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- July 25, 2010
- 08:50 PM
- 529 views
On individuality, stochasticity and buffering
by Pablo Astudillo in astu's science blog
One of the most exciting fields opened in the last years is the new understanding of the existence of something that we could call as “biological heterogeneity”. This new field of study is focused in observing and understanding the differences between reactions of a same kind, between cells of a same kind, and ultimately, between [...]... Read more »
Altschuler, S., & Wu, L. (2010) Cellular Heterogeneity: Do Differences Make a Difference?. Cell, 141(4), 559-563. DOI: 10.1016/j.cell.2010.04.033
Huang, S. (2009) Non-genetic heterogeneity of cells in development: more than just noise. Development, 136(23), 3853-3862. DOI: 10.1242/dev.035139
Raj, A., & Vanoudenaarden, A. (2008) Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences. Cell, 135(2), 216-226. DOI: 10.1016/j.cell.2008.09.050
Samoilov, M., Price, G., & Arkin, A. (2006) From Fluctuations to Phenotypes: The Physiology of Noise. Science's STKE, 2006(366). DOI: 10.1126/stke.3662006re17
Novick, A. (1957) Enzyme Induction as an All-or-None Phenomenon. Proceedings of the National Academy of Sciences, 43(7), 553-566. DOI: 10.1073/pnas.43.7.553
Zernicka-Goetz, M., Morris, S., & Bruce, A. (2009) Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo. Nature Reviews Genetics, 10(7), 467-477. DOI: 10.1038/nrg2564
Goentoro, L., & Kirschner, M. (2009) Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling. Molecular Cell, 36(5), 872-884. DOI: 10.1016/j.molcel.2009.11.017
Goentoro, L., Shoval, O., Kirschner, M., & Alon, U. (2009) The Incoherent Feedforward Loop Can Provide Fold-Change Detection in Gene Regulation. Molecular Cell, 36(5), 894-899. DOI: 10.1016/j.molcel.2009.11.018
Gujral TS, & MacBeath G. (2010) A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation. PloS one, 5(4). PMID: 20383323
Johnston Jr., R., & Desplan, C. (2010) A Penetrating Look at Stochasticity in Development. Cell, 140(5), 610-612. DOI: 10.1016/j.cell.2010.02.018
Raj, A., Rifkin, S., Andersen, E., & van Oudenaarden, A. (2010) Variability in gene expression underlies incomplete penetrance. Nature, 463(7283), 913-918. DOI: 10.1038/nature08781
- July 12, 2010
- 01:35 AM
- 488 views
Global Biodiversity Indicators at-a-glance
by Pablo Astudillo in astu's science blog
I really wanted to talk about this article before. A few weeks ago, it was published in Science a work by an extensive work by a high number of researchers, focused in the review and discussion of indicators of global indicators of biodiversity. Citing the article, in 2002 world leaders committed, through the Convention on [...]... Read more »
Butchart, S., Walpole, M., Collen, B., van Strien, A., Scharlemann, J., Almond, R., Baillie, J., Bomhard, B., Brown, C., Bruno, J.... (2010) Global Biodiversity: Indicators of Recent Declines. Science, 328(5982), 1164-1168. DOI: 10.1126/science.1187512
Secretariat of the Convention on Biological Diversity (2010) Global Biodiversity Outlook 3., & Montréal, 94 pages. (2010) Global Biodiversity Outlook 3. Convention on Biological Diversity. info:other/
- March 15, 2010
- 09:03 PM
- 588 views
The Red Queen hypothesis in a glass
by Pablo Astudillo in astu's science blog
What factors predominate in evolution? In daily life, the constant evolution of our lives is influenced by our conditions and by external factors. If I want to build a house with my own hands, I have to consider my abilities, some of which are genetic (I am small, thin and I am not strong, so [...]... Read more »
Benton MJ. (2009) The Red Queen and the Court Jester: species diversity and the role of biotic and abiotic factors through time. Science (New York, N.Y.), 323(5915), 728-32. PMID: 19197051
Paterson S, Vogwill T, Buckling A, Benmayor R, Spiers AJ, Thomson NR, Quail M, Smith F, Walker D, Libberton B.... (2010) Antagonistic coevolution accelerates molecular evolution. Nature, 464(7286), 275-8. PMID: 20182425
Falush D. (2009) Toward the use of genomics to study microevolutionary change in bacteria. PLoS genetics, 5(10). PMID: 19855823
- March 7, 2010
- 09:39 PM
- 648 views
Milk, Prions and Evolution
by Pablo Astudillo in astu's science blog
Prion protein (PrP) is the focus of some neurodegenerative diseases. It is believed that misfolded prion protein (PrPsc, or “scrapie”) is the infectious agent responsible for bovine spongiform encephalopathy (BSE), and Creutzfeldt-Jacob disease (CJD), among others. PrPsc propagates by conversion of normal (healthy) prion protein (PrPc).
Several questions arise in the research community. Two of [...]... Read more »
Didier A, Gebert R, Dietrich R, Schweiger M, Gareis M, Märtlbauer E, & Amselgruber WM. (2008) Cellular prion protein in mammary gland and milk fractions of domestic ruminants. Biochemical and biophysical research communications, 369(3), 841-4. PMID: 18325321
Konold T, Moore SJ, Bellworthy SJ, & Simmons HA. (2008) Evidence of scrapie transmission via milk. BMC veterinary research, 14. PMID: 18397513
Supattapone S. (2010) Biochemistry. What makes a prion infectious?. Science (New York, N.Y.), 327(5969), 1091-2. PMID: 20185716
Li J, Browning S, Mahal SP, Oelschlegel AM, & Weissmann C. (2010) Darwinian evolution of prions in cell culture. Science (New York, N.Y.), 327(5967), 869-72. PMID: 20044542
- March 3, 2010
- 11:38 PM
- 640 views
Science predicted the Chile’s Earthquake
by Pablo Astudillo in astu's science blog
I am finally back, repairing some of the damages in our labs. The situation in Chile is not good. The deaths are raising slowly, but continoulsy, over 800 people now. Also, some data regarding thousands of missing people is also of great concern.
Regarding to science, several laboratories have reported serious damages, including lost of data, [...]... Read more »
Ruegg, J., Rudloff, A., Vigny, C., Madariaga, R., de Chabalier, J., Campos, J., Kausel, E., Barrientos, S., & Dimitrov, D. (2009) Interseismic strain accumulation measured by GPS in the seismic gap between Constitución and Concepción in Chile. Physics of the Earth and Planetary Interiors, 175(1-2), 78-85. DOI: 10.1016/j.pepi.2008.02.015
Richard A. Kerr. (2010) Did Darwin Help Predict Chilean Quake?. Science Now. info:/
- August 26, 2009
- 10:41 AM
- 883 views
The ring of life
by Pablo Astudillo in astu's science blog
I was really surprised, due to my lack of knowledge in too many areas of life sciences, that our history, the history of all species, from bacterias to humans, it is not like a tree. Usually we think about evolution as a tree, where some species have developed and give rise to a new, improved [...]... Read more »
Lake JA. (2009) Evidence for an early prokaryotic endosymbiosis. Nature, 460(7258), 967-71. PMID: 19693078
Rivera MC, & Lake JA. (2004) The ring of life provides evidence for a genome fusion origin of eukaryotes. Nature, 431(7005), 152-5. PMID: 15356622
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