in Laika's Medliblog

April 8th is Cushing’s Awareness Day. This day has been chosen as a day of awareness as it is the birthday of Dr. Harvey Cushing, a neurosurgeon, who discovered this illness.
Cushing’s disease is a rare hormone disease caused by prolonged exposure to high levels of the stress hormone cortisol in the blood, whereas Addison’s disease [...]... Read more »

Tiemensma J, Kokshoorn NE, Biermasz NR, Keijser BJ, Wassenaar MJ, Middelkoop HA, Pereira AM, & Romijn JA. (2010) Subtle Cognitive Impairments in Patients with Long-Term Cure of Cushing's Disease. The Journal of clinical endocrinology and metabolism. PMID: 20371667

Patil CG, Lad SP, Katznelson L, & Laws ER Jr. (2007) Brain atrophy and cognitive deficits in Cushing's disease. Neurosurgical focus, 23(3). PMID: 17961025

March 14, 2010
07:59 AM
676 views

Sugar-Sweetened Beverages, Diet Coke & Health. Part I.

by Laika in Laika's Medliblog

At Medical and Technology of Joseph Kim, the upcoming Grand Rounds host, I saw the blog post “Need your help on Facebook to get Diet Coke to Donate $50,000 to the Foundation for NIH”.
National Heart Lung and Blood Institute has started a national campaign in the US, The Heart Truth®. They issued a challenge in [...]... Read more »

Litsa K Lambrakos, Pamela Coxson, Lee Goldman, Kirsten Bibbins-Domingo. (2010) Sugar-Sweetened Beverage Consumption and the Attributable Burden to Diabetes and Coronary Heart Disease. Circulation. info:other/

Malik VS, Schulze MB, & Hu FB. (2006) Intake of sugar-sweetened beverages and weight gain: a systematic review. The American journal of clinical nutrition, 84(2), 274-88. PMID: 16895873

Wolff E, & Dansinger ML. (2008) Soft drinks and weight gain: how strong is the link?. Medscape journal of medicine, 10(8), 189. PMID: 18924641

Forshee RA, Anderson PA, & Storey ML. (2008) Sugar-sweetened beverages and body mass index in children and adolescents: a meta-analysis. The American journal of clinical nutrition, 87(6), 1662-71. PMID: 18541554

Gibson S. (2008) Sugar-sweetened soft drinks and obesity: a systematic review of the evidence from observational studies and interventions. Nutrition research reviews, 21(2), 134-47. PMID: 19087367

Janssen I, Katzmarzyk PT, Boyce WF, Vereecken C, Mulvihill C, Roberts C, Currie C, Pickett W, & Health Behaviour in School-Aged Children Obesity Working Group. (2005) Comparison of overweight and obesity prevalence in school-aged youth from 34 countries and their relationships with physical activity and dietary patterns. Obesity reviews : an official journal of the International Association for the Study of Obesity, 6(2), 123-32. PMID: 15836463

February 15, 2010
04:00 AM
616 views

Finally a Viral Cause of Chronic Fatigue Syndrome? Or Not? – How Results Can Vary and Depend on Multiple Factors

by Laika Spoetnik in Laika's Medliblog

Last week @F1000 (on Twitter) alerted me to an interesting discussion at F1000 on a paper in Science, that linked Chronic fatigue syndrome (CFS) to a newly discovered human virus XRMV [1. This finding was recently disputed by another study in PLOS [2], ... Read more »

Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B.... (2009) Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science (New York, N.Y.), 326(5952), 585-9. PMID: 19815723

Erlwein, O., Kaye, S., McClure, M., Weber, J., Wills, G., Collier, D., Wessely, S., & Cleare, A. (2010) Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008519

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